Validation of Thin Layer Chromatography with AccuTOF-DART™ Detection for Forensic Drug Analysis

Journal of Forensic Sciences

Volumn 56, Issue 5, 2011, Pages 1261-1267

  Howlett, Susanne E ^a,c   Steiner, Robert R ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Virginia Department of Forensic Science   (United States)

^c FBI LABORATORY   (United States)

Author keywords

Controlled substances; Direct analysis in real time; Forensic science; Mass spectrometry; Thin layer chromatography; Time of flight

Indexed keywords

EID: 80052506931     PISSN: 00221198     EISSN: 15564029     Source Type: Journal    
DOI: 10.1111/j.1556-4029.2011.01881.x     Document Type: Article

References (61)

1. Moffat AC. Thin layer chromatography. In: Clarke EC, editor. Clarke's isolation and identification of drugs. London, UK: The Pharmaceutical Press, 1972;160-77.
2. Stahl E. Thin-layer chromatography, 2nd edn. Berlin, Germany: Springer-Verlag, 1969.
3. U.S. Department of Justice. Basic training program for forensic chemists. Washington, DC: U.S. Department of Justice, Drug Enforcement Administration, Office of Science and Technology, 4-39-49 (restricted to forensic chemists working with law enforcement agencies), 1982.
4. Randerath K. Thin-layer chromatography, 2nd edn. New York, NY: Academic Press, 1968.
5. Butler WP. Methods of analysis for alkaloids, opiates, marihuana, barbiturates, and miscellaneous drugs (U.S. Internal Revenue Service, Publication, no. 341). Washington, DC: U.S. Government Printing Office, 1970.
6. Liu R, Gadzala D. Handbook of drug analysis: applications in forensic and clinical laboratories. Washington, DC: American Chemical Society, 1997;67.
7. Sunshine I. Manual of analytical toxicology. Cleveland, OH: CRC Press, 1971.
8. Bauer K, Gros L, Sauer W. Thin layer chromatography. Heidelberg, Germany: EM Science, 1991.
9. Macek K. Pharmaceutical applications of thin layer and paper chromatography. New York, NY: Elsevier Publishing Company, 1972;654.
10. Virginia department of forensic science procedures manual. (accessed March 10, 2010).
11. Cody RB, Laramée JA, Durst HD. Versatile new ion source for the analysis of materials in open air under ambient conditions. Anal Chem 2005;77(8):2297-302.
12. Cody RB, Laramée JA, Nilles JM, Durst HD. Direct analysis in real time (DART™) mass spectrometry. JEOL News 2005;40(1):8-12.
13. Fernández FM, Cody RB, Green MD, Hampton CY, McGready R, Sengaloundeth S, et al. Characterization of solid counterfeit drug samples by desorption electrospray ionization and direct-analysis-in-real-time coupled to time-of-flight mass spectrometry. ChemMedChem 2006;1(7):702-5.
14. Jones RW, Cody RB, McClelland JF. Differentiating writing inks using direct analysis in real time mass spectrometry. J Forensic Sci 2006;51(4):915-8.
15. Morlock G, Schwack W. Determination of isopropylthioxanthone (ITX) in milk, yoghurt and fat by HPTLC-FLD, HPTLC-ESI/MS and HPTLC-DART/MS. Anal Bioanal Chem 2006;385(3):586-95.
16. Williams JP, Patel VJ, Holland R, Scrivens JH. The use of recently described ionization techniques for the rapid analysis of some common drugs and samples of biological origin. Rapid Commun Mass Spectrom 2006;20:1447-56.
17. Laramée JA, Cody RB. Chemi-ionization and direct analysis in real time (DART™) mass spectrometry. In: Gross ML, Caprioli RM, editors. The encyclopedia of mass spectrometry volume 6: ionization methods. Amsterdam, Netherlands: Elsevier Publishing Company, 2007;377-88.
18. Laramée JA, Cody RB, Nilles JM, Durst HD. Forensic application of DART™ (direct analysis in real time) mass spectrometry. In: Blackledge RD, editor. Forensic analysis on the cutting edge: new methods for trace evidence analysis. Hoboken, NJ: Wiley-Interscience, 2007;175-94.
19. Petucci C, Diffendal J, Kaufman D, Mekonnen B, Terefenko G, Musselman B. Direct analysis in real time for reaction monitoring in drug discovery. Anal Chem 2007;79(13):5064-70.
20. Pierce CY, Barr JR, Cody RB, Massung RF, Woolfitt AR, Moura H, et al. Ambient generation of fatty acid methyl ester ions from bacterial whole cells by direct analysis in real time (DART™) mass spectrometry. Chem Commun 2007;8:807-9.
21. TM) and signature analysis for the identification of constituents of refined illicit cocaine. Microgram J 2007;5(14):5-10.
22. Saitoh K. Direct analysis for fragrance ingredients using DART-TOFMS. Aroma Res 2007;8(4):366-9.
23. Vail TM, Jones PR, Sparkman OD. Rapid and unambiguous identification of melamine in contaminated pet food based on mass spectrometry with four degrees of confirmation. J Anal Toxicol 2007;31(6):304-12.
24. Haefliger OP, Jeckelmann N. Direct mass spectrometric analysis of flavors and fragrances in real applications using DART™. Rapid Commun Mass Spectrom 2007;21(8):1361-6.
25. Kpegba K, Spadaro T, Cody RB, Nesnas N, Olson JA. Analysis of self-assembled monolayers on gold surfaces using direct analysis in real time mass spectrometry. Anal Chem 2007;79(14):5479-83.
26. Kusai A. Fundamental and application of the direct analysis in real time mass spectrometry. Bunseki 2007;3:124-7.
27. Banerjee S, Madhusudanan KP. Expression of tropane alkaloids in the hairy root culture of Atropa acuminate substantiated by DART™ mass spectrometric technique. Biomed Chromatogr 2008;22(8):830-4.
28. Banerjee S, Madhusudanan KP, Khanuja SPS, Chattopadhyay SK. Analysis of cell cultures of Taxus wallichiana using direct analysis in real-time mass spectrometric technique. Biomed Chromatogr 2008;22(3):250-3.
29. Cajka TV, Vaclavik L, Riddellova K, Hajslova J. GC-TOF-MS and DART-TOF-MS: challenges in the analysis of soft drinks. LC-GC Europe 2008;21(5):250-6.
30. Cajka TV, Vaclavik L, Riddellova K, Hajslova J. DART-TOFMS: a challenging approach in rapid monitoring of brominated flame retardants in environmental matrices. Organohalogen Compd 2008;70:922-5.
31. Coates CM, Coticone S, Barreto PD, Cobb AE, Cody RB, Barreto JC. Flammable solvent detection directly from common household materials yields differential results: an application of direct analysis in real-time mass spectrometry. J Forensic Identif 2008;58(6):624-31.
32. Fernandez FM, Green MD, Newton PN. Prevalence and detection of counterfeit pharmaceuticals: a mini review. Ind Eng Chem Res 2008;47(3):585-90.
33. Grange AH, Sovocool GW. Automated determination of precursor ion, product ion, and neutral loss compositions and deconvolution of composite mass spectra using ion correlation based on exact masses and relative isotopic abundances. Rapid Commun Mass Spectrom 2008;22(15):2375-90.
34. Grange AH. An inexpensive autosampler to maximize throughput for an ion source that samples surfaces in open air. Environ Forensics 2008;9(2-3):127-36.
35. Grange AH. An integrated wipe sample transport/autosampler to maximize throughput for a direct analysis in real time (DART™)/orthogonal acceleration, time-of-flight mass spectrometer (oa-TOFMS). Environ Forensics 2008;9(2-3):137-43.
36. Grange AH. An autosampler and field sample carrier for maximizing throughput using an open-air source for MS. Am Lab 2008;September:11-3.
37. Laramée JA, Durst HD, Connell TR, Nilles JM. Detection of chemical warfare agents on surfaces relevant to homeland security by direct analysis in real-time spectrometry. Am Lab 2008;40:16-20.
38. Madhusudanan KP, Banerjee S, Khanuja SPS. Analysis of hairy root culture of Rauwolfia serpentina using direct analysis in real time mass spectrometric technique. Biomed Chromatogr 2008;22(6):596-600.
39. Newton PN, Fernandez FM, Plancon A, Mildenhall DC, Green MD, Ziyong L, et al. A collaborative epidemiological investigation into the criminal fake artesunate trade in South East Asia. PLoS Med 2008;5(2):e32.
40. Newton PN, Hampton CY, Alter-Hall K, Teerwarakulpana T, Prakongpan S, Ruangveerayuth R, et al. Characterization of "Yaa Chud" medicine on the Thailand-Myanmar border: selecting for drug-resistant malaria and threatening public health. Am J Trop Med Hyg 2008;79(5):662-9.
41. Schurek J, Vaclavik L, Hooijerink H, Lacina O, Poustika J, Sharman M, et al. Control of Strobilurin fungicides in wheat using direct analysis in real time accurate time-of-flight and desorption electrospray ionization linear ion trap mass spectrometry. Anal Chem 2008;80(24):9567-75.
42. Smith NJ, Domin MA, Scott LT. HRMS directly from TLC slides. A powerful tool for rapid analysis of organic mixtures. Org Lett 2008;10(16):3493-6.
43. Vaclavik L, Schurek J, Cajka T, Hajslova J. Direct analysis in real time-time-of-flight mass spectrometry: analysis of pesticide residues and environmental contaminants. Chemicke Listy 2008;102:s324-7.
44. Wells JM, Roth MJ, Keil AD, Grossenbacher JW, Justes DR, Patterson GE, et al. Implementation of DART™ and DESI ionization on a fieldable mass spectrometer. J Am Soc Mass Spectrom 2008;19(10):1419-24.
45. Yew JY, Cody RB, Kravitz EA. Cuticular hydrocarbon analysis of an awake behaving fly using direct analysis in real-time time-of-flight mass spectrometry. Proc Natl Acad Sci USA 2008;105(20):7135-40.
46. Zhao Y, Lam M, Wu D, Mak R. Quantification of small molecules in plasma with direct analysis in real time tandem mass spectrometry, without sample preparation and liquid chromatographic separation. Rapid Commun Mass Spectrom 2008;22(20):3217-24.
47. Bennett MJ, Steiner RR. Detection of gamma-hydroxybutyric acid in various drink matrices via AccuTOF-DART™. J Forensic Sci 2009;54(2):370-5.
48. Cody RB. Observation of molecular ions and analysis of nonpolar compounds with the direct analysis in real time ion source. Anal Chem 2009;81(3):1101-7.
49. Harris GA, Fernandez FM. Simulations and experimental investigation of atmospheric transport in an ambient metastable-induced chemical ionization source. Anal Chem 2009;81(1):322-9.
50. Jagerdeo E, Abdel-Rehim M. Screening of cocaine and its metabolites in human urine samples by direct analysis in real-time source coupled to time-of-flight mass spectrometry after online preconcentration utilizing microextraction by packed sorbent. J Am Soc Mass Spectrom 2009;20(5):891-9.
51. Maleknia SD, Bell TL, Adam MA. Eucalypt smoke and wildfires: temperature dependent emissions of biogenic volatile organic compounds. Int J Mass Spectrom 2009;279(2-3):126-33.
52. Song L, Dykstra AB, Yao H, Bartmess JE. Ionization mechanism of negative ion- direct analysis in real time: a comparative study with negative ion-atmospheric pressure photoionization. J Am Soc Mass Spectrom 2009;20(1):42-50.
53. Yu S, Crawford E, Tice J, Musselman B, Wu JT. Bioanalysis without sample cleanup or chromatography: the evaluation and initial implementation of direct analysis in real time ionization mass spectrometry for the quantification of drugs in biological matrixes. Anal Chem 2009;81(1):193-202.
54. Kim HJ, Jang YP. Direct analysis of curcumin in turmeric by DART-MS. Phytochem Anal 2009;20(5):372-7.
55. Dytkiewitz E, Morlock GE. Analytical strategy for rapid identification and quantification of lubricant additives in mineral oil by high-performance thin-layer chromatography with UV absorption and fluorescence detection combined with mass spectrometry and infrared spectrometry. J AOAC Int 2008;91(5):1237-43.
56. Kusai A, Konuma K, Kobayashi M, Vargas D. New development of thin layer chromatography/time-of-flight mass spectrometry with DART™. In: Proceedings of the 55th ASMS Conference on Mass Spectrometry; 2007 June 3-7; Indianapolis, IN. Santa Fe, NM: American Society for Mass Spectrometry, 2007; poster.
57. Morlock GE, Ueda Y. New coupling of planar chromatography with direct analysis in real time mass spectrometry. J Chromatogr A 2007;1143(1-2):243-51.
58. Steiner RR, Larson RL. Validation of the direct analysis in real time source for use in forensic drug screening. J Forensic Sci 2009;54(3):617-22.
59. Scientific working group for the analysis of seized drugs (SWGDRUG) recommendations. (accessed March 10, 2010).
60. Thompson Reuters (Healthcare). Physicians' desk reference for prescription drugs (PDR), 63rd edn. Montvale, NJ: Physicians' Desk Reference, Inc, 2008.
61. Thompson Healthcare Inc. Physicians' desk reference for non-prescription drugs, 28th edn. Montvale, NJ: Thompson PDR, 2006.