A cell factory of Bacillus subtilis engineered for the simple bioconversion of myo-inositol to scyllo-inositol, a potential therapeutic agent for Alzheimer's disease

Microbial Cell Factories

Volumn 10, Issue , 2011, Pages

  Yamaoka, Masaru ^a   Osawa, Shin ^a   Morinaga, Tetsuro ^b   Takenaka, Shinji ^a   Yoshida, Ken Ichi ^a  

^a KOBE UNIVERSITY   (Japan)

^b SYSMEX CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INOSITOL; SCYLLO INOSITOL; UNCLASSIFIED DRUG; SCYLLITOL;

ALZHEIMER DISEASE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL METABOLISM; BACTERIAL STRAIN; BIOENGINEERING; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CULTURE MEDIUM; NONHUMAN; STEREOISOMERISM; GENETIC ENGINEERING; GENETICS; HUMAN; METABOLISM; MUTATION;

BACILLUS SUBTILIS;

ALZHEIMER DISEASE; BACILLUS SUBTILIS; GENETIC ENGINEERING; HUMANS; INOSITOL; MUTATION; STEREOISOMERISM;

EID: 80052592484     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-10-69     Document Type: Article

References (26)

1. What is Alzheimer's disease?. , http://www.alzheimers.org.uk/site/scripts/documents_info.php?documentID=100
2. Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer's disease. Alzheimers Dement 2007, 3:186-191. 10.1016/j.jalz.2007.04.381, 19595937.
3. Irvine RF, Schell MJ. Back in the water: the return of the inositol phosphates. Nat Rev Mol Cell Biol 2001, 2:327-338.
4. Reddy NR, Sathe SK, Salunkhe DK. Phytates in legumes and cereals. Adv Food Res 1982, 28:1-92.
5. Larner J. D-chiro-inositol-its functional role in insulin action and its deficit in insulin resistance. Int J Exp Diabetes Res 2002, 3:47-60. 10.1080/15604280212528, 2478565, 11900279.
6. Nestler JE, Jakubowicz DJ, Reamer P, Gunn RD, Allan G. Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N Engl J Med 1999, 340:1314-1320. 10.1056/NEJM199904293401703, 10219066.
7. McLaurin J, Kierstead ME, Brown ME, Hawkes CA, Lambermon MH, Phinney AL, Darabie AA, Cousins JE, French JE, Lan MF, Chen F, Wong SS, Mount HT, Fraser PE, Westaway D, St George-Hyslop P. Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model. Nat Med 2006, 12:801-808. 10.1038/nm1423, 16767098.
8. Spector R. The transport and metabolism of scyllo-inositol in the central nervous system. J Neurochem 1978, 31:1113-1115. 10.1111/j.1471-4159.1978.tb00157.x, 702143.
9. Geylis V, Steinitz M. Immunotherapy of Alzheimer's disease (AD): from murine models to anti-amyloid beta (Abeta) human monoclonal antibodies. Autoimmun Rev 2006, 5:33-39. 10.1016/j.autrev.2005.06.007, 16338209.
10. McLaurin J, Golomb R, Jurewicz A, Antel JP, Fraser PE. Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta-induced toxicity. J Biol Chem 2000, 275:18495-18502. 10.1074/jbc.M906994199, 10764800.
11. Hawkes CA, Deng LH, Shaw JE, Nitz M, McLaurin J. Small molecule beta-amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer's disease. Eur J Neurosci 2010, 31:203-213. 10.1111/j.1460-9568.2009.07052.x, 20074226.
12. McLaurin J. Methods of preventing, treating and diagnosing disorders of protein aggregation. , http://www.freepatentsonline.com/7521481.pdf
13. Anti-Aβ Oligomer Headed for Phase 3 Clinical Trial. , http://www.alzforum.org/new/detail.asp?id=2530
14. Morinaga T, Ashida H, Yoshida K. Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis. Microbiology 2010, 156:1538-1546. 10.1099/mic.0.037499-0, 20133360.
15. Yoshida K, Aoyama D, Ishio I, Shibayama T, Fujita Y. Organization and transcription of the myo-inositol operon, iol, of Bacillus subtilis. J Bacteriol 1997, 179:4591-4598. 179296, 9226270.
16. Yoshida K, Yamaguchi M, Morinaga T, Ikeuchi M, Kinehara M, Ashida H. Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome. Appl Environ Microbiol 2006, 72:1310-1315. 10.1128/AEM.72.2.1310-1315.2006, 1392952, 16461681.
17. Yoshida K, Yamaguchi M, Ikeda H, Omae K, Tsurusaki K, Fujita Y. The fifth gene of the iol operon of Bacillus subtilis, iolE, encodes 2-keto-myo-inositol dehydratase. Microbiology 2004, 150:571-580. 10.1099/mic.0.26768-0, 14993306.
18. Yoshida K, Yamaguchi M, Morinaga T, Kinehara M, Ikeuchi M, Ashida H, Fujita Y. myo-Inositol catabolism in Bacillus subtilis. J Biol Chem 2008, 283:10415-10424. 10.1074/jbc.M708043200, 18310071.
19. Yoshida K, Shibayama T, Aoyama D, Fujita Y. Interaction of a repressor and its binding sites for regulation of the Bacillus subtilis iol divergon. J Mol Biol 1999, 285:917-929. 10.1006/jmbi.1998.2398, 9887260.
20. Hasunuma T, Sanda T, Yamada R, Yoshimura K, Ishii J, Kondo A. Metabolic pathway engineering based on metabolomics confers acetic and formic acid tolerance to a recombinant xylose-fermenting strain of Saccharomyces cerevisiae. Microb Cell Fact 2011, 10:2. 10.1186/1475-2859-10-2, 3025834, 21219616.
21. Hipps PP, Holland WH, Sherman WR. Interconversion of myo- and scyllo-inositol with simultaneous formation of neo-inositol by an NADP+ dependent epimerase from bovine brain. Biochem Biophys Res Commun 1977, 77:340-346. 10.1016/S0006-291X(77)80202-7, 19018.
22. Yamaguchi M, Kita Y, Mori T, Kanbe K, Tomoda A, Takahashi A, Ichikawa W. Method for producing scyllo-inositol, United States Patent US7745671. , http://www.freepatentsonline.com/7745671.pdf
23. Morinaga T, Matsuse T, Ashida H, Yoshida K. Differential substrate specificity of two inositol transporters of Bacillus subtilis. Biosci Biotechnol Biochem 2010, 74:1312-1314. 10.1271/bbb.100125, 20530884.
24. Yoshida K, Fujita Y, Ehrlich SD. Three asparagine synthetase genes of Bacillus subtilis. J Bacteriol 1999, 181:6081-6091. 103636, 10498721.
25. Sambrook J, Russell DW. Molecular Cloning: A Laboratory Manual 2001, Cold Spring Harbor, Cold Spring Harbor Press.
26. Vagner V, Dervyn E, Ehrlich SD. A vector for systematic gene inactivation in Bacillus subtilis. Microbiology 1998, 144:3097-3104. 10.1099/00221287-144-11-3097, 9846745.