MicroRNAs: Their discovery, biogenesis, function and potential use as biomarkers in non-invasive prenatal diagnostics

International Journal of Molecular Epidemiology and Genetics

Volumn 2, Issue 3, 2011, Pages 253-260

  Ladomery, Michael R ^a   Maddocks, Deborah G ^a   Wilson, Ian D ^a  

^a UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

Author keywords

Circulating nucleic acids; Maternal plasma biomarkers; miRNAs; Prenatal diagnostics; Small non coding RNAs

Indexed keywords

ARGONAUTE PROTEIN; MICRORNA; RNA POLYMERASE; RNA POLYMERASE II;

3' UNTRANSLATED REGION; BIOGENESIS; CAENORHABDITIS ELEGANS; CYTOPLASM; DEVELOPMENT; EPIGENETICS; FETUS CELL; FETUS DEVELOPMENT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC SCREENING; HUMAN; MATERNAL PLASMA; ONCOGENE C H RAS; ONCOGENE K RAS; ONCOGENE N RAS; PHYSIOLOGY; PLACENTA; PRENATAL DIAGNOSIS; PROTEIN RNA BINDING; REVIEW; RNA INTERFERENCE; RNA SEQUENCE; RNA TRANSCRIPTION; TRANSLATION REGULATION;

EID: 80052570544     PISSN: None     EISSN: 19481756     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. Lee RC, Feinbaum, RL and Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75: 843-854.
2. Johnson, SM, Grosshans, H, Shingara, J, Byrom, M, Jarvis, R, Cheng, A, Labourier, E, Reinert, KL, Brown, D and Slack, FJ. RAS is regulated by the let-7 miRNA family. Cell 2005; 120: 635-647.
3. Huang, Y, Shen, ZJ, Zou, Q, Wang, SP, Tang, SM, Zhang, GZ. Biological functions of microRNAs: a review. J Physiol Biochem 2011; 67: 129-139.
4. Chen X. Small RNAs and their roles in plant development. Annu Rev Cell Dev Biol. 2009; 25: 21-44.
5. Jones-Rhoades MW, Bartel DP, Bartel B. MiRNAS and their regulatory roles in plants. Annu Rev Plant Biol 2006; 57: 19-53.
6. Martin RC, Liu PP, Goloviznina NA, Nonogaki H. MiRNA, seeds, and Darwin?: diverse function of miRNA in seed biology and plant responses to stress. J Exp Bot 2010; 61: 2229-2234.
7. da Costa Martins PA, Leptidis S, Salic K, De Windt LJ. MiRNA regulation in cardiovascular disease. Curr Drug Targets 2010; 11: 900-906.
8. Güller I, Russell AP. MiRNAs in skeletal muscle: their role and regulation in development, disease and function. J Physiol 2010; 588: 4075-4087.
9. Zhang C. Novel functions for small RNA molecules. Curr Opin Mol Ther. 2009; 11: 641-651.
10. Leung AK, Sharp PA. MiRNA functions in stress responses. Mol Cell 2010; 40: 205-215.
11. Ruan K, Fang X, Ouyang G. MiRNAs: novel regulators in the hallmarks of human cancer. Cancer Lett 2009; 285: 116-126.
12. Li C, Feng Y, Coukos G, Zhang L. Therapeutic miRNA strategies in human cancer. AAPS J 2009; 11: 747-757.
13. Ferland-McCollough D, Ozanne SE, Siddle K, Willis AE, Bushell M. The involvement of miRNAs in Type 2 diabetes. Biochem Soc Trans 2010; 38: 1565-1570.
14. De Smaele E, Ferretti E, Gulino A. MiRNAs as biomarkers for CNS cancer and other disorders. Brain Res 2010; 1338: 100-111.
15. Mayor-Lynn, K, Toloubeydokhti, T, Cruz, AC, Chegini, N. Expression profile of microRNAs and mRNAs in human placentas from pregnancies complicated by preeclampsia and preterm labor. Repr Sci 2011; 18: 46-56.
16. Beezhold, KJ, Castranova, V and Chen F. Microprocessor of miRNAs: regulation and potential for therapeutic intervention. Mol Cancer 2010; 9: 134-143.
17. Zhou, H, Huang, X, Cui, H, Luo, X, Tang, Y, Chen, S, Wu, L, Shen, N. miR155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells. Blood 2010; 116: 5885-5994.
18. Ro, S, Oark, C, Young, D, Saunders, KM, Yan, W. Tissue-dependent paired expression of miRNAs. Nuc Acids Res 2007; 35: 5944-5953.
19. Bartel, DP. MiRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-233.
20. Zhang, X and Zeng, Y. Regulation of mammalian miRNA expression. J Cardiovasc Trans Res 2010; 3: 197-203.
21. Golan, D, Levy, C, Friedman, B, Shomron, N. Biased hosting of intronic microRNA genes. Bioinformatics 2010; 26: 992-995.
22. Feng, Z, Zhang, C, Wu, R, Hu, W. Tumour suppressor p53 meets microRNAs. J Mol Cell Biol 2011; 3: 44-50.
23. Ribas J, Ni X, Haffner M, Wentzel EA, Salmasi AH, Chowdhury WH, Kudrolli TA, Yegnasubramanian S, Luo J, Rodriguez R, Mendell JT, Lupold SE. miR-21: an androgen receptorregulated miRNA that promotes hormonedependent and hormone-independent prostate cancer growth. Cancer Res 2009; 69: 7165-7169.
24. Ribas J, Lupold SE. The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer. Cell Cycle 2010; 9: 923-929.
25. Obernosterer G, Leuschner PJ, Alenius M, Martinez J. Post-transcriptional regulation of miRNA expression. RNA 2006; 12: 1161-1167.
26. Guil S, Cáceres JF. The multifunctional RNAbinding protein hnRNP A1 is required for processing of miR-18a. Nat Struct Mol Biol 2007; 14: 591-596.
27. Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of miRNA processing by Lin28. Science 2008; 320: 97-100.
28. Zhu H, Shah S, Shyh-Chang N, Shinoda G, Einhorn WS, Viswanathan SR, Takeuchi A, Grasemann C, Rinn JL, Lopez MF, Hirschhorn JN, Palmert MR, Daley GQ. Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet 2010; 42: 626-630.
29. Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, Takeyama K, Minami Y, O'Malley BW, Kato S. Maturation of miRNA is hormonally regulated by a nuclear receptor. Mol Cell 2009; 36: 340-347.
30. Hamada H, Arinami T, Kubo T. Hamaguchi H, Iwasaki H. Fetal nucleated cells in maternal peripheral blood: frequency and relationship to gestational age. Hum Genet 1993; 91: 427-432.
31. Hung EC, Chiu RW, Lo YM. Detection of circulating fetal nucleic acids: a review of methods and applications. J Clin Pathol 2009; 62: 308-313.
32. Lo YM, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, Wainscoat JS. Presence of fetal DNA in maternal plasma and serum. Lancet 1997; 350: 485-487.
33. Gilad S, Meiri E, Yogev Y, Benjamin S, Lebanony D, Yerushalmi N, Benjamin H, Kushnir M, Cholakh H, Melamed N, Bentwich Z, Hod M, Goren Y, Chajut A. Serum miRNAs are promising novel biomarkers. PLoS One 2008; 3: e3148.
34. Miura K, Miura S, Yamasaki K, Higashijima A, Kinoshita A, Yoshiura K, Masuzaki H. Identification of pregnancy-associated miRNAs in maternal plasma. Clin Chem 2010; 56: 1767-1771
35. Chim SS, Shing TK, Hung EC, Leung TY, Lau TK, Chiu RW, Lo YM. Detection and characterization of placental miRNAs in maternal plasma. Clin Chem 2008; 54: 482-490.
36. Kotlabova K, Doucha J, Hromadnikova I. Placental-specific microRNA in maternal circulation-identification of appropriate pregnancyassociated microRNAs with diagnostic potential. J Rep Immunol 2011; 89: 185-191.
37. Luo SS, Ishibashi O, Ishikawa G, Ishikawa T, Katayama A, Mishima T, Takizawa T, Shigihara T, Goto T, Izumi A, Ohkuchi A, Matsubara S, Takeshita T, Takizawa T. Human villous trophoblasts express and secrete placentaspecific miRNAs into maternal circulation via exosomes. Biol Reprod 2009; 81: 717-729.
38. Chiu RWK, Lo YMD. Pregnancy-associated miRNAs in maternal plasma: a channel for fetal-maternal communication? Clin Chem 2010; 65: 1656-1657.
39. Noack F, Ribbat-Idel J, Thorns C, Chiriac A, Axt-Fliedner R, Diedrich K, Feller AC. miRNA expression profiling in formalin-fixed and paraffinembedded placental tissue samples from pregnancies with severe preeclampsia. J Perinat Med 2011; (in press).
40. Shookhoff JM Gallicano GI. A new perspective on neural tube defects: folic acid and miRNA misexpression. Genesis 2010; 48: 282-294.
41. Wang LL, Zhang Z, Li Q, Yang R, Pei X, Xu Y, Wang J, Zhou SF, Li Y. Ethanol exposure induces differential miRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Human Rep 2009; 24: 562-579.
42. Yu Z, Han S, Hu P, Zhu C, Wang X, Qian L, Guo X. Potential role of maternal serum miRNAs as a biomarker for fetal congenital heart defects. Med Hypotheses 2011; 76: 424-426.
43. Jone PN, Schowengerdt KO. Prenatal diagnosis of congenital heart disease. Pediatr Clin North Am 2009; 56: 709-715.
44. Trojnarska O, Grajek S, Katarzynski S, Kramer I. Predictors of mortality in adult patients with congenital heart disease. Cardiol J 2009; 16: 341-347.
45. Liang Y, Ridzon D, Wong I Chen C. Characterization of miRNA expression profiles in normal human tissues. BMC Genomics 2007; 8: 166.