Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells

Cellular and Molecular Biology Letters

Volumn 16, Issue 3, 2011, Pages 385-397

  Yamaguchi, Hiroshi ^a   Kojima, Takashi ^a   Ito, Tatsuya ^a   Kyuno, Daisuke ^a   Kimura, Yasutoshi ^a   Imamura, Masafumi ^a   Hirata, Koichi ^a   Sawada, Norimasa ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Claudin 4; CPE; Human pancreatic cancer cells; Human pancreatic duct epithelial cells; Tight junction

Indexed keywords

BACTERIAL TOXIN; CLAUDIN 4; CLOSTRIDIUM PERFRINGENS ENTEROTOXIN; SMALL INTERFERING RNA; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CANCER CELL; CANCER CELL CULTURE; CLOSTRIDIUM PERFRINGENS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG SENSITIVITY; GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; PANCREAS ISLET BETA CELL; PANCREATIC DUCT EPITHELIAL CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; TERT GENE; TIGHT JUNCTION; WESTERN BLOTTING;

CLOSTRIDIUM PERFRINGENS;

EID: 80052429727     PISSN: 14258153     EISSN: 16891392     Source Type: Journal    
DOI: 10.2478/s11658-011-0014-z     Document Type: Article

References (12)

1. Morin, P. J. Claudin proteins in human cancer: promising new targets for diagnosis and therapy. Cancer Res. 65 (2005) 9603-9606.
2. Tsukita, S., Yamazaki, Y., Katsuno, T., Tamura, A. and Tsukita, S. Tight junction-based epithelial microenvironment and cell proliferation. Oncogene27 (2008) 6930-6938.
3. Tsukita, S., Furuse, M. and Itoh, M. Multifunctional strands in tight junctions. Nat. Rev. Mol. Cell Biol. 2 (2001) 285-293.
4. Fujita, K., Katahira, J., Horiguchi, Y., Sonoda, N., Furuse, M. and Tsukita, S. Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. FEBS Lett. 476 (2000) 258-261.
5. McClane, B. A. and Chakrabarti, G. New insights into the cytotoxic mechanisms of Clostridium perfringens enterotoxin. Anaerobe10 (2004) 107-114.
6. Michl, P., Buchholz, M., Rolke, M., Kunsch, S., Löhr, M., McClane, B., Tsukita, S., Leder, G., Adler, G. and Gress, T. M. Claudin-4: a new target for pancreatic cancer treatment using Clostridium Perfringens enterotoxin. Gastroenterology121 (2001) 678-684.
7. Katahira, J., Sugiyama, H, Inoue, N., Horiguchi, Y., Matsuda, M. and Sugimoto, N. Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J. Biol. Chem. 272 (1997) 26652-26658.
8. Yamaguchi, H., Kojima, T., Ito, T., Kimura, Y., Imamura, M., Son, S., Koizumi, J., Murata, M., Nagayama, M., Nobuoka, T., Tanaka, S., Hirata, K. and Sawada, N. Transcriptional control of tight junction proteins via a PKC signal pathway in hTERT-transfected human pancreatic duct epithelial cells. Am. J. Pathol. 177 (2010) 698-712.
9. Kojima, T., Fuchimoto, J., Takasawa, A., Yamaguchi, H., Ito, T., Ninomiya, T., Kikuchi, S., Ogasawara, N., Ohkuni, T., Masaki, T., Hirata, K., Himi, T. and Sawada, N. c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells. J. Cell. Physiol. 225 (2010) 720-733.
10. Deer, E. L., González-Hernández, J., Coursen, J. D., Shea, J. E., Ngatia, J., Scaife, C. L., Firpo, M. A. and Mulvihill, S. J. Phenotype and genotype of pancreatic cancer cell lines. Pancreas39 (2010) 425-435.
11. Winkler, L., Gehring, C., Wenzel, A., Müller, S. L., Piehl, C., Krause, G., Blasig, I. E. and Piontek, J. Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3. J. Biol. Chem. 284 (2009) 18863-18872.
12. Sonoda, N., Furuse, M., Sasaki, H., Yonemura, S., Katahira, J., Horiguchi, Y. and Tsukita, S. Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J. Cell Biol. 147 (1999) 195-204.