Acetaminophen psi parameter: A useful tool to quantify hepatotoxicity risk in acute acetaminophen overdose

Clinical Toxicology

Volumn 49, Issue 7, 2011, Pages 664-667

  Chomchai, Summon ^a   Chomchai, Chulithida ^b   Anusornsuwan, Taweepong ^c  

^a MAHIDOL UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c Sungnoen Hospital   (Thailand)

Author keywords

Analgesics; Gut and hepatotoxicity; Paracetamol

Indexed keywords

ACETYLCYSTEINE; PARACETAMOL;

ADULT; ARTICLE; CLINICAL ASSESSMENT TOOL; COMPARATIVE STUDY; DRUG OVERDOSE; FEMALE; HUMAN; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PSI PARAMETER; RISK ASSESSMENT; THAILAND; TOXICOKINETICS; TOXICOLOGICAL PARAMETERS;

ACETAMINOPHEN; ACETYLCYSTEINE; ADOLESCENT; ADULT; ANALGESICS, NON-NARCOTIC; ANTIDOTES; DRUG ADMINISTRATION SCHEDULE; DRUG-INDUCED LIVER INJURY; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; LOGISTIC MODELS; MALE; OVERDOSE; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; THAILAND; YOUNG ADULT;

EID: 80052502643     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2011.597031     Document Type: Article

References (14)

1. Eddleston M. Patterns and problems of deliberate self-poisoning in the developing world. QJM 2000; 93:715-731.
2. Wananukul W, Sriapha C, Tongpoo A, Sadabthammarak U, Wongvisawakorn S, Kaojarern S. Human poisoning in Thailand: the Ramathibodi Poison Center 's experience (2001-2004). Clin Toxicol (Phila) 2007; 45:582-588.
3. Rumack BH. Acetaminophen hepatotoxicity: the fi rst 35 years. J Toxicol Clin Toxicol 2002; 40:3-20. (Pubitemid 34438289)
4. Prescott LF, Illingworth RN, Critchley JA, Stewart MJ, Adam RD, Proudfoot AT. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J 1979; 2:1097-1100. (Pubitemid 10249121)
5. Doyon S, Klein-Schwartz W. Hepatotoxicity despite early administration of intravenous N-acetylcysteine for acute acetaminophen overdose. Acad Emerg Med 2009; 16:34-39.
6. Sivilotti ML, Good AM, Yarema MC, Juurlink DN, Johnson DW. A new predictor of toxicity following acetaminophen overdose based on pretreatment exposure. Clin Toxicol (Phila) 2005; 43:229-234. (Pubitemid 41073020)
7. Sivilotti ML, Yarema MC, Juurlink DN, Good AM, Johnson DW. A risk quantifi cation instrument for acute acetaminophen overdose patients treated with N-acetylcysteine. Ann Emerg Med 2005; 46: 263-271. (Pubitemid 41218716)
8. Yarema MC, Johnson DW, Berlin RJ, Sivilotti ML, Nettel-Aguirre A, Brant RF, et al. Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med 2009; 54:606-614.
9. Fish LJ. Why multivariate methods are usually vital. Meas Eval Counsel Dev 1988; 21:130-137.
10. Sangrajrang S, Jedpiyawongse A, Srivatanakul P. Genetic polymorphisms of CYP2E1 and GSTM1 in a Thai population. Asian Pac J Cancer Prev 2006; 7:415-419.
11. Ueshima Y, Tsutsumi M, Takase S, Matsuda Y, Kawahara H. Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes. Alcohol Clin Exp Res 1996; 20(1 Suppl):25A-28A.
12. Manyike PT, Kharasch ED, Kalhorn TF, Slattery JT. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Clin Pharmacol Ther 2000; 67:275-282. (Pubitemid 30176386)
13. Peduzzi P, Concato J, Feinstein AR, Holford TR. Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol 1995; 48:1503-1510. (Pubitemid 26035533)
14. Chomchai S, Anusornsuwan T, Chomchai C, Plubjui P. Relationship of Acetaminophen Psi Parameter and Hepatotoxicity Secondary to Acute Acetaminophen Overdose in Thai Population. Clinical Toxicology. 2010;48:146.