Pharmacokinetic study of a novel stroke therapeutic, 2-[[(1,1- dimethylethyl)oxidoimino]methyl]-3,5,6-trimethylpyrazine, by a simple HPLC-UV method in rats
ACCURACY;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
AREA UNDER THE CURVE;
ARTICLE;
CONTROLLED STUDY;
DRUG BIOAVAILABILITY;
DRUG BLOOD LEVEL;
DRUG CLEARANCE;
DRUG DETERMINATION;
DRUG DISTRIBUTION;
DRUG ELIMINATION;
DRUG HALF LIFE;
DRUG ISOLATION;
DRUG MEGADOSE;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
LIMIT OF DETECTION;
LIMIT OF QUANTITATION;
LOW DRUG DOSE;
MAXIMUM PLASMA CONCENTRATION;
NONHUMAN;
QUANTITATIVE ANALYSIS;
RAT;
SINGLE DRUG DOSE;
TIME TO MAXIMUM PLASMA CONCENTRATION;
ULTRAVIOLET SPECTROSCOPY;
ANIMAL;
CALIBRATION;
HALF LIFE TIME;
QUALITY CONTROL;
REPRODUCIBILITY;
SPRAGUE DAWLEY RAT;
STANDARD;
STROKE;
ULTRAVIOLET SPECTROPHOTOMETRY;
ANIMALS;
CALIBRATION;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
HALF-LIFE;
INDICATORS AND REAGENTS;
PYRAZINES;
QUALITY CONTROL;
RATS;
RATS, SPRAGUE-DAWLEY;
REFERENCE STANDARDS;
REPRODUCIBILITY OF RESULTS;
SPECTROPHOTOMETRY, ULTRAVIOLET;
STROKE;
Pharmacokinetics studies on tetramethylpyrazine by intravenous administration in rats
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