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Volumn 129, Issue 3, 2011, Pages 819-827

A phase II neoadjuvant trial of anastrozole, fulvestrant, and gefitinib in patients with newly diagnosed estrogen receptor positive breast cancer

Author keywords

Breast cancer; EGFR; Endocrine resistance; Estrogen receptor; Proliferation

Indexed keywords

ANASTROZOLE; CYCLIN D1; ESTROGEN RECEPTOR; FULVESTRANT; GEFITINIB; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROGESTERONE RECEPTOR; PROTEIN BCL 2; PROTEIN KINASE B;

EID: 80052602648     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1679-8     Document Type: Article
Times cited : (28)

References (38)
  • 1
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • DOI 10.1016/S0140-6736(05)66544-0, PII S0140673605665440
    • EBCTCG 2005 Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials Lancet 365 1687 1717 10.1016/S0140-6736(05)66544-0 (Pubitemid 40719106)
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 5
    • 0034607235 scopus 로고    scopus 로고
    • Tumor characteristics and clinical outcome of elderly women with breast cancer
    • S Diab R Elledge G Clark 2000 Tumor characteristics and clinical outcome of elderly women with breast cancer J Natl Cancer Inst 92 7 550 556 10749910 10.1093/jnci/92.7.550 1:STN:280:DC%2BD3c3hsFSgsg%3D%3D (Pubitemid 30212316)
    • (2000) Journal of the National Cancer Institute , vol.92 , Issue.7 , pp. 550-556
    • Diab, S.G.1    Elledge, R.M.2    Clark, G.M.3
  • 7
    • 0032974601 scopus 로고    scopus 로고
    • Aromatase inhibitors in relation to other forms of endocrine therapy for breast cancer
    • DOI 10.1677/erc.0.0060271
    • CK Osborne 1999 Aromatase inhibitors in relation to other forms of endocrine therapy for breast cancer Endocr Relat Cancer 6 2 271 276 10731120 10.1677/erc.0.0060271 1:CAS:528:DyaK1MXktVygtbc%3D (Pubitemid 29260063)
    • (1999) Endocrine-Related Cancer , vol.6 , Issue.2 , pp. 271-276
    • Osborne, C.K.1
  • 8
    • 1842684035 scopus 로고    scopus 로고
    • Fulvestrant: An oestrogen receptor antagonist with a novel mechanism of action
    • DOI 10.1038/sj.bjc.6601629
    • C Osborne A Wakeling R Nicholson 2004 Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action Br J Cancer 90 Suppl 1 S2 S6 15094757 10.1038/sj.bjc.6601629 1:CAS:528:DC%2BD2cXjtFaktbY%3D (Pubitemid 38482618)
    • (2004) British Journal of Cancer , vol.90 , Issue.SUPPL. 1
    • Osborne, C.K.1    Wakeling, A.2    Nicholson, R.I.3
  • 9
    • 0035664709 scopus 로고    scopus 로고
    • Neoadjuvant endocrine therapy for breast cancer: Medical perspectives
    • MJ Ellis 2001 Neoadjuvant endocrine therapy for breast cancer: medical perspectives Clin Cancer Res 7 12 Suppl 4388s 4391s 11916229 1:CAS:528:DC%2BD38Xltlyjuw%3D%3D discussion 4411s-4412s (Pubitemid 34031584)
    • (2001) Clinical Cancer Research , vol.7 , Issue.12 SUPPL.
    • Ellis, M.J.1    Goss, P.2
  • 10
    • 24644490871 scopus 로고    scopus 로고
    • Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: The Immediate Preoperative Anastrozole, Tamoxifen, or Combined With Tamoxifen (IMPACT) multicenter double-blind randomized trial
    • DOI 10.1200/JCO.2005.04.005
    • IE Smith M Dowsett SR Ebbs JM Dixon A Skene J-U Blohmer SE Ashley S Francis I Boeddinghaus G Walsh 2005 Neoadjuvant treatment of postmenopausal breast cancer patients with anastrozole, tamoxifen, or both in combination: the immediate preoperative anastrozole, tamoxifen, or combined with tamoxifen (IMPACT) multicenter double-blind randomized trial J Clin Oncol 23 22 5108 5116 15998903 10.1200/JCO.2005.04.005 1:CAS:528:DC%2BD2MXpsFWmtLY%3D (Pubitemid 46224019)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.22 , pp. 5108-5116
    • Smith, I.E.1    Dowsett, M.2    Ebbs, S.R.3    Dixon, J.M.4    Skene, A.5    Blohmer, J.-U.6    Ashley, S.E.7    Francis, S.8    Boeddinghaus, I.9    Walsh, G.10
  • 11
    • 33748068094 scopus 로고    scopus 로고
    • Mechanisms of tumor regression and resistance to estrogen deprivation and fulvestrant in a model of estrogen receptor-positive, HER-2/neu-positive breast cancer
    • DOI 10.1158/0008-5472.CAN-05-4045
    • S Massarweh CK Osborne S Jiang AE Wakeling M Rimawi SK Mohsin S Hilsenbeck R Schiff 2006 Mechanisms of tumor regression and resistance to estrogen deprivation and fulvestrant in a model of estrogen receptor-positive, HER-2/neu-positive breast cancer Cancer Res 66 16 8266 8273 16912207 10.1158/0008-5472.CAN-05-4045 1:CAS:528:DC%2BD28XotFWqurs%3D (Pubitemid 44299196)
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 8266-8273
    • Massarweh, S.1    Osborne, C.K.2    Jiang, S.3    Wakeling, A.E.4    Rimawi, M.5    Mohsin, S.K.6    Hilsenbeck, S.7    Schiff, R.8
  • 12
    • 80052563678 scopus 로고    scopus 로고
    • Estrogen deprivation is crucial for the antitumor effect of fulvestrant and adding the HER inhibitor gefitinib delays acquired resistance in a xenograft model of ER-positive breast cancer. Breast Cancer Res and Treat
    • Abstract # 2090
    • Massarweh S, Osborne CK, Weiss H, Schiff R (2007) Estrogen deprivation is crucial for the antitumor effect of fulvestrant and adding the HER inhibitor gefitinib delays acquired resistance in a xenograft model of ER-positive breast cancer. Breast Cancer Res and Treat.In: Proceedings of the 30th Annual SAN ANTONIO BREAST SYMPOSIUM-December 2007, 106 (Supplement 1):Abstract # 2090, S2115
    • (2007) Proceedings of the 30th Annual SAN ANTONIO BREAST SYMPOSIUM-December 2007 , vol.106 , Issue.SUPPL. 1
    • Massarweh, S.1    Osborne, C.K.2    Weiss, H.3    Schiff, R.4
  • 13
    • 0028142049 scopus 로고
    • p53 protein accumulation detected by five different antibodies: Relationship to prognosis and heat shock protein 70 in breast cancer
    • RM Elledge GM Clark SAW Fuqua Y-Y Yu DC Allred 1994 p53 Protein accumulation detected by five different antibodies: relationship to prognosis and heat shock protein 70 in breast cancer Cancer Res 54 14 3752 3757 8033095 1:STN:280:DyaK2czgs1ersw%3D%3D (Pubitemid 24241192)
    • (1994) Cancer Research , vol.54 , Issue.14 , pp. 3752-3757
    • Elledge, R.M.1    Clark, G.M.2    Fuqua, S.A.W.3    Yu, Y.-Y.4    Allred, D.C.5
  • 14
    • 0035884620 scopus 로고    scopus 로고
    • Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a phase III randomized trial
    • MJ Ellis A Coop B Singh L Mauriac A Llombert-Cussac F Janicke WR Miller DB Evans M Dugan C Brady, et al. 2001 Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial J Clin Oncol 19 18 3808 3816 11559718 1:CAS:528:DC%2BD3MXnsVKqsbo%3D (Pubitemid 32880059)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.18 , pp. 3808-3816
    • Ellis, M.J.1    Coop, A.2    Singh, B.3    Mauriac, L.4    Llombert-Cussac, A.5    Janicke, F.6    Miller, W.R.7    Evans, D.B.8    Dugan, M.9    Brady, C.10    Quebe-Fehling, E.11    Borgs, M.12
  • 15
    • 0035793042 scopus 로고    scopus 로고
    • Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection
    • DOI 10.1073/pnas.011404098
    • C Li WH Wong 2001 Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection PNAS 98 1 31 36 11134512 10.1073/pnas.011404098 1:CAS:528:DC%2BD3MXkslKnuw%3D%3D (Pubitemid 32095858)
    • (2001) Proceedings of the National Academy of Sciences of the United States of America , vol.98 , Issue.1 , pp. 31-36
    • Li, C.1    Wong, W.H.2
  • 16
    • 0001677717 scopus 로고
    • Controlling the false discovery rate-a practical and powerful approach to multiple testing
    • Y Benjamini Y Hochberg 1995 Controlling the false discovery rate-a practical and powerful approach to multiple testing J R Stat Soc Ser B Methodol 57 1 289 300
    • (1995) J R Stat Soc ser B Methodol , vol.57 , Issue.1 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 17
    • 3142673366 scopus 로고    scopus 로고
    • Using the gene ontology for microarray data mining: A comparison of methods and application to age effects in human prefrontal cortex
    • DOI 10.1023/B:NERE.0000023608.29741.45
    • P Pavlidis J Qin V Arango JJ Mann E Sibille 2004 Using the gene ontology for microarray data mining: a comparison of methods and application to age effects in human prefrontal cortex Neurochem Res 29 6 1213 1222 15176478 10.1023/B:NERE.0000023608.29741.45 1:CAS:528:DC%2BD2cXjtVWmtLY%3D (Pubitemid 39023495)
    • (2004) Neurochemical Research , vol.29 , Issue.6 , pp. 1213-1222
    • Pavlidis, P.1    Qin, J.2    Arango, V.3    Mann, J.J.4    Sibille, E.5
  • 19
    • 0033834513 scopus 로고    scopus 로고
    • Molecular markers for predicting response to tamoxifen in breast cancer patients
    • 11051041 10.1385/ENDO:13:1:1 1:CAS:528:DC%2BD3cXms1ygurg%3D
    • DR Ciocca R Elledge 2000 Molecular markers for predicting response to tamoxifen in breast cancer patients Endocrine 13 1 1 10 11051041 10.1385/ENDO:13:1:1 1:CAS:528:DC%2BD3cXms1ygurg%3D
    • (2000) Endocrine , vol.13 , Issue.1 , pp. 1-10
    • Ciocca, D.R.1    Elledge, R.2
  • 21
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: Increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    • J Shou S Massarweh C Osborne A Wakeling S Ali H Weiss R Schiff 2004 Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer J Natl Cancer Inst 96 12 926 935 15199112 10.1093/jnci/djh166 1:CAS:528:DC%2BD2cXltVWmtLY%3D (Pubitemid 38868139)
    • (2004) Journal of the National Cancer Institute , vol.96 , Issue.12 , pp. 926-935
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3    Wakeling, A.E.4    Ali, S.5    Weiss, H.6    Schiff, R.7
  • 22
    • 78049505385 scopus 로고    scopus 로고
    • Insights into the place of fulvestrant for the treatment of advanced endocrine responsive breast cancer
    • 20855842 10.1200/JCO.2010.30.6266 1:CAS:528:DC%2BC3cXhsFaitL7L
    • A Howell J Bergh 2010 Insights into the place of fulvestrant for the treatment of advanced endocrine responsive breast cancer J Clin Oncol 28 30 4548 4550 20855842 10.1200/JCO.2010.30.6266 1:CAS:528:DC%2BC3cXhsFaitL7L
    • (2010) J Clin Oncol , vol.28 , Issue.30 , pp. 4548-4550
    • Howell, A.1    Bergh, J.2
  • 23
    • 33846965616 scopus 로고    scopus 로고
    • Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer
    • 17228000 10.1093/jnci/djk020 1:CAS:528:DC%2BD2sXhvVOhtbc%3D
    • M Dowsett IE Smith SR Ebbs JM Dixon A Skene R A'Hern J Salter S Detre M Hills G Walsh 2007 Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer J Natl Cancer Inst 99 2 167 170 17228000 10.1093/jnci/djk020 1:CAS:528:DC%2BD2sXhvVOhtbc%3D
    • (2007) J Natl Cancer Inst , vol.99 , Issue.2 , pp. 167-170
    • Dowsett, M.1    Smith, I.E.2    Ebbs, S.R.3    Dixon, J.M.4    Skene, A.5    A'Hern, R.6    Salter, J.7    Detre, S.8    Hills, M.9    Walsh, G.10
  • 24
    • 0034458854 scopus 로고    scopus 로고
    • Regulation of the functional interaction between cyclin D1 and the estrogen receptor
    • DOI 10.1128/MCB.20.23.8667-8675.2000
    • J Lamb MH Ladha C McMahon RL Sutherland ME Ewen 2000 Regulation of the functional interaction between cyclin D1 and the estrogen receptor Mol Cell Biol 20 23 8667 8675 11073968 10.1128/MCB.20.23.8667-8675.2000 1:CAS:528: DC%2BD3MXitFGkurY%3D (Pubitemid 32245900)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.23 , pp. 8667-8675
    • Lamb, J.1    Ladha, M.H.2    McMahon, C.3    Sutherland, R.L.4    Ewen, M.E.5
  • 25
    • 0038356604 scopus 로고    scopus 로고
    • EGFR, HER-2/neu, cyclin D1, p21 and p53 in correlation to cell proliferation and steroid hormone receptor status in ductal carcinoma in situ of the breast
    • DOI 10.1023/A:1023958324448
    • A Lebeau A Unholzer G Amann M Kronawitter I Bauerfeind A Sendelhofert A Iff U Lohrs 2003 EGFR, HER-2/neu, cyclin D1, p21, and p53 in correlation to cell proliferation and steroid hormone receptor status in ductal carcinoma in situ of the breast Breast Cancer Res Treat 79 2 187 198 12825853 10.1023/A: 1023958324448 1:CAS:528:DC%2BD3sXktV2quro%3D (Pubitemid 36649168)
    • (2003) Breast Cancer Research and Treatment , vol.79 , Issue.2 , pp. 187-198
    • Lebeau, A.1    Unholzer, A.2    Amann, G.3    Kronawitter, M.4    Bauerfeind, I.5    Sendelhofert, A.6    Iff, A.7    Lohrs, U.8
  • 26
    • 33845786458 scopus 로고    scopus 로고
    • Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells
    • DOI 10.1158/0008-5472.CAN-06-1755
    • RL Kilker MD Planas-Silva 2006 Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells Cancer Res 66 23 11478 11484 17145896 10.1158/0008-5472.CAN-06-1755 1:CAS:528: DC%2BD28Xht1KnsLrP (Pubitemid 46009981)
    • (2006) Cancer Research , vol.66 , Issue.23 , pp. 11478-11484
    • Kilker, R.L.1    Planas-Silva, M.D.2
  • 29
    • 77149162377 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes
    • 20082448 10.1002/cncr.24816
    • MF Rimawi PB Shetty HL Weiss R Schiff CK Osborne GC Chamness RM Elledge 2010 Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes Cancer 116 5 1234 1242 20082448 10.1002/cncr.24816
    • (2010) Cancer , vol.116 , Issue.5 , pp. 1234-1242
    • Rimawi, M.F.1    Shetty, P.B.2    Weiss, H.L.3    Schiff, R.4    Osborne, C.K.5    Chamness, G.C.6    Elledge, R.M.7
  • 30
    • 33846869263 scopus 로고    scopus 로고
    • Resistance to endocrine therapy in breast cancer: Exploiting estrogen receptor/growth factor signaling crosstalk
    • DOI 10.1677/erc.1.01273
    • S Massarweh R Schiff 2006 Resistance to endocrine therapy in breast cancer: exploiting estrogen receptor/growth factor signaling crosstalk Endocr Relat Cancer 13 Suppl 1 S15 S24 17259554 10.1677/erc.1.01273 1:CAS:528:DC%2BD2sXivF2mtLk%3D (Pubitemid 46219245)
    • (2006) Endocrine-Related Cancer , vol.13 , Issue.SUPPL. 1
    • Massarweh, S.1    Schiff, R.2
  • 31
    • 19944408390 scopus 로고    scopus 로고
    • Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor- positive primary breast cancer: A double-blind placebo-controlled phase II randomised trial
    • DOI 10.1016/S1470-2045(05)70176-5, PII S1470204505701765
    • A Polychronis HD Sinnett D Hadjiminas H Singhal JL Mansi D Shivapatham S Shousha J Jiang D Peston N Barrett, et al. 2005 Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial Lancet Oncol 6 6 383 391 15925816 10.1016/S1470-2045(05)70176-5 1:CAS:528:DC%2BD2MXltFWktL0%3D (Pubitemid 40753744)
    • (2005) Lancet Oncology , vol.6 , Issue.6 , pp. 383-391
    • Polychronis, A.1    Sinnett, H.D.2    Hadjiminas, D.3    Singhal, H.4    Mansi, J.L.5    Shivapatham, D.6    Shousha, S.7    Jiang, J.8    Peston, D.9    Barrett, N.10    Vigushin, D.11    Morrison, K.12    Beresford, E.13    Ali, S.14    Slade, M.J.15    Coombes, R.C.16
  • 33
    • 77949754385 scopus 로고    scopus 로고
    • Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer
    • 20215537 10.1158/1078-0432.CCR-09-2282 1:CAS:528:DC%2BC3cXjtFyhurs%3D
    • M Cristofanilli V Valero A Mangalik M Royce I Rabinowitz FP Arena JF Kroener E Curcio C Watkins S Bacus, et al. 2010 Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer Clin Cancer Res 16 6 1904 1914 20215537 10.1158/1078-0432.CCR-09-2282 1:CAS:528:DC%2BC3cXjtFyhurs%3D
    • (2010) Clin Cancer Res , vol.16 , Issue.6 , pp. 1904-1914
    • Cristofanilli, M.1    Valero, V.2    Mangalik, A.3    Royce, M.4    Rabinowitz, I.5    Arena, F.P.6    Kroener, J.F.7    Curcio, E.8    Watkins, C.9    Bacus, S.10
  • 34
    • 79952259688 scopus 로고    scopus 로고
    • Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: A randomized phase II study
    • 21220480 10.1158/1078-0432.CCR-10-1869 1:CAS:528:DC%2BC3MXis1eitrk%3D
    • CK Osborne P Neven LY Dirix JR Mackey J Robert C Underhill R Schiff C Gutierrez I Migliaccio VK Anagnostou, et al. 2011 Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase II study Clin Cancer Res 17 5 1147 1159 21220480 10.1158/1078-0432.CCR-10-1869 1:CAS:528:DC%2BC3MXis1eitrk%3D
    • (2011) Clin Cancer Res , vol.17 , Issue.5 , pp. 1147-1159
    • Osborne, C.K.1    Neven, P.2    Dirix, L.Y.3    MacKey, J.R.4    Robert, J.5    Underhill, C.6    Schiff, R.7    Gutierrez, C.8    Migliaccio, I.9    Anagnostou, V.K.10
  • 35
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study
    • 19786670 10.1200/JCO.2008.20.6847 1:CAS:528:DC%2BC3cXhtVWit78%3D
    • B Kaufman JR Mackey MR Clemens PP Bapsy A Vaid A Wardley S Tjulandin M Jahn M Lehle A Feyereislova, et al. 2009 Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study J Clin Oncol 27 33 5529 5537 19786670 10.1200/JCO.2008.20.6847 1:CAS:528:DC%2BC3cXhtVWit78%3D
    • (2009) J Clin Oncol , vol.27 , Issue.33 , pp. 5529-5537
    • Kaufman, B.1    MacKey, J.R.2    Clemens, M.R.3    Bapsy, P.P.4    Vaid, A.5    Wardley, A.6    Tjulandin, S.7    Jahn, M.8    Lehle, M.9    Feyereislova, A.10
  • 36
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • 19786658 10.1200/JCO.2009.23.3734 1:CAS:528:DC%2BC3cXhtVWit7w%3D
    • S Johnston J Pippen Jr X Pivot M Lichinitser S Sadeghi V Dieras HL Gomez G Romieu A Manikhas MJ Kennedy, et al. 2009 Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer J Clin Oncol 27 33 5538 5546 19786658 10.1200/JCO.2009.23.3734 1:CAS:528:DC%2BC3cXhtVWit7w%3D
    • (2009) J Clin Oncol , vol.27 , Issue.33 , pp. 5538-5546
    • Johnston, S.1    Pippen Jr., J.2    Pivot, X.3    Lichinitser, M.4    Sadeghi, S.5    Dieras, V.6    Gomez, H.L.7    Romieu, G.8    Manikhas, A.9    Kennedy, M.J.10
  • 37
    • 37249069903 scopus 로고    scopus 로고
    • Reversal of the estrogen receptor-negative phenotype in breast cancer and restoration of antiestrogen response
    • DOI 10.1158/1078-0432.CCR-07-0587
    • J Bayliss A Hilger P Vishnu K Diehl D El-Ashry 2007 Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response Clin Cancer Res 13 23 7029 7036 18056179 10.1158/1078-0432.CCR-07-0587 1:CAS:528:DC%2BD2sXhtlyitL%2FM (Pubitemid 350276884)
    • (2007) Clinical Cancer Research , vol.13 , Issue.23 , pp. 7029-7036
    • Bayliss, J.1    Hilger, A.2    Vishnu, P.3    Diehl, K.4    El-Ashry, D.5
  • 38
    • 38849091433 scopus 로고    scopus 로고
    • Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function
    • DOI 10.1158/0008-5472.CAN-07-2707
    • S Massarweh CK Osborne CJ Creighton L Qin A Tsimelzon S Huang H Weiss M Rimawi R Schiff 2008 Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function Cancer Res 68 3 826 833 18245484 10.1158/0008-5472.CAN-07-2707 1:CAS:528:DC%2BD1cXhtlygtrY%3D (Pubitemid 351206760)
    • (2008) Cancer Research , vol.68 , Issue.3 , pp. 826-833
    • Massarweh, S.1    Osborne, C.K.2    Creighton, C.J.3    Qin, L.4    Tsimelzon, A.5    Huang, S.6    Weiss, H.7    Rimawi, M.8    Schiff, R.9


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