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Bork K, Barnstedt S (2003) Laryngeal edema and death from asphyxiation after tooth extraction in four patients with hereditary angioedema. J Am Dent Assoc 134:1088-1094 (Pubitemid 38175476)
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Lumry WR, Castaldo AJ, Vernon MK, et al. The humanistic burden of hereditary angioedema: impact on health-related quality of life, productivity, and depression. Allergy Asthma Proc. 2010;31:407-14. Little quantitative research has examined the burden of illness associated with HAE. This publication provides unique insight into the effect of C1INH deficiency on individuals.
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Longhurst HJ, Bork K (2006) Hereditary angioedema: causes, manifestations, and treatment. Br J Hosp Med (Lond) 67:654-657 (Pubitemid 46094089)
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Bork K, Bygum A, Hardt J (2008) Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients. Ann Allergy Asthma Immunol 100:153-161 (Pubitemid 351238551)
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Craig TJ (2008) Appraisal of danazol prophylaxis for hereditary angioedema. Allergy Asthma Proc 29:225-231
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Zuraw B (2010) HAE therapies: past, present, and future. Allergy Asthma Clin Immunol 6:23
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Zuraw, B.1
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Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks
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This was a recent rigorous phase 3 study that demonstrated important dose-related efficacy for pasteurized C1INH therapy in treating HAE attacks
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Craig TJ, Levy RJ, Wasserman RL, et al. Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks. J Allergy Clin Immunol 2009;124:801-8. This was a recent rigorous phase 3 study that demonstrated important dose-related efficacy for pasteurized C1INH therapy in treating HAE attacks.
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Craig, T.J.1
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31
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Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema
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This was a recent paper reporting pivotal outcomes data from phase 3 studies of nanofiltered C1INH for both acute and long-term prophylactic treatment of HAE
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Zuraw BL, Busse PJ, White M, et al. Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema. N Engl J Med 2010;363:513-22. This was a recent paper reporting pivotal outcomes data from phase 3 studies of nanofiltered C1INH for both acute and long-term prophylactic treatment of HAE.
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Zuraw, B.L.1
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32
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Recombinant human C1- Inhibitor for the treatment of acute angioedema attacks in patients with hereditary angioedema
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This article reported pivotal phase 3 study results for the efficacy and safety of rhC1INH in treating HAE attacks
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Zuraw B, Cicardi M, Levy R, et al. Recombinant human C1- inhibitor for the treatment of acute angioedema attacks in patients with hereditary angioedema. J Allergy Clin Immunol 2010;126:821-7. This article reported pivotal phase 3 study results for the efficacy and safety of rhC1INH in treating HAE attacks.
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J Allergy Clin Immunol
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Ecallantide for the treatment of acute attacks in hereditary angioedema
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This article reported initial phase 3 study data on the efficacy and safety of ecallantide in treating HAE attacks
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Cicardi M, Levy RJ, McNeil DL, et al. Ecallantide for the treatment of acute attacks in hereditary angioedema. N Engl J Med 2010;363:523-31. This article reported initial phase 3 study data on the efficacy and safety of ecallantide in treating HAE attacks.
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Cicardi, M.1
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This article reported the pivotal study data from two controlled phase 3 studies (FAST-1 and FAST-2) investigating the efficacy and safety of icatibant in treating HAE attacks
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CicardiM, Banerji A, Bracho F, et al. Icatibant, a new bradykininreceptor antagonist, in hereditary angioedema. N Engl J Med 2010; 363:532-41. This article reported the pivotal study data from two controlled phase 3 studies (FAST-1 and FAST-2) investigating the efficacy and safety of icatibant in treating HAE attacks.
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Price DD, Finniss DG, Benedetti F (2008) A comprehensive review of the placebo effect: recent advances and current thought. Annu Rev Psychol 59:565-590
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Price, D.D.1
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36
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78650897413
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2010 international consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
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This is a recent expert consensus document incorporating new HAE therapeutics into the management approach. Additional international, evidence-based consensus documents are in development
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Bowen T, Cicardi M, Farkas H, et al. 2010 international consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. Allergy Asthma Clin Immunol. 2010;6:24. This is a recent expert consensus document incorporating new HAE therapeutics into the management approach. Additional international, evidence-based consensus documents are in development.
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Bowen, T.1
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HAE international home therapy consensus document
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This article provides important data and expert opinion regarding the benefits and potential risks of patient selfadministered therapy in managing HAE
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Longhurst HJ, Farkas H, Craig T, et al. HAE international home therapy consensus document. Allergy Asthma Clin Immunol. 2010;6:22 This article provides important data and expert opinion regarding the benefits and potential risks of patient selfadministered therapy in managing HAE.
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C1-inhibitor concentrate home therapy for hereditary angioedema: A viable, effective treatment option
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Longhurst HJ, Carr S, Khair K (2007) C1-inhibitor concentrate home therapy for hereditary angioedema: a viable, effective treatment option. Clin Exp Immunol 147:11-17 (Pubitemid 44915550)
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Levy RJ, Lumry WR, McNeil DL et al (2010) EDEMA4: a phase 3, double-blind study of subcutaneous ecallantide treatment for acute attacks of hereditary angioedema. Ann Allergy Asthma Immunol 104:523-529
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