Low urine pH is a predictor of chronic kidney disease

Kidney and Blood Pressure Research

Volumn 35, Issue 2, 2012, Pages 77-81

  Nakanishi, Naoko ^a   Fukui, Michiaki ^a   Tanaka, Muhei ^a   Toda, Hitoshi ^b   Imai, Saeko ^c   Yamazaki, Masahiro ^a   Hasegawa, Goji ^a   Oda, Yohei ^a   Nakamura, Naoto ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b Sakazaki Clinic   (Japan)

^c Osaka Prefecture University   (Japan)

Author keywords

Acidic urine; Chronic kidney disease; Low urine pH

Indexed keywords

CHOLESTEROL; GLUCOSE; PROTEIN; URIC ACID;

ADULT; AGE; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; FEMALE; GENDER; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; PREDICTION; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RISK FACTOR; SMOKING; SYSTOLIC BLOOD PRESSURE; URIC ACID BLOOD LEVEL; URINE PH;

ACIDS; ADULT; COHORT STUDIES; FASTING; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 80052566621     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000330487     Document Type: Article

References (27)

1. Levey AS, Atkins R, Coresh J, Cohen EP, Collins AJ, Eckardt KU, Nahas ME, Jaber BL, Jadoul M, Levin A, Powe NR, Rossert J, Wheeler DC, Lameire N, Eknoyan G: Chronic kidney disease as a global public health problem: approaches and initiatives - a position statement from Kidney Disease Improving Global Outcomes. Kidney Int 2007;72:247-259. (Pubitemid 47172384)
2. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004;351:1296-1305.
3. Chen J, Muntner P, Hamm LL, Jones DW, Batuman V, Fonseca V, Whelton PK, He J: The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med 2004;140:167-174.
4. Kurella M, Lo JC, Chertow GM: Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol 2005;16:2134-2140. (Pubitemid 41716445)
5. Eckel RH, Grundy SM, Zimmet PZ: The metabolic syndrome. Lancet 2005;365:1415-1428. (Pubitemid 40523737)
6. Takahashi S, Inokuchi T, Kobayashi T, Ka T, Tsutsumi Z, Moriwaki Y, Yamamoto T: Relationship between insulin resistance and low urinary pH in patients with gout, and effects of PPAR alpha agonists on urine pH. Horm Metab Res 2007;39:511-514. (Pubitemid 47204195)
7. Maalouf NM, Cameron MA, Moe OW, Adams-Huet B, Sakhaee K: Low urine pH: a novel feature of the metabolic syndrome. Clin J Am Soc Nephrol 2007;2:883-888.
8. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A: Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 2009;53:982-992.
9. Manjunath G, Tighiouart H, Coresh J, Macleod B, Salem DN, Griffith JL, Levey AS, Sarnak MJ: Level of kidney function as a risk factor for cardiovascular outcomes in the elderly. Kidney Int 2003;63:1121-1129. (Pubitemid 36315592)
10. Nakamura K, Okamura T, Hayakawa T, Kadowaki T, Kita Y, Ohnishi H, Saitoh S, Sakata K, Okayama A, Ueshima H, NIPPON DATA90 Research Group: Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan: NIPPON DATA90. Circ J 2006;70:954-999.
11. Cusumano AM, Bodkin NL, Hansen BC, Iotti R, Owens J, Klotman PE, Kopp JB: Glomerular hypertrophy is associated with hyperinsulinemia and precedes overt diabetes in aging rhesus monkeys. Am J Kidney Dis 2002;40:1075-1085. (Pubitemid 35265489)
12. Kamijo A, Kimura K, Sugaya T, Yamanouchi M, Hase H, Kaneko T, Hirata Y, Goto A, Fujita T, Omata M: Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage. Kidney Int 2002;62:1628-1637. (Pubitemid 35286270)
13. Maalouf NM, Sakhaee K, Parks JH, Coe FL, Adams-Huet B, Pak CY: Association of urinary pH with body weight in nephrolithiasis. Kidney Int 2004;65:1422-1425. (Pubitemid 38406983)
14. Taylor EN, Curhan GC: Body size and 24-hour urine composition. Am J Kidney Dis 2006;48:905-915. (Pubitemid 44895373)
15. DuBose TD Jr, Good DW, Hamm LL, Wall SM: Ammonium transport in the kidney: New physiological concepts and their clinical implications. J Am Soc Nephrol 1991;1:1193-1203.
16. Agarwal BN, Cabebe FG: Renal acidification in elderly subjects. Nephron 1980;26:291-295. (Pubitemid 10007728)
17. Nissim I, States B, Nissim I, Lin ZP, Yudkoff M: Hormonal regulation of glutamine metabolism by OK cells. Kidney Int 1975;47:96-105.
18. Klisic J, Hu MC, Nief V, Reyes L, Fuster D, Moe OW, Ambühl PM: Insulin activates Na+/H+ exchanger 3: biphasic response and glucocorticoid dependence. Am J Physiol Renal Physiol 2002;283:532-539.
19. Tomita M, Mizuno S, Yamanaka H, Hosoda Y, Sakuma K, Matuoka Y, Odaka M, Yamaguchi M, Yosida H, Morisawa H, Murayama T: Does hyperuricemia affect mortality? A prospective cohort study of Japanese male workers. J Epidemiol 2000;10:403-409.
20. Iseki K, Ikemiya Y, Inoue T, Iseki C, Kinjo K, Takishita S: Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort. Am J Kidney Dis 2004;44:642-650. (Pubitemid 39237608)
21. Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang D-H, Gordon KL, Lan HY, Kivlighn S, Johnson RJ: Elevated uric acid increases blood pressure in the rat by a novel crys talin-dependent mechanism. Hypertension 2001;38:1101-1106. (Pubitemid 34252813)
22. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, Truong L, Harris R, Johnson RJ: A role for uric acid in the progression of renal disease. J Am Soc Nephrol 2002;13:2888-2897. (Pubitemid 35386908)
23. Kiyosue A, Hirata Y, Ando J, Fujita H, Morita T, Takahashi M, Nagata D, Kohro T, Imai Y, Nagai R: Relationship between renal dysfunction and severity of coronary artery disease in Japanese patients. Circ J 2010;74:786-791.
24. Lin J, Fung TT, Hu FB, Curhan GC: Association of dietary patterns with albuminuria and kidney function decline in older white women: a subgroup analysis from the Nurses'Health Study. Am J Kidney Dis 2011;57:245-254.
25. Capolongo G, Sakhaee K, Pak CY, Maalouf NM: Fasting versus 24-hour urine pH in the evaluation of nephrolithiasis. Urol Res 2011, E-pub ahead of print.
26. Desai RA, Assimos DG: Accuracy of urinary dipstick testing for pH manipulation therapy. J Endourol 2008;22:1367-1370. (Pubitemid 351913494)
27. Mahajan A, Simoni J, Sheather SJ, Broglio KR, Rajab MH, Wesson DE: Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. Kidney Int 2010;78:303-309.