An improved LC-MS/MS method for quantitative determination of metolazone in human plasma and its application to a pharmacokinetic study

Biomedical Chromatography

Volumn 25, Issue 10, 2011, Pages 1138-1143

  Jia, Yanyan ^a   Zhang, Yan ^b   Wang, Chao ^a   Wang, Zhirui ^a   Liu, Yu ^a   Wang, Jingwen ^a   Wen, Aidong ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

LC MS MS; Metolazone; Pharmacokinetics

Indexed keywords

LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

HUMAN PLASMAS; ITS APPLICATIONS; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; METOLAZONE; PHARMACOKINETIC STUDIES; QUANTITATIVE DETERMINATIONS; SIMPLE++;

PHARMACOKINETICS;

METHANOL; METOLAZONE; WATER;

ADULT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STABILITY; ELUTION; FEMALE; FLOW RATE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 80052529067     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1583     Document Type: Article

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