Tarka® overdose in a young child

Human and Experimental Toxicology

Volumn 30, Issue 9, 2011, Pages 1392-1398

  Doǧan, Murat ^a   Basaranoglu, Murat ^a   Peker, Erdal ^a   Akbayram, Sinan ^a   Sahin, Musa ^a   Uner, Abdurrahman ^a   Caksen, Huseyin ^a  

^a YUZUNCU YIL UNIVERSITY   (Turkey)

Author keywords

Tarka overdose; young children

Indexed keywords

ACTIVATED CARBON; ADRENALIN; DOPAMINE; LACTULOSE; TRANDOLAPRIL PLUS VERAPAMIL;

ARTERIAL PRESSURE; ARTICLE; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; CASE REPORT; CHILD; DRUG INTOXICATION; DRUG OVERDOSE; ELECTROCARDIOGRAM; FEMALE; FLUSHING; HEART MURMUR; HEART RHYTHM; HOSPITALIZATION; HUMAN; HYDRATION; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPOTENSION; LETHARGY; LEUKOCYTOSIS; PACEMAKER; PRESCHOOL CHILD; PRIORITY JOURNAL; PULSE RATE; QT PROLONGATION; SOMNOLENCE; SPASTICITY; STOMACH LAVAGE;

CHILD, PRESCHOOL; DRUG COMBINATIONS; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; INDOLES; OVERDOSE; PACEMAKER, ARTIFICIAL; TREATMENT OUTCOME; VERAPAMIL;

EID: 80052537536     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110389834     Document Type: Article

References (33)

1. Prisant LM, Doll NC. Hypertension: the rediscovery of combination therapy. Geriatrics. 1997 ; 52: 28-30
2. Schamroth L, Krikler DM, Garrett C. Immediate effects of intravenous verapamil in cardiac arrhythmias. Br Med J. 1972 ; 1: 660-662
3. Hilleman DE, Ryschon KL, Mohiuddin SM, Wurdeman RL. Fixed-dose combination vs monotherapy in hypertension: a meta-analysis evaluation. J Hum Hypertens. 1999 ; 13: 477-483 (Pubitemid 29355891)
4. Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med. 2007 ; 120: 713-719 (Pubitemid 47176510)
5. Sica DA. Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats. Drugs. 2002 ; 62: 443-462 (Pubitemid 34208333)
6. Ruggenenti P, Fassi A, Ilieva AP, Bruno S, Iliev IP, Brusegan V, et al. Bergamo Nephrologic Diabetes Complications Trial (BENEDICT) Investigators. Preventing microalbuminuria in type 2 diabetes. N Engl J Med. 2004 ; 351: 1941-1951
7. Triggle DJ, Janis RA. Recent development in calcium channel antagonists. Magnesium. 1989 ; 8: 213-222 (Pubitemid 20038792)
8. Samniah N, Schlaeffer F. Cerebral infarction associated with oral verapamil overdose. J Toxicol Clin Toxicol. 1988 ; 26: 365-369 (Pubitemid 19007873)
9. Shah AR, Passalacqua BR. Case report: sustained-release verapamil overdose causing stroke: an unusual complication. Am J Med Sci. 1992 ; 304: 357-359 (Pubitemid 23011309)
10. Barrow PM, Houston PL, Wong DT. Overdose of sustained-release verapamil. Br J Anaesth. 1994 ; 72: 361-365 (Pubitemid 24089753)
11. Tom PA, Morrow CT, Kelen GD. Delayed hypotension after overdose of sustained release verapamil. J Emerg Med. 1994 ; 12: 621-625 (Pubitemid 24294692)
12. Tracqui A, Tournoud C, Kintz P, Villain M, Kummerlen C, Sauder P, et al. HPLC/MS findings in a fatality involving sustained-release verapamil. Hum Exp Toxicol. 2003 ; 22: 515-521 (Pubitemid 37279294)
13. Rankin RJ, Edwards IR. Overdose of sustained release verapamil. N Z Med J. 1990 ; 103: 165 (Pubitemid 20383263)
14. Cohen V, Jellinek SP, Fancher L, Sangwan G, Wakslak M, Marquart E, et al. Tarka(R) (Trandolapril/Verapamil hydrochloride extended-release) overdose. J Emerg Med. 2009 ;:
15. Ashraf M, Chaudhary K, Nelson J, Thompson W. Massive overdose of sustained-release verapamil: a case report and review of literature. Am J Med Sci. 1995 ; 310: 258-263 (Pubitemid 26001207)
16. Ramoska EA, Spiller HA, Myers A. Calcium channel blocker toxicity. Ann Emerg Med. 1990 ; 19: 649-653
17. The internet drug index, http://www.rxlist.com/mavik-drug.htm (Accessed, September 2010).
18. Batalis NI, Harley RA, Schandl CA. Verapamil toxicity: an unusual case report and review of the literature. Am J Forensic Med Pathol. 2007 ; 28: 137-140 (Pubitemid 47164692)
19. Gokel Y, Paydas S, Duru M. High-dose verapamil-trandolapril induced rhabdomyolysis and acute renal failure. Am J Emerg Med. 2000 ; 18: 738-739
20. Gokel Y, Paydas S, Acikalin A, Bozkurt A. High-dose verapamil + trandolapril-induced thrombotic microangiopathy. Haematologia. 2002 ; 32: 281-285 (Pubitemid 36124116)
21. Chyka PA, Seger D, Krenzelok EP, Vale JA. Position paper: Single-dose activated charcoal. Clin Toxicol (Phila). 2005 ; 43: 61-87
22. Laine K, Kivistö KT, Neuvonen PJ. Effect of delayed administration of activated charcoal on the absorption of conventional and slow-release verapamil. J Toxicol Clin Toxicol. 1997 ; 35: 263-268 (Pubitemid 27208383)
23. Kenny J. Treating overdose with calcium channel blockers. BMJ. 1994 ; 308: 992-993 (Pubitemid 24115029)
24. Kuhlmann U, Schoenemann H, Müller TF, Keuchel M, Lange H. Plasmapheresis in fatal overdose with verapamil. Intensive Care Med. 1999 ; 25: 1473
25. Proano L, Chiang WK, Wang RY. Calcium channel blocker overdose. Am J Emerg Med. 1995 ; 13: 444-450
26. Crump BJ, Holt DW, Vale JA. Lack of response to intravenous calcium in severe verapamil poisoning. Lancet. 1982 ; 2: 939-940 (Pubitemid 12028432)
27. Tebbutt S, Harvey M, Nicholson T, Cave G. Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med. 2006 ; 13: 134-139 (Pubitemid 43155818)
28. Boyer EW, Shannon M. Treatment of calcium-channel-blocker intoxication with insulin infusion. N Engl J Med. 2001 ; 344: 1721-1722 (Pubitemid 32479976)
29. Boyer EW, Duic PA, Evans A. Hyperinsulinemia/euglycemia therapy for calcium channel blocker poisoning. Pediatr Emerg Care. 2002 ; 18: 36-37 (Pubitemid 34174344)
30. Erickson FC, Ling LJ, Grande GA, Anderson DL. Diltiazem overdose: case report and review. J Emerg Med. 1991 ; 9: 357-366
31. McGlinchey PG, McNeill AJ. Drug overdoses requiring temporary cardiac pacing; a study of six cases treated at Altnagelvin Hospital, Londonderry. Ulster Med J. 1998 ; 67: 13-188
32. Punukollu G, Gowda RM, Khan IA, Dogan OM. Delayed presentation of calcium channel antagonist overdose. Am J Ther. 2003 ; 10: 132-134
33. Radovanović MR, Miletić GM, Radovanović MS. Successful treatment of polymedicamentous poisoning with metoprolol, diltiazem and cilazapril. Vojnosanit Pregl. 2009 ; 66: 904-908