The effects of a novel therapeutic device on acute kidney injury outcomes in the intensive care unit: A pilot study

ASAIO Journal

Volumn 57, Issue 5, 2011, Pages 426-432

  Ding, Feng ^a   Yevzlin, Alexander S ^b   Xu, Z Y ^a   Zhou, Y ^a   Xie, Q H ^a   Liu, J F ^a   Zheng, Y ^a   Dasilva, J Ricardo ^c   Humes, H D ^d  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c CytoPherx Inc   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE INFLAMMATORY RESPONSE; AFTER-TREATMENT; CELLULAR DAMAGE; CLINICAL OUTCOME; FOOD AND DRUG ADMINISTRATION; MULTIPLE REGRESSION ANALYSIS; ORGAN FAILURE; PILOT STUDIES; RENAL REPLACEMENT THERAPIES; TREATMENT GROUP;

BODY FLUIDS; RATING; REGRESSION ANALYSIS;

INTENSIVE CARE UNITS;

ACUTE KIDNEY FAILURE; ADOLESCENT; ADULT; AGED; ARTICLE; DEVICE APPROVAL; FEMALE; FOOD AND DRUG ADMINISTRATION; HUMAN; INTENSIVE CARE; INTENSIVE CARE UNIT; INTERVENTION STUDY; MALE; METHODOLOGY; MIDDLE AGED; PILOT STUDY; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; TREATMENT OUTCOME; UNITED STATES;

ACUTE KIDNEY INJURY; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DEVICE APPROVAL; FEMALE; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; INTERVENTION STUDIES; MALE; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; RENAL DIALYSIS; TREATMENT OUTCOME; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 80052479955     PISSN: 10582916     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAT.0b013e31820a1494     Document Type: Article

References (29)

1. Waikar SS, Curhan GC, Wald R, et al: Declining mortality in patients with acute renal failure, 1988 to 2002. J Am Soc Nephrol 17: 1143-1150, 2006.
2. Xue JL, Daniels F, Star RA, et al: Incidence and mortality of acute renal failure in Medicare beneficiaries, 1991-2002. J Am Soc Nephrol 17: 1135-1142, 2006.
3. Yevzlin AS, Humes HD: Cell therapy, advanced materials, and new approaches to acute kidney injury. Hosp Pract 37: 1, 2010.
4. Uchino S, Kellum JA, Bellomo R, et al: For the Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA 294: 813-818, 2005.
5. Mehta RL, Pascual MT, Soroko S, et al: Program to improve care in acute renal disease. Spectrum of acute renal failure in the intensive care unit: The PICARD experience. Kidney Int 66: 1613-1621, 2004. (Pubitemid 39298397)
6. Breen D, Bihari D: Acute renal failure as a part of multiple organ failure: The slippery slope of critical illness. Kidney Int Suppl 66: S25-S33, 1998.
7. Humes HD: Bioartificial kidney for full renal replacement therapy. Semin Nephrol 20: 71-82, 2000. (Pubitemid 30048831)
8. Humes HD, MacKay SM, Funke AJ, Buffington DA: The bioartificial renal tubule assist device to enhance CRRT in acute renal failure. Am J Kidney Dis 30: S28-S31, 1997. (Pubitemid 27465337)
9. Lu CY, Hartono J, Senitko M, Chen J: The inflammatory response to ischemic acute kidney injury: A result of the 'right stuff' in the 'wrong place'? Curr Opin Nephrol Hypertens 16: 83-89, 2007.
10. Okusa MD: The inflammatory cascade in acute ischemic renal failure. Nephron 90: 133-138, 2002. (Pubitemid 34701986)
11. Humes HD, Sobota JT, Feng D, Song JH: A selective cytopheretic inhibitory device to treat the immunological dysregulation of acute and chronic renal failure. Blood Purif 29: 183-190, 2010.
12. Tintinger G, Steel HC, Anderson R: Taming the neutrophil: Calcium clearance and influx mechanisms as novel targets for pharmacological control. Clin Exp Immunol 141:191-200, 2005. (Pubitemid 41003342)
13. Mandeville JTH, Maxfield FR: Calcium and signal transduction in granulocytres. Curr Opin Hematol 3: 63-70, 1996.
14. Ding F, Song JH, Lou L, et al: Novel selective cytopheretic inhibitory device (SCD) inhibits circulating leukocyte activation and ameliorates multiorgan dysfunction in a porcine model of septic shock. J Am Soc Nephrol 19: 458A, 2008.
15. Bishop GA, Waugh JA, Hall BM: Expression of HLA antigens on renal tubular cells in culture. II. Effect of increased HLA antigen expression on tubular cell stimulation of lymphocyte activation and on their vulnerability to cell-mediated lysis. Transplantation 46: 303-310, 1988.
16. Wahl P, Schoop R, Bilic G, et al: Renal tubular epithelial expression of the costimulatory molecule B7RP-1 (inducible costimulator ligand). J Am Soc Nephrol 13: 1517-1526, 2002. (Pubitemid 34579241)
17. Prodjosudjadi W, Gerritsma JS, Klar-Mohamad N, et al: Production and cytokine-mediated regulation of monocyte chemoattractant protein-1 by human proximal tubular epithelial cells. Kidney Int 48: 1477-1486, 1995.
18. Deneke SM, Fanburg BL: Regulation of cellular glutathione. Am J Physiol 257: L163-L173, 1989.
19. Stadnyk AW: Cytokine production by epithelial cells. FASEB J 8: 1041-1047, 1994. (Pubitemid 24338549)
20. Humes HD: Bioartificial kidney for full renal replacement therapy. Semin Nephrol 20: 71-82, 2000. (Pubitemid 30048831)
21. Kaneider NC, Leger AJ, Kuliopulos A. Therapeutic targeting of molecules involved in leukocyte- endothelial cell interactions. FEBS J 273: 4416-4424, 2006. (Pubitemid 44401593)
22. Ulbrich H, Eriksson EE, Lindbom L: Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease. Trends Pharmacol Sci 24: 640-647, 2003. (Pubitemid 37494786)
23. Mocco J, Choudhri T, Huang J, et al: HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke. Circ Res 91: 907-914, 2002. (Pubitemid 35373590)
24. Xia L, Sperandio M, Yago T, et al: P-selectin glycoprotein ligand-1- deficient mice have impaired leukocyte tethering to E-selectin under flow. J Clin Invest 109: 939-950, 2002. (Pubitemid 34275115)
25. Shimaoka M, Springer TA: Therapeutic antagonists and conformational regulation of integrin function. Nat Rev Drug Discov 2: 703-716, 2003. (Pubitemid 37361786)
26. Humes HD, Buffington DA: Selected cytopheresis device and related methods thereof. US Patent WO2009/02981. June 4, 2009.
27. Kroll MH, Hellums JD, McIntire LV, et al: Platelets and shear stress. Blood 88: 1525-1541, 1996. (Pubitemid 26307046)
28. Oudemans-van Straaten HM, Bosman RJ, Koopmans M, et al: Citrate anticoagulation for continuous venovenous hemofiltration. Crit Care Med 37: 545-552, 2009.
29. Oudemans-van Straaten HM. Citrate anticoagulation for continuous renal replacement therapy in the critically ill. Blood Purif 29: 191-196, 2010.