Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5999-6002

  Teng, Heidi ^a   Thakur, Ganesh A ^a   Makriyannis, Alexandros ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Cannabinoid; CB2 selective; Partial agonist

Indexed keywords

3 (2 HYDROXYMETHYLINDANYL 4 OXY)PHENYL 4,4,4 TRIFLUORO 1 SULFONATE; AM 7526; AM 7528; AM 7535; AM 7536; AM 7585; BAY 38 7271; BAY 59 3074; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; DIBENZOFURAN DERIVATIVE; DRONABINOL; LIGAND; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; MOUSE; NONHUMAN; RAT;

ALKANESULFONATES; ANALGESICS; ANIMALS; BENZOFURANS; BENZOPYRANS; CHRONIC PAIN; COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; MICE; MOLECULAR CONFORMATION; MOLECULAR TARGETED THERAPY; NEURALGIA; NITRILES; PROTEIN BINDING; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 80052576087     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.017     Document Type: Article

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