Haemoglobin decreases in NSAID users over time: An analysis of two large outcome trials

Alimentary Pharmacology and Therapeutics

Volumn 34, Issue 7, 2011, Pages 808-816

  Goldstein, J L ^a   Chan, F K L ^b   Lanas, A ^c   Wilcox, C M ^d   Peura, D ^e   Sands, G H ^f   Berger, M F ^f   Nguyen, H ^f   Scheiman, J M ^g  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d University of Alabama at Birmingham   (United States)

^e UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^f PFIZER INC   (United States)

^g UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; DICLOFENAC; HEMOGLOBIN; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE;

ADULT; ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSAGE FORM COMPARISON; DRUG INDUCED DISEASE; FEMALE; GASTROINTESTINAL HEMORRHAGE; HELICOBACTER PYLORI; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBINOPATHY; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SIDE EFFECT; TIME;

ADULT; AGED; ANEMIA; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, RHEUMATOID; ASPIRIN; CYCLOOXYGENASE 2 INHIBITORS; DICLOFENAC; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS; PROSPECTIVE STUDIES; PYRAZOLES; SULFONAMIDES;

EID: 80052475882     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2011.04790.x     Document Type: Article

References (26)

1. Scheiman JM, Hindley CE,. Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events. Clin Ther 2010; 32: 667-77.
2. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI,. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N Engl J Med 1992; 327: 749-54.
3. Lanas A, Sopena F,. Nonsteroidal anti-inflammatory drugs and lower gastrointestinal complications. Gastroenterol Clin North Am 2009; 38: 333-52.
4. Bombardier C, Laine L, Reicin A, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med 2000; 343: 1520-8.
5. Cannon CP, Curtis SP, FitzGerald GA, et al. Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. Lancet 2006; 368: 1771-81. (Pubitemid 44739003)
6. Schnitzer TJ, Burmester GR, Mysler E, et al. Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. Lancet 2004; 364: 665-74. (Pubitemid 39140622)
7. Silverstein FE, Graham DY, Senior JR, et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1995; 123: 241-9.
8. Silverstein FE, Faich G, Goldstein JL, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. JAMA 2000; 284: 1247-55.
9. Singh G, Fort JG, Goldstein JL, et al. Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study. Am J Med 2006; 119: 255-66. (Pubitemid 43255067)
10. Bjarnason I, O'Morain C, Levi AJ, Peters TJ,. Absorption of 51chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease. Gastroenterology 1983; 85: 318-22. (Pubitemid 13070915)
11. Chan FK, Hung LC, Suen BY, et al. Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer bleeding in patients with arthritis. N Engl J Med 2002; 347: 2104-10. (Pubitemid 36015122)
12. Goldstein JL, Eisen GM, Lewis B, Gralnek IM, Zlotnick S, Fort JG,. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol 2005; 3: 133-41. (Pubitemid 40220308)
13. Graham DY, Opekun AR, Willingham FF, Qureshi WA,. Visible small-intestinal mucosal injury in chronic NSAID users. Clin Gastroenterol Hepatol 2005; 3: 55-9. (Pubitemid 40092944)
14. Laine L, Connors LG, Reicin A, et al. Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use. Gastroenterology 2003; 124: 288-92. (Pubitemid 36169245)
15. Thiefin G, Beaugerie L,. Toxic effects of nonsteroidal antiinflammatory drugs on the small bowel, colon, and rectum. Joint Bone Spine 2005; 72: 286-94. (Pubitemid 40994974)
16. Chan FK, Lanas A, Scheiman J, Berger MF, Nguyen H, Goldstein JL,. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet 2010; 376: 173-9.
17. Chan FK, Cryer B, Goldstein JL, et al. A novel composite endpoint to evaluate the gastrointestinal (GI) effects of nonsteroidal antiinflammatory drugs through the entire GI tract. J Rheumatol 2010; 37: 167-74.
18. FDA. Advisory Committee Briefing Document. Available at:. Accessed January 4, 2010.
19. Chaves PH, Xue QL, Guralnik JM, Ferrucci L, Volpato S, Fried LP,. What constitutes normal hemoglobin concentration in community-dwelling disabled older women? J Am Geriatr Soc 2004; 52: 1811-6. (Pubitemid 41710264)
20. Eisenstaedt R, Penninx BW, Woodman RC,. Anemia in the elderly: current understanding and emerging concepts. Blood Rev 2006; 20: 213-26. (Pubitemid 43729336)
21. Penninx BW, Pluijm SM, Lips P, et al. Late-life anemia is associated with increased risk of recurrent falls. J Am Geriatr Soc 2005; 53: 2106-11. (Pubitemid 43001190)
22. Penninx BW, Pahor M, Woodman RC, Guralnik JM,. Anemia in old age is associated with increased mortality and hospitalization. J Gerontol A Biol Sci Med Sci 2006; 61: 474-9. (Pubitemid 43794706)
23. FDA. Gastrointestinal Drug Advisory Committee Meeting. Available at:. Accessed January 4, 2010.
24. Lanas A,. A review of the gastrointestinal safety data - a gastroenterologist's perspective. Rheumatology (Oxford) 2010; 49 (Suppl 2): ii3-10.
25. Penninx BW, Pahor M, Cesari M, et al. Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc 2004; 52: 719-24. (Pubitemid 38596489)
26. Goldstein JL, Eisen GM, Lewis B, et al. Small bowel mucosal injury is reduced in healthy subjects treated with celecoxib compared with ibuprofen plus omeprazole, as assessed by video capsule endoscopy. Aliment Pharmacol Ther 2007; 25: 1211-22. (Pubitemid 46650300)