Structure and function of the perinucleolar compartment in cancer cells

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 75, Issue , 2010, Pages 599-605

  Slusarczyk, A ^a   Kamath, R ^a   Wang, C ^a   Anchel, D ^b   Pollock, C ^a   Lewandowska, M A ^a   Fitzpatrick, T ^a   Bazett Jones, D P ^b   Huang, S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; MESSENGER RNA; POLYPYRIMIDINE TRACT BINDING PROTEIN; RIBONUCLEOPROTEIN; RNA BINDING PROTEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 1; RIBONUCLEASE A; RIBONUCLEASE P; SIGNAL RECOGNITION PARTICLE;

ARTICLE; AUGER ELECTRON SPECTROSCOPY; CANCER CELL; CELL COMPARTMENTALIZATION; CELL DENSITY; CELL FUNCTION; CELL LYSATE; CELL MOTILITY; CELL STRUCTURE; CHROMATIN; COMPLEX FORMATION; GEL ELECTROPHORESIS; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; IMMUNOFLUORESCENCE; PERINUCLEOLAR COMPARTMENT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; TRANSMISSION ELECTRON MICROSCOPY; ANTIBODY LABELING; ANTIGEN RETRIEVAL; BREAST TISSUE; FEMALE; FOLLOW UP; GENE CONTROL; GENE EXPRESSION; HELA CELL LINE; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SPACE; MOLECULAR BIOLOGY; TISSUE SECTION; WESTERN BLOTTING;

CELL COMPARTMENTATION; CELL NUCLEOLUS; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; HELA CELLS; HUMANS; NEOPLASMS; NUCLEAR PROTEINS; PHENOTYPE; POLYPYRIMIDINE TRACT-BINDING PROTEIN; RNA;

EID: 80052424757     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2010.75.026     Document Type: Article

References (30)

1. Ahmed K, Li R, Bazett-Jones DP. 2009. Electron spectroscopic imaging of the nuclear landscape. Methods Mol Biol 464: 415-423.
2. Anand A, Villella A, Ryner LC, Carlo T, Goodwin SF, Song HJ, Gailey DA, Morales A, Hall JC, Baker BS, et al. 2001. Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. Genetics 158: 1569-1595.
3. Bazett-Jones DP, Hendzel MJ. 1999. Electron spectroscopic imaging of chromatin. Methods 17: 188-200.
4. Charlet BN, Savkur RS, Singh G, Philips AV, Grice EA, Cooper TA. 2002. Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing. Mol Cell 10: 45-53.
5. Dellaire G, Nisman R, Bazett-Jones DP. 2004. Correlative light and electron spectroscopic imaging of chromatin in situ. Methods Enzymol 375: 456-478.
6. Gall JG. 2003. The centennial of the Cajal body. Nat Rev Mol Cell Biol 4: 975-980.
7. Grossman JS, Meyer MI, Wang YC, Mulligan GJ, Kobayashi R, Helfman DM. 1998. The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points. RNA 4: 613-625.
8. Hall MP, Huang S, Black DL. 2004. Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA. Mol Biol Cell 15: 774-786.
9. Huang S, Deerinck TJ, Ellisman MH, Spector DL. 1998. The perinucleolar compartment and transcription. J Cell Biol 143: 35-47.
10. Huttelmaier S, Illenberger S, Grosheva I, Rudiger M, Singer RH, Jockusch BM. 2001. Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins. J Cell Biol 155: 775-786.
11. Kamath RV, Thor AD, Wang C, Edgerton SM, Slusarczyk A, Leary DJ, Wang J, Wiley EL, Jovanovic B, Wu Q, et al. 2005. Perinucleolar compartment prevalence has an independent prognostic value for breast cancer. Cancer Res 65: 246-253.
12. Lamond AI, Earnshaw WC. 1998. Structure and function in the nucleus. Science 280: 547-553.
13. Lamond AI, Spector DL. 2003. Nuclear speckles: A model for nuclear organelles. Nat Rev Mol Cell Biol 4: 605-612.
14. Lee B, Matera AG, Ward DC, Craft J. 1996. Association of RNase mitochondrial RNA processing enzyme with ribonuclease P in higher ordered structures in the nucleolus: A possible coordinate role in ribosome biogenesis. Proc Natl Acad Sci 93: 11471-11476.
15. Liu JL, Wu Z, Nizami Z, Deryusheva S, Rajendra TK, Beumer KJ, Gao H, Matera AG, Carroll D, Gall JG. 2009. Coilin is essential for Cajal body organization in Drosophila melanogaster. Mol Biol Cell 20: 1661-1670.
16. Maraia RJ. 2001. La protein and the trafficking of nascent RNA polymerase III transcripts. J Cell Biol 153: F13-F18.
17. Matera AG, Frey MR, Margelot K, Wolin SL 1995. A perinucleolar compartment contains several RNA polymerase III transcripts as well as the polypyrimidine tract-binding protein, hnRNP I. J Cell Biol 129: 1181-1193.
18. Norton JT, Pollock CB, Wang C, Schink JC, Kim JJ, Huang S. 2008. Perinucleolar compartment prevalence is a phenotypic pancancer marker of malignancy. Cancer 113: 861-869.
19. Norton JT, Wang C, Gjidoda A, Henry RW, Huang S. 2009. The perinucleolar compartment is directly associated with DNA. J Biol Chem 284: 4090-4101.
20. Oakes M, Siddiqi I, Vu L, Aris J, Nomura M. 1999. Transcription factor UAF, expansion and contraction of ribosomal DNA (rDNA) repeats, and RNA polymerase switch in transcription of yeast rDNA. Mol Cell Biol 19: 8559-8569.
21. Paillard L, Legagneux V, Beverley Osborne H. 2003. A functional deadenylation assay identifies human CUG-BP as a deadenylation factor. Biol Cell 95: 107-113.
22. Pederson T. 1998. The plurifunctional nucleolus. Nucleic Acids Res 26: 3871-3876.
23. Pollock C, Daily K, Nguyen VT, Wang C, Lewnadowska M, Bensaude O, Huang S. 2010. Characterization of MRP RNA-protein interactions within the perinucleolar compartment. Mol Biol Cell (in press).
24. Savkur RS, Philips AV, Cooper TA. 2001. Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nat Genet 29: 40-47.
25. Spector DL. 2003. The dynamics of chromosome organization and gene regulation. Annu Rev Biochem 72: 573-608.
26. Strzelecka M, Trowitzsch S, Weber G, Luhrmann R, Oates AC, Neugebauer KM. 2010. Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis. Nat Struct Mol Biol 17: 403-409.
27. Timchenko LT, Miller JW, Timchenko NA, DeVore DR, Datar KV, Lin L, Roberts R, Caskey CT, Swanson MS. 1996. Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. Nucleic Acids Res 24: 4407-4414.
28. Tucker KE, Berciano MT, Jacobs EY, LePage DF, Shpargel KB, Rossire JJ, Chan EK, Lafarga M, Conlon RA, Matera AG. 2001. Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. J Cell Biol 154: 293-307.
29. Wagner EJ, Garcia-Blanco MA. 2002. RNAi-mediated PTB depletion leads to enhanced exon definition. Mol Cell 10: 943-949.
30. Wang C, Politz JC, Pederson T, Huang S. 2003. RNA polymerase III transcripts and the PTB protein are essential for the integrity of the perinucleolar compartment. Mol Biol Cell 14: 2425-2435