Decrease in glutathione may be involved in pathogenesis of acne vulgaris

Journal of Cosmetic Dermatology

Volumn 10, Issue 3, 2011, Pages 240-244

  Ikeno, Hiroshi ^a   Tochio, Takumi ^b   Tanaka, Hiroshi ^b   Nakata, Satoru ^b  

^a Ikeno Clinic of Dermatology and Dermatologic Surgery   (Japan)

^b Nippon Menard Cosmetic Co Ltd   (Japan)

Author keywords

Acne; Acne vulgaris; Oxidative stress

Indexed keywords

ALPHA INTERMEDIN; ANTIOXIDANT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE;

ACNE VULGARIS; ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; FEMALE; HUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; STRATUM CORNEUM;

ACNE VULGARIS; ADOLESCENT; ADULT; ALPHA-MSH; ANALYSIS OF VARIANCE; ANTIOXIDANTS; CELLS, CULTURED; FEMALE; GENE EXPRESSION; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; KERATINOCYTES; OXIDATIVE STRESS; SKIN; YOUNG ADULT;

EID: 80052448395     PISSN: 14732130     EISSN: 14732165     Source Type: Journal    
DOI: 10.1111/j.1473-2165.2011.00570.x     Document Type: Article

References (31)

1. Strauss JS, Pochi PE, Downing DT. Acne: perspectives. J Invest Dermatol 1974; 62: 321-5.
2. Downing DT, Stewart ME, Wertz PW, Strauss JS. Essential fatty acids and acne. J Am Acad Dermatol 1986; 14: 221-5.
3. Yamamoto A, Takenouchi K, Ito M. Impaired water barrier function in acne vulgaris. Arch Dermatol Res 1995; 287: 214-8.
4. Melnik B, Kinner T, Plewig G. Influence of oral isotretinoin treatment on the composition of comedonal lipids. Implications for comedogenesis in acne vulgaris. Arch Dermatol Res 1988; 280: 97-102.
5. Guy R, Green MR, Kealey T. Modeling acne in vitro. J Invest Dermatol 1996; 106: 176-82.
6. Kim J, Ochoa MT, Krutzik SR et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 2002; 169: 1535-41.
7. Heymann WR. Toll-like receptors in acne vulgaris. J Am Acad Dermatol 2006; 55: 691-2.
8. Ottaviani M, Alestas T, Flori E et al. Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris. J Invest Dermatol 2006; 126: 2430-7.
9. Ikeno H, Ohmori K, Yunoki S, Nishikawa T. Open study comparing 5% sodium L-ascorbyl-2-phosphate lotion versus 1% clindamycin phosphate lotion for acne vulgaris. Cosmet Dermatol 2006; 19: 43-8.
10. Ikeno H, Ohmori K. Open study comparing sodium L-ascorbyl-2-phosphate 5% lotion versus adapalene 0.1% gel for acne vulgaris. Cosmet Dermatol 2007; 20: 368-72.
11. Tochio T, Tanaka H, Nakata S, Ikeno H. Accumulation of lipid peroxide in the content of comedones may be involved in the progression of comedogenesis and inflammatory changes in comedones. J Cosmet Dermatol 2009; 8: 152-8.
12. Lotlikar PD, Raj HG, Prasanna HR et al. Role of glutathione (GSH) and GSH S-transferases in conjugation of reactive metabolites of chemical carcinogens. Indian J Biochem Biophys 1987; 24: 36-43.
13. Mitchell JB, Russo A. The role of glutathione in radiation and drug induced cytotoxicity. Br J Cancer Suppl 1987; 8: 96-104.
14. Pompella A, Visvikis A, Paolicchi A et al. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol 2003; 66: 1499-503.
15. Engin A. Glutathione content of human skin carcinomas. Arch Dermatol Res 1976; 257: 53-5.
16. Nogués MR, Giralt M, Cervelló I et al. Parameters related to oxygen free radicals in human skin: a study comparing healthy epidermis and skin cancer tissue. J Invest Dermatol 2002; 119: 645-52.
17. De Bersaques J. Glutathione in human epidermal tumors. Basal and squamous cell epithelioma, verruca seborrhoeica. Arch Dermatol Res 1980; 269: 75-9.
18. Cohn VH, Lyle J. A fluorometric assay for glutathione. Anal Biochem 1966; 14: 434-40.
19. Weber SU, Thiele JJ, Cross CE, Packer L. Vitamin C, uric acid, and glutathione gradients in murine stratum corneum and their susceptibility to ozone exposure. J Invest Dermatol 1999; 113: 1128-32.
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402-8.
21. Sander CS, Chang H, Hamm F et al. Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis. Int J Dermatol 2004; 43: 326-35.
22. Kon T, Tanigawa T, Hayamizu K et al. Singlet oxygen quenching activity of human serum. Redox Rep 2004; 9: 325-30.
23. Aybey B, Ergenekon G, Hekim N et al. Glutathione peroxidase (GSH-Px) enzyme levels of patients with acne vulgaris. J Eur Acad Dermatol Venereol 2005; 19: 766-7.
24. Basak PY, Gultekin F, Kilinc I. The role of the antioxidative defense system in papulopustular acne. J Dermatol 2001; 28: 123-7.
25. Ganceviciene R, Böhm M, Fimmel S, Zouboulis CC. The role of neuropeptides in the multifactorial pathogenesis of acne vulgaris. Dermatoendocrinol 2009; 1: 170-6.
26. Cone RD, Lu D, Koppula S et al. The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res 1996; 51: 287-318.
27. Böhm M, Schiller M, Ständer S et al. Evidence for expression of melanocortin-1 receptor in human sebocytes in vitro and in situ. J Invest Dermatol 2002; 118: 533-9.
28. Lipton JM, Catania A. Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH. Immunol Today 1997; 18: 140-5.
29. Bhardwaj RS, Schwarz A, Becher E et al. Pro-opiomelanocortin-derived peptides induce IL-10 production in human monocytes. J Immunol 1996; 156: 2517-21.
30. Kokot A, Metze D, Mouchet N et al. Alpha-melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf-dependent gene expression in human skin. Endocrinology 2009; 150: 3197-206.
31. Song X, Mosby N, Yang J et al. Alpha-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes. Pigment Cell Melanoma Res 2009; 22: 809-18.