Comparative biodistribution of 12 111In-labelled gastrin/CCK2 receptor-targeting peptides

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 38, Issue 8, 2011, Pages 1410-1416

  Laverman, Peter ^a   Joosten, Lieke ^a   Eek, Annemarie ^a   Roosenburg, Susan ^a   Peitl, Petra Kolenc ^b   Maina, Theodosia ^c   Mäcke, Helmut ^d   Aloj, Luigi ^e   Von Guggenber, Elisabeth ^f   Sosabowski, Jane K ^g   De Jong, Marion ^h   Reubi, Jean Claude ⁱ   Oyen, Wim J G ^a   Boerman, Otto C ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^c INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^d UNIVERSITY OF FREIBURG   (Germany)

^e NATIONAL CANCER INSTITUTE   (Italy)

^f INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^h ERASMUS MEDICAL CENTER   (Netherlands)

ⁱ UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cholecystokinin; DOTA; Gastrin; Tumour

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; GASTRIN RECEPTOR; INDIUM 111;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONJUGATION; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG UPTAKE; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY TUBULE ABSORPTION; MOUSE; NONHUMAN; RECEPTOR BINDING; SUBCUTANEOUS TISSUE TUMOR;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; FEMALE; HUMANS; INDIUM RADIOISOTOPES; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR IMAGING; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; RECEPTOR, CHOLECYSTOKININ B;

EID: 80052573912     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-011-1806-0     Document Type: Article

References (13)

1. Reubi JC, Schaer JC, Waser B. Cholecystokinin(CCK)-A and CCK-B/gastrin receptors in human tumors. Cancer Res. 1997;57 (7):1377-86. (Pubitemid 27152565)
2. Smeets RL, Fouraux MA, van Emst-de Vries SE, De Pont JJ, Willems PH. Protein kinase C-mediated inhibition of transmembrane signalling through CCK(A) and CCK(B) receptors. Br J Pharmacol. 1998;123(6):1189-97. (Pubitemid 28120518)
3. Aloj L, Caraco C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, et al. In vitro and in vivo evaluation of In-111-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging. J Nucl Med. 2004;45(3):485-94. (Pubitemid 47618625)
4. Laverman P, Behe M, Oyen WJ, Willems PH, Corstens FH, Behr TM, et al. Two technetium-99m-labeled cholecystokinin- 8 (CCK8) peptides for scintigraphic imaging of CCK receptors. Bioconjug Chem. 2004;15(3):561-8. (Pubitemid 38657862)
5. Roosenburg S, Laverman P, Joosten L, Eek A, Oyen WJ, De JM, et al. Stabilized 111In-labeled sCCK8 analogues for targeting CCK2-receptor positive tumors: Synthesis and evaluation. Bioconjug Chem. 2010;21(4):663-70.
6. Marsouvanidis PJ, Tatsi A, Nock BA, Krenning EP, Maina T, de Jong M. [111In]Sargastrin, a Gastrin I-based radioligand targeting CCK2-R-positive tumors in vivo (abstract). Eur J Nucl Med Mol Imaging. 2009;36 Suppl 2:S259.
7. Good S, Walter MA, Waser B, Wang X, Muller-Brand J, Behe MP, et al. Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours. Eur J Nucl Med Mol Imaging. 2008;35(10):1868-77.
8. Mather SJ, McKenzie AJ, Sosabowski JK, Morris TM, Ellison D, Watson SA. Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy. JNuclMed. 2007;48(4):615-22. (Pubitemid 47571419)
9. Sosabowski JK, Matzow T, Foster JM, Finucane C, Ellison D, Watson SA, et al. Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide. J Nucl Med. 2009;50 (12):2082-9.
10. von Guggenberg E, Sallegger W, Helbok A, Ocak M, King R, Mather SJ, et al. Cyclic minigastrin analogues for gastrin receptor scintigraphy with technetium-99m: Preclinical evaluation. J Med Chem. 2009;52(15):4786-93.
11. Dijkgraaf I, Kruijtzer JA, Liu S, Soede AC, Oyen WJ, Corstens FH, et al. Improved targeting of the alpha(v)beta(3) integrin by multimerisation of RGD peptides. Eur J Nucl Med Mol Imaging. 2007;34(2):267-73. (Pubitemid 46147510)
12. Vegt E, Eek A, Oyen WJ, De JM, Gotthardt M, Boerman OC. Albumin-derived peptides efficiently reduce renal uptake of radiolabelled peptides. Eur J NuclMedMol Imaging. 2010;37(2):226-34.
13. Béhé M, Kluge G, Becker W, Gotthardt M, Behr TM. Use of polyglutamic acids to reduce uptake of radiometal-labeled minigastrin in the kidneys. J Nucl Med. 2005;46(6):1012-5. (Pubitemid 43733517)