Confocal imaging studies cast doubt on nuclear localization of JAK2V617F

Blood

Volumn 118, Issue 9, 2011, Pages 2633-2634

  Girodon, François ^a,b   Steinkamp, Mara P ^b   Cleyrat, Cédric ^b,c   Hermouet, Sylvie ^c   Wilson, Bridget S ^b  

^a DIJON UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c NANTES UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2;

CELL LINE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME LOCALIZATION; LETTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSIENT TRANSFECTION; WESTERN BLOTTING;

EID: 80052491021     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-02-336479     Document Type: Letter

References (6)

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2. Rinaldi C.R., Rinaldi P., Alagia A., et al. Preferential nuclear accumulation of JAK2V617F in CD34+ but not in granulocytic, megakaryocytic, or erythroid cells of patients with Philadelphia-negative myeloproliferative neoplasia. Blood 2010;116(26):6023-6026.
3. Dawson M.A., Bannister A.J., Gottgens B., et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature. 2009;461(7265):819- 822.
4. Behrmann I., Smyczek T., Heinrich P.C., et al. Janus kinase (Jak) subcellular localization revisited: The exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase. J Biol Chem. 2004;279(34):35486-35493. (Pubitemid 39100548)
5. Lobie P.E., Ronsin B., Silvennoinen O., Haldosen L.A., Norstedt G., Morel G. Constitutive nuclear localization of Janus kinases 1 and 2. Endocrinology. 1996;137(9):4037-4045. (Pubitemid 26284681)
6. Ram P.A., Waxman D.J. Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. J Biol Chem. 1997;272(28):17694-17702. (Pubitemid 27311207)