Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies

International Urogynecology Journal

Volumn 22, Issue 6, 2011, Pages 725-730

  Hazewinkel, Menke H ^a   Stalpers, Lukas J A ^a   Dijkgraaf, Marcel G ^a   Roovers, Jan Paul W R ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

0.2 Chondroitin sulfate; Acute radiation cystitis; Intravesical instillations; Overactive bladder; Pelvic radiotherapy

Indexed keywords

CHONDROITIN SULFATE; GEPAN; UNCLASSIFIED DRUG;

ACUTE RADIATION SYNDROME; ADULT; AGED; ARTICLE; BRACHYTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTALGIA; CYSTITIS; DRUG EFFICACY; DRUG INSTILLATION; DRUG TOLERABILITY; FEASIBILITY STUDY; FEMALE; GYNECOLOGIC CANCER; HUMAN; HYPERTHERMIC THERAPY; MICTURITION; MICTURITION DISORDER; OVERACTIVE BLADDER; PRIORITY JOURNAL; QUALITY OF LIFE; SCORING SYSTEM; URINE INCONTINENCE; UROGENITAL DISTRESS INVENTORY; VISUAL ANALOG SCALE;

EID: 80052439733     PISSN: 09373462     EISSN: 14333023     Source Type: Journal    
DOI: 10.1007/s00192-010-1357-0     Document Type: Article

References (16)

1. Shakespeare TP, Lim KH, Lee KM, Back MF, Mukherjee R, Lu JD (2006) Phase II study of the American Brachytherapy Society guidelines for the use of high-dose rate brachytherapy in the treatment of cervical carcinoma: is 45-50.4 Gy radiochemotherapy plus 31.8 Gy in six fractions high-dose rate brachytherapy tolerable? Int J Gynecol Cancer 16(1):277-282
2. Yalman D, Arican A, Ozsaran Z, Celik OK, Yurut V, Esassolak M et al (2002) Evaluation of morbidity after external radiotherapy and intracavitary brachytherapy in 771 patients with carcinoma of the uterine cervix or endometrium. Eur J Gynaecol Oncol 23 (1):58-62 (Pubitemid 34178103)
3. Coyne KS, Sexton CC, Irwin DE, Kopp ZS, Kelleher CJ, Milsom I (2008) The impact of overactive bladder, incontinence and other lower urinary tract symptoms on quality of life, work productivity, sexuality and emotional well-being in men and women: results from the EPIC study. BJU Int 101(11):1388-1395 (Pubitemid 351623990)
4. Maduro JH, Pras E, Willemse PH, de Vries EG (2003) Acute and long-term toxicity following radiotherapy alone or in combination with chemotherapy for locally advanced cervical cancer. Cancer Treat Rev 29(6):471-488 (Pubitemid 37428320)
5. Butrick CW (2000) Radiation cystitis. In: Howard FM, Perry CP, Carter JE, El-Minawi AM (eds) Pelvic pain: diagnosis and management, 1st edn. Williams and Wilkins, Baltimore
6. Pavlidakey PG, MacLennan GT (2009) Radiation cystitis. J Urol 182(3):1172-1173
7. Butrick CW, Sanford D, Hou Q, Mahnken JD (2009) Chronic pelvic pain syndromes: clinical, urodynamic, and urothelial observations. Int Urogynecol J Pelvic Floor Dysfunct 20 (9):1047-1053
8. Farquharson DI, Shingleton HM, Sanford SP, Soong SJ, Varner RE Jr, Hester S (1987) The short-term effect of pelvic irradiation for gynecologic malignancies on bladder function. Obstet Gynecol 70(1):81-84 (Pubitemid 17085525)
9. Jereczek-Fossa BA, Badzio A, Jassem J (2003) Factors determining acute normal tissue reactions during postoperative radiotherapy in endometrial cancer: analysis of 317 consecutive cases. Radiother Oncol 68(1):33-39 (Pubitemid 37289334)
10. Perez CA, Grigsby PW, Lockett MA, Chao KS, Williamson J (1999) Radiation therapy morbidity in carcinoma of the uterine cervix: dosimetric and clinical correlation. Int J Radiat Oncol Biol Phys 44(4):855-866 (Pubitemid 29284135)
11. Kyker KD, Coffman J, Hurst RE (2005) Exogenous glycosaminoglycans coat damaged bladder surfaces in experimentally damaged mouse bladder. BMC Urol 5:4
12. Nordling J, van Ophoven A (2008) Intravesical glycosaminoglycan replenishment with chondroitin sulphate in chronic forms of cystitis. A multi-national, multi-centre, prospective observational clinical trial. Arzneimittelforschung 58(7):328-335
13. Steinhoff G, Ittah B, Rowan S (2002) The efficacy of chondroitin sulfate 0.2% in treating interstitial cystitis. Can J Urol 9(1):1454-1458
14. van der Vaart CH, de Leeuw JR, Roovers JP, Heintz AP (2003) Measuring health-related quality of life in women with urogenital dysfunction: the urogenital distress inventory and incontinence impact questionnaire revisited. Neurourol Urodyn 22(2):97-104 (Pubitemid 36222868)
15. Roovers JP, van der Bom JG, Huub van der Vaart C, Fousert DM, Heintz AP (2001) Does mode of hysterectomy influence micturition and defecation? Acta Obstet Gynecol Scand 80(10):945-951 (Pubitemid 33010528)
16. Jackson KS, Naik R (2006) Pelvic floor dysfunction and radical hysterectomy. Int J Gynecol Cancer 16(1):354-363