Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication

Human and Experimental Toxicology

Volumn 30, Issue 9, 2011, Pages 1350-1358

  Kandiş, Hayati ^a   Erkan, Melih Engin ^a   Yildirim, Ümran ^a   Güneş, Harun ^a   Erbaş, Mesut ^a   Yildirim, Hayriye A K ^a   Gezer, Suat ^a   Kara, Ismail Hamdi ^a  

^a DUZCE UNIVERSITY   (Turkey)

Author keywords

erdosteine; N acetyl cysteine; paracetamol; radionuclide imaging; renal toxicity

Indexed keywords

ACETYLCYSTEINE; CREATININE; ERDOSTEINE; PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOCHEMISTRY; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; EXCRETION; FEMALE; HISTOPATHOLOGY; INTERSTITIAL NEPHRITIS; INTOXICATION; KIDNEY INJURY; KIDNEY TUBULE NECROSIS; MAINTENANCE DRUG DOSE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL PROTECTION; SCINTISCANNING; TREATMENT DURATION; TUBULAR VACUOLIZATION; UREA NITROGEN BLOOD LEVEL;

ACETAMINOPHEN; ACETYLCYSTEINE; ACUTE KIDNEY INJURY; ANIMALS; ANTIOXIDANTS; DATA INTERPRETATION, STATISTICAL; FEMALE; KIDNEY; KIDNEY FUNCTION TESTS; RATS; RATS, WISTAR; THIOGLYCOLATES; THIOPHENES;

RATTUS; RATTUS NORVEGICUS;

EID: 80052524784     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110391384     Document Type: Article

References (30)

1. Hung OL, Nelson LS Emergency medicine. A comprehensive study guide. Tintinalli JE Kelen GD Stapczynski JS, ed. New-York: McGraw-Hill ; 2004: 1088-1094.
2. Bartlett D. Acetaminophen toxicity. J Emerg Nurs. 2004 ; 30 (3). 281-281
3. Mladenović D, Radosavljević T, Ninković M, Vucević D, Jesić-Vukićević R, Todorović V. Liver antioxidant capacity in the early phase of acute paracetamol-induced liver injury in mice. Food Chem Toxicol. 2009 ; 47 (4). 866-866
4. Blakey P, McDonald BR. Acute renal failure due to acetaminophen ingestion: a case report and review of the literature. J Am Soc Nephrol. 1995 ; 6 (1). 48-53
5. da Silva Melo DA, Saciura VC, Poloni JA, Oliveira CS, Filho JC, Padilha RZ, et al. Evaluation of renal enzymuria and cellular excretion as a marker of acute nephrotoxicity due to an overdose of paracetamol in Wistar rats. Clin Chim. 2006 ; 373 (1-2). 88-91 (Pubitemid 44292177)
6. Moller-Hartmann W, Seigers CP. Nephrotoxicity of paracetamol in rat. Mechanistic and therapeutic aspects. J Appl Toxicol. 1991 ; 11 (2). 141-146
7. Nelson S, Nelson D. Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury. Drug Metab Rev. 1995 ; 27 (1-2). 147-77
8. Placke ME, Wyand DS, Cohen SD. Extrahepatic lesions induced by acetaminophen in the mouse. Toxicol Pathol. 1987 ; 15 (4). 381-381
9. Isik B, Bayrak R, Akcay A, Sogut S. Erdosteine against acetaminophen induced Renal toxicity. Mol Cell Biochem. 2006 ; 287 (1-2). 185-191 (Pubitemid 44057406)
10. Mitchell JR, McMurty RJ, Statham CN, Nelson SD. Molecular basis for several drug induced nephropathies. Am J Med. 1977 ; 62 ( 4 518 ):
11. Buckley NA, Whyte IM, O'Connell DL, Dawson AH. Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose. J Toxicol Clin Toxicol. 1999 ; 37 (6). 753-753
12. Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002 ; 40 (1). 3-3
13. Yagmurca M, Bas O, Mollaoglu H, Sahin O, Nacar A, Karaman O, et al. Protective effects of erdosteine on doxorubicin-induced hepatotoxicity in rats. Arch Med Res. 2007 ; 38: 380-385 (Pubitemid 46528559)
14. Kuvandik G, Duru M, Nacar A, Yonden Z, Helvaci R, Koc A, et al. Effects of erdosteine on acetaminophen-induced hepatotoxicity in rats. Toxicol Pathol. 2008 ; 36 (5). 714-719
15. Dechant KL, Noble S. Erdosteine. Drugs. 1996 ; 52 (6). 875-875
16. Fadillioglu E, Erdogan H, Sogut S, Kuku I. Protective effects of erdosteine against doxorubicin-induced cardiomyopathy in rats. J Appl Toxicol. 2003 ; 23 (1). 71-71
17. Gazzani G, Fregnan GB, Vandoni G. In vitro protection by erdosteine against oxidative inactivation of alpha-1-antitrypsin by cigarette smoke. Respiration. 1989 ; 55 (2). 113-113
18. Hart SG, Beierschmitt WP, Wyand DS, Khairallah EA, Cohen SD. Acetaminophen toxicity in CD-0 mice: I. Evidence of a role for in situ activation in selective covalent binding and toxicity. Toxicol Appl Pharmacol. 1994 ; 126 (2). 267-267
19. Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB. Acetaminophen induced hepatic necrosis: IV. Protective role of glutathione. J Pharmacol Exp Ther. 1973 ; 187 (1). 211-211
20. De la Cruz Rodriguez LC, Araujo NCR, Pos Leman SE, Rey MR. Attenuation of gentamicin-induced nephrotoxicity: trimetazidine versus N-acetyl cysteine. J App Toxicol. 2010 ;:
21. Chen N, Aleksa K, Woodland C, Rieder M, Koren G. The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: invitro studies in renal tubular cells. Transl Res. 2007 ; 150 (1). 51-57 (Pubitemid 46935594)
22. Cabuk M, Gurel A, Sen F, Demircan N. Renoprotective effect of erdosteine in rats against gentamicin nephrotoxicity: a comparison of 99mTc-DMSA uptake with biochemical studies. Mol Cell Biochem. 2008 ; 308 (1-2). 35-42 (Pubitemid 351167842)
23. Yagmurca M, Fadillioglu E, Erdogan H, Ucar M, Sogut S, Irmak MK. Erdosteine prevents doxorubicin-induced cardiotoxicity in rats. Pharmacol Res. 2003 ; 48 (4). 377-382 (Pubitemid 36945336)
24. Ozyurt H, Yildirim Z, Kotuk M, Yilmaz HR, Yagmurca M, Iraz M, et al. Cisplatin-induced acute renal failure is ameliorated by erdosteine in a dose-dependent manner. J Appl Toxicol. 2004 ; 24 (4). 269-269
25. Selcoki Y, Uz E, Bayrak R, Sahin S, Kaya A, Uz B, et al. The protective effect of erdosteine against cyclosporine A-induced cardiotoxicity in rats. Toxicology. 2007 ; 239 (1-2). 53-59 (Pubitemid 47284610)
26. Trumper L, Monasterolo LA, Elias MM. Probenecid protects against invivo acetaminophen-induced nephrotoxicity in male Wistar rats. J Pharmacol Exp Ther. 1998 ; 284 (2). 606-610 (Pubitemid 28086648)
27. Li C, Liu J, Saavedra JE, Keefer LK, Waalkes MP. The nitric oxide donor, VPYRRO/NO, protects against acetaminophen-induced nephrotoxicity. Toxicology. 2003 ; 189 (3). 173-173
28. Meyer MH, Meyer RA, Gray RW, Irwin RL. Picric acid methods greatly overestimate serum creatinine in mice: more accurate results with high-performance liquid chromatography. Anal Biochem. 1985 ; 144 (1). 285-290 (Pubitemid 15127439)
29. Owunwanne A, Shihab-Eldeen A, Yacoub T, Ziada G. The use of radiopharmaceuticals as an effective toxicologic technique for studying nephrotoxicity of drugs: cyclosporine-A. Hum Exp Toxicol. 1998 ; 17 (11). 613-613
30. Roberts J, Chen B, Curtis LM, Agarwal A, Sanders PW, Zinn KR. Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia reperfusion injury. Am J Physiol Renal Physiol. 2007 ; 293 (4). 1408-1412