-
1
-
-
34547655744
-
ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST segment elevation myocardial infarction
-
Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST segment elevation myocardial infarction. J Am Coll Cardiol 2007; 50:1-157
-
(2007)
J Am Coll Cardiol
, vol.50
, pp. 1-157
-
-
Anderson, J.L.1
Adams, C.D.2
Antman, E.M.3
-
2
-
-
68949131480
-
The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA·CER) trial: Study design and rationale
-
The TRA·CER Executive and Steering Committees
-
The TRA·CER Executive and Steering Committees. The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA·CER) trial: Study design and rationale. Am Heart J 2009;158:327-334
-
(2009)
Am Heart J
, vol.158
, pp. 327-334
-
-
-
4
-
-
77649207578
-
Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome
-
Goto S, Yamaguchi T, Ikeda Y, et al. Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome. J Atheroscler Thromb 2010;17:156-164.
-
(2010)
J Atheroscler Thromb
, vol.17
, pp. 156-164
-
-
Goto, S.1
Yamaguchi, T.2
Ikeda, Y.3
-
5
-
-
77949876317
-
The potential of antiplatelet medication SCH 530348
-
Thrombin receptor antagonism
-
Macaulay TE, Allen C, Ziad KM. Thrombin receptor antagonism: The potential of antiplatelet medication SCH 530348. Exp Opin Pharmacother 2010;11:1015-1022
-
(2010)
Exp Opin Pharmacother
, vol.11
, pp. 1015-1022
-
-
Macaulay, T.E.1
Allen, C.2
Ziad, K.M.3
-
6
-
-
44949114152
-
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity
-
Chackalamannil S, Wang Y, Greenlee WJ, et al. Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity. J Med Chem 2008;51: 3061-3064
-
(2008)
J Med Chem
, vol.51
, pp. 3061-3064
-
-
Greenlee, W.J.1
-
7
-
-
76549094772
-
Pharmacokinetic, pharmacodynamic, and clinical profile of novel antiplatelet drugs targeting vascular disease
-
Siller-Matula JM, Krumphuber J, Jilma B. Pharmacokinetic, pharmacodynamic, and clinical profile of novel antiplatelet drugs targeting vascular disease. Br J Pharmacol 2010;159:502-517
-
(2010)
Br J Pharmacol
, vol.159
, pp. 502-517
-
-
Siller-Matula, J.M.1
Krumphuber, J.2
Jilma, B.3
-
8
-
-
68949156886
-
Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)-TIMI 50 trial
-
Morrow DA, Scirica BM, Fox KA, et al. Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)-TIMI 50 trial. Am Heart J 2009;158;335-341
-
(2009)
Am Heart J
, vol.158
, pp. 335-341
-
-
Morrow, D.A.1
Scirica, B.M.2
Fox, K.A.3
-
9
-
-
80052590030
-
-
National Center for Biotechnology Information, National Institutes of Health. Available at, Accessed August 2
-
National Center for Biotechnology Information, National Institutes of Health. Vorapaxar. Available at: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10077130. Accessed August 2, 2011
-
(2011)
Vorapaxar
-
-
-
10
-
-
47649086806
-
Pharmacodynamics and pharmacokinetics of a novel protease-activated receptor (PAR-1) antagonist SCH 530348 (Abstract)
-
Kosoglou T, Reyderman L, Fales RR, et al. Pharmacodynamics and pharmacokinetics of a novel protease-activated receptor (PAR-1) antagonist SCH 530348 (Abstract) Circulation 2005;112(Suppl II): II-32
-
(2005)
Circulation
, vol.112
, Issue.SUPPL. 2
-
-
Kosoglou, T.1
Reyderman, L.2
Fales, R.R.3
-
11
-
-
69549143568
-
TRAP-induced platelet aggregation following single and multiple rising doses of SCH 530348, a novel thrombin receptor antagonist, in healthy volunteers (Abstract)
-
Kosoglou T, Reyderman L, Tiessen R, et al. TRAP-induced platelet aggregation following single and multiple rising doses of SCH 530348, a novel thrombin receptor antagonist, in healthy volunteers (Abstract).Clin Pharmacol Ther 2009; 85(Suppl 1):S21
-
(2009)
Clin Pharmacol Ther
, vol.85
, Issue.SUPPL. 1
-
-
Kosoglou, T.1
Reyderman, L.2
Tiessen, R.3
-
12
-
-
58149156653
-
Optimizing dose of the novel thrombin receptor antagonist SCH 530348 based on pharmacodynamics and pharmacokinetics in healthy subjects (Abstract)
-
Kosoglou T, Reyderman L, Kassera C, et al. Optimizing dose of the novel thrombin receptor antagonist SCH 530348 based on pharmacodynamics and pharmacokinetics in healthy subjects (Abstract). Clin Pharmacol Ther 2008;83(Suppl 1): S55
-
(2008)
Clin Pharmacol Ther
, vol.83
, Issue.SUPPL. 1
-
-
Kosoglou, T.1
Reyderman, L.2
Kassera, C.3
-
13
-
-
69549093093
-
The effect of food and antacid on pharmacokinetics of SCH 530348 in healthy subjects (Abstract)
-
Reyderman L, Kosoglou T, Tseng J, et al. The effect of food and antacid on pharmacokinetics of SCH 530348 in healthy subjects (Abstract). Clin Pharmacol Ther 2009;85(Suppl 1):S21
-
(2009)
Clin Pharmacol Ther
, vol.85
, Issue.SUPPL. 1
-
-
Reyderman, L.1
Kosoglou, T.2
Tseng, J.3
-
14
-
-
69549093093
-
Lack of ethnic differences in the pharmacodynamics and pharmacokinetics of SCH 530348, a novel oral antiplatelet agent, in Japanese and Caucasian subjects (Abstract)
-
Reyderman L, Kosoglou T, Kasserra C, et al. Lack of ethnic differences in the pharmacodynamics and pharmacokinetics of SCH 530348, a novel oral antiplatelet agent, in Japanese and Caucasian subjects (Abstract). Clin Pharmacol Ther 2009;85(Suppl 1):S21.
-
(2009)
Clin Pharmacol Ther
, vol.85
, Issue.SUPPL. 1
-
-
Reyderman, L.1
Kosoglou, T.2
Kasserra, C.3
-
15
-
-
61849180442
-
Safety and tolerability of SCH530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebocontrolled phase II study
-
Becker RC, Moliterno DJ, Jennings LK, et al. Safety and tolerability of SCH530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebocontrolled phase II study. Lancet 2009; 373:919-928.
-
(2009)
Lancet
, vol.373
, pp. 919-928
-
-
Becker, R.C.1
Moliterno, D.J.2
Jennings, L.K.3
-
16
-
-
80052779693
-
Safety of the novel protease-activated receptor1 antagonist vorapaxar in Japanese patients with a history of ischemic stroke
-
October 13, 2010 (online). Accessed March 1
-
Shinohara Y, Goto S, Doi M, et al. Safety of the novel protease-activated receptor1 antagonist vorapaxar in Japanese patients with a history of ischemic stroke. J Stroke Cerebrovasc, October 13, 2010 (online). Accessed March 1, 2011.
-
(2011)
J Stroke Cerebrovasc
-
-
Shinohara, Y.1
Goto, S.2
Doi, M.3
-
17
-
-
80052569718
-
-
January 13, Available at, Accessed March 1, 2011
-
Merck Statement on Changes to Clinical Studies of Vorapaxar. January 13, 2011. Available at: www.merck.com/newsroom/news-release-archive/research-anddevelopment/2011_0113.html. Accessed March 1, 2011
-
(2011)
Merck Statement on Changes to Clinical Studies of Vorapaxar
-
-
-
18
-
-
58149156652
-
SCH 530348, a novel oral antiplatelet agent, demonstrated no bleeding risk alone or in combination with aspirin and clopidogrel in cynomolgus monkeys (Abstract)
-
Chintala M, Vemulapalli S, Kurowski S, et al. SCH 530348, a novel oral antiplatelet agent, demonstrated no bleeding risk alone or in combination with aspirin and clopidogrel in cynomolgus monkeys (Abstract). Arterioscler Thromb Vasc Biol 2008;28:e138-e139
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
-
-
Chintala, M.1
Vemulapalli, S.2
Kurowski, S.3
-
19
-
-
58149143160
-
Basic and translational research on proteinase-activated receptors: Antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic disease
-
Chintala M, Shimizu K, Ogawa M, et al. Basic and translational research on proteinase-activated receptors: Antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic disease. J Pharmacol Sci 2008;108:433-438.
-
(2008)
J Pharmacol Sci
, vol.108
, pp. 433-438
-
-
Chintala, M.1
Shimizu, K.2
Ogawa, M.3
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