Genomic architecture of aggression: Rare copy number variants in intermittent explosive disorder

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 156, Issue 7, 2011, Pages 808-816

  Vu, Tiffany H ^a   Coccaro, Emil F ^b   Eichler, Evan E ^a   Girirajan, Santhosh ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

15q13.3; Aggression; Array CGH; Genomic disorders; Segmental duplication

Indexed keywords

BUNGAROTOXIN RECEPTOR;

ADULT; AGGRESSION; ALCOHOLISM; ANTISOCIAL BEHAVIOR; ARTICLE; AVOIDANT PERSONALITY DISORDER; BORDERLINE STATE; CHROMOSOME 16Q; CHROMOSOME 1Q; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DEPENDENT PERSONALITY DISORDER; DRUG DEPENDENCE; DYSTHYMIA; FEMALE; GENE; GENE DELETION; GENOME; HISTRIONIC PERSONALITY DISORDER; HUMAN; INTERMITTENT EXPLOSIVE DISORDER; MAJOR DEPRESSION; MALE; NARCISSISM; OBSESSIVE COMPULSIVE DISORDER; PARANOIA; PERSONALITY DISORDER; PHOBIA; PRIORITY JOURNAL; SCHIZOIDISM;

AGGRESSION; DNA COPY NUMBER VARIATIONS; FEMALE; GENOME, HUMAN; HUMANS; IMPULSE CONTROL DISORDERS; MALE; PEDIGREE; PERSONALITY DISORDERS;

EID: 80052487379     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31225     Document Type: Article

References (59)

1. Alderson NL, Rembiesa BM, Walla MD, Bielawska A, Bielawski J, Hama H. 2004. The human FA2H gene encodes a fatty acid 2-hydroxylase. J Biol Chem 279(47): 48562-48568.
2. Araki T, Nagarajan R, Milbrandt J. 2001. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. J Biol Chem 276(36): 34131-34141.
3. Association AP. 1994. Diagnostic and statistical manual of mental disorders. 4th edition. Washington, DC: American Psychiatric Association Press.
4. Bailey JA, Gu Z, Clark RA, Reinert K, Samonte RV, Schwartz S, Adams MD, Myers EW, Li PW, Eichler EE. 2002. Recent segmental duplications in the human genome. Science 297(5583): 1003-1007.
5. Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nothen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Hofels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ. 2008. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry 13(2): 197-207.
6. Ben-Shachar S, Lanpher B, German JR, Qasaymeh M, Potocki L, Nagamani SC, Franco LM, Malphrus A, Bottenfield GW, Spence JE, Amato S, Rousseau JA, Moghaddam B, Skinner C, Skinner SA, Bernes S, Armstrong N, Shinawi M, Stankiewicz P, Patel A, Cheung SW, Lupski JR, Beaudet AL, Sahoo T. 2009. Microdeletion 15q13.3: A locus with incomplete penetrance for autism, mental retardation, and psychiatric disorders. J Med Genet 46(6): 382-388.
7. Bevilacqua L, Doly S, Kaprio J, Yuan Q, Tikkanen R, Paunio T, Zhou Z, Wedenoja J, Maroteaux L, Diaz S, Belmer A, Hodgkinson CA, Dell'osso L, Suvisaari J, Coccaro E, Rose RJ, Peltonen L, Virkkunen M, Goldman D. 2010. A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature 468(7327): 1061-1066.
8. Bochukova EG, Huang N, Keogh J, Henning E, Purmann C, Blaszczyk K, Saeed S, Hamilton-Shield J, Clayton-Smith J, O'Rahilly S, Hurles ME, Farooqi IS. 2010. Large, rare chromosomal deletions associated with severe early-onset obesity. Nature 463(7281): 666-670.
9. Brunetti-Pierri N, Berg JS, Scaglia F, Belmont J, Bacino CA, Sahoo T, Lalani SR, Graham B, Lee B, Shinawi M, Shen J, Kang SH, Pursley A, Lotze T, Kennedy G, Lansky-Shafer S, Weaver C, Roeder ER, Grebe TA, Arnold GL, Hutchison T, Reimschisel T, Amato S, Geragthy MT, Innis JW, Obersztyn E, Nowakowska B, Rosengren SS, Bader PI, Grange DK, Naqvi S, Garnica AD, Bernes SM, Fong CT, Summers A, Walters WD, Lupski JR, Stankiewicz P, Cheung SW, Patel A. 2008. Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities. Nat Genet 40(12): 1466-1471.
10. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. 1993. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262(5133): 578-580.
11. Buss AH, Perry M. 1992. The aggression questionnaire. J Pers Soc Psychol 63(3): 452-459.
12. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. 2002. Role of genotype in the cycle of violence in maltreated children. Science 297(5582): 851-854.
13. Coccaro EF. 2011. Intermittent explosive disorder: Development of integrated research criteria for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Compr Psychiatry 52(2): 119-125.
14. Coccaro EF, Berman ME, Kavoussi RJ. 1997. Assessment of life history of aggression: Development and psychometric characteristics. Psychiatry Res 73(3): 147-157.
15. Coccaro EF, Kavoussi RJ, Berman ME, Lish JD. 1998. Intermittent explosive disorder-revised: Development, reliability, and validity of research criteria. Compr Psychiatry 39(6): 368-376.
16. Coccaro EF, Posternak MA, Zimmerman M. 2005. Prevalence and features of intermittent explosive disorder in a clinical setting. J Clin Psychiatry 66(10): 1221-1227.
17. Coccaro EF, Lee R, Kavoussi RJ. 2009. Aggression, suicidality, and intermittent explosive disorder: Serotonergic correlates in personality disorder and healthy control subjects. Neuropsychopharmacology 35(2): 435-444.
18. Consortium IS. 2008. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455(7210): 237-241.
19. Craig IW, Halton KE. 2009. Genetics of human aggressive behaviour. Hum Genet 126(1): 101-113.
20. Cubells JF, DeOreo EH, Harvey PD, Garlow SJ, Garber K, Adam MP, Martin CL. 2011. Pharmaco-genetically guided treatment of recurrent rage outbursts in an adult male with 15q13.3 deletion syndrome. Am J Med Genet Part A 155A(4): 805-810.
21. Davidson RJ, Putnam KM, Larson CL. 2000. Dysfunction in the neural circuitry of emotion regulation-A possible prelude to violence. Science 289(5479): 591-594.
22. Eysenck HJ, Eysenck SBG. 1975. Manual of the Eysenck personality questionnaire (junior and adult). London: Hodder and Stoughton.
23. Girirajan S, Rosenfeld JA, Cooper GM, Antonacci F, Siswara P, Itsara A, Vives L, Walsh T, McCarthy SE, Baker C, Mefford HC, Kidd JM, Browning SR, Browning BL, Dickel DE, Levy DL, Ballif BC, Platky K, Farber DM, Gowans GC, Wetherbee JJ, Asamoah A, Weaver DD, Mark PR, Dickerson J, Garg BP, Ellingwood SA, Smith R, Banks VC, Smith W, McDonald MT, Hoo JJ, French BN, Hudson C, Johnson JP, Ozmore JR, Moeschler JB, Surti U, Escobar LF, El-Khechen D, Gorski JL, Kussmann J, Salbert B, Lacassie Y, Biser A, McDonald-McGinn DM, Zackai EH, Deardorff MA, Shaikh TH, Haan E, Friend KL, Fichera M, Romano C, Gecz J, DeLisi LE, Sebat J, King MC, Shaffer LG, Eichler EE. 2010. A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay. Nat Genet 42(3): 203-209.
24. Hannes FD, Sharp AJ, Mefford HC, de Ravel T, Ruivenkamp CA, Breuning MH, Fryns JP, Devriendt K, Van Buggenhout G, Vogels A, Stewart H, Hennekam RC, Cooper GM, Regan R, Knight SJ, Eichler EE, Vermeesch JR. 2009. Recurrent reciprocal deletions and duplications of 16p13.11: The deletion is a risk factor for MR/MCA while the duplication may be a rare benign variant. J Med Genet 46(4): 223-232.
25. Helbig I, Mefford HC, Sharp AJ, Guipponi M, Fichera M, Franke A, Muhle H, de Kovel C, Baker C, von Spiczak S, Kron KL, Steinich I, Kleefuss-Lie AA, Leu C, Gaus V, Schmitz B, Klein KM, Reif PS, Rosenow F, Weber Y, Lerche H, Zimprich F, Urak L, Fuchs K, Feucht M, Genton P, Thomas P, Visscher F, de Haan GJ, Moller RS, Hjalgrim H, Luciano D, Wittig M, Nothnagel M, Elger CE, Nurnberg P, Romano C, Malafosse A, Koeleman BP, Lindhout D, Stephani U, Schreiber S, Eichler EE, Sander T. 2009. 15q13.3 microdeletions increase risk of idiopathic generalized epilepsy. Nat Genet 41(2): 160-162.
26. Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, Lim KO. 2002. Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: A preliminary study. Biol Psychiatry 52(1): 9-14.
27. Ingason A, Rujescu D, Cichon S, Sigurdsson E, Sigmundsson T, Pietilainen OP, Buizer-Voskamp JE, Strengman E, Francks C, Muglia P, Gylfason A, Gustafsson O, Olason PI, Steinberg S, Hansen T, Jakobsen KD, Rasmussen HB, Giegling I, Moller HJ, Hartmann A, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Bramon E, Kiemeney LA, Franke B, Murray R, Vassos E, Toulopoulou T, Muhleisen TW, Tosato S, Ruggeri M, Djurovic S, Andreassen OA, Zhang Z, Werge T, Ophoff RA, Rietschel M, Nothen MM, Petursson H, Stefansson H, Peltonen L, Collier D, Stefansson K, Clair DM. 2009. Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol Psychiatry 16(1): 17-25.
28. Itsara A, Cooper GM, Baker C, Girirajan S, Li J, Absher D, Krauss RM, Myers RM, Ridker PM, Chasman DI, Mefford H, Ying P, Nickerson DA, Eichler EE. 2009. Population analysis of large copy number variants and hotspots of human genetic disease. Am J Hum Genet 84(2): 148-161.
29. Kessler RC, Ustun TB. 2004. The World Mental Health (WMH) Survey Initiative Version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI). Int J Methods Psychiatr Res 13(2): 93-121.
30. Kessler RC, Coccaro EF, Fava M, Jaeger S, Jin R, Walters E. 2006. The prevalence and correlates of DSM-IV intermittent explosive disorder in the National Comorbidity Survey Replication. Arch Gen Psychiatry 63(6): 669-678.
31. Lupski JR. 1998. Genomic disorders: Structural features of the genome can lead to DNA rearrangements and human disease traits. Trends Genet 14(10): 417-422.
32. Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF. 1999. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry 45(5): 603-614.
33. Marques-Bonet T, Girirajan S, Eichler EE. 2009. The origins and impact of primate segmental duplications. Trends Genet 25(10): 443-454.
34. Mefford HC, Eichler EE. 2009. Duplication hotspots, rare genomic disorders, and common disease. Curr Opin Genet Dev 19(3): 196-204.
35. Mefford HC, Mulley JC. 2010. Genetically complex epilepsies, copy number variants and syndrome constellations. Genome Med 2(10): 71.
36. Mefford HC, Sharp AJ, Baker C, Itsara A, Jiang Z, Buysse K, Huang S, Maloney VK, Crolla JA, Baralle D, Collins A, Mercer C, Norga K, de Ravel T, Devriendt K, Bongers EM, de Leeuw N, Reardon W, Gimelli S, Bena F, Hennekam RC, Male A, Gaunt L, Clayton-Smith J, Simonic I, Park SM, Mehta SG, Nik-Zainal S, Woods CG, Firth HV, Parkin G, Fichera M, Reitano S, Lo Giudice M, Li KE, Casuga I, Broomer A, Conrad B, Schwerzmann M, Raber L, Gallati S, Striano P, Coppola A, Tolmie JL, Tobias ES, Lilley C, Armengol L, Spysschaert Y, Verloo P, De Coene A, Goossens L, Mortier G, Speleman F, van Binsbergen E, Nelen MR, Hochstenbach R, Poot M, Gallagher L, Gill M, McClellan J, King MC, Regan R, Skinner C, Stevenson RE, Antonarakis SE, Chen C, Estivill X, Menten B, Gimelli G, Gribble S, Schwartz S, Sutcliffe JS, Walsh T, Knight SJ, Sebat J, Romano C, Schwartz CE, Veltman JA, de Vries BB, Vermeesch JR, Barber JC, Willatt L, Tassabehji M, Eichler EE. 2008. Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes. N Engl J Med 359(16): 1685-1699.
37. Miles DR, Carey G. 1997. Genetic and environmental architecture of human aggression. J Pers Soc Psychol 72(1): 207-217.
38. Miller DT, Shen Y, Weiss LA, Korn J, Anselm I, Bridgemohan C, Cox GF, Dickinson H, Gentile J, Harris DJ, Hegde V, Hundley R, Khwaja O, Kothare S, Luedke C, Nasir R, Poduri A, Prasad K, Raffalli P, Reinhard A, Smith SE, Sobeih MM, Soul JS, Stoler J, Takeoka M, Tan WH, Thakuria J, Wolff R, Yusupov R, Gusella JF, Daly MJ, Wu BL. 2009. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J Med Genet 46(4): 242-248.
39. Moldin SO. 2003. NIMH human genetics initiative: 2003 update. Am J Psychiatry 160(4): 621-622.
40. Rajender S, Pandu G, Sharma JD, Gandhi KP, Singh L, Thangaraj K. 2008. Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior. Int J Legal Med 122(5): 367-372.
41. Rhee SH, Waldman ID. 2002. Genetic and environmental influences on antisocial behavior: A meta-analysis of twin and adoption studies. Psychol Bull 128(3): 490-529.
42. Schmidt CA, Fallon AE, Coccaro EF. 2004. Assessment of behavioral and cognitive impulsivity: Development and validation of the Lifetime History of Impulsive Behaviors Interview. Psychiatry Res 126(2): 107-121.
43. Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, Spence SJ, Lee AT, Puura K, Lehtimaki T, Ledbetter D, Gregersen PK, Bregman J, Sutcliffe JS, Jobanputra V, Chung W, Warburton D, King MC, Skuse D, Geschwind DH, Gilliam TC, Ye K, Wigler M. 2007. Strong association of de novo copy number mutations with autism. Science 316(5823): 445-449.
44. Selzer RR, Richmond TA, Pofahl NJ, Green RD, Eis PS, Nair P, Brothman AR, Stallings RL. 2005. Analysis of chromosome breakpoints in neuroblastoma at sub-kilobase resolution using fine-tiling oligonucleotide array CGH. Genes Chromosomes Cancer 44(3): 305-319.
45. Seroczynski AD, Bergeman CS, Coccaro EF. 1999. Etiology of the impulsivity/aggression relationship: Genes or environment? Psychiatry Res 86(1): 41-57.
46. Sharp AJ, Hansen S, Selzer RR, Cheng Z, Regan R, Hurst JA, Stewart H, Price SM, Blair E, Hennekam RC, Fitzpatrick CA, Segraves R, Richmond TA, Guiver C, Albertson DG, Pinkel D, Eis PS, Schwartz S, Knight SJ, Eichler EE. 2006. Discovery of previously unidentified genomic disorders from the duplication architecture of the human genome. Nat Genet 38(9): 1038-1042.
47. Shinawi M, Schaaf CP, Bhatt SS, Xia Z, Patel A, Cheung SW, Lanpher B, Nagl S, Herding HS, Nevinny-Stickel C, Immken LL, Patel GS, German JR, Beaudet AL, Stankiewicz P. 2009. A small recurrent deletion within 15q13.3 is associated with a range of neurodevelopmental phenotypes. Nat Genet 41(12): 1269-1271.
48. Siever LJ. 2008. Neurobiology of aggression and violence. Am J Psychiatry 165(4): 429-442.
49. Slutske WS. 2001. The genetics of antisocial behavior. Curr Psychiatry Rep 3(2): 158-162.
50. Stankiewicz P, Lupski JR. 2010. Structural variation in the human genome and its role in disease. Annu Rev Med 61: 437-455.
51. Stefansson H, Rujescu D, Cichon S, Pietilainen OP, Ingason A, Steinberg S, Fossdal R, Sigurdsson E, Sigmundsson T, Buizer-Voskamp JE, Hansen T, Jakobsen KD, Muglia P, Francks C, Matthews PM, Gylfason A, Halldorsson BV, Gudbjartsson D, Thorgeirsson TE, Sigurdsson A, Jonasdottir A, Bjornsson A, Mattiasdottir S, Blondal T, Haraldsson M, Magnusdottir BB, Giegling I, Moller HJ, Hartmann A, Shianna KV, Ge D, Need AC, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Paunio T, Toulopoulou T, Bramon E, Di Forti M, Murray R, Ruggeri M, Vassos E, Tosato S, Walshe M, Li T, Vasilescu C, Muhleisen TW, Wang AG, Ullum H, Djurovic S, Melle I, Olesen J, Kiemeney LA, Franke B, Sabatti C, Freimer NB, Gulcher JR, Thorsteinsdottir U, Kong A, Andreassen OA, Ophoff RA, Georgi A, Rietschel M, Werge T, Petursson H, Goldstein DB, Nothen MM, Peltonen L, Collier DA, St Clair D, Stefansson K. 2008. Large recurrent microdeletions associated with schizophrenia. Nature 455(7210): 232-236.
52. Szafranski P, Schaaf CP, Person RE, Gibson IB, Xia Z, Mahadevan S, Wiszniewska J, Bacino CA, Lalani S, Potocki L, Kang SH, Patel A, Cheung SW, Probst FJ, Graham BH, Shinawi M, Beaudet AL, Stankiewicz P. 2010. Structures and molecular mechanisms for common 15q13.3 microduplications involving CHRNA7: Benign or pathological? Hum Mutat 31(7): 840-850.
53. Talati A, Fyer AJ, Weissman MM. 2008. A comparison between screened NIMH and clinically interviewed control samples on neuroticism and extraversion. Mol Psychiatry 13(2): 122-130.
54. Ullmann R, Turner G, Kirchhoff M, Chen W, Tonge B, Rosenberg C, Field M, Vianna-Morgante AM, Christie L, Krepischi-Santos AC, Banna L, Brereton AV, Hill A, Bisgaard AM, Muller I, Hultschig C, Erdogan F, Wieczorek G, Ropers HH. 2007. Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation. Hum Mutat 28(7): 674-682.
55. van Bon BW, Mefford HC, Menten B, Koolen DA, Sharp AJ, Nillesen WM, Innis JW, de Ravel TJ, Mercer CL, Fichera M, Stewart H, Connell LE, Ounap K, Lachlan K, Castle B, Van der Aa N, van Ravenswaaij C, Nobrega MA, Serra-Juhe C, Simonic I, de Leeuw N, Pfundt R, Bongers EM, Baker C, Finnemore P, Huang S, Maloney VK, Crolla JA, van Kalmthout M, Elia M, Vandeweyer G, Fryns JP, Janssens S, Foulds N, Reitano S, Smith K, Parkel S, Loeys B, Woods CG, Oostra A, Speleman F, Pereira AC, Kurg A, Willatt L, Knight SJ, Vermeesch JR, Romano C, Barber JC, Mortier G, Perez-Jurado LA, Kooy F, Brunner HG, Eichler EE, Kleefstra T, de Vries BB. 2009. Further delineation of the 15q13 microdeletion and duplication syndromes: A clinical spectrum varying from non-pathogenic to a severe outcome. J Med Genet 46(8): 511-523.
56. Volavka J. 1999. The neurobiology of violence: An update. J Neuropsychiatry Clin Neurosci 11(3): 307-314.
57. Walsh T, McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, Makarov V, Lakshmi B, Findling RL, Sikich L, Stromberg T, Merriman B, Gogtay N, Butler P, Eckstrand K, Noory L, Gochman P, Long R, Chen Z, Davis S, Baker C, Eichler EE, Meltzer PS, Nelson SF, Singleton AB, Lee MK, Rapoport JL, King MC, Sebat J. 2008. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320(5875): 539-543.
58. Walters RG, Jacquemont S, Valsesia A, de Smith AJ, Martinet D, Andersson J, Falchi M, Chen F, Andrieux J, Lobbens S, Delobel B, Stutzmann F, El-Sayed Moustafa JS, Chevre JC, Lecoeur C, Vatin V, Bouquillon S, Buxton JL, Boute O, Holder-Espinasse M, Cuisset JM, Lemaitre MP, Ambresin AE, Brioschi A, Gaillard M, Giusti V, Fellmann F, Ferrarini A, Hadjikhani N, Campion D, Guilmatre A, Goldenberg A, Calmels N, Mandel JL, Le Caignec C, David A, Isidor B, Cordier MP, Dupuis-Girod S, Labalme A, Sanlaville D, Beri-Dexheimer M, Jonveaux P, Leheup B, Ounap K, Bochukova EG, Henning E, Keogh J, Ellis RJ, Macdermot KD, van Haelst MM, Vincent-Delorme C, Plessis G, Touraine R, Philippe A, Malan V, Mathieu-Dramard M, Chiesa J, Blaumeiser B, Kooy RF, Caiazzo R, Pigeyre M, Balkau B, Sladek R, Bergmann S, Mooser V, Waterworth D, Reymond A, Vollenweider P, Waeber G, Kurg A, Palta P, Esko T, Metspalu A, Nelis M, Elliott P, Hartikainen AL, McCarthy MI, Peltonen L, Carlsson L, Jacobson P, Sjostrom L, Huang N, Hurles ME, O'Rahilly S, Farooqi IS, Mannik K, Jarvelin MR, Pattou F, Meyre D, Walley AJ, Coin LJ, Blakemore AI, Froguel P, Beckmann JS. 2010. A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature 463(7281): 671-675.
59. Yeh MT, Coccaro EF, Jacobson KC. 2010. Multivariate behavior genetic analyses of aggressive behavior subtypes. Behav Genet 40(5): 603-617.