Polymorphism in the PAI-1 (SERPINE1) gene and the risk of osteonecrosis in children with acute lymphoblastic leukemia

Blood

Volumn 118, Issue 9, 2011, Pages 2632-2633

  Bond, Jonathan ^a,b,c   Adams, Stuart ^b   Richards, Susan ^d   Vora, Ajay ^e   Mitchell, Christopher ^f   Goulden, Nicholas ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

^f JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE MACROGOL; DEXAMETHASONE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PREDNISOLONE;

ACUTE LYMPHOBLASTIC LEUKEMIA; BONE NECROSIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; GENOTYPE; HUMAN; LETTER; MALE; MORBIDITY; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 80052433727     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-05-355206     Document Type: Letter

References (7)

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3. Mattano L.A. Jr, Sather H.N., Trigg M.E., Nachman J.B. Osteonecrosis as a complication of treating acute lymphoblastic leukemia in children: A report from the Children's Cancer Group. J Clin Oncol. 2000;18(18):3262-3272.
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6. French D., Hamilton L.H., Mattano L.A. Jr, et al. A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: A report from the Children's Oncology Group. Blood. 2008;111(9):4496-4499.
7. Kawedia J.D., Kaste S.C., Pei D., et al. Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia. Blood. 2011;117(8):2340-2347.