Genetic variants near the IRS1 gene, physical activity and type 2 diabetes in US men and women

Diabetologia

Volumn 54, Issue 6, 2011, Pages 1579-1582

  He, M A ^a,b   Workalemahu, T ^a   Cornelis, M C ^a   Hu, F B ^a,c   Qi, L ^a,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

IRS1; Physical activity; Polymorphism; Type 2 diabetes

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN;

ALLELE; BODY MASS; CASE CONTROL STUDY; DIABETOGENESIS; ENZYME ACTIVATION; FEMALE; GENE; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HIGH RISK PATIENT; HUMAN; IRS1 GENE; LETTER; MAJOR CLINICAL STUDY; MALE; METABOLIC EQUIVALENT; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES; GENETICS; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREVALENCE; RISK FACTOR; SEXUAL DEVELOPMENT; STATISTICAL MODEL;

CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC VARIATION; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; LOGISTIC MODELS; MALE; MOTOR ACTIVITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; RISK FACTORS; SEX CHARACTERISTICS; UNITED STATES;

EID: 80052523526     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2123-7     Document Type: Letter

References (8)

1. Sun XJ, Rothenberg P, Kahn CR et al (1991) Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352:73-77 (Pubitemid 21896701)
2. Rung J, Cauchi S, Albrechtsen A et al (2009) Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet 41:1110-1115
3. Qi L, Hu FB, Hu G (2008) Genes, environment, and interactions in prevention of type 2 diabetes: a focus on physical activity and lifestyle changes. Curr Mol Med 8:519-532
4. Kirwan JP, del Aguila LF, Hernandez JM et al (2000) Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle. J Appl Physiol 88:797-803 (Pubitemid 30097130)
5. Bax L, Yu LM, Ikeda N, Tsuruta H, Moons KG (2006) Development and validation of MIX: comprehensive free software for meta-analysis of causal research data. BMC Med Res Methodol 6:50
6. Jellema A, Zeegers MP, Feskens EJ, Dagnelie PC, Mensink RP (2003) Gly972Arg variant in the insulin receptor substrate-1 gene and association with type 2 diabetes: a meta-analysis of 27 studies. Diabetologia 46:990-995 (Pubitemid 36961324)
7. Cornelis MC, Qi L, Zhang C et al (2009) Joint effects of common genetic variants on the risk for type 2 diabetes in US men and women of European ancestry. Ann Intern Med 150:541-550
8. Speliotes EK, Willer CJ, Berndt SI et al (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42:937-948