Understanding and mitigating impact of immunogenicity on pharmacokinetic assays

Bioanalysis

Volumn 3, Issue 16, 2011, Pages 1799-1803

  White, Joleen T ^a   Golob, Michaela ^b   Sailstad, Jeffrey ^c  

^a BIOGEN   (United States)

^b MS RD DMPK/rADME ^*  (Germany)

^c Sailstad and Associates Inc   (United States)

Author keywords

anti drug antibodies; immunogenicity; interference; pharmacodynamics; pharmacokinetic

Indexed keywords

DRUG; DRUG ANTIBODY; MONOCLONAL ANTIBODY;

ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; BINDING ASSAY; BINDING SITE; DRUG DETERMINATION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INDUSTRY; DRUG SAFETY; IMMUNE RESPONSE; IMMUNOGENICITY; LIGAND BINDING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PHARMACODYNAMICS; PHARMACOKINETICS; REVIEW; WESTERN BLOTTING;

BIOTECHNOLOGY; DRUG DESIGN; FEMALE; HUMANS; IMMUNOGENETIC PROCESSES; MALE; PHARMACOKINETICS;

EID: 80052500100     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.11.162     Document Type: Review

References (4)

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