Timing of heparin and perfusion temperature during procurement of organs with extracorporeal support in donors after circulatory determination of death

ASAIO Journal

Volumn 57, Issue 5, 2011, Pages 368-374

  Rojas Pena, Alvaro ^a   Hall, Candice M ^b   Cook, Keith E ^a   Bartlett, Robert H ^a   Arenas, Juan D ^c   Punch, Jeffrey D ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c Division of Transplantation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC ARREST; ETHICAL CONCERNS; HEPARINIZATION; ORGAN PERFUSION; ROOM TEMPERATURE; TARGET FLOW; TEMPERATURE STUDY; WORK STUDY;

BODY FLUIDS; PHILOSOPHICAL ASPECTS; RESUSCITATION; TEMPERATURE DISTRIBUTION; TIMING CIRCUITS;

POLYSACCHARIDES;

HEPARIN;

ANIMAL; ARTICLE; DEATH; DONOR; EXTRACORPOREAL CIRCULATION; HEART ARREST; HUMAN; METHODOLOGY; PERFUSION; RESUSCITATION; SWINE; TEMPERATURE; TIME; TRANSPLANTATION;

ANIMALS; CARDIOPULMONARY RESUSCITATION; DEATH; EXTRACORPOREAL CIRCULATION; HEART ARREST; HEPARIN; HUMANS; PERFUSION; SWINE; TEMPERATURE; TIME FACTORS; TISSUE AND ORGAN HARVESTING; TISSUE DONORS;

EID: 80052455137     PISSN: 10582916     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAT.0b013e318227f8a2     Document Type: Article

References (36)

1. Available at: Http://www.unos.org/. Accessed May 1, 2011.
2. Traffic Safety Facts Annual Report. Available at: Http://www-nrd. nhtsa.dot.gov/Pubs/TSF2006FE.PDF. Accessed January 10, 2008.
3. Zaroff JG, Rosengard BR, Armstrong WF, et al: Consensus conference report: Maximizing use of organs recovered from the cadaver donor: Cardiac recommendations, March 28-29, 2001, Crystal City, VA. Circulation 106: 836-841, 2002.
4. OPTN. Donors Recovered in the U.S. by Donor Type. Available at: Http://www.optn.org/latestData/rptData.asp, 2008. Accessed June 12, 2008.
5. Punch JD, Hayes DH, LaPorte FB, et al: Organ donation and utilization in the United States, 1996-2005. Am J Transplant 7: 1327-1338, 2007. (Pubitemid 46606938)
6. Herdman R, Beauchamp TL, Potts JT: The Institute of Medicine's report on non-heart-beating organ transplantation. Kennedy Inst Ethics J 8: 83-90, 1998.
7. Emond JC, Freeman RB Jr, Renz JF, et al: Optimizing the use of donated cadaver livers: Analysis and policy development to increase the application of split-liver transplantation. Liver Transpl 8: 863-872, 2002. (Pubitemid 35154014)
8. Abadie A, Gay S: The impact of presumed consent legislation on cadaveric organ donation: A cross-country study. J Health Econ 25: 599-620, 2006. (Pubitemid 43994191)
9. Abouna GM: Ethical issues in organ and tissue transplantation. Exp Clin Transplant 1: 125-138, 2003.
10. Johnson EJ, Goldstein DG: Defaults and donation decisions. Transplantation 78: 1713-1716, 2004. (Pubitemid 40041635)
11. Life-Saving Incentives: Consequences, Costs and Solutions to the Organ Shortage. Library of Economics and Liberty, 2004. Accessed January 10, 2008. Available at: Library/Columns/y2004/Tabarrokorgans.html#affiliation.
12. Castelao AM, Grino JM, Gonzalez C, et al: Update of our experience in long-term renal function of kidneys transplanted from non-heart-beating cadaver donors. Transplant Proc 25: 1513-1515, 1993. (Pubitemid 23079082)
13. Rigotti P, Morpurgo E, Comandella MG, et al: Non-heart-beating donors: An alternative organ source in kidney transplantation. Transplant Proc 23: 2579-2580, 1991.
14. A definition of irreversible coma. Report of the Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death. JAMA 205: 337-340, 1968.
15. Kowalski AE, Light JA, Ritchie WO, et al: A new approach for increasing the organ supply. Clin Transplant 10: 653-657, 1996. (Pubitemid 27010918)
16. Light JA, Kowalski AE, Sasaki TM, et al: A rapid organ recovery program for non-heart-beating donors. Transplant Proc 29: 3553-3556, 1997. (Pubitemid 28008594)
17. Nunez JR, Del Rio F, Lopez E, et al: Non-heart-beating donors: An excellent choice to increase the donor pool. Transplant Proc 37: 3651-3654, 2005. (Pubitemid 43015122)
18. Kootstra G, Daemen JH: The non-heart-beating donor. Transplant Proc 28: 16, 1996. (Pubitemid 26073627)
19. IOM. Organ Donation: Opportunities for Action. Washington, DC, the National Academies Press, 2006.
20. Magliocca JF, Magee JC, Rowe SA, et al: Extracorporeal support for organ donation after cardiac death effectively expands the donor pool. J Trauma 58: 1095-1101, 2005, discussion 101-102.
21. Net M, Valero R, Almenara R, et al: The effect of normothermic recirculation is mediated by ischemic preconditioning in NHBD liver transplantation. Am J Transplant 5: 2385-2392, 2005.
22. Arias-Diaz J, Alvarez J, Gomez M, et al: Changes in adenine nucleotides and lipid hydroperoxides during normothermic cardiopulmonary bypass in a porcine model of type II nonheart- beating donor. Transplant Proc 29: 3486-3487, 1997.
23. Gravel MT, Arenas JD, Chenault R 2nd, et al: Kidney transplantation from organ donors following cardiopulmonary death using extracorporeal membrane oxygenation support. Ann Transplant 9: 57-58, 2004.
24. Rojas A, Chen L, Bartlett RH, Arenas JD: Assessment of liver function during extracorporeal membrane oxygenation in the non-heart beating donor swine. Transplant Proc 36: 1268-1270, 2004. (Pubitemid 38902954)
25. Kootstra G, Daemen JH, Oomen AP: Categories of non-heartbeating donors. Transplant Proc 27: 2893-2894, 1995.
26. Streat S: Clinical review: Moral assumptions and the process of organ donation in the intensive care unit. Crit Care 8: 382-388, 2004. (Pubitemid 39468061)
27. Truog RD, Robinson WM: Role of brain death and the dead-donor rule in the ethics of organ transplantation. Crit Care Med 31: 2391-2396, 2003. (Pubitemid 37100844)
28. Motta ED: The ethics of heparin administration to the potential non-heart-beating organ donor. J Prof Nurs 21: 97-102, 2005. (Pubitemid 40439380)
29. DuBois JM, Delmonico FL, D'Alessandro AM: When organ donors are still patients: Is premortem use of heparin ethically acceptable? Am J Crit Care 16: 396-400, 2007.
30. Okazaki M, Date H, Inokawa H, et al: Optimal time for postmortem heparinization in canine lung transplantation with nonheart- beating donors. J Heart Lung Transplant 25: 454-460, 2006.
31. Gok MA, Shenton BK, Buckley PE, et al: Use of thrombolytic streptokinase as a preflush in the NHBD procurement. Transplant Proc 35: 769-770, 2003. (Pubitemid 36338150)
32. Inci I, Zhai W, Arni S, et al: Fibrinolytic treatment improves the quality of lungs retrieved from non-heart-beating donors. J Heart Lung Transplant 26: 1054-1060, 2007. (Pubitemid 47494662)
33. Umemori Y, Date H, Uno K, et al: Improved lung function by urokinase infusion in canine lung transplantation using nonheart- beating donors. Ann Thorac Surg 59: 1513-1518, 1995.
34. Endoh T, Ohkohchi N, Katoh H, et al: Graft conditioning of liver in non-heart-beating donors by an artificial heart and lung machine in situ. Transplant Proc 28: 110-115, 1996. (Pubitemid 26073663)
35. Reoma JL, Rojas A, Krause EM, et al: Lung physiology during ECS resuscitation of DCD donors followed by in situ assessment of lung function. ASAIO J 55: 388-394, 2009.
36. Rojas-Pena A, Reoma JL, Krause E, et al: Extracorporeal support: Improves donor renal graft function after cardiac death. Am J Transplant 10: 1365-1374, 2010.