A novel immune evasion mechanism of LMP-1, an EBV-primary oncogene, in nasopharyngeal Carcinoma

Advances in Oto-Rhino-Laryngology

Volumn 72, Issue , 2011, Pages 157-159

  Yoshizaki, Tomokazu ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EBV ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN BARR VIRUS; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; EPITOPE; MATRIX PROTEIN;

CELLULAR IMMUNITY; CONFERENCE PAPER; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; GENETICS; HUMAN; IMMUNE EVASION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; NASOPHARYNX CARCINOMA; NASOPHARYNX TUMOR; VIROLOGY;

EPITOPES, T-LYMPHOCYTE; EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNE EVASION; IMMUNITY, CELLULAR; LYMPHOCYTE ACTIVATION; NASOPHARYNGEAL NEOPLASMS; VIRAL MATRIX PROTEINS;

EID: 80052513386     PISSN: 00653071     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000324780     Document Type: Conference Paper

References (7)

1. Rowe M, Khanna R, Jacob CA, et al: Restoration of endogenous antigen processing in Burkitt's lymphoma cells by Epstein-Barr virus latent membrane protein-1: Coordinated up-regulation of peptide transporters and HLA-class I antigen expression. Eur J Immunol 1995;25:1374-1384.
2. Yoshizaki T, Sato H, Furukawa M, Pagano J: The expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1. Proc Natl Acad Sci USA 1998;95: 3621-3626.
3. Wakisaka N, Kondo S, Yoshizaki T, Murono S, Furukawa M, Pagano JS: Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxiainducible factor 1{alpha}. Mol Cell Biol 2004;24:5223-5234. (Pubitemid 38738158)
4. Kondo S, Seo SY, Yoshizaki T, Wakisaka N, Furukawa M, Joab I, Jang KL, Pagano JS: EBV latent membrane protein 1 upregulates hypoxia-inducible factor 1alpha through Siah1-mediated downregulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells. Cancer Res 2006;66:9870-9877. (Pubitemid 44672038)
5. Khanna R, Burrows SR: Role of cytotoxic T lymphocytes in Epstein-Barr virusassociated diseases. Annu Rev Microbiol 2000;54:19-48.
6. Smith C, Cooper L, Burgess M, et al: Functional reversion of antigen-specific CD8+ T cells from patients with Hodgkin lymphoma following in vitro stimulation with recombinant polyepitope. J Immunol 2006;177: 4897-4906. (Pubitemid 44469826)
7. Smith C, Wakisaka N, Crough T, Peet J, Yoshizaki T, Beagley L, Khanna R: Discerning regulation of cis-and trans-presentation of CD8+ T-cell epitopes by EBV-encoded oncogene LMP-1 through self-aggregation. Blood 2009;113:6148-6152.