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Volumn 36, Issue 9, 2011, Pages 564-568

Vorapaxar: Targeting a novel antiplatelet pathway

Author keywords

[No Author keywords available]

Indexed keywords

VORAPAXAR;

EID: 80052569494     PISSN: 10521372     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note
Times cited : (17)

References (19)
  • 1
    • 34547655744 scopus 로고    scopus 로고
    • ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST segment elevation myocardial infarction
    • Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST segment elevation myocardial infarction. J Am Coll Cardiol 2007; 50:1-157
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1-157
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3
  • 2
    • 68949131480 scopus 로고    scopus 로고
    • The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA·CER) trial: Study design and rationale
    • The TRA·CER Executive and Steering Committees
    • The TRA·CER Executive and Steering Committees. The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA·CER) trial: Study design and rationale. Am Heart J 2009;158:327-334
    • (2009) Am Heart J , vol.158 , pp. 327-334
  • 4
    • 77649207578 scopus 로고    scopus 로고
    • Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome
    • Goto S, Yamaguchi T, Ikeda Y, et al. Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome. J Atheroscler Thromb 2010;17:156-164.
    • (2010) J Atheroscler Thromb , vol.17 , pp. 156-164
    • Goto, S.1    Yamaguchi, T.2    Ikeda, Y.3
  • 5
    • 77949876317 scopus 로고    scopus 로고
    • The potential of antiplatelet medication SCH 530348
    • Thrombin receptor antagonism
    • Macaulay TE, Allen C, Ziad KM. Thrombin receptor antagonism: The potential of antiplatelet medication SCH 530348. Exp Opin Pharmacother 2010;11:1015-1022
    • (2010) Exp Opin Pharmacother , vol.11 , pp. 1015-1022
    • Macaulay, T.E.1    Allen, C.2    Ziad, K.M.3
  • 6
    • 44949114152 scopus 로고    scopus 로고
    • Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity
    • Chackalamannil S, Wang Y, Greenlee WJ, et al. Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity. J Med Chem 2008;51: 3061-3064
    • (2008) J Med Chem , vol.51 , pp. 3061-3064
    • Greenlee, W.J.1
  • 7
    • 76549094772 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and clinical profile of novel antiplatelet drugs targeting vascular disease
    • Siller-Matula JM, Krumphuber J, Jilma B. Pharmacokinetic, pharmacodynamic, and clinical profile of novel antiplatelet drugs targeting vascular disease. Br J Pharmacol 2010;159:502-517
    • (2010) Br J Pharmacol , vol.159 , pp. 502-517
    • Siller-Matula, J.M.1    Krumphuber, J.2    Jilma, B.3
  • 8
    • 68949156886 scopus 로고    scopus 로고
    • Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)-TIMI 50 trial
    • Morrow DA, Scirica BM, Fox KA, et al. Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)-TIMI 50 trial. Am Heart J 2009;158;335-341
    • (2009) Am Heart J , vol.158 , pp. 335-341
    • Morrow, D.A.1    Scirica, B.M.2    Fox, K.A.3
  • 9
    • 80052590030 scopus 로고    scopus 로고
    • National Center for Biotechnology Information, National Institutes of Health. Available at, Accessed August 2
    • National Center for Biotechnology Information, National Institutes of Health. Vorapaxar. Available at: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10077130. Accessed August 2, 2011
    • (2011) Vorapaxar
  • 10
    • 47649086806 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of a novel protease-activated receptor (PAR-1) antagonist SCH 530348 (Abstract)
    • Kosoglou T, Reyderman L, Fales RR, et al. Pharmacodynamics and pharmacokinetics of a novel protease-activated receptor (PAR-1) antagonist SCH 530348 (Abstract) Circulation 2005;112(Suppl II): II-32
    • (2005) Circulation , vol.112 , Issue.SUPPL. 2
    • Kosoglou, T.1    Reyderman, L.2    Fales, R.R.3
  • 11
    • 69549143568 scopus 로고    scopus 로고
    • TRAP-induced platelet aggregation following single and multiple rising doses of SCH 530348, a novel thrombin receptor antagonist, in healthy volunteers (Abstract)
    • Kosoglou T, Reyderman L, Tiessen R, et al. TRAP-induced platelet aggregation following single and multiple rising doses of SCH 530348, a novel thrombin receptor antagonist, in healthy volunteers (Abstract).Clin Pharmacol Ther 2009; 85(Suppl 1):S21
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.SUPPL. 1
    • Kosoglou, T.1    Reyderman, L.2    Tiessen, R.3
  • 12
    • 58149156653 scopus 로고    scopus 로고
    • Optimizing dose of the novel thrombin receptor antagonist SCH 530348 based on pharmacodynamics and pharmacokinetics in healthy subjects (Abstract)
    • Kosoglou T, Reyderman L, Kassera C, et al. Optimizing dose of the novel thrombin receptor antagonist SCH 530348 based on pharmacodynamics and pharmacokinetics in healthy subjects (Abstract). Clin Pharmacol Ther 2008;83(Suppl 1): S55
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.SUPPL. 1
    • Kosoglou, T.1    Reyderman, L.2    Kassera, C.3
  • 13
    • 69549093093 scopus 로고    scopus 로고
    • The effect of food and antacid on pharmacokinetics of SCH 530348 in healthy subjects (Abstract)
    • Reyderman L, Kosoglou T, Tseng J, et al. The effect of food and antacid on pharmacokinetics of SCH 530348 in healthy subjects (Abstract). Clin Pharmacol Ther 2009;85(Suppl 1):S21
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.SUPPL. 1
    • Reyderman, L.1    Kosoglou, T.2    Tseng, J.3
  • 14
    • 69549093093 scopus 로고    scopus 로고
    • Lack of ethnic differences in the pharmacodynamics and pharmacokinetics of SCH 530348, a novel oral antiplatelet agent, in Japanese and Caucasian subjects (Abstract)
    • Reyderman L, Kosoglou T, Kasserra C, et al. Lack of ethnic differences in the pharmacodynamics and pharmacokinetics of SCH 530348, a novel oral antiplatelet agent, in Japanese and Caucasian subjects (Abstract). Clin Pharmacol Ther 2009;85(Suppl 1):S21.
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.SUPPL. 1
    • Reyderman, L.1    Kosoglou, T.2    Kasserra, C.3
  • 15
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of SCH530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebocontrolled phase II study
    • Becker RC, Moliterno DJ, Jennings LK, et al. Safety and tolerability of SCH530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebocontrolled phase II study. Lancet 2009; 373:919-928.
    • (2009) Lancet , vol.373 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3
  • 16
    • 80052779693 scopus 로고    scopus 로고
    • Safety of the novel protease-activated receptor1 antagonist vorapaxar in Japanese patients with a history of ischemic stroke
    • October 13, 2010 (online). Accessed March 1
    • Shinohara Y, Goto S, Doi M, et al. Safety of the novel protease-activated receptor1 antagonist vorapaxar in Japanese patients with a history of ischemic stroke. J Stroke Cerebrovasc, October 13, 2010 (online). Accessed March 1, 2011.
    • (2011) J Stroke Cerebrovasc
    • Shinohara, Y.1    Goto, S.2    Doi, M.3
  • 17
    • 80052569718 scopus 로고    scopus 로고
    • January 13, Available at, Accessed March 1, 2011
    • Merck Statement on Changes to Clinical Studies of Vorapaxar. January 13, 2011. Available at: www.merck.com/newsroom/news-release-archive/research-anddevelopment/2011_0113.html. Accessed March 1, 2011
    • (2011) Merck Statement on Changes to Clinical Studies of Vorapaxar
  • 18
    • 58149156652 scopus 로고    scopus 로고
    • SCH 530348, a novel oral antiplatelet agent, demonstrated no bleeding risk alone or in combination with aspirin and clopidogrel in cynomolgus monkeys (Abstract)
    • Chintala M, Vemulapalli S, Kurowski S, et al. SCH 530348, a novel oral antiplatelet agent, demonstrated no bleeding risk alone or in combination with aspirin and clopidogrel in cynomolgus monkeys (Abstract). Arterioscler Thromb Vasc Biol 2008;28:e138-e139
    • (2008) Arterioscler Thromb Vasc Biol , vol.28
    • Chintala, M.1    Vemulapalli, S.2    Kurowski, S.3
  • 19
    • 58149143160 scopus 로고    scopus 로고
    • Basic and translational research on proteinase-activated receptors: Antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic disease
    • Chintala M, Shimizu K, Ogawa M, et al. Basic and translational research on proteinase-activated receptors: Antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic disease. J Pharmacol Sci 2008;108:433-438.
    • (2008) J Pharmacol Sci , vol.108 , pp. 433-438
    • Chintala, M.1    Shimizu, K.2    Ogawa, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.