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Volumn 13, Issue 4, 2011, Pages 318-324

Antihypertensive therapy in diabetes: The legacy effect and RAAS blockade

Author keywords

High blood pressure; Keywords Diabetes; Legacy effect; Oxidative stress; Renin angiotensin aldosterone system; Vascular remodeling

Indexed keywords

ALISKIREN; AMLODIPINE; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; ATENOLOL; BENAZEPRIL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENALAPRIL; FOSINOPRIL; INDAPAMIDE PLUS PERINDOPRIL; IRBESARTAN; LOSARTAN; NISOLDIPINE; OLMESARTAN; RAMIPRIL; TELMISARTAN; THIAZIDE DIURETIC AGENT; VALSARTAN;

EID: 80052562488     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-011-0205-z     Document Type: Article
Times cited : (27)

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    • · Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008;358:580-91. This trial demonstrates that in patients with type 2 diabetes, intensive intervention with multiple drug combinations and behavior modification has sustained beneficial effects on vascular complications and rates of death from any cause and from cardiovascular causes. These results highlight the importance of lifestyle changes and global cardiovascular risk reduction in the diabetic population. (Pubitemid 351214285)
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    • The shape of the metabolic memory of HbA1c: Re-analysing the DCCT with respect to time-dependent effects
    • In this report, Lind et al. analyzed the impact of glycosylated hemoglobin and found that HbA1c still had an important impact on the development of microvascular complications for up to 8 years. In other words, this study demonstrates that initially high levels of HbA1c are a strong predictor of events even if normalization of such values is achieved in ensuing years
    • · Lind M, Odén A, Fahlén M, Eliasson B. The shape of the metabolic memory of HbA1c: re-analysing the DCCT with respect to time-dependent effects. Diabetologia. 2010;53:1093-8. In this report, Lind et al. analyzed the impact of glycosylated hemoglobin and found that HbA1c still had an important impact on the development of microvascular complications for up to 8 years. In other words, this study demonstrates that initially high levels of HbA1c are a strong predictor of events even if normalization of such values is achieved in ensuing years.
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    • Effects of intensive blood-pressure control in type 2 diabetes mellitus
    • · ACCORD Study Group, In the ACCORD trial, diabetic patients achieving a BP target less than 120 mm Hg had an increased rate of myocardial infarction. These findings suggest that an intensive BP-lowering strategy may prove detrimental in diabetic patients
    • · ACCORD Study Group, Cushman WC, Evans GW, Byington RP, et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362:1575-85. In the ACCORD trial, diabetic patients achieving a BP target less than 120 mm Hg had an increased rate of myocardial infarction. These findings suggest that an intensive BP-lowering strategy may prove detrimental in diabetic patients.
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    • Cushman, W.C.1    Evans, G.W.2    Byington, R.P.3
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    • ONTARGET investigators. Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study
    • Sleight P, Redon J, Verdecchia P, et al. ONTARGET investigators. Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study. J Hypertens. 2009;27:1360-9.
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    • Sleight, P.1    Redon, J.2    Verdecchia, P.3
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    • ACCOMPLISH Trial Investigators. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients
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    • Jamerson, K.1    Weber, M.A.2    Bakris, G.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.