Micellar electrokinetic chromatographic analysis for in vitro accumulation of anthracyclines enhanced by inhibitors of cell membrane transporter-proteins in cancer cells

Biomedical Chromatography

Volumn 25, Issue 10, 2011, Pages 1168-1174

  Mbuna, Julius ^a,b   Kaneta, Takashi ^a   Imasaka, Totaro ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b UNIVERSITY OF DAR ES SALAAM   (Tanzania)

Author keywords

Anthracyclines; In vitro accumulation; Membrane transporter proteins; Micellar electrokinetic chromatography

Indexed keywords

CANCER CELLS; CELL CULTURE; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DISEASES; DRUG PRODUCTS; ELECTRODYNAMICS; PROTEINS; SODIUM DODECYL SULFATE;

ANTHRACYCLINES; CANCER CELLS; IN VITRO ACCUMULATION; IN-VITRO; MEMBRANE TRANSPORTER-PROTEIN; MICELLAR ELECTROKINETIC CHROMATOGRAPHIC; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; PROBENECID; TRANSPORTER PROTEINS; VERAPAMIL;

CELLS;

CYCLOSPORIN A; DAUNORUBICIN; DOXORUBICIN; EPIRUBICIN; IDARUBICIN; PROBENECID; VERAPAMIL;

ARTICLE; CANCER CELL; CELL MEMBRANE; CELL TYPE; CULTURE MEDIUM; DRUG ACCUMULATION; DRUG DETERMINATION; DRUG POTENTIATION; FLUORESCENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; MICELLAR ELECTROKINETIC CHROMATOGRAPHY;

EID: 80052542026     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1589     Document Type: Article

References (27)

1. Borst P and Elferink RO. A family of drug transporters: the multidrug resistance-associated proteins. Annual Review of Biochemistry 2002; 71: 537-592.
2. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM and Deeley RG. Overexpression of a transporter gene in amultidrug-resistant human lung cancer cell line. Science 1992; 258: 1650-1654.
3. Consoli U, Priebe W, Ling YH, Mahadevia R, Griffin M, Zhao S, Perez-Soler R and Andreeff M. The novel anthracycline annamycin is not affected by P-glycoprotein-related multidrug resistance: comparison with idarubicin and doxorubicin in HL-60 Leukemia Cell Lines. Blood 1996; 88: 633-644.
4. Fonari FA, Jarvis WD, Grant S, Orr MS, Randolph JK, White FKH, Murmaw VR, Lovings ET, Freeman RH and Gerwitz DA. Induction of differentiation and growth arrest associated with nanscent (nonoligosomal) DNA fragmentation and reduced c-myc in MCF-7 human breast tumor cells after continuous exposure to sublethal concentration of doxorubicin. Cell Growth & Differentiation 1994; 5: 723-733.
5. Gergely S, Paterson JK, Ludwig JA, Catherine B-G and Gottesman MM. Targeting multidrug resistance in cancer. Nature Reviews. Drug Discovery 2006; 5: 221-234.
6. Gottesman MM. How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal foundation award lecture. Cancer Research 1993; 53: 747-754.
7. Gottesman MM, Fojo T and Bates SE. Multidrug resistance in cancer: role ofATP-dependent transporters. Nature Reviews. Cancer 2002; 2: 48-58.
8. Heijn M, Roberge S and Jain RK. Cellular membrane permeability of anthracyclines does not correlate with their delivery in tissue isolated tumor. Cancer Research 1999; 59 4458-4463.
9. Higgins CF. Multiple molecular mechanisms for multidrug resistance transporters. Nature 2007; 446: 749-757.
10. Kokenberg E, Sonneveld P, Sizoo W, Hagenbeek A and Lowenberg B. Cellular pharmacokinetics of daunorubicin: relationships with the response to treatment in patients with acute myeloid leukemia. Journal of Clinical Oncology 1988; 6: 802-812.
11. Lee K, Qian DZ, Rey S, Wei H, Liud JO and Semenza GL. Anthracycline chemotherapy inhibits HIF-1transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proceedings of the National Academy of Sciences of the United States of America 2009; 106: 2353-2358.
12. Liu YY, Han TY, Giuliano AE and Cabot MC. Ceramide glycosylation potentiates cellular multidrug resistance. The FASEB Journal 2001; 15: 719-730.
13. Lowe SW, Ruley HE, Jacks T and Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 1993; 74: 957-967.
14. Mbuna J, Kaneta T and Imasaka T. Measurement of intracellular accumulation of anthracyclines in cancerous cells by direct injection of cell lysate in MEKC/LIF detection. Electrophoresis 2010; 31: 1396-1404.
15. Muller C, Chatelut E, Gualano V, De Forni M, Huguet F, Attal M, Canal P and Laurent G. Cellular pharmacokinetics of doxorubicin in patients with chronic lymphocytic leukemia: comparison of bolus administration and continuous infusion. Cancer Chemotherapy and Pharmacology 1993; 32: 379-384.
16. Perez-Ruiz T, Martinez-Lozano C, Sanz A and Bravo E. Simultaneous detection of doxorubicin, daunorubicin, and idarubicin by capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis 2001; 22: 134-138.
17. Rao US and Scarborough GA. Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein. Molecular Pharmacology 1994; 45: 773-776.
18. Reinhoud NJ, Tjaden UR, Irth H and van der Greef J. Bioanalysis of some anthracyclines in human plasma by capillary electrophoresis with laser-induced fluorescence detector. Journal of Chromatography 1992; 574: 327-334.
19. Ricardo P-T. Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Current Medicinal Chemistry 2006; 13: 1859-1876.
20. Schuetz EG, Beck WT and Schuetz JD. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Molecular Pharmacology 1996; 49: 311-318.
21. 14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake. Journal of Cellular Physiology 2000; 183: 108-116.
22. Shen F, Chu S, Bence AK, Bailey B, Xue X, Priscilla AE, Montrose MH, Beck WT and Erickson LC. Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. The Journal of Pharmacology and Experimental Therapeutics 2008; 324: 95-102.
23. Stefanska B, Arciemiuk M, Bontemps-Gracz MM, Dzieduszycka M, Kupiec A, Martelli S and Borowski E. Synthesis and biological evaluation of 2, 7-Dihydro-3H-dibenzo[de, h]cinnoline-3, 7-dione derivatives, a novel group of anticancer agents active on a multidrug resistant cell line. Bioorganic & Medicinal Chemistry 2003; 11: 561-572.
24. Ueda K, Cardarelli C, Gottesman MM and Pastan I. Expression of a full-length cDNA for the human MDR1 geneconfers resistance to colchicine, doxorubicin, and vinblastine. Proceedings of the National Academy of Sciences of the United States of America 1987; 84: 3004-3008.
25. Vanhuyse M, Kluza J, Tardy C, Otero G, Cuevas C, Bailly C and Lansiaux A. Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux. Cancer Letters 2005; 221: 165-175.
26. Wielinga PR, Westerhoff HV and Lankelma J. The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells. European Journal of Biochemistry 2000; 267: 649-657.
27. Zhou S-F, Wang L-L, Di YM, Xue CC, Duan W, Li CG and Li Y. Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development, Current Medicinal Chemistry 2008; 15: 1981-2039.