-
3
-
-
33847638137
-
Estimates of the cancer incidence and mortality in Europe in 2006
-
Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007;18:581-92.
-
(2007)
Ann Oncol
, vol.18
, pp. 581-592
-
-
Ferlay, J.1
Autier, P.2
Boniol, M.3
Heanue, M.4
Colombet, M.5
Boyle, P.6
-
4
-
-
18244390213
-
Chemotherapy in non-small cell lung cancer: An update of an individual patient data-based meta-analysis
-
Burdett S, Stewart L, Pignon JP. Chemotherapy in non-small cell lung cancer: An update of an individual patient data-based meta-analysis. J Thorac Cardiovasc Surg 2005;129:1205.
-
(2005)
J Thorac Cardiovasc Surg
, vol.129
, pp. 1205
-
-
Burdett, S.1
Stewart, L.2
Pignon, J.P.3
-
5
-
-
53749097825
-
Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled, trials
-
NSCLC Meta analyses collaborative group
-
NSCLC Meta analyses collaborative group. Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled trials. J Clin Oncol 2008;26:4617-25.
-
(2008)
J. Clin Oncol
, vol.26
, pp. 4617-4625
-
-
-
6
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002;346:92-8.
-
(2002)
N Engl J Med
, vol.346
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
Langer, C.4
Sandler, A.5
Krook, J.6
-
7
-
-
0036843105
-
Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer
-
Scagliotti GV, De Marinis F, Rinaldi M, Crinò L, Gridelli C, Ricci S, et al. Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer. J Clin Oncol 2002;20:4285-91.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4285-4291
-
-
Scagliotti, G.V.1
De Marinis, F.2
Rinaldi, M.3
Crinò, L.4
Gridelli, C.5
Ricci, S.6
-
8
-
-
0042413836
-
Randomized, multinational, phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non-small-cell lung cancer: the TAX 326 study group
-
Fossella F, Pereira JR, von Pawel J, Pluzanska A, Gorbounova V, Kaukel E, et al. Randomized, multinational, phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non-small-cell lung cancer: the TAX 326 study group. J Clin Oncol 2003;21:3016-24.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3016-3024
-
-
Fossella, F.1
Pereira, J.R.2
von Pawel, J.3
Pluzanska, A.4
Gorbounova, V.5
Kaukel, E.6
-
9
-
-
0035397994
-
Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: a Southwest Oncology Group trial
-
Kelly K, Crowley J, Bunn PA Jr, Presant CA, Grevstad PK, Moinpour CM, et al. Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small-cell lung cancer: a Southwest Oncology Group trial. J Clin Oncol 2001;19:3210-8.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3210-3218
-
-
Kelly, K.1
Crowley, J.2
Bunn Jr., P.A.3
Presant, C.A.4
Grevstad, P.K.5
Moinpour, C.M.6
-
10
-
-
0042661285
-
Gemcitabine plus cisplatin vs. gemcitabine plus carboplatin in stage IIIb and IV non-small cell lung cancer: a phase III randomized trial
-
Zatloukal P, Petruzelka L, Zemanová M, Kolek V, Skricková J, Pesek M, et al. Gemcitabine plus cisplatin vs. gemcitabine plus carboplatin in stage IIIb and IV non-small cell lung cancer: a phase III randomized trial. Lung Cancer 2003;41:321-31.
-
(2003)
Lung Cancer
, vol.41
, pp. 321-331
-
-
Zatloukal, P.1
Petruzelka, L.2
Zemanová, M.3
Kolek, V.4
Skricková, J.5
Pesek, M.6
-
11
-
-
0346560025
-
Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975
-
Smit EF, van Meerbeeck JP, Lianes P, Debruyne C, Legrand C, Schramel F, et al. Three-arm randomized study of two cisplatin-based regimens and paclitaxel plus gemcitabine in advanced non-small-cell lung cancer: a phase III trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group-EORTC 08975. J Clin Oncol 2003;21:3909-17.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3909-3917
-
-
Smit, E.F.1
van Meerbeeck, J.P.2
Lianes, P.3
Debruyne, C.4
Legrand, C.5
Schramel, F.6
-
12
-
-
3242803674
-
Benefits of adding a drug to a single-agent or a 2-agent chemotherapy regimen in advanced non-small-cell lung cancer: a meta-analysis
-
Delbaldo C, Michiels S, Syz N, Soria JC, Le Chevalier T, Pignon JP. Benefits of adding a drug to a single-agent or a 2-agent chemotherapy regimen in advanced non-small-cell lung cancer: a meta-analysis. JAMA 2004;292:470-84
-
(2004)
JAMA
, vol.292
, pp. 470-484
-
-
Delbaldo, C.1
Michiels, S.2
Syz, N.3
Soria, J.C.4
Le Chevalier, T.5
Pignon, J.P.6
-
13
-
-
63049099070
-
Third generation triplet cytotoxic chemotherapy in advanced non-small cell lung cancer: a systematic overview
-
Azim HA Jr, Elattar I, Loberiza FR Jr, Azim H, Mok T, Ganti AK. Third generation triplet cytotoxic chemotherapy in advanced non-small cell lung cancer: a systematic overview. Lung Cancer 2009;64:194-8.
-
(2009)
Lung Cancer
, vol.64
, pp. 194-198
-
-
Azim Jr., H.A.1
Elattar, I.2
Loberiza Jr., F.R.3
Azim, H.4
Mok, T.5
Ganti, A.K.6
-
14
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
-
Cappuzzo F, Ciuleanu T, Stelmakh L, Cicenas S, Szczésna A, Juhász E, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 2010;11:521-9.
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
Cicenas, S.4
Szczésna, A.5
Juhász, E.6
-
15
-
-
78349272806
-
A randomized phase III study of the docetaxel/carboplatin combination versus docetaxel single-agent as second line treatment for patients with advanced/metastatic non-small cell lung cancer
-
Pallis AG, Agelaki S, Agelidou A, Varthalitis I, Syrigos K, Kentepozidis N, et al. A randomized phase III study of the docetaxel/carboplatin combination versus docetaxel single-agent as second line treatment for patients with advanced/metastatic non-small cell lung cancer. BMC Cancer 2010;10:633.
-
(2010)
BMC Cancer
, vol.10
, pp. 633
-
-
Pallis, A.G.1
Agelaki, S.2
Agelidou, A.3
Varthalitis, I.4
Syrigos, K.5
Kentepozidis, N.6
-
16
-
-
77957054505
-
Second-line treatment for non-small-cell lung cancer: one size does not fit all
-
Caponi S, Vasile E, Ginocchi L, Tibaldi C, Borghi F, D'Incecco A, et al. Second-line treatment for non-small-cell lung cancer: one size does not fit all. Clin Lung Cancer 2010;11:320-7.
-
(2010)
Clin Lung Cancer
, vol.11
, pp. 320-327
-
-
Caponi, S.1
Vasile, E.2
Ginocchi, L.3
Tibaldi, C.4
Borghi, F.5
D'Incecco, A.6
-
17
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995;19:183-232.
-
(1995)
Crit Rev Oncol Hematol
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
Normanno, N.4
-
18
-
-
0027159063
-
Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung
-
Rusch V, Baselga J, Cordon-Cardo C, Orazem J, Zaman M, Hoda S, et al. Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lung. Cancer Res 1993;53:2379-85.
-
(1993)
Cancer Res
, vol.53
, pp. 2379-2385
-
-
Rusch, V.1
Baselga, J.2
Cordon-Cardo, C.3
Orazem, J.4
Zaman, M.5
Hoda, S.6
-
19
-
-
0030297662
-
A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer
-
Fujino S, Enokibori T, Tezuka N, Asada Y, Inoue S, Kato H, et al. A comparison of epidermal growth factor receptor levels and other prognostic parameters in non-small cell lung cancer. Eur J Cancer 1996;32A:2070-4.
-
(1996)
Eur J Cancer
, vol.32 A
, pp. 2070-2074
-
-
Fujino, S.1
Enokibori, T.2
Tezuka, N.3
Asada, Y.4
Inoue, S.5
Kato, H.6
-
20
-
-
0031907022
-
Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival
-
Fontanini G, De Laurentiis M, Vignati S, Chinè S, Lucchi M, Silvestri Vet, et al. Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: amphiregulin and microvessel count are independent prognostic indicators of survival. Clin Cancer Res 1998;4:241-9.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 241-249
-
-
Fontanini, G.1
De Laurentiis, M.2
Vignati, S.3
Chinè, S.4
Lucchi, M.5
Silvestri, V.6
-
21
-
-
18344390418
-
ERBB receptors and cancer: the complexity of targeted inhibitors
-
Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005;5:341-54.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
22
-
-
42549089715
-
Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond
-
Ladanyi M, Pao W. Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond. Mod Pathol 2008;21:s16-22.
-
(2008)
Mod Pathol
, vol.21
-
-
Ladanyi, M.1
Pao, W.2
-
23
-
-
0028168569
-
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity
-
Guy PM, Platko JV, Cantley LC, Cerione RA, Carraway KL 3rd. Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. Proc Natl Acad Sci USA 1994;91:8132-6.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8132-8136
-
-
Guy, P.M.1
Platko, J.V.2
Cantley, L.C.3
Cerione, R.A.4
Carraway 3rd, K.L.5
-
26
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 2003;21:2237-46.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.Y.6
-
27
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
-
Kris MG, Natale RB, Herbst RS, Lynch TJ Jr, Prager D, Belani CP, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003;290:2149-58.
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch Jr., T.J.4
Prager, D.5
Belani, C.P.6
-
28
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527-37.
-
(2005)
Lancet
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
Rodrigues Pereira, J.4
Ciuleanu, T.5
von Pawel, J.6
-
29
-
-
33750962024
-
Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer
-
Hirsch FR, Varella-Garcia M, Bunn PA Jr, Franklin WA, Dziadziuszko R, Thatcher N, et al. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer. J Clin Oncol 2006;24:5034-42.
-
(2006)
J Clin Oncol
, vol.24
, pp. 5034-5042
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Bunn Jr., P.A.3
Franklin, W.A.4
Dziadziuszko, R.5
Thatcher, N.6
-
30
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1
-
Giaccone G, Herbst RS, Manegold C, Scagliotti G, Rosell R, Miller V, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1. J Clin Oncol 2004;22:777-84.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Rosell, R.5
Miller, V.6
-
31
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2
-
Herbst RS, Giaccone G, Schiller JH, Natale RB, Miller V, Manegold C, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2. J Clin Oncol 2004;22:785-94.
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
Natale, R.B.4
Miller, V.5
Manegold, C.6
-
32
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan EH, Hirsh V, Thongprasert S, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-32.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
Tan, E.H.4
Hirsh, V.5
Thongprasert, S.6
-
33
-
-
33750491653
-
Targeted therapy in advanced non-small cell lung cancer (NSCLC): Where do we stand?
-
Azim HA Jr, Ganti AK. Targeted therapy in advanced non-small cell lung cancer (NSCLC): Where do we stand? Cancer Treat Rev 32:630-6.
-
Cancer Treat Rev
, vol.32
, pp. 630-636
-
-
Azim Jr., H.A.1
Ganti, A.K.2
-
34
-
-
33745928129
-
Smoking history and epidermal growth factor receptor expression as predictors of survival benefit from erlotinib for patients with non-small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group study BR
-
Clark GM, Zborowski DM, Santabarbara P, Ding K, Whitehead M, Seymour L, et al. Smoking history and epidermal growth factor receptor expression as predictors of survival benefit from erlotinib for patients with non-small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group study BR.21. Clin Lung Cancer 2006;7:389-94.
-
(2006)
21. Clin Lung Cancer
, vol.7
, pp. 389-394
-
-
Clark, G.M.1
Zborowski, D.M.2
Santabarbara, P.3
Ding, K.4
Whitehead, M.5
Seymour, L.6
-
35
-
-
22044453790
-
Erlotinib in lung cancer - molecular and clinical predictors of outcome
-
Tsao MS, Sakurada A, Cutz JC, Zhu CQ, Kamel-Reid S, Squire J, et al. Erlotinib in lung cancer - molecular and clinical predictors of outcome. N Engl J Med 2005;353:133-44.
-
(2005)
N Engl J Med
, vol.353
, pp. 133-144
-
-
Tsao, M.S.1
Sakurada, A.2
Cutz, J.C.3
Zhu, C.Q.4
Kamel-Reid, S.5
Squire, J.6
-
36
-
-
34248140107
-
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial
-
Gatzemeier U, Pluzanska A, Szczesna A, Kaukel E, Roubec J, De Rosa F, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol 2007;25:1545-52.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1545-1552
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
Kaukel, E.4
Roubec, J.5
De Rosa, F.6
-
37
-
-
24944440830
-
TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
-
Herbst RS, Prager D, Hermann R, Fehrenbacher L, Johnson BE, Sandler A, et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005;23:5892-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
Fehrenbacher, L.4
Johnson, B.E.5
Sandler, A.6
-
38
-
-
10844250444
-
Long survival of never smoking non-small cell lung cancer (NSCLC) patients (pts) treated with erlotin ib HCl (OSI-774) and chemotherapy: Sub-group analysis of TRIBUTE
-
Miller VA, Herbst R, Prager D, Fehrenbacher L, Hermann R, Hoffman P, et al. Long survival of never smoking non-small cell lung cancer (NSCLC) patients (pts) treated with erlotin ib HCl (OSI-774) and chemotherapy: Sub-group analysis of TRIBUTE. J Clin Oncol 2004;22:7061.
-
(2004)
J Clin Oncol
, vol.22
, pp. 7061
-
-
Miller, V.A.1
Herbst, R.2
Prager, D.3
Fehrenbacher, L.4
Hermann, R.5
Hoffman, P.6
-
39
-
-
24944497744
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5900-5909
-
-
Eberhard, D.A.1
Johnson, B.E.2
Amler, L.C.3
Goddard, A.D.4
Heldens, S.L.5
Herbst, R.S.6
-
40
-
-
37349080007
-
Schedule-dependent apoptosis in K-ras mutant non-small-cell lung cancer cell lines treated with docetaxel and erlotinib: rationale for pharmacodynamic separation
-
Mahaffey CM, Davies AM, Lara PN Jr, Pryde B, Holland W, Mack PC, et al. Schedule-dependent apoptosis in K-ras mutant non-small-cell lung cancer cell lines treated with docetaxel and erlotinib: rationale for pharmacodynamic separation. Clin Lung Cancer 2007;8:548-53.
-
(2007)
Clin Lung Cancer
, vol.8
, pp. 548-553
-
-
Mahaffey, C.M.1
Davies, A.M.2
Lara Jr., P.N.3
Pryde, B.4
Holland, W.5
Mack, P.C.6
-
41
-
-
77954243176
-
Taipei Veterans General Hospital. Taipei-Veterans General Hospital. Combination effects of gefitinib plus cisplatin in non-small cell lung cancer (NSCLC): Why have phase III trials failed?
-
Tsai C, Chen T, Chang K, Hsiao S, Taipei Veterans General Hospital, Taipei-Veterans General Hospital. Combination effects of gefitinib plus cisplatin in non-small cell lung cancer (NSCLC): Why have phase III trials failed? J Clin Oncol 2009;27:11022.
-
(2009)
J Clin Oncol
, vol.27
, pp. 11022
-
-
Tsai, C.1
Chen, T.2
Chang, K.3
Hsiao, S.4
-
42
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-43.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
-
43
-
-
63849163410
-
Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
-
Cappuzzo F, Marchetti A, Skokan M, Rossi E, Gajapathy S, Felicioni L, et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol 2009;27:1667-74.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1667-1674
-
-
Cappuzzo, F.1
Marchetti, A.2
Skokan, M.3
Rossi, E.4
Gajapathy, S.5
Felicioni, L.6
-
44
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 2009;27:4247-53.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
Digumarthy, S.R.4
Costa, D.B.5
Heist, R.S.6
-
45
-
-
42949176742
-
Survival of cancer cells is maintained by EGFR independent of its kinase activity
-
Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ, et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 2008;13:385-93.
-
(2008)
Cancer Cell
, vol.13
, pp. 385-393
-
-
Weihua, Z.1
Tsan, R.2
Huang, W.C.3
Wu, Q.4
Chiu, C.H.5
Fidler, I.J.6
-
46
-
-
84861975426
-
Gefitinib versus chemotherapy as first-line treatment in elder patients with advanced non-small-cell lung cancer: P3-163
-
Zhang XT, Li LY, Wang MZ, Zhang L, Zhong W. Gefitinib versus chemotherapy as first-line treatment in elder patients with advanced non-small-cell lung cancer: P3-163. J Thorac Oncol 2007;2:s749.
-
(2007)
J Thorac Oncol
, vol.2
-
-
Zhang, X.T.1
Li, L.Y.2
Wang, M.Z.3
Zhang, L.4
Zhong, W.5
-
47
-
-
68349103830
-
Phase II study of gefitinib as a first-line therapy in elderly patients with lung adenocarcinoma (WJTOG 0402-DI): P3-121
-
Nishimura T, Katakami N, Masashi K, Kaoru M, Koji T, Hisao U, et al. Phase II study of gefitinib as a first-line therapy in elderly patients with lung adenocarcinoma (WJTOG 0402-DI): P3-121. J Thorac Oncol 2007;2:s730-1.
-
(2007)
J Thorac Oncol
, vol.2
-
-
Nishimura, T.1
Katakami, N.2
Masashi, K.3
Kaoru, M.4
Koji, T.5
Hisao, U.6
-
48
-
-
58949088423
-
A phase II trial of gefitinib monotherapy in chemotherapy-naive patients of 75 years or older with advanced non-small cell lung cancer
-
Ebi N, Semba H, Tokunaga SJ, Takayama K, Wataya H, Kuraki T, et al. A phase II trial of gefitinib monotherapy in chemotherapy-naive patients of 75 years or older with advanced non-small cell lung cancer. J Thorac Oncol 2008;3:1166-71.
-
(2008)
J Thorac Oncol
, vol.3
, pp. 1166-1171
-
-
Ebi, N.1
Semba, H.2
Tokunaga, S.J.3
Takayama, K.4
Wataya, H.5
Kuraki, T.6
-
49
-
-
69549103046
-
IFCT-0401 Trial: a phase II study of gefitinib administered as first-line treatment in advanced adenocarcinoma with bronchioloalveolar carcinoma subtype
-
Cadranel J, Quoix E, Baudrin L, Mourlanette P, Moro-Sibilot D, Morere JF, et al. IFCT-0401 Trial: a phase II study of gefitinib administered as first-line treatment in advanced adenocarcinoma with bronchioloalveolar carcinoma subtype. J Thorac Oncol 2009;4:1126-35.
-
(2009)
J Thorac Oncol
, vol.4
, pp. 1126-1135
-
-
Cadranel, J.1
Quoix, E.2
Baudrin, L.3
Mourlanette, P.4
Moro-Sibilot, D.5
Morere, J.F.6
-
50
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
Yang, C.H.4
Chu, D.T.5
Saijo, N.6
-
51
-
-
77952526670
-
A small step towards personalized medicine for non- small cell lung cancer
-
Mok T, Wu YL, Zhang L. A small step towards personalized medicine for non- small cell lung cancer. Discov Med 2009;8:227-31.
-
(2009)
Discov Med
, vol.8
, pp. 227-231
-
-
Mok, T.1
Wu, Y.L.2
Zhang, L.3
-
52
-
-
78650837687
-
Final overall survival (OS) results from a phase III, randomised, open-label, first-line study of Gefitinib (G) vs Carboplatin/ Paclitaxel (C/P) in clinically selected patients with advanced Non Small Cell Lung Cancer (NSCLC) in Asia (IPASS)
-
Yang CH, Fukuoka M, Mok TS, Wu YL, Thongprasert S, Saijo N, et al. Final overall survival (OS) results from a phase III, randomised, open-label, first-line study of Gefitinib (G) vs Carboplatin/ Paclitaxel (C/P) in clinically selected patients with advanced Non Small Cell Lung Cancer (NSCLC) in Asia (IPASS). Ann Oncol 2010;s21:viii1-2.
-
(2010)
Ann Oncol
, vol.s21
-
-
Yang, C.H.1
Fukuoka, M.2
Mok, T.S.3
Wu, Y.L.4
Thongprasert, S.5
Saijo, N.6
-
53
-
-
69949186250
-
Screening for epidermal growth factor receptor mutations in lung cancer
-
Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009;361:958-67.
-
(2009)
N Engl J Med
, vol.361
, pp. 958-967
-
-
Rosell, R.1
Moran, T.2
Queralt, C.3
Porta, R.4
Cardenal, F.5
Camps, C.6
-
54
-
-
78650927471
-
Randomized phase II trial of erlotinib (E) alone or in combination with carboplatin/paclitaxel (CP) in never or light former smokers with advanced lung adenocarcinoma: CALGB 30406
-
Janne PA, Wang XF, Socinski MA, Crawford J, Capelletti M, Edelman MJ, et al. Randomized phase II trial of erlotinib (E) alone or in combination with carboplatin/paclitaxel (CP) in never or light former smokers with advanced lung adenocarcinoma: CALGB 30406. J Clin Oncol 2010;28:7503.
-
(2010)
J Clin Oncol
, vol.28
, pp. 7503
-
-
Janne, P.A.1
Wang, X.F.2
Socinski, M.A.3
Crawford, J.4
Capelletti, M.5
Edelman, M.J.6
-
55
-
-
79954606282
-
Efficacy results from the randomised phase III OPTIMAL (CTONG 0802) study comparing first-line erlotinib versus carboplatin plus gemcitabine in Chinese advanced non-small cell lung cancer patients with EGFR activating mutations
-
Zhou C, Wu YL, Chen G, Feng J, Liu X, Wang C, et al. Efficacy results from the randomised phase III OPTIMAL (CTONG 0802) study comparing first-line erlotinib versus carboplatin plus gemcitabine in Chinese advanced non-small cell lung cancer patients with EGFR activating mutations. Ann Oncol 2010;s21:viii6.
-
(2010)
Ann Oncol
, vol.s21
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
Feng, J.4
Liu, X.5
Wang, C.6
-
56
-
-
78149249388
-
Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy?
-
Roberts PJ, Stinchcombe TE, Der CJ, Socinski MA. Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy? J Clin Oncol 2010;28:4769-77.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4769-4777
-
-
Roberts, P.J.1
Stinchcombe, T.E.2
Der, C.J.3
Socinski, M.A.4
-
57
-
-
65249095599
-
The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with type EGFR and KRAS
-
Wong DW, Leung EL, So KK, Tam IY, Sihoe AD, Cheng LC, et al. The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with type EGFR and KRAS. Cancer 2009;115:1723-33.
-
(2009)
Cancer
, vol.115
, pp. 1723-1733
-
-
Wong, D.W.1
Leung, E.L.2
So, K.K.3
Tam, I.Y.4
Sihoe, A.D.5
Cheng, L.C.6
-
58
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
Shaw, A.T.4
Solomon, B.5
Maki, R.G.6
-
59
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
-
Cappuzzo F, Ciuleanu T, Stelmakh L, Cicenas S, Szczésna A, Juhász E, et al. Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 2010;11:521-9.
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
Cicenas, S.4
Szczésna, A.5
Juhász, E.6
-
60
-
-
77649203360
-
Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: results of a west Japan thoracic oncology group trial (WJTOG0203)
-
Takeda K, Hida T, Sato T, Ando M, Seto T, Satouchi M, et al. Randomized phase III trial of platinum-doublet chemotherapy followed by gefitinib compared with continued platinum-doublet chemotherapy in Japanese patients with advanced non-small-cell lung cancer: results of a west Japan thoracic oncology group trial (WJTOG0203). J Clin Oncol 2010;28:753-60.
-
(2010)
J Clin Oncol
, vol.28
, pp. 753-760
-
-
Takeda, K.1
Hida, T.2
Sato, T.3
Ando, M.4
Seto, T.5
Satouchi, M.6
-
61
-
-
78651110155
-
A double-blind, randomized, placebo-controlled phase III intergroup study of gefitinib (G) in patients (pts) with advanced NSCLC, non-progressing after first-line platinum-based chemotherapy (EORTC 08021-ILCP 01/03)
-
Gaafar RM, Surmont V, Scagliotti G, Van Klaverenet R, Papamichael D, Welch G, et al. A double-blind, randomized, placebo-controlled phase III intergroup study of gefitinib (G) in patients (pts) with advanced NSCLC, non-progressing after first-line platinum-based chemotherapy (EORTC 08021-ILCP 01/03). J Clin Oncol 2010;28:7518.
-
(2010)
J Clin Oncol
, vol.28
, pp. 7518
-
-
Gaafar, R.M.1
Surmont, V.2
Scagliotti, G.3
Van Klaverenet, R.4
Papamichael, D.5
Welch, G.6
-
62
-
-
33947420511
-
Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell lines
-
Kurai J, Chikumi H, Hashimoto K, Yamaguchi K, Yamasaki A, Sako T, et al. Antibody-dependent cellular cytotoxicity mediated by cetuximab against lung cancer cell lines. Clin Cancer Res 2007;13:1552-61.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 1552-1561
-
-
Kurai, J.1
Chikumi, H.2
Hashimoto, K.3
Yamaguchi, K.4
Yamasaki, A.5
Sako, T.6
-
63
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004;351:337-45.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
-
64
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354:567-78.
-
(2006)
N Engl J Med
, vol.354
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
Azarnia, N.4
Shin, D.M.5
Cohen, R.B.6
-
65
-
-
58949087252
-
Phase II study of paclitaxel, carboplatin, and cetuximab as first line treatment, for patients with advanced non-small cell lung cancer (NSCLC): results of OPN-017
-
Borghaei H, Langer CJ, Millenson M, Ruth KJ, Litwin S, Tuttle H, et al. Phase II study of paclitaxel, carboplatin, and cetuximab as first line treatment, for patients with advanced non-small cell lung cancer (NSCLC): results of OPN-017. J Thorac Oncol 2008;3:1286-92.
-
(2008)
J Thorac Oncol
, vol.3
, pp. 1286-1292
-
-
Borghaei, H.1
Langer, C.J.2
Millenson, M.3
Ruth, K.J.4
Litwin, S.5
Tuttle, H.6
-
66
-
-
33144484457
-
Multicenter phase I/II study of cetuximab with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer
-
Thienelt CD, Bunn PA Jr, Hanna N, Rosenberg A, Needle MN, Long ME, et al. Multicenter phase I/II study of cetuximab with paclitaxel and carboplatin in untreated patients with stage IV non-small-cell lung cancer. J Clin Oncol 2005;23:8786-93.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8786-8793
-
-
Thienelt, C.D.1
Bunn Jr., P.A.2
Hanna, N.3
Rosenberg, A.4
Needle, M.N.5
Long, M.E.6
-
67
-
-
33144481184
-
Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced non-small-cell lung cancer
-
Robert F, Blumenschein G, Herbst RS, Fossella FV, Tseng J, Saleh MN, et al. Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced non-small-cell lung cancer. J Clin Oncol 2005;23:9089-96.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9089-9096
-
-
Robert, F.1
Blumenschein, G.2
Herbst, R.S.3
Fossella, F.V.4
Tseng, J.5
Saleh, M.N.6
-
68
-
-
78149240941
-
Phase II selection design trial of concurrent chemotherapy and cetuximab versus chemotherapy followed by cetuximab in advanced-stage non-small-cell lung cancer: Southwest Oncology Group study S0342
-
Herbst RS, Kelly K, Chansky K, Mack PC, Franklin WA, Hirsch FR, et al. Phase II selection design trial of concurrent chemotherapy and cetuximab versus chemotherapy followed by cetuximab in advanced-stage non-small-cell lung cancer: Southwest Oncology Group study S0342. J Clin Oncol 2010;28:4747-54.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4747-4754
-
-
Herbst, R.S.1
Kelly, K.2
Chansky, K.3
Mack, P.C.4
Franklin, W.A.5
Hirsch, F.R.6
-
69
-
-
66149192655
-
A randomized, phase II trial of two dose schedules of carboplatin/paclitaxel/cetuximab in stage IIIB/IV non-small-cell lung cancer (NSCLC)
-
Socinski MA, Saleh MN, Trent DF, Dobbs TW, Zehngebot LM, Levine MA, et al. A randomized, phase II trial of two dose schedules of carboplatin/paclitaxel/cetuximab in stage IIIB/IV non-small-cell lung cancer (NSCLC). Ann Oncol 2009;20:1068-73.
-
(2009)
Ann Oncol
, vol.20
, pp. 1068-1073
-
-
Socinski, M.A.1
Saleh, M.N.2
Trent, D.F.3
Dobbs, T.W.4
Zehngebot, L.M.5
Levine, M.A.6
-
70
-
-
77949891126
-
Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099
-
Lynch TJ, Patel T, Dreisbach L, McCleod M, Heim WJ, Hermann RC, et al. Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099. J Clin Oncol 2010;28:911-7.
-
(2010)
J Clin Oncol
, vol.28
, pp. 911-917
-
-
Lynch, T.J.1
Patel, T.2
Dreisbach, L.3
McCleod, M.4
Heim, W.J.5
Hermann, R.C.6
-
71
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial
-
Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 2009;373:1525-31.
-
(2009)
Lancet
, vol.373
, pp. 1525-1531
-
-
Pirker, R.1
Pereira, J.R.2
Szczesna, A.3
von Pawel, J.4
Krzakowski, M.5
Ramlau, R.6
-
72
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009;360:1408-17.
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Köhne, C.H.2
Hitre, E.3
Zaluski, J.4
Chang Chien, C.R.5
Makhson, A.6
-
73
-
-
77949886293
-
Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer
-
Khambata-Ford S, Harbison CT, Hart LL, Awad M, Xu LA, Horak CE, et al. Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer. J Clin Oncol 2010;28:918-27.
-
(2010)
J Clin Oncol
, vol.28
, pp. 918-927
-
-
Khambata-Ford, S.1
Harbison, C.T.2
Hart, L.L.3
Awad, M.4
Xu, L.A.5
Horak, C.E.6
-
74
-
-
68949124435
-
Molecular and clinical predictors of outcome for cetuximab in non-small cell lung cancer (NSCLC): Data from the FLEX study
-
O'Byrne KJ, Bondarenko I, Barrios C, Eschbach C, Martens U, Hotko Y. et al. Molecular and clinical predictors of outcome for cetuximab in non-small cell lung cancer (NSCLC): Data from the FLEX study. J Clin Oncol 2009;27:8007.
-
(2009)
J Clin Oncol
, vol.27
, pp. 8007
-
-
O'Byrne, K.J.1
Bondarenko, I.2
Barrios, C.3
Eschbach, C.4
Martens, U.5
Hotko, Y.6
-
75
-
-
36148941301
-
Cetuximab for the treatment of colorectal cancer
-
Jonker DJ, O'Callaghan CJ, Karapetis CS, Zalcberg JR, Tu D, Au HJ, et al. Cetuximab for the treatment of colorectal cancer. N Engl J Med 2007;357:2040-8.
-
(2007)
N Engl J Med
, vol.357
, pp. 2040-2048
-
-
Jonker, D.J.1
O'Callaghan, C.J.2
Karapetis, C.S.3
Zalcberg, J.R.4
Tu, D.5
Au, H.J.6
-
76
-
-
77952514740
-
A proposed EGFR inhibitor dermatologic adverse event-specific grading scale from the MASCC skin toxicity study group
-
Lacouture ME, Maitland ML, Segaert S, Setser A, Baran R, Fox LP, et al. A proposed EGFR inhibitor dermatologic adverse event-specific grading scale from the MASCC skin toxicity study group. Support Care Cancer 2010;18:509-22.
-
(2010)
Support Care Cancer
, vol.18
, pp. 509-522
-
-
Lacouture, M.E.1
Maitland, M.L.2
Segaert, S.3
Setser, A.4
Baran, R.5
Fox, L.P.6
|