Effects of cholinesterase inhibitors on postoperative outcomes of older adults with dementia undergoing hip fracture surgery

American Journal of Geriatric Psychiatry

Volumn 19, Issue 9, 2011, Pages 803-813

  Seitz, Dallas P ^a,b   Gill, Sudeep S ^c,d   Gruneir, Andrea ^b,c   Austin, Peter C ^c,f   Anderson, Geoff ^c,f   Reimer, Cara L ^e   Rochon, Paula A ^b,c  

^a Kunin Lunenfeld Applied Research Unit and Department of Food and Nutrition Services and Baycrest Centre for Geriatric Care   (Canada)

^b WOMEN S COLLEGE HOSPITAL   (Canada)

^c INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^d Department of Medicine ^*  (Canada)

^e QUEEN S UNIVERSITY   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

Author keywords

Anesthesia; Cholinesterase inhibitor; Dementia; Hip fracture; Observational study

Indexed keywords

DONEPEZIL; GALANTAMINE; RIVASTIGMINE;

AGED; ARTICLE; COMMUNITY CARE; DEMENTIA; GENERAL ANESTHESIA; HIP FRACTURE; HUMAN; INTENSIVE CARE UNIT; NURSING HOME; PNEUMONIA; POSTOPERATIVE COMPLICATION; REGIONAL ANESTHESIA; RESPIRATORY FAILURE; RESUSCITATION; RISK ASSESSMENT; SURGICAL MORTALITY;

EID: 80052425510     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1097/JGP.0b013e3181ff67a1     Document Type: Article

References (50)

1. Lanctot KL, Herrmann N, Yau KK, et al: Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: A meta-analysis. CMAJ 2003; 169:557-564 (Pubitemid 37174596)
2. Hogan DB, Bailey P, Carswell A, et al: Management of mild to moderate Alzheimer's disease and dementia. Alzheimers Dement 2007; 3:355-384 (Pubitemid 47535132)
3. Birks J, Harvey RJ: Donepezil for dementia due to Alzheimer's disease. Cochrane Database Syst Rev 2006; 1:CD001190
4. Birks J, Grimley Evans J, Iakovidou V, et al: Rivastigmine for Alzheimer's disease. Cochrane Database Syst Rev 2009; 2:CD001191
5. Loy C, Schneider L: Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev 2009; 1:CD001747
6. Maidment I, Fox C, Boustani M: Cholinesterase inhibitors for Parkinson's disease dementia. Cochrane Database Syst Rev 2006; 1:CD004747
7. Wild R, Pettit TACL, Burns A: Cholinesterase inhibitors for dementia with Lewy bodies. Cochrane Database Syst Rev 2003; 3:CD003672
8. Kavirajan H, Schneider LS: Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials. Lancet Neurol 2007;6:782-792 (Pubitemid 47243710)
9. Mamdani M, Rapoport M, Shulman KI, et al: Mental health-related drug utilization among older adults: prevalence, trends, and costs. Am J Geriatr Psychiatry 2005;13:892-900 (Pubitemid 46638678)
10. Seitz DP, Gruneir A, Conn DK, et al: Cholinesterase inhibitor use in US. nursing homes: results from the National Nursing Home Survey. J Am Geriatr Soc 2009; 57:2269-2274
11. Pedone C, Lapane KL, Mor V, et al: Donepezil use in US nursing homes. Aging Clin Exp Res 2004; 16:60-67 (Pubitemid 38514852)
12. Gruber-Baldini AL, Stuart B, Zuckerman IH, et al: Treatment of dementia in community-dwelling and institutionalized medicare beneficiaries. J Am Geriatr Soc 2007;55:1508-1516 (Pubitemid 47508513)
13. Francis PT, Palmer AM, Snape M, et al: The cholinergic hypothesis of Alzheimer's disease: a review of progress. J Neurol Neurosurg Psychiatry 1999;66:137-147 (Pubitemid 29103513)
14. Gill SS, Anderson GM, Fischer HD, et al: Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors. Arch Intern Med 2009; 169:867-873
15. Canadian Pharmacists Association: Compendium of Pharaceuticals and Specialties. Ottawa, Ontario, Canada, Canadian Pharmacists Association, 2009
16. Pantuck EJ: Plasma cholinesterase: gene and variations. Anesth Analg 1993; 77:380-386 (Pubitemid 23221441)
17. Lindsay PA, Lumley J: Suxamethonium apnoea masked by tetrahydroaminacrine. Anaesthesia 1978; 33:620-622 (Pubitemid 8365425)
18. Berg H, Roed J, Viby-Mogensen J, et al: Residual neuromuscular block is a risk factor for postoperative pulmonary complications. A prospective, randomised, and blinded study of postoperative pulmonary complications after atracurium, vecuronium and pancuronium. Acta Anaesthesiol Scand 1997; 41: 1095-1103
19. Jann MW, Shirley KL, Small GW: Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clin Pharmacokinet 2002; 41:719-739 (Pubitemid 34948194)
20. Crowe S, Collins L: Suxamethonium and donepezil: a cause of prolonged paralysis. Anesthesiology 2003; 98:574-575 (Pubitemid 36592827)
21. Sanchez Morillo J, Demartini Ferrari A, et al: Interaction of donepezil and muscular blockers in Alzheimer's disease. Rev Esp Anestesiol Reanim 2003; 50:97-100
22. Sprung J, Castellani WJ, Srinivasan V, et al: The effects of donepezil and neostigmine in a patient with unusual pseudocholinesterase activity. Anesth Analg 1998; 87:1203-1205 (Pubitemid 28501187)
23. Bhat RS, Mayur P, Chakrabarti I, et al: ECT-donepezil interaction: a single case report. Int J Geriatr Psychiatry 2004; 19: 594-595 (Pubitemid 38878014)
24. Zink M, Sartorius A, Lederbogen F, et al: Electroconvulsive therapy in a patient receiving rivastigmine. J ECT 2002; 18: 162-164 (Pubitemid 35192431)
25. Baruah J, Easby J, Kessell G: Effects of acetylcholinesterase inhibitor therapy for Alzheimer's disease on neuromuscular block. Br J Anaesth 2008; 100:420 (Pubitemid 351773661)
26. Tavassoli N, Sommet A, Lapeyre-Mestre M, et al: Drug interactions with cholinesterase inhibitors: an analysis of the French Pharmacovigilance database and a comparison of two national drug formularies (Vidal, British National Formulary). Drug Safety 2007; 30:1063-1071 (Pubitemid 350036604)
27. Statistics Canada: Population by Sex and Age Group, by Province and Territory.2009. Available at: http://www.statcan.gc.ca/startdebut-eng.html. Accessed November 24, 2010
28. Gill SS, Bronskill SE, Normand SL, et al: Antipsychotic drug use andmortality in older adults with dementia. Ann Intern Med 2007; 146:775-786 (Pubitemid 351650498)
29. Richards J, Brown A, Homan C: The Data Quality Study of the Canadian Discharge Abstract Database. Proceedings of Statistics Canada Symposium 2001 Achieving Data Quality in a Statistical Agency: A Methodological Perspectiv; Hull, Canada, 2001.
30. Levy AR, O'Brien BJ, Sellors C, et al: Coding accuracy of administrative drug claims in the Ontario Drug Benefit database. Can J Clin Pharmacol 2003; 10:67-71 (Pubitemid 37028596)
31. Scales DC, Guan J, Martin CM, et al: Administrative data accurately identified intensive care unit admissions in Ontario. J Clin Epidemiol 2006; 59:802-807 (Pubitemid 43975722)
32. Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45:613-619
33. Schneeweiss S, Seeger JD, Maclure M, et al: Performance of comorbidity scores to control for confounding in epidemiologic studies using claims data. Am J Epidemiol 2001; 154:854-864 (Pubitemid 33000813)
34. D'Agostino RB: Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med 1998; 17:2265-2281
35. Austin PC, Grootendorst P, Anderson GM: A comparison of the ability of different propensity score models to balance measured variables between treated and untreated subjects: a Monte Carlo study. Stat Med 2007; 26:734-753 (Pubitemid 46206593)
36. Austin PC: A critical appraisal of propensity-score matching in the medical literature between 1996 and 2003. Stat Med 2008; 27:2037-2049 (Pubitemid 351772300)
37. Austin PC: Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Stat Med 2009; 28:3083-3107
38. Austin PC,Mamdani MM: A comparison of propensity score methods: a case-study estimating the effectiveness of post-AMI statin use. Stat Med 2006; 25:2084-2106 (Pubitemid 43950281)
39. McNutt LA, Wu C, Xue X, et al: Estimating the relative risk in cohort studies and clinical trials of common outcomes. Am J Epidemiol 2003; 157:940-943 (Pubitemid 36555054)
40. Austin PC: Type I error rates, coverage of confidence intervals, and variance estimation in propensity-scorematched analyses. Int J Biostat 2009; 5:Article 13
41. Ibebunjo C, Donati F, Fox GS, et al: The effects of chronic tacrine therapy on d-tubocurarine blockade in the soleus and tibialis muscles of the rat. Anesth Analg 1997; 85:431-436 (Pubitemid 27349159)
42. Herrmann N, Gill SS, Bell CM, et al: A population-based study of cholinesterase inhibitor use for dementia. J Am Geriatr Soc 2007; 55:1517-1523 (Pubitemid 47508507)
43. Duysen EG, Li B, Darvesh S, et al: Sensitivity of butyrylcholinesterase knockout mice to (?)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. Toxicology 2007; 233:60-69 (Pubitemid 46509686)
44. Walker C, Perks D: Do you know about donepezil and succinylcholine? Anaesthesia 2002; 57:1041
45. Marcantonio ER, Flacker JM, Michaels M, et al: Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc 2000; 48:618-624 (Pubitemid 30390450)
46. Hshieh TT, Fong TG, Marcantonio ER, et al: Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence. J Gerontol A Biol Sci Med Sci 2008; 63A:764-772
47. Sampson EL, Raven PR, Ndhlovu PN, et al: A randomized, doubleblind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement. Int J Geriatr Psychiatry 2007; 22:343-349 (Pubitemid 46680845)
48. Liptzin B, Laki A, Garb JL, et al: Donepezil in the prevention and treatment of post-surgical delirium. Am J Geriatr Psychiatry 2005; 13:1100-1106 (Pubitemid 46638655)
49. Gamberini M, Bolliger D, Lurati Buse GA, et al: Rivastigmine for the prevention of postoperative delirium in elderly patients undergoing elective cardiac surgery-a randomized controlled trial. Crit Care Med 2009; 37:1762-1768
50. Redelmeier DA, Thiruchelvam D, DanemanN: Delirium after elective surgery among elderly patients taking statins. CMAJ 2008; 179:645-652