Autonomic dysfunction in patients with Brugada syndrome: Further biochemical evidence of altered signaling pathways

PACE - Pacing and Clinical Electrophysiology

Volumn 34, Issue 9, 2011, Pages 1147-1153

  Paul, Matthias ^a   Meyborg, Matthias ^a   Boknik, Peter ^a   Gergs, Ulrich ^b   Schmitz, Wilhelm ^a   Breithardt, Günter ^a   Wichter, Thomas ^a,c   Neumann, Joachim ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c MarienHospital Osnabruck   (Germany)

Author keywords

autonomic nervous system; Brugada syndrome; cAMP; signaling pathway

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR; CALSEQUESTRIN; CYCLIC AMP; HEAT SHOCK PROTEIN 70; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; NORADRENALIN; NORADRENALIN TRANSPORTER; PHOSPHOPROTEIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TROPONIN I;

ADULT; AGED; ARTICLE; AUTONOMIC DYSFUNCTION; BRUGADA SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART MUSCLE BIOPSY; HUMAN; HUMAN TISSUE; MALE; PARASYMPATHETIC FUNCTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYMPATHETIC FUNCTION; TISSUE LEVEL;

ADULT; AUTONOMIC NERVOUS SYSTEM; BIOPSY; BRUGADA SYNDROME; CYCLIC AMP; EPINEPHRINE; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEART; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; NOREPINEPHRINE; SIGNAL TRANSDUCTION; TROPONIN;

EID: 80052551314     PISSN: 01478389     EISSN: 15408159     Source Type: Journal    
DOI: 10.1111/j.1540-8159.2011.03127.x     Document Type: Article

References (33)

1. Brugada P, Brugada J,. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 1992; 20: 1391-1396.
2. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, et al,. Brugada syndrome: Report of the second consensus conference: Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005; 111: 659-670.
3. Schulze-Bahr E, Eckardt L, Breithardt G, Seidl K, Wichter T, Wolpert C, Borggrefe M, et al,. Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: Different incidences in familial and sporadic disease. Hum Mutat 2003; 21: 651-652.
4. Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S,. Autonomic and antiarrhythmic drug modulation of ST-segment elevation in patients with Brugada syndrome. J Am Coll Cardiol 1996; 27: 1061-1070. (Pubitemid 26119611)
5. Wichter T,. What role for autonomic dysfunction in Brugada Syndrome? Pathophysiological and prognostic implications. Europace 2008; 10: 782-783. (Pubitemid 351882064)
6. Babaee Bigi MA, Aslani A, Aslani A,. Significance of cardiac autonomic neuropathy in risk stratification of Brugada syndrome. Europace 2008; 10: 821-824. (Pubitemid 351882050)
7. Wichter T, Matheja P, Eckardt L, Kies P, Schäfers K, Schulze-Bahr E, Haverkamp W, et al,. Cardiac autonomic dysfunction in Brugada syndrome. Circulation 2002; 105: 702-706. (Pubitemid 34157373)
8. Kies P, Wichter T, Schäfers M, Paul M, Schäfers KP, Eckardt L, Stegger L, et al,. Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Circulation 2004; 110: 3017-3022. (Pubitemid 39491992)
9. Ikeda T, Abe A, Yusu S, Nakamura K, Ishiguro H, Mera H, Yotsukura M, et al,. The full stomach test as a novel diagnostic technique for identifying patients at risk of Brugada syndrome. J Cardiovasc Electrophysiol 2006; 17: 602-607.
10. Mizumaki K, Fujiki A, Nishida K, Iwamoto J, Sakamoto T, Sakabe M, Tsuneda T, et al,. Postprandial augmentation of bradycardia-dependent ST elevation in patients with Brugada syndrome. J Cardiovasc Electrophysiol 2007; 18: 839-844. (Pubitemid 47093076)
11. Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, Corrado D, et al,. Proposed diagnostic criteria for the Brugada syndrome. Eur Heart J 2002; 23: 1648-1654. (Pubitemid 36287775)
12. 2+ handling, contractility, and heart failure. Am J Physiol Heart Circ Physiol 2007; 293: H728-H734. (Pubitemid 47105135)
13. Lüss H, Boknik P, Heusch G, Müller FU, Neumann J, Schmitz W, Schulz R,. Expression of calcium regulatory proteins in short-term hibernation and stunning in the in situ porcine heart. Cardiovasc Res 1998; 37: 606-617. (Pubitemid 28231155)
14. Vahlhaus C, Neumann J, Lüss H, Wenzelburger F, Tjan TD, Hammel D, Scheld HH, et al,. Ischemic preconditioning by unstable angina reduces the release of CK-MB following CABG and stimulates left ventricular HSP-72 protein expression. J Card Surg 2005; 20: 412-419. (Pubitemid 41742893)
15. Neumann J, Boknik P, Bodor GS, Jones LR, Schmitz W, Scholz H,. Effects of adenosine receptor and muscarinic cholinergic receptor agonists on cardiac protein phosphorylation. Influence of pertussis toxin. J Pharmacol Exp Ther 1994; 269: 1310-1318. (Pubitemid 24204219)
16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ,. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
17. Neumann J, Schmitz W, Scholz H, Stein B,. Effects of adenosine analogues on contractile response and cAMP content in guinea-pig isolated ventricular myocytes. Naunyn-Schmiedeberg′s Arch Pharmacol 1989; 340: 689-695. (Pubitemid 20023158)
18. 4- receptors in the isolated human atrium. Naunyn-Schmiedeberg′s Arch Pharmacol 2009; 379: 349-359.
19. Hasenfuss G, Pieske B,. Calcium cycling in congestive heart failure. J Mol Cell Cardiol 2002; 34: 951-969. (Pubitemid 35316143)
20. Danielsen W, v der Leyen H, Meyer W, Neumann J, Schmitz W, Scholz H, Starbatty J, et al,. Basal and isoprenaline-stimulated cAMP content in failing versus nonfailing human cardiac preparations. J Cardiovasc Pharmacol 1989; 14: 171-173. (Pubitemid 19158089)
21. Armoundas AA, Wu R, Juang G, Marbán E, Tomaselli GF,. Electrical and structural remodeling of the failing ventricle. Pharmacol Ther 2001; 92: 213-230. (Pubitemid 34251134)
22. Pogwizd SM, Bers DM,. Calcium cycling in heart failure: The arrhythmia connection. J Cardiovasc Electrophysiol 2002; 13: 88-91. (Pubitemid 34113628)
23. Antzelevitch C,. Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am J Physiol Heart Circ Physiol 2007; 293: H2024-H2038. (Pubitemid 47605847)
24. Gussak I, Antzelevitch C, Bjerregaard P, Towbin JA, Chaitman BR,. The Brugada syndrome: Clinical, electrophysiologic and genetic aspects. J Am Coll Cardiol 1999; 33: 5-15. (Pubitemid 29064065)
25. Neumann J, Schmitz W, Scholz H, von Meyerinck L, Döring V, Kalmár P,. Increase in myocardial Gi-proteins in heart failure. Lancet 1988; II: 936-937.
26. Gaborit N, Wichter T, Varro A, Szuts V, Lamirault G, Eckardt L, Paul M, et al,. Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases. Eur Heart J 2009; 30: 487-496.
27. Linck B, Bokník P, Eschenhagen T, Müller FU, Neumann J, Nose M, Jones LR, et al,. Messenger RNA expression and immunological quantification of phospholamban and SR-Ca(2+)-ATPase in failing and nonfailing human hearts. Cardiovasc Res 1996; 31: 625-632.
28. 2+ uptake and Ca(2+)-ATPase activity of cardiac sarcoplasmic reticulum from dilated cardiomyopathy patients compared with patients with nonfailing hearts. Circulation 1995; 92: 3220-3228.
29. Böhm M, La Rosée K, Schwinger RH, Erdmann E,. Evidence for reduction of norepinephrine uptake sites in the failing human heart. J Am Coll Cardiol 1995; 25: 146-153.
30. Neumann J, Eschenhagen T, Jones LR, Linck B, Schmitz W, Scholz H, Zimmermann N,. Increased expression of cardiac phosphatases in patients with end-stage heart failure. J Mol Cell Cardiol 1997; 29: 265-272. (Pubitemid 27129150)
31. Bodor GS, Oakeley AE, Allen PD, Crimmins DL, Ladenson JH, Anderson PA,. Troponin I phosphorylation in the normal and failing adult human heart. Circulation 1997; 96: 1495-1500. (Pubitemid 27375342)
32. Bartel S, Stein B, Eschenhagen T, Mende U, Neumann J, Schmitz W, Krause EG, et al,. Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts. Mol Cell Biochem 1996; 157: 171-179. (Pubitemid 26142450)
33. Ungerer M, Parruti G, Böhm M, Puzicha M, DeBlasi A, Erdmann E, Lohse MJ,. Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart. Circ Res 1994; 74: 206-213.