Effects of immunization against luteinizing hormone-releasing hormone and treatment with trenbolone acetate on reproductive function of beef bulls and steers

Journal of Animal Science

Volumn 89, Issue 7, 2011, Pages 2086-2095

  Geary, T W ^a   Wells, K J ^b   deAvila, D M ^b   deAvila, J ^b   Conforti, V A ^b   Mclean, D J ^b   Roberts, A J ^a   Waterman, R W ^a   Reeves, J J ^b  

^a USDA ARS Fort Keogh Livestock and Range Research Laboratory   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Androgen; Bull; Cattle; Gonadotropin; Gonadotropin releasing hormone immunosterilization; Luteinizing hormone releasing hormone

Indexed keywords

ANTIBODY; DRUG DERIVATIVE; GONADORELIN; GONADOTROPIN; TRENBOLONE; TRENBOLONE ACETATE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; CATTLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION REGULATION; HISTOLOGY; HYPOPHYSIS; IMMUNOLOGY; MALE; METABOLISM; ORCHIECTOMY; ORGAN SIZE; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SPERM; SPERMATOZOON; TESTIS; TIME;

ANIMALS; ANTIBODIES; CATTLE; GENE EXPRESSION REGULATION; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; MALE; ORCHIECTOMY; ORGAN SIZE; PITUITARY GLAND; SEMEN; SPERMATOZOA; TESTIS; TIME FACTORS; TRENBOLONE;

ANIMALIA; BOS;

EID: 80052565783     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2010-3565     Document Type: Article

References (32)

1. Acosta, B., G. K. Tarnavsky, T. E. Platt, D. L. Hamernik, J. L. Brown, H. M. Schoenemann, and J. J. Reeves. 1983. Nursing enhances the negative effect of estrogen on LH release in the cow. J. Anim. Sci. 57:1530-1536.
2. Adams, T. E., and B. E. Adams. 1986. Gonadotrope function in ovariectomized ewes actively immunized against gonadotropinreleasing hormone (GnRH). Biol. Reprod. 35:360-367.
3. Adams, T. E., C. A. Daley, B. M. Adams, and H. Sakurai. 1993. Testis function and feedlot performance of bulls actively immunized against gonadotropin-releasing hormone: Effect of implants containing progesterone and estradiol benzoate. J. Anim. Sci. 71:811-817.
4. Aïssat, D., J. M. Sosa, D. M. de Avila, K. P. Bertrand, and J. J. Reeves. 2002. Endocrine, growth, and carcass characteristics of bulls immunized against luteinizing hormone-releasing hormone fusion proteins. J. Anim. Sci. 80:2209-2213.
5. Arimura, A., H. Sato, T. Haumasaka, R. B. Wonobec, L. Debeljak, J. Dunn, and A. V. Schally. 1973. Production of antiserum to LH-releasing hormone (LHRH) associated with gonadal atrophy in rabbits: Development of radioimmunoassays for LHRH. Endocrinology 93:1092-1103.
6. Barth, A. D., and R. J. Oko. 1977. Abnormal morphology of bovine spermatozoa. Iowa State University Press, Ames.
7. D'Occhio, M. J., J. E. Kinder, and B. D. Schanbacher. 1982. Patterns of LH secretion in castrated bulls (Steers) during intravenous infusion of androgenic and estrogenic steroids: Pituitary response to exogenous luteinizing hormone-releasing hormone. Biol. Reprod. 26:249-257.
8. Delettré, J., J. P. Mornon, G. Lepicard, T. Ojasoo, and J. P. Raynaud. 1980. Steroid flexibility and receptor specificity. J. Steroid Biochem. 13:45-59.
9. Fabry, J., R. Renaville, V. Halleux, and A. Burny. 1983. Testosterone and LH responses in double-muscled bulls treated with trenbolone acetate and zeranol. J. Anim. Sci. 57:1138-1145.
10. Field, R. A. 1971. Effect of castration on meat quality and quantity. J. Anim. Sci. 32:849-858.
11. Geary, T. W., E. E. Grings, M. D. MacNeil, D. M. de Avila, and J. J. Reeves. 2006. Use of recombinant gonadotropin-releasing hormone antigens for immunosterilization of beef heifers. J. Anim. Sci. 84:343-350.
12. Gettys, T. W., M. J. D'Occhio, D. M. Henricks, and B. D. Schanbacher. 1984. Suppression of LH secretion by oestradiol, dihydrotestosterone, and trenbolone acetate in the acutely castrated bull. J. Endocrinol. 100:107-112.
13. Golter, T. D., J. J. Reeves, C. C. O'Mary, A. Arimura, and A. V. Schally. 1973. Serum LH levels in bulls treated with synthetic luteinizing hormone-releasing hormone/follicle stimulating hormone releasing hormone (LH-RH/FSH-RH). J. Anim. Sci. 37:123-127.
14. Henricks, D. M., R. T. Brandt Jr., E. C. Titgemeyer, and C. T. Milton. 1997. Serum concentrations of trenbolone-17ß and estradiol-17ß and performance of heifers treated with trenbolone acetate, melengestrol acetate, or estradiol-17ß. J. Anim. Sci. 75:2627-2633.
15. Hernandez, J. A., E. L. Zanella, R. Bogden, D. M. de Avila, C. T. Gaskins, and J. J. Reeves. 2005. Reproductive characteristics of grass-fed, luteinizing hormone-releasing hormone-immunocastrated Bos indicus bulls. J. Anim. Sci. 83:2901-2907.
16. Huxsoll, C. C., E. O. Price, and T. E. Adams. 1998. Testis function, carcass traits, and aggressive behavior of beef bulls actively immunized against gonadotropin-releasing hormone. J. Anim. Sci. 76:1760-1766.
17. Johnson, H. E., D. M. de Avila, C. F. Chang, and J. J. Reeves. 1988. Active immunization of heifers against luteinizing hormone-releasing hormone, human chorionic gonadotropin, and bovine luteinizing hormone. J. Anim. Sci. 66:719-726.
18. Keel, B. A., B. D. Schanbacher, and H. E. Grotjan. 1987. Ovine luteinizing hormone. I. Effects of castration and steroid administration on the charge heterogeneity of pituitary luteinizing hormone. Biol. Reprod. 36:1102-1113.
19. Lunstra, D. D. 2002. Procedures for bull semen collection, handling and evaluation. USDA-ARS, USMARC, Clay Center, NE.
20. Muller, P. Y., H. Janovjak, A. R. Miserez, and Z. Dobbie. 2002. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32:1372-1374.
21. Norwitz, E. R., K.-H. Jeong, and W. W. Chin. 1999. Molecular mechanisms of gonadotropin-releasing hormone receptor gene regulation. J. Soc. Gynecol. Investig. 6:169-178.
22. Preston, R. L. 1999. Hormone containing growth promoting implants in farmed livestock. Adv. Drug Deliv. Rev. 38:123-138.
23. Quesnell, M. M., Y. Zhang, D. M. de Avila, K. P. Bertrand, and J. J. Reeves. 2000. Immunization of male mice with luteinizing hormone-releasing hormone fusion proteins reduces testicular and accessory sex gland function. Biol. Reprod. 63:347-353.
24. Reeves, J. J., C. F. Chang, D. M. de Avila, D. M. Grieger, H. E. Johnson, and A. J. Roberts. 1989. Vaccines against endogenous hormones: A possible future tool in animal production. J. Dairy Sci. 72:3363-3371.
25. Renaville, R., A. Burny, M. Sneyers, S. Rochart, D. Portetelle, and A. Thewis. 1988. Effects of an anabolic treatment before puberty with trenbolone acetate-oestradiol or oestradiol alone on growth rate, testicular development, and luteinizing hormone and testosterone plasma concentrations. Theriogenology 29:461-476.
26. Richards, J. B., D. M. Hallford, and G. C. Duff. 1999. Serum luteinizing hormone, testosterone, and thyroxine and growth responses of ram lambs fed locoweed (Oxytropis sericea) and treated with vitamin E/selenium. Theriogenology 52:1055-1066.
27. Schanbacher, B. D., M. J. D'Occhio, and T. W. Gettys. 1983. Pulsatile LH secretion in the castrate male bovine: Effects of testosterone or estradiol replacement therapy. J. Anim. Sci. 56:132-138.
28. Stevens, J. D., J. M. Sosa, D. M. de Avila, J. M. Oatley, K. P. Bertrand, C. T. Gaskins, and J. J. Reeves. 2005. Luteinizing hormone-releasing hormone fusion protein vaccines block estrous cycle activity in beef heifers. J. Anim. Sci. 83:152-159.
29. Stumpf, T. T., M. W. Wolfe, M. S. Roberson, G. Caddy, R. J. Kittok, B. D. Schanbacher, H. E. Grotjan, and J. E. Kinder. 1992. Bovine luteinizing hormone (LH) isoforms and amounts of messenger ribonucleic acid for alpha and LH beta-subunits in pituitaries of cows immunized against LH-releasing hormone. Biol. Reprod. 47:776-781.
30. Turzillo, A. M., and T. M. Nett. 1997. Effects of bovine follicular fluid and passive immunization against gonadotropin-releasing hormone (GnRH) on messenger ribonucleic acid for GnRH receptor and gonadotropin subunits in ovariectomized ewes. Biol. Reprod. 56:1537-1543.
31. Turzillo, A. M., and T. M. Nett. 1999. Regulation of GnRH receptor gene expression in sheep and cattle. J. Reprod. Fertil. Suppl. 54:75-86.
32. Zhang, Y., T. G. Rozell, D. M. DeAvila, K. P. Bertrand, and J. J. Reeves. 1999. Development of recombinant ovalbumin-luteinizing hormone releasing hormone as a potential sterilization vaccine. Vaccine 17:2185-2191.