-
1
-
-
70350566149
-
Hepatitis B virus X gene is implicated in liver carcinogenesis
-
Koike K. Hepatitis B virus X gene is implicated in liver carcinogenesis Cancer Lett 2009; 286: 60-8
-
(2009)
Cancer Lett
, vol.286
, pp. 60-8
-
-
Koike, K.1
-
2
-
-
31944438515
-
Effects of hepatitis B virus X protein on the development of liver cancer
-
DOI 10.1016/j.lab.2005.10.003, PII S0022214305003823
-
Zhang X, Zhang H, Ye L. Effects of hepatitis B virus X protein on the development of liver cancer. J Lab Clin Med 2006; 147: 58-66 (Pubitemid 43188997)
-
(2006)
Journal of Laboratory and Clinical Medicine
, vol.147
, Issue.2
, pp. 58-66
-
-
Zhang, X.1
Zhang, H.2
Ye, L.3
-
3
-
-
33845920091
-
Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax
-
Liang X, Liu Y, Zhang Q, Gao L, Han L, Ma C, et al. Hepatitis B virus sensitizes hepatocytes to TRAIL-induced apoptosis through Bax. Jmmunol 2007; 178: 503-10 (Pubitemid 46033634)
-
(2007)
Journal of Immunology
, vol.178
, Issue.1
, pp. 503-510
-
-
Liang, X.1
Liu, Y.2
Zhang, Q.3
Gao, L.4
Han, L.5
Ma, C.6
Zhang, L.7
Chen, Y.H.8
Sun, W.9
-
4
-
-
33846333916
-
Kip1
-
DOI 10.1042/BJ20061091
-
Mukherji A, Janbandhu VC, Kumar V. HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1. Biochem J 2007; 401: 247-56 (Pubitemid 46114617)
-
(2007)
Biochemical Journal
, vol.401
, Issue.1
, pp. 247-256
-
-
Mukherji, A.1
Janbandhu, V.C.2
Kumar, V.3
-
5
-
-
77952099246
-
Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop nvolving arachidonic acid metabolism and p-ERK1/2
-
Shan C, Xu F, Zhang S, You J, You X, Qiu L, et al. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop nvolving arachidonic acid metabolism and p-ERK1/2. Cell Res 2010; 20: 563-75
-
(2010)
Cell Res
, vol.20
, pp. 563-75
-
-
Shan, C.1
Xu, F.2
Zhang, S.3
You, J.4
You, X.5
Qiu, L.6
-
6
-
-
68349120124
-
Transformation of human liver L-O2 cells mediated by stable HBx transfection
-
Zhang WY, Cai N, Ye LH, Zhang XD. Transformation of human liver L-O2 cells mediated by stable HBx transfection. Acta Pharmacol Sin 2009; 30: 1153-61.
-
(2009)
Acta Pharmacol Sin
, vol.30
, pp. 1153-61
-
-
Zhang, W.Y.1
Cai, N.2
Ye, L.H.3
Zhang, X.D.4
-
7
-
-
0025907983
-
HBx gene of hepatitis B virus induces liver cancer in transgenic mice
-
Kim CM, Koike K, Saito I, Miyamura T, Jay G. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 1991; 351: 317-20 (Pubitemid 21896589)
-
(1991)
Nature
, vol.351
, Issue.6324
, pp. 317-320
-
-
Kim, C.-M.1
Koike, K.2
Saito, I.3
Miyamura, T.4
Jay, G.5
-
8
-
-
0027409855
-
Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway
-
DOI 10.1038/361742a0
-
Kekule AS, Lauer U, Weiss L, Luber B, Hofschneider PH. Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway Nature 1993; 361: 742-5 (Pubitemid 23070485)
-
(1993)
Nature
, vol.361
, Issue.6414
, pp. 742-745
-
-
Kekule, A.S.1
Lauer, U.2
Weiss, L.3
Luber, B.4
Hofschneider, P.H.5
-
9
-
-
0028946695
-
Modulation of intracellular signal transduction pathways by the hepatitis B virus transactivator p X
-
Natoli G, Avantaggiati ML, Chirillo P, De Marzio E, Collepardo D, Falco M, et al. Modulation of intracellular signal transduction pathways by the hepatitis B virus transactivator p X. J Hepatol 1995; 22: 14-20.
-
(1995)
J Hepatol
, vol.22
, pp. 14-20
-
-
Natoli, G.1
Avantaggiati, M.L.2
Chirillo, P.3
De Marzio, E.4
Collepardo, D.5
Falco, M.6
-
10
-
-
0032566516
-
HBx protein of hepatitis B virus activates Jak1-STAT signaling
-
DOI 10.1074/jbc.273.39.25510
-
Lee YH, Yun Y. HBx protein of hepatitis B virus activates Jak1-STAT signaling. J Biol Chem 1998; 273: 25510-5 (Pubitemid 28443322)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.39
, pp. 25510-25515
-
-
Lee, Y.-H.1
Yun, Y.2
-
11
-
-
0035896631
-
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway
-
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, et al. X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway J Biol Chem 2001; 276: 8328-40
-
(2001)
J Biol Chem
, vol.276
, pp. 8328-40
-
-
Diao, J.1
Khine, A.A.2
Sarangi, F.3
Hsu, E.4
Iorio, C.5
Tibbles, L.A.6
-
12
-
-
77749270475
-
A mutant of HBx (HBx Delta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase
-
Wang Q, Zhang WY, Ye LH, Zhang XD. A mutant of HBx (HBx Delta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin 2010; 31: 367-74
-
(2010)
Acta Pharmacol Sin
, vol.31
, pp. 367-74
-
-
Wang, Q.1
Zhang, W.Y.2
Ye, L.H.3
Zhang, X.D.4
-
13
-
-
76749141309
-
A mutant of hepa-titis B virus X protein (HBx Delta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase
-
Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye L, et al. A mutant of hepa-titis B virus X protein (HBx Delta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. Neoplasia 2010; 12: 103-15.
-
(2010)
Neoplasia
, vol.12
, pp. 103-15
-
-
Wang, Q.1
Zhang, W.2
Liu, Q.3
Zhang, X.4
Lv, N.5
Ye, L.6
-
14
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
-
DOI 10.1210/er.22.2.153
-
Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 2001; 22: 153-83 (Pubitemid 32458157)
-
(2001)
Endocrine Reviews
, vol.22
, Issue.2
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Gibson, T.B.3
Xu, B.-E.4
Karandikar, M.5
Berman, K.6
Cobb, M.H.7
-
15
-
-
0035805552
-
MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression
-
Su B, Cheng J, Yang J, Guo Z. MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression. J Bio Chem 2001; 276: 14784-90
-
(2001)
J Bio Chem
, vol.276
, pp. 14784-90
-
-
Su, B.1
Cheng, J.2
Yang, J.3
Guo, Z.4
-
16
-
-
0035836668
-
Role of MEKK2-MEK5 in the regulation of TNF-α gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells
-
DOI 10.1073/pnas.081021898
-
Chayama K, Papst PJ, Garrington TP, Pratt JC, Ishizuka T, Webb S, et al. Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-termina kinase in mast cells. Proc Natl Acad Sci U S A 2001; 98: 4599-604 (Pubitemid 32295022)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.8
, pp. 4599-4604
-
-
Chayama, K.1
Papst, P.J.2
Garrington, T.P.3
Pratt, J.C.4
Ishizuka, T.5
Webb, S.6
Ganiatsas, S.7
Zon, L.I.8
Sun, W.9
Johnson, G.L.10
Gelfand, E.W.11
-
17
-
-
0033213597
-
Live cell fluorescence imaging of T cell MEKK2: Redistribution and activation in response to antigen stimulation of the T cell receptor
-
DOI 10.1016/S1074-7613(00)80116-8
-
Schaefer BC, Ware MF, Marrack P, Fanger GR, Kappler JW, Johnson GL, et al. Live cell fuorescence imaging of T cell MEKK2: redistri bu-tion and activation in response to antigen stimulation of the T cel receptor. Immunity 1999; 11: 411-21. (Pubitemid 29504196)
-
(1999)
Immunity
, vol.11
, Issue.4
, pp. 411-421
-
-
Schaefer, B.C.1
Ware, M.F.2
Marrack, P.3
Fanger, G.R.4
Kappler, J.W.5
Johnson, G.L.6
Monks, C.R.F.7
-
18
-
-
0037378478
-
MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src
-
DOI 10.1128/MCB.23.7.2298-2308.2003
-
Sun W, Wei X, Kesavan K, Garrington TP, Fan R, Mei J, et al. MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src. Mo Cell Biol 2003; 23: 2298-308 (Pubitemid 36351013)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.7
, pp. 2298-2308
-
-
Sun, W.1
Wei, X.2
Kesavan, K.3
Garrington, T.P.4
Fan, R.5
Mei, J.6
Anderson, S.M.7
Gelfand, E.W.8
Johnson, G.L.9
-
19
-
-
17044414102
-
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
-
Yamashita M, Ying SX, Zhang GM, Li C, Cheng SY, Deng CX, et al. Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 2005; 121: 101-13.
-
(2005)
Cell
, vol.121
, pp. 101-13
-
-
Yamashita, M.1
Ying, S.X.2
Zhang, G.M.3
Li, C.4
Cheng, S.Y.5
Deng, C.X.6
-
20
-
-
1642444091
-
Regulation of c-Jun N-Terminal Kinase by MEKK-2 and Mitogen-Activated Protein Kinase Kinase Kinases in Rheumatoid Arthritis
-
Hammaker DR, Boyle DL, Chabaud-Riou M, Firestein GS. Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis. J Immunol 2004; 172: 1612-8. (Pubitemid 38116808)
-
(2004)
Journal of Immunology
, vol.172
, Issue.3
, pp. 1612-1618
-
-
Hammaker, D.R.1
Boyle, D.L.2
Chabaud-Riou, M.3
Firestein, G.S.4
-
21
-
-
0029895723
-
Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases
-
Jacqueline B, Fei S, Margherita D, Robert JS. Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinases. J Virol 1996; 70: 4978-85
-
(1996)
J Virol
, vol.70
, pp. 4978-85
-
-
Jacqueline, B.1
Fei, S.2
Margherita, D.3
Robert, J.S.4
-
22
-
-
0037458701
-
MEKK1 is required for inducible urokinase-type plasminogen activator expression
-
DOI 10.1074/jbc.M212363200
-
Witowsky J, Abell A, Johnson NL, Johnson GL, Cuevas BD. MEKK1 is required for inducible urokinase-type plasminogen activator expression. J Biol Chem 2003; 278: 5941-6 (Pubitemid 36800841)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.8
, pp. 5941-5946
-
-
Witowsky, J.1
Abell, A.2
Johnson, N.L.3
Johnson, G.L.4
Cuevas, B.D.5
-
23
-
-
0034675925
-
MEKK2 gene disruption causes loss of cytokine production in response to Ig e and c-Kit ligand stimulation of ES cell-derived mast cells
-
Garrington TP, Ishizuka T, Papst PJ, Chayama K, Webb S, Yujiri T, et al. MEKK2 gene disruption causes loss of cytokine production in response to Ig E and c-Kit ligand stimulation of ES cell-derived mast cells. EMBO J 2000; 19: 5387-95
-
(2000)
EMBO J
, vol.19
, pp. 5387-95
-
-
Garrington, T.P.1
Ishizuka, T.2
Papst, P.J.3
Chayama, K.4
Webb, S.5
Yujiri, T.6
-
24
-
-
69949095925
-
Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue
-
Cazares LH, Troyer D, Mendrinos S, Lance RA, Nyalwidhe JO, Beydoun HA, et al. Imaging mass spectrometry of a specific fragment of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue Clin Cancer Res 2009; 15: 5541-51.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5541-51
-
-
Cazares, L.H.1
Troyer, D.2
Mendrinos, S.3
Lance, R.A.4
Nyalwidhe, J.O.5
Beydoun, H.A.6
-
26
-
-
33847201190
-
Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells
-
Wang FZ, Sha L, Zhang WY, Wu LY, Qiao L, Li N, et al. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. Acta Pharmacol Sin 2007; 28: 431-8.
-
(2007)
Acta Pharmacol Sin
, vol.28
, pp. 431-8
-
-
Wang, F.Z.1
Sha, L.2
Zhang, W.Y.3
Wu, L.Y.4
Qiao, L.5
Li, N.6
-
27
-
-
25844451103
-
Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues
-
DOI 10.1002/jmv.20466
-
Zhang X, Dong N, Yin L, Cai N, Ma H, You J, et al. Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues. J Med Virol 2005; 77: 374-81 (Pubitemid 41395868)
-
(2005)
Journal of Medical Virology
, vol.77
, Issue.3
, pp. 374-381
-
-
Zhang, X.1
Dong, N.2
Yin, L.3
Cai, N.4
Ma, H.5
You, J.6
Zhang, H.7
Wang, H.8
He, R.9
Ye, L.10
-
28
-
-
41549120029
-
Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation
-
DOI 10.1111/j.1745-7254.2008.00764.x
-
Zhang H, Shan CL, Li N, Zhang X, Zhang XZ, Xu FQ, et al. Identifcation of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation. Acta Pharmacol Sin 2008; 29: 473-80 (Pubitemid 351465506)
-
(2008)
Acta Pharmacologica Sinica
, vol.29
, Issue.4
, pp. 473-480
-
-
Zhang, H.1
Shan, C.-L.2
Li, N.3
Zhang, X.4
Zhang, X.-Z.5
Xu, F.-Q.6
Zhang, S.7
Qiu, L.-Y.8
Ye, L.-H.9
Zhang, X.-D.10
-
29
-
-
52149104245
-
XIAP regulates bi-phasic NF-kappa B induction involving physica nteraction and ubiquitination of MEKK2
-
Winsauer G, Resch U, Hofer-Warbinek R, Schichl YM, de Martin R. XIAP regulates bi-phasic NF-kappa B induction involving physica nteraction and ubiquitination of MEKK2. Cell Signal 2008; 20 :2107-12.
-
(2008)
Cell Signal
, vol.20
, pp. 2107-12
-
-
Winsauer, G.1
Resch, U.2
Hofer-Warbinek, R.3
Schichl, Y.M.4
De Martin, R.5
-
30
-
-
41749118129
-
Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene
-
DOI 10.1159/000120289
-
Ye L, Dong N, Wang Q, Xu Z, Cai N, Wang H, et al. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology 2008; 51: 50-8. (Pubitemid 351489178)
-
(2008)
Intervirology
, vol.51
, Issue.1
, pp. 50-58
-
-
Ye, L.1
Dong, N.2
Wang, Q.3
Xu, Z.4
Cai, N.5
Wang, H.6
Zhang, X.7
-
31
-
-
0036098552
-
AP-1 as a regulator of cell life and death
-
DOI 10.1038/ncb0502-e131
-
Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 2002; 4: E131-6. (Pubitemid 34521026)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.5
-
-
Shaulian, E.1
Karin, M.2
-
32
-
-
77956944503
-
Activated Notch signaling is required for hepatitis B virus X protein to promote proliferation and survival of human hepatic cells
-
Wang F, Zhou H, Xia X, Sun Q, Wang Y, Cheng B. Activated Notch signaling is required for hepatitis B virus X protein to promote proliferation and survival of human hepatic cells. Cancer Lett 2010; 298: 64-73
-
(2010)
Cancer Lett
, vol.298
, pp. 64-73
-
-
Wang, F.1
Zhou, H.2
Xia, X.3
Sun, Q.4
Wang, Y.5
Cheng, B.6
-
33
-
-
0038558163
-
Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal
-
DOI 10.1093/emboj/cdg210
-
Kim KH, Seong BL. Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-nducing signal. EMBO J 2003; 22: 2104-16 (Pubitemid 36565535)
-
(2003)
EMBO Journal
, vol.22
, Issue.9
, pp. 2104-2116
-
-
Kim, K.-H.1
Seong, B.L.2
-
34
-
-
0034682769
-
Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway
-
Shih WL, Kuo ML, Chuang SE, Cheng AL, Doong SL. Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway J Bio Chem 2000; 275: 25858-64
-
(2000)
J Bio Chem
, vol.275
, pp. 25858-64
-
-
Shih, W.L.1
Kuo, M.L.2
Chuang, S.E.3
Cheng, A.L.4
Doong, S.L.5
-
35
-
-
0034785734
-
Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo
-
DOI 10.1128/JVI.75.21.10348-10358.2001
-
Nijhara R, Jana SS, Goswami SK, Rana A, Majumdar SS, Kumar V, et al. Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo. J Virol 2001; 75: 10348-58 (Pubitemid 32948065)
-
(2001)
Journal of Virology
, vol.75
, Issue.21
, pp. 10348-10358
-
-
Nijhara, R.1
Jana, S.S.2
Goswami, S.K.3
Rana, A.4
Majumdar, S.S.5
Kumar, V.6
Sarkar, D.P.7
|