메뉴 건너뛰기




Volumn 2, Issue 8, 2011, Pages 1057-1077

Subunit vaccines of the future: The need for safe, customized and optimized particulate delivery systems

Author keywords

[No Author keywords available]

Indexed keywords

ADJUPHOS; ALUMINUM HYDROXIDE; ALUMINUM PHOSPHATE; ALUMINUM POTASSIUM SULFATE; AS 01; AS 02; AS 03; AS 04; CAF 01; CANCER VACCINE; CHITOSAN DERIVATIVE; CIMAVAX EGF; CPG OLIGODEOXYNUCLEOTIDE; HEPATITIS A VACCINE; HEPATITIS B VACCINE; IMMUNOLOGICAL ADJUVANT; INFLUENZA VACCINE; ISCOM; LIPOSOME; MALARIA VACCINE; MIFAMURTIDE; MONTANIDE ISA 51; NY ESO 1 ANTIGEN; PHOSPHORYL LIPID A; POLYINOSINIC POLYCYTIDYLIC ACID; TETANUS TOXOID; TREHALOSEDIBEHENATE; UNCLASSIFIED DRUG; VACCINE; WART VIRUS VACCINE;

EID: 80052422744     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.11.68     Document Type: Review
Times cited : (114)

References (208)
  • 2
    • 0348078311 scopus 로고    scopus 로고
    • The value of vaccination: A global perspective
    • DOI 10.1016/S0264-410X(03)00377-3
    • Ehreth J. The value of vaccination: a global perspective. Vaccine 21(27-30), 4105-4117 (2003). (Pubitemid 37130255)
    • (2003) Vaccine , vol.21 , Issue.27-30 , pp. 4105-4117
    • Ehreth, J.1
  • 3
    • 0037047626 scopus 로고    scopus 로고
    • Medicine-the intangible value of vaccination
    • Rappuoli R, Miller HI, Falkow S. Medicine-the intangible value of vaccination. Science 297(5583), 937-940 (2002).
    • (2002) Science , vol.297 , Issue.5583 , pp. 937-940
    • Rappuoli, R.1    Miller, H.I.2    Falkow, S.3
  • 4
    • 36849091434 scopus 로고    scopus 로고
    • Bridging the knowledge gaps in vaccine design
    • DOI 10.1038/nbt1207-1361, PII NBT12071361
    • Rappuoli R. Bridging the knowledge gaps in vaccine design. Nat. Biotechnol. 25(12), 1361-1366 (2007). (Pubitemid 350233122)
    • (2007) Nature Biotechnology , vol.25 , Issue.12 , pp. 1361-1366
    • Rappuoli, R.1
  • 7
    • 67349087922 scopus 로고    scopus 로고
    • The path to a successful vaccine adjuvant-the long and winding road
    • O'Hagan DT, De Gregorio E. The path to a successful vaccine adjuvant-the long and winding road. Drug Discov. Today 14(11-12), 541-551 (2009).
    • (2009) Drug Discov. Today , vol.14 , Issue.11-12 , pp. 541-551
    • O'Hagan, D.T.1    De Gregorio, E.2
  • 8
    • 0142058176 scopus 로고    scopus 로고
    • Recent advances in the discovery and delivery of vaccine adjuvants
    • O'Hagan DT, Valiante NM. Recent advances in the discovery and delivery of vaccine adjuvants. Nat. Rev. Drug Discovery 2(9), 727-735 (2003). (Pubitemid 37361788)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.9 , pp. 727-735
    • O'Hagan, D.T.1    Valiante, N.M.2
  • 9
    • 34250331531 scopus 로고    scopus 로고
    • The perfect mix: Recent progress in adjuvant research
    • DOI 10.1038/nrmicro1681, PII NRMICRO1681
    • Guy B. The perfect mix: recent progress in adjuvant research. Nat. Rev. Microbiol. 5(7), 505-517 (2007). (Pubitemid 46925379)
    • (2007) Nature Reviews Microbiology , vol.5 , Issue.7 , pp. 505-517
    • Guy, B.1
  • 10
    • 77955053157 scopus 로고    scopus 로고
    • Glycoconjugate vaccines and immune interference: A review
    • Dagan R, Poolman J, Siegrist CA. Glycoconjugate vaccines and immune interference: a review. Vaccine 28(34), 5513-5523 (2010).
    • (2010) Vaccine , vol.28 , Issue.34 , pp. 5513-5523
    • Dagan, R.1    Poolman, J.2    Siegrist, C.A.3
  • 11
    • 0037205084 scopus 로고    scopus 로고
    • The global impact of vaccines containing aluminium adjuvants
    • PII S0264410X02001688
    • Clements CJ, Griffths E. The global impact of vaccines containing aluminium adjuvants. Vaccine 20, S24-S33 (2002). (Pubitemid 34607672)
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 3
    • Clements, C.J.1    Griffiths, E.2
  • 12
    • 4243187214 scopus 로고    scopus 로고
    • Aluminium adjuvants-in retrospect and prospect
    • Lindblad EB. Aluminium adjuvants-in retrospect and prospect. Vaccine 22(27-28), 3658-3668 (2004).
    • (2004) Vaccine , vol.22 , Issue.27-28 , pp. 3658-3668
    • Lindblad, E.B.1
  • 13
    • 35348968868 scopus 로고    scopus 로고
    • Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation
    • DOI 10.1586/14760584.6.5.685
    • Hem SL, Hogenesch H. Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation. Expert Rev. Vaccines 6(5), 685-698 (2007). (Pubitemid 47607846)
    • (2007) Expert Review of Vaccines , vol.6 , Issue.5 , pp. 685-698
    • Hem, S.L.1    Hogenesch, H.2
  • 14
    • 78650555727 scopus 로고    scopus 로고
    • Vaccines with aluminum-containing adjuvants: Optimizing vaccine effcacy and thermal stability
    • Clapp T, Siebert P, Chen D, Jones BL. Vaccines with aluminum-containing adjuvants: optimizing vaccine effcacy and thermal stability. J. Pharm. Sci. 100(2), 388-401 (2011).
    • (2011) J. Pharm. Sci. , vol.100 , Issue.2 , pp. 388-401
    • Clapp, T.1    Siebert, P.2    Chen, D.3    Jones, B.L.4
  • 15
    • 63149126030 scopus 로고    scopus 로고
    • Towards an understanding of the adjuvant action of aluminium
    • Marrack P, Mckee AS, Munks MW. Towards an understanding of the adjuvant action of aluminium. Nat. Rev. Immunol. 9(4), 287-293 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , Issue.4 , pp. 287-293
    • Marrack, P.1    McKee, A.S.2    Munks, M.W.3
  • 17
    • 13444292001 scopus 로고    scopus 로고
    • Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro
    • DOI 10.1016/j.vaccine.2004.07.050
    • Morefeld GL, Sokolovska A, Jiang DP, Hogenesch H, Robinson JP, Hem SL. Role of aluminum-containing adjuvants in antigen internalization by dendritic cells in vitro. Vaccine 23(13), 1588-1595 (2005). (Pubitemid 40203396)
    • (2005) Vaccine , vol.23 , Issue.13 , pp. 1588-1595
    • Morefield, G.L.1    Sokolovska, A.2    Jiang, D.3    Hogenesch, H.4    Robinson, J.P.5    Hem, S.L.6
  • 18
    • 67349269509 scopus 로고    scopus 로고
    • Mechanism of action of licensed vaccine adjuvants
    • Tritto E, Mosca F, De Gregorio E. Mechanism of action of licensed vaccine adjuvants. Vaccine 27(25-26), 3331-3334 (2009).
    • (2009) Vaccine , vol.27 , Issue.25-26 , pp. 3331-3334
    • Tritto, E.1    Mosca, F.2    De Gregorio, E.3
  • 19
    • 0030921599 scopus 로고    scopus 로고
    • Local tissue irritating effects and adjuvant activities of calcium phosphate and aluminium hydroxide with different physical properties
    • DOI 10.1016/S0264-410X(97)00054-6, PII S0264410X97000546
    • Goto N, Kato H, Maeyama J et al. Local tissue irritating effects and adjuvant activities of calcium phosphate and aluminium hydroxide with different physical properties. Vaccine 15(12-13), 1364-1371 (1997). (Pubitemid 27397815)
    • (1997) Vaccine , vol.15 , Issue.12-13 , pp. 1364-1371
    • Goto, N.1    Kato, H.2    Maeyama, J.-I.3    Shibano, M.4    Saito, T.5    Yamaguchi, J.6    Yoshihara, S.7
  • 20
    • 79953747554 scopus 로고    scopus 로고
    • Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
    • Flach TL, Ng G, Hari A et al. Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nat. Med. 17(4), 479-487 (2011).
    • (2011) Nat. Med. , vol.17 , Issue.4 , pp. 479-487
    • Flach, T.L.1    Ng, G.2    Hari, A.3
  • 21
    • 67650360784 scopus 로고    scopus 로고
    • Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators
    • Nordly P, Madsen HB, Nielsen HM, Foged C. Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators. Expert Opin. Drug Deliv. 6(7), 657-672 (2009).
    • (2009) Expert Opin. Drug Deliv. , vol.6 , Issue.7 , pp. 657-672
    • Nordly, P.1    Madsen, H.B.2    Nielsen, H.M.3    Foged, C.4
  • 22
    • 79955117153 scopus 로고    scopus 로고
    • MF59 adjuvant: The best insurance against infuenza strain diversity
    • O'Hagan DT, Rappuoli R, De GE, Tsai T, Del GG. MF59 adjuvant: the best insurance against infuenza strain diversity. Expert Rev. Vaccines 10(4), 447-462 (2011).
    • (2011) Expert Rev. Vaccines , vol.10 , Issue.4 , pp. 447-462
    • O'Hagan, D.T.1    Rappuoli, R.2    De Ge Tsai, T.3    Del, G.G.4
  • 25
    • 84887212536 scopus 로고    scopus 로고
    • MF59 (R)-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults
    • Banzhoff A, Gasparini R, Laghi-Pasini F et al. MF59 (R)-adjuvanted H5N1 vaccine induces immunologic memory and heterotypic antibody responses in non-elderly and elderly adults. PloS One 4(2), e4384 (2009).
    • (2009) PloS One , vol.4 , Issue.2
    • Banzhoff, A.1    Gasparini, R.2    Laghi-Pasini, F.3
  • 27
    • 66049086576 scopus 로고    scopus 로고
    • Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine
    • Galli G, Hancock K, Hoschler K et al. Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine. Proc. Natl Acad. Sci. USA 106(19), 7962-7967 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.19 , pp. 7962-7967
    • Galli, G.1    Hancock, K.2    Hoschler, K.3
  • 28
    • 62649105609 scopus 로고    scopus 로고
    • + T cell response that predicts long-term persistence of protective antibody levels
    • + T cell response that predicts long-term persistence of protective antibody levels. Proc. Natl Acad. Sci. USA 106(10), 3877-3882 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.10 , pp. 3877-3882
    • Galli, G.1    Medini, D.2    Borgogni, E.3
  • 29
    • 35349028297 scopus 로고    scopus 로고
    • GlaxoSmithKline Adjuvant Systems in vaccines: Concepts, achievements and perspectives
    • DOI 10.1586/14760584.6.5.723
    • Garcon N, Chomez P, Van Mechelen M. GlaxoSmithKline Adjuvant systems in vaccines: concepts, achievements and perspectives. Expert Rev. Vaccines 6(5), 723-739 (2007). (Pubitemid 47607848)
    • (2007) Expert Review of Vaccines , vol.6 , Issue.5 , pp. 723-739
    • Garcon, N.1    Chomez, P.2    Van Mechelen, M.3
  • 30
    • 75249101993 scopus 로고    scopus 로고
    • Immunogenicity and safety in adults of one dose of infuenza A H1N1v 2009 vaccine formulated with and without AS03A-adjuvant: Preliminary report of an observer-blind, randomised trial
    • Roman F, Vaman T, Gerlach B, Markendorf A, Gillard P, Devaster JM. Immunogenicity and safety in adults of one dose of infuenza A H1N1v 2009 vaccine formulated with and without AS03A-adjuvant: preliminary report of an observer-blind, randomised trial. Vaccine 28(7), 1740-1745 (2010).
    • (2010) Vaccine , vol.28 , Issue.7 , pp. 1740-1745
    • Roman, F.1    Vaman, T.2    Gerlach, B.3    Markendorf, A.4    Gillard, P.5    Devaster, J.M.6
  • 31
    • 78649493970 scopus 로고    scopus 로고
    • Monovalent inactivated split-virion AS03-adjuvanted pandemic infuenza A (H1N1) vaccine Expert Rev
    • Walker WT, Faust SN. Monovalent inactivated split-virion AS03-adjuvanted pandemic infuenza A (H1N1) vaccine. Expert Rev. Vaccines 9(12), 1385-1398 (2010).
    • (2010) Vaccines , vol.9 , Issue.12 , pp. 1385-1398
    • Walker, W.T.1    Faust, S.N.2
  • 32
    • 72449127030 scopus 로고    scopus 로고
    • Trial of 2009 infuenza A (H1N1) monovalent MF59-adjuvanted vaccine
    • Clark T W, Pareek M, Hoschler K et al. Trial of 2009 infuenza A (H1N1) monovalent MF59-adjuvanted vaccine. N. Engl. J. Med. 361(25), 2424-2435 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.25 , pp. 2424-2435
    • Clark, T.W.1    Pareek, M.2    Hoschler, K.3
  • 33
    • 82555199134 scopus 로고    scopus 로고
    • Safety surveillance of infuenza A(H1N1)v monovalent vaccines during the 2009-2010 mass vaccination campaign in France
    • Caillet C, Durrieu G, Jacquet A et al. Safety surveillance of infuenza A(H1N1)v monovalent vaccines during the 2009-2010 mass vaccination campaign in France. Eur. J. Clin. Pharmacol. (2010).
    • (2010) Eur. J. Clin. Pharmacol.
    • Caillet, C.1    Durrieu, G.2    Jacquet, A.3
  • 34
    • 77949657463 scopus 로고    scopus 로고
    • AF03-adjuvanted and non-adjuvanted pandemic infuenza A (H1N1) 2009 vaccines induce strong antibody responses in seasonal infuenza vaccine-primed and unprimed mice
    • Caillet C, Piras F, Bernard MC et al. AF03-adjuvanted and non-adjuvanted pandemic infuenza A (H1N1) 2009 vaccines induce strong antibody responses in seasonal infuenza vaccine-primed and unprimed mice. Vaccine 28(18), 3076-3079 (2010).
    • (2010) Vaccine , vol.28 , Issue.18 , pp. 3076-3079
    • Caillet, C.1    Piras, F.2    Bernard, M.C.3
  • 35
    • 48749120743 scopus 로고    scopus 로고
    • Molecular and cellular signatures of human vaccine adjuvants
    • Mosca F, Tritto E, Muzzi A et al. Molecular and cellular signatures of human vaccine adjuvants. Proc. Natl Acad. Sci. USA 105(30), 10501-10506 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.30 , pp. 10501-10506
    • Mosca, F.1    Tritto, E.2    Muzzi, A.3
  • 36
    • 44749087196 scopus 로고    scopus 로고
    • Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions
    • Fox CB, Anderson RC, Dutill TS, Goto Y, Reed SG, Vedvick TS. Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions. Colloids Surf. B 65(1), 98-105 (2008).
    • (2008) Colloids Surf. B , vol.65 , Issue.1 , pp. 98-105
    • Fox, C.B.1    Anderson, R.C.2    Dutill, T.S.3    Goto, Y.4    Reed, S.G.5    Vedvick, T.S.6
  • 37
    • 79952704589 scopus 로고    scopus 로고
    • Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes
    • Calabro S, Tortoli M, Baudner BC et al. Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes. Vaccine 29(9), 1812-1823 (2011).
    • (2011) Vaccine , vol.29 , Issue.9 , pp. 1812-1823
    • Calabro, S.1    Tortoli, M.2    Baudner, B.C.3
  • 39
  • 41
    • 84855170210 scopus 로고    scopus 로고
    • A Phase i study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen
    • DOI: 10.1002/ijc.25955 Epub ahead of print
    • Kakimi K, Isobe M, Uenaka A et al. A Phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen. Int. J. Cancer DOI: 10.1002/ijc.25955 (2011) (Epub ahead of print).
    • (2011) Int. J. Cancer
    • Kakimi, K.1    Isobe, M.2    Uenaka, A.3
  • 42
    • 52049088540 scopus 로고    scopus 로고
    • Safety and immunogenicity study of NY-ESO-1b peptide and montanide ISA-51 vaccination of patients with epithelial ovarian cancer in high-risk frst remission
    • Diefenbach CSM, Gnjatic S, Sabbatini P et al. Safety and immunogenicity study of NY-ESO-1b peptide and montanide ISA-51 vaccination of patients with epithelial ovarian cancer in high-risk frst remission. Clin. Cancer Res. 14(9), 2740-2748 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.9 , pp. 2740-2748
    • Csm, D.1    Gnjatic, S.2    Sabbatini, P.3
  • 43
    • 77649229271 scopus 로고    scopus 로고
    • Clinical development and perspectives of CIMAvax EGF, cuban vaccine for non-small-cell lung cancer therapy
    • Rodriguez PC, Rodriguez G, Gonzalez G, Lage A. Clinical development and perspectives of CIMAvax EGF, cuban vaccine for non-small-cell lung cancer therapy. MEDICC Rev. 12(1), 17-23 (2010).
    • (2010) MEDICC Rev. , vol.12 , Issue.1 , pp. 17-23
    • Rodriguez, P.C.1    Rodriguez, G.2    Gonzalez, G.3    Lage, A.4
  • 44
    • 77957773809 scopus 로고    scopus 로고
    • Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity
    • Graham BS, McElrath MJ, Keefer MC et al. Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity. PloS One 5(8), e11995 (2010).
    • (2010) PloS One , vol.5 , Issue.8
    • Graham, B.S.1    McElrath, M.J.2    Keefer, M.C.3
  • 45
    • 49949097129 scopus 로고    scopus 로고
    • Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51
    • Wu Y, Ellis RD, Shaffer D et al. Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51. PloS One 3(7), e2636 (2008).
    • (2008) PloS One , vol.3 , Issue.7
    • Wu, Y.1    Ellis, R.D.2    Shaffer, D.3
  • 46
    • 49749105995 scopus 로고    scopus 로고
    • An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results
    • Schiller JT, Castellsague X, Villa LL, Hildesheim A. An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results. Vaccine 26(Suppl. 10), K53-K61 (2008).
    • (2008) Vaccine , vol.26 , Issue.SUPPL. 10
    • Schiller, J.T.1    Castellsague, X.2    Villa, L.L.3    Hildesheim, A.4
  • 47
    • 0037146938 scopus 로고    scopus 로고
    • New technology platforms in the development of vaccines for the future
    • DOI 10.1016/S0264-410X(02)00513-3, PII S0264410X02005133
    • Gluck R, Metcalfe IC. New technology platforms in the development of vaccines for the future. Vaccine 20(Suppl. 5), B10-B16 (2002). (Pubitemid 35435391)
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 5
    • Gluck, R.1    Metcalfe, I.C.2
  • 49
    • 33846222438 scopus 로고    scopus 로고
    • ®) in elderly subjects
    • DOI 10.1016/j.vaccine.2006.05.035, PII S0264410X06006207, Proceedings of the Second European Influenza Conference
    • ®) in elderly subjects. Vaccine 24(44-46), 6629-6631 (2006). (Pubitemid 46107151)
    • (2006) Vaccine , vol.24 , Issue.44-46 , pp. 6629-6631
    • De Bruijn, I.A.1    Nauta, J.2    Gerez, L.3    Palache, A.M.4
  • 50
    • 47949114435 scopus 로고    scopus 로고
    • Recent advances with a virosomal hepatitis A vaccine
    • Bovier PA. Recent advances with a virosomal hepatitis A vaccine. Expert Opin. Biol. Therapy 8(8), 1177-1185 (2008).
    • (2008) Expert Opin. Biol. Therapy , vol.8 , Issue.8 , pp. 1177-1185
    • Bovier, P.A.1
  • 51
    • 73949091123 scopus 로고    scopus 로고
    • Papillomavirus prophylactic vaccines: Established successes, new approaches
    • Campo MS, Roden RB. Papillomavirus prophylactic vaccines: established successes, new approaches. J. Virol. 84(3), 1214-1220 (2010).
    • (2010) J. Virol. , vol.84 , Issue.3 , pp. 1214-1220
    • Campo, M.S.1    Roden, R.B.2
  • 53
    • 5444268171 scopus 로고    scopus 로고
    • gag virus-like particles: Potent stimulators of innate and acquired immune responses
    • DOI 10.1016/j.molimm.2004.06.028, PII S0161589004002500, Innate Immunology and HIV
    • Deml L, Speth C, Dierich MP, Wolf H, Wagner R. Recombinant HIV-1 Pr55gag virus-like particles: potent stimulators of innate and acquired immune responses. Mol. Immunol. 42(2), 259-277 (2005). (Pubitemid 39361454)
    • (2005) Molecular Immunology , vol.42 , Issue.2 , pp. 259-277
    • Deml, L.1    Speth, C.2    Dierich, M.P.3    Wolf, H.4    Wagner, R.5
  • 54
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • DOI 10.1038/nrd1632
    • Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat. Rev. Drug Discovery 4(2), 145-160 (2005). (Pubitemid 40282557)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.2 , pp. 145-160
    • Torchilin, V.P.1
  • 56
    • 67649336398 scopus 로고    scopus 로고
    • ® and Iscomatrix™
    • ® and Iscomatrix™. Vaccine 27(33), 4388-4401 (2009).
    • (2009) Vaccine , vol.27 , Issue.33 , pp. 4388-4401
    • Sun, H.X.1    Xie, Y.2    Ye, Y.P.3
  • 58
    • 78650373117 scopus 로고    scopus 로고
    • Designing polymeric particles for antigen delivery
    • De Koker S, Lambrecht BN, Willart MA et al. Designing polymeric particles for antigen delivery. Chem. Soc. Rev 40(1), 320-339 (2011).
    • (2011) Chem. Soc. Rev , vol.40 , Issue.1 , pp. 320-339
    • De Koker, S.1    Lambrecht, B.N.2    Willart, M.A.3
  • 59
    • 0343632356 scopus 로고    scopus 로고
    • New advances in microsphere-based single-dose vaccines
    • DOI 10.1016/S0169-409X(97)00053-7, PII S0169409X97000537
    • Langer R, Cleland JL, Hanes J. New advances in microsphere-based single-dose vaccines. Adv. Drug Delivery Rev. 28(1), 97-119 (1997). (Pubitemid 27497676)
    • (1997) Advanced Drug Delivery Reviews , vol.28 , Issue.1 , pp. 97-119
    • Hanes, J.1    Cleland, J.L.2    Langer, R.3
  • 60
    • 34548064944 scopus 로고    scopus 로고
    • Development of synthetic biodegradable microparticulate vaccines: A roller coaster story
    • DOI 10.1586/14760584.6.4.471
    • Johansen P, Gomez JMM, Gander B. Development of synthetic biodegradable microparticulate vaccines: a roller coaster story. Expert Rev. Vaccines 6(4), 471-474 (2007). (Pubitemid 47304024)
    • (2007) Expert Review of Vaccines , vol.6 , Issue.4 , pp. 471-474
    • Johansen, P.1    Martinez Gomez, J.M.2    Gander, B.3
  • 61
    • 9244255681 scopus 로고    scopus 로고
    • Formulation aspects of biodegradable polymeric microspheres for antigen delivery
    • DOI 10.1016/j.addr.2004.09.002, PII S0169409X04002078
    • Tamber H, Johansen P, Merkle HP, Gander B. Formulation aspects of biodegradable polymeric microspheres for antigen delivery. Adv. Drug Delivery Rev. 57(3), 357-376 (2005). (Pubitemid 39555502)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.3 SPEC. ISS. , pp. 357-376
    • Tamber, H.1    Johansen, P.2    Merkle, H.P.3    Gander, B.4
  • 62
    • 2642677624 scopus 로고    scopus 로고
    • Improving protein therapeutics with sustained-release formulations
    • Putney SD, Burke PA. Improving protein therapeutics with sustained-release formulations. Nat. Biotechnol. 16(2), 153-157 (1998). (Pubitemid 128723585)
    • (1998) Nature Biotechnology , vol.16 , Issue.2 , pp. 153-157
    • Putney, S.D.1    Burke, P.A.2
  • 63
    • 0034623966 scopus 로고    scopus 로고
    • Towards clinical testing of a single-administration tetanus vaccine based on PLA/PLGA microspheres
    • DOI 10.1016/S0264-410X(00)00343-1, PII S0264410X00003431
    • Johansen P, Estevez F, Zurbriggen R et al. Towards clinical testing of a single-administration tetanus vaccine based on PLA/PLGA microspheres. Vaccine 19(9-10), 1047-1054 (2000). (Pubitemid 32008269)
    • (2000) Vaccine , vol.19 , Issue.9-10 , pp. 1047-1054
    • Johansen, P.1    Estevez, F.2    Zurbriggen, R.3    Merkle, H.P.4    Gluck, R.5    Corradin, G.6    Gander, B.7
  • 64
    • 33645776262 scopus 로고    scopus 로고
    • Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres
    • Feng L, Qi MR, Zhou XJ et al. Pharmaceutical and immunological evaluation of a single-dose hepatitis B vaccine using PLGA microspheres. J. Control. Release 112(1), 35-42 (2006).
    • (2006) J. Control. Release , vol.112 , Issue.1 , pp. 35-42
    • Feng, L.1    Qi, M.R.2    Zhou, X.J.3
  • 65
    • 70350457752 scopus 로고    scopus 로고
    • Concomitant delivery of a CTL-restricted peptide antigen and CpG ODN by PLGA microparticles induces cellular immune response
    • Fischer S, Schlosser E, Mueller M et al. Concomitant delivery of a CTL-restricted peptide antigen and CpG ODN by PLGA microparticles induces cellular immune response. J. Drug Targeting 17(8), 652-661 (2009).
    • (2009) J. Drug Targeting , vol.17 , Issue.8 , pp. 652-661
    • Fischer, S.1    Schlosser, E.2    Mueller, M.3
  • 66
    • 79952173864 scopus 로고    scopus 로고
    • Programming the magnitude and persistence of antibody responses with innate immunity
    • Kasturi SP, Skountzou I, Albrecht RA et al. Programming the magnitude and persistence of antibody responses with innate immunity. Nature 470(7335), 543-547 (2011).
    • (2011) Nature , vol.470 , Issue.7335 , pp. 543-547
    • Kasturi, S.P.1    Skountzou, I.2    Albrecht, R.A.3
  • 67
    • 67650550954 scopus 로고    scopus 로고
    • Chitosan-based systems for the delivery of vaccine antigens
    • Arca HC, Gunbeyaz M, Senel S. Chitosan-based systems for the delivery of vaccine antigens. Expert Rev. Vaccines 8(7), 937-953 (2009).
    • (2009) Expert Rev. Vaccines , vol.8 , Issue.7 , pp. 937-953
    • Arca, H.C.1    Gunbeyaz, M.2    Senel, S.3
  • 69
    • 78649587261 scopus 로고    scopus 로고
    • Adjuvanted intranasal norwalk virus-like particle vaccine elicits antibodies and antibody-secreting cells that express homing receptors for mucosal and peripheral lymphoid tissues
    • El-Kamary SS, Pasetti MF, Mendelman PM et al. Adjuvanted intranasal norwalk virus-like particle vaccine elicits antibodies and antibody-secreting cells that express homing receptors for mucosal and peripheral lymphoid tissues. J. Infect. Dis. 202(11), 1649-1658 (2010).
    • (2010) J. Infect. Dis. , vol.202 , Issue.11 , pp. 1649-1658
    • El-Kamary, S.S.1    Pasetti, M.F.2    Mendelman, P.M.3
  • 70
    • 33644789168 scopus 로고    scopus 로고
    • Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform
    • DOI 10.1080/10611860500353195, PII U66108167224
    • Baudner BC, Verhoef JC, Giuliani MM et al. Protective immune responses to meningococcal C conjugate vaccine after intranasal immunization of mice with the LTK63 mutant plus chitosan or trimethyl chitosan chloride as novel delivery platform. J. Drug Targeting 13(8-9), 489-498 (2005). (Pubitemid 43347846)
    • (2005) Journal of Drug Targeting , vol.13 , Issue.8-9 , pp. 489-498
    • Baudner, B.C.1    Verhoef, J.C.2    Giuliani, M.M.3    Peppoloni, S.4    Rappuoli, R.5    Del Giudice, G.6    Junginger, H.E.7
  • 71
    • 70350618801 scopus 로고    scopus 로고
    • Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal infuenza vaccine
    • Hagenaars N, Verheul RJ, Mooren I et al. Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal infuenza vaccine. J. Control. Release 140(2), 126-133 (2009).
    • (2009) J. Control. Release , vol.140 , Issue.2 , pp. 126-133
    • Hagenaars, N.1    Verheul, R.J.2    Mooren, I.3
  • 72
    • 77953806925 scopus 로고    scopus 로고
    • Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal infuenza vaccine
    • Hagenaars N, Mania M, de Jong P et al. Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal infuenza vaccine. J. Control. Release 144(1), 17-24 (2010).
    • (2010) J. Control. Release , vol.144 , Issue.1 , pp. 17-24
    • Hagenaars, N.1    Mania, M.2    De Jong, P.3
  • 73
    • 22144431850 scopus 로고    scopus 로고
    • Local and systemic activity of the polysaccharide chitosan at lymphoid tissues after oral administration
    • DOI 10.1189/jlb.0904541
    • Porporatto C, Bianco ID, Correa SG. Local and systemic activity of the polysaccharide chitosan at lymphoid tissues after oral administration. J. Leukocyte Biol. 78(1), 62-69 (2005). (Pubitemid 40979944)
    • (2005) Journal of Leukocyte Biology , vol.78 , Issue.1 , pp. 62-69
    • Porporatto, C.1    Bianco, I.D.2    Correa, S.G.3
  • 74
    • 1842555353 scopus 로고    scopus 로고
    • Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery
    • DOI 10.1023/B:PHAM.0000022414.17183.58
    • Nagamoto T, Hattori Y, Takayama K, Maitani Y. Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery. Pharm. Res. 21(4), 671-674 (2004). (Pubitemid 38457290)
    • (2004) Pharmaceutical Research , vol.21 , Issue.4 , pp. 671-674
    • Nagamoto, T.1    Hattori, Y.2    Takayama, K.3    Maitani, Y.4
  • 75
    • 78649925718 scopus 로고    scopus 로고
    • Antigen-adjuvant nanoconjugates for nasal vaccination: An improvement over the use of nanoparticles? Mol
    • Slutter B, Bal SM, Que I et al. Antigen-adjuvant nanoconjugates for nasal vaccination: an improvement over the use of nanoparticles? Mol. Pharmaceutics 7(6), 2207-2215 (2010).
    • (2010) Pharmaceutics , vol.7 , Issue.6 , pp. 2207-2215
    • Slutter, B.1    Bal, S.M.2    Que, I.3
  • 76
    • 70350302216 scopus 로고    scopus 로고
    • Polyelectrolyte microcapsules as antigen delivery vehicles to dendritic cells: Uptake, processing, and cross-presentation of encapsulated antigens
    • De Koker S, De Geest BG, Singh SK et al. Polyelectrolyte microcapsules as antigen delivery vehicles to dendritic cells: uptake, processing, and cross-presentation of encapsulated antigens. Angew. Chem., Int. Ed. 48(45), 8485-8489 (2009).
    • (2009) Angew. Chem., Int. Ed. , vol.48 , Issue.45 , pp. 8485-8489
    • De Koker, S.1    De Geest, B.G.2    Singh, S.K.3
  • 77
    • 77954244726 scopus 로고    scopus 로고
    • Polyelectrolyte capsules-containing HIV-1 p24 and poly I:C modulate dendritic cells to stimulate HIV-1-specifc immune responses
    • De Haes W, De Koker S, Pollard C et al. Polyelectrolyte capsules-containing HIV-1 p24 and poly I:C modulate dendritic cells to stimulate HIV-1-specifc immune responses. Mol. Ther. 18(7), 1408-1416 (2010).
    • (2010) Mol. Ther. , vol.18 , Issue.7 , pp. 1408-1416
    • De Haes, W.1    De Koker, S.2    Pollard, C.3
  • 78
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • Iwasaki A, Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science 327(5963), 291-295 (2010).
    • (2010) Science , vol.327 , Issue.5963 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 79
    • 77958498224 scopus 로고    scopus 로고
    • Vaccine adjuvants: Putting innate immunity to work
    • Coffman RL, Sher A, Seder RA. Vaccine adjuvants: putting innate immunity to work. Immunity 33(4), 492-503 (2010).
    • (2010) Immunity , vol.33 , Issue.4 , pp. 492-503
    • Coffman, R.L.1    Sher, A.2    Seder, R.A.3
  • 80
  • 81
    • 12344335678 scopus 로고    scopus 로고
    • Innate and adaptive immunity: Specificities and signaling hierarchies revisited
    • DOI 10.1038/ni1153
    • Vivier E, Malissen B. Innate and adaptive immunity: specifcities and signaling hierarchies revisited. Nat. Rev. Immunol. 6(1), 17-21 (2005). (Pubitemid 40136691)
    • (2005) Nature Immunology , vol.6 , Issue.1 , pp. 17-21
    • Vivier, E.1    Malissen, B.2
  • 82
    • 0037066502 scopus 로고    scopus 로고
    • Decoding the patterns of self and nonself by the innate immune system
    • DOI 10.1126/science.1068883
    • Medzhitov R, Janeway CA Jr. Decoding the patterns of self and nonself by the innate immune system. Science 296(5566), 298-300 (2002). (Pubitemid 34303673)
    • (2002) Science , vol.296 , Issue.5566 , pp. 298-300
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 83
    • 78650576197 scopus 로고    scopus 로고
    • Use of defned TLR ligands as adjuvants within human vaccines
    • Duthie MS, Windish HP, Fox CB, Reed SG. Use of defned TLR ligands as adjuvants within human vaccines. Immunol. Rev. 239(1), 178-196 (2011).
    • (2011) Immunol. Rev. , vol.239 , Issue.1 , pp. 178-196
    • Duthie, M.S.1    Windish, H.P.2    Fox, C.B.3    Reed, S.G.4
  • 84
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila toll protein signals activation of adaptive immunity
    • DOI 10.1038/41131
    • Medzhitov R, Preston-Hurlburt P, Janeway CA. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388(6640), 394-397 (1997). (Pubitemid 27334820)
    • (1997) Nature , vol.388 , Issue.6640 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 85
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4(7), 499-511 (2004). (Pubitemid 38931765)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 86
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11(5), 373-384 (2010).
    • (2010) Nat. Immunol. , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 87
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. Toll-like receptors in innate immunity. Int. Immunol. 17(1), 1-14 (2005).
    • (2005) Int. Immunol. , vol.17 , Issue.1 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 88
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1(2), 135-145 (2001). (Pubitemid 33741967)
    • (2001) Nature Reviews Immunology , vol.1 , Issue.2 , pp. 135-145
    • Medzhitov, R.1
  • 89
    • 34548459868 scopus 로고    scopus 로고
    • Structure and function of Toll receptors and their ligands
    • Gay NJ, Gangloff M. Structure and function of Toll receptors and their ligands. Annu. Rev. Biochem. 76, 141-165 (2007).
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 141-165
    • Gay, N.J.1    Gangloff, M.2
  • 90
    • 5144228220 scopus 로고    scopus 로고
    • The role of Toll-like receptors and Nod proteins in bacterial infection
    • DOI 10.1016/j.molimm.2004.06.012, PII S0161589004002196
    • Philpott DJ, Girardin SE. The role of Toll-like receptors and Nod proteins in bacterial infection. Mol. Immunol. 41(11), 1099-1108 (2004). (Pubitemid 39345391)
    • (2004) Molecular Immunology , vol.41 , Issue.11 SPEC. ISS. , pp. 1099-1108
    • Philpott, D.J.1    Girardin, S.E.2
  • 91
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • DOI 10.1146/annurev.immunol.20.100301.064842
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709-760 (2002). (Pubitemid 34293438)
    • (2002) Annual Review of Immunology , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 92
    • 0242580118 scopus 로고    scopus 로고
    • Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos
    • Agrawal S, Agrawal A, Doughty B et al. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen- activated protein kinase and c-Fos. J. Immunol. 171(10), 4984-4989 (2003). (Pubitemid 37432777)
    • (2003) Journal of Immunology , vol.171 , Issue.10 , pp. 4984-4989
    • Agrawal, S.1    Agrawal, A.2    Doughty, B.3    Gerwitz, A.4    Blenis, J.5    Van Dyke, T.6    Pulendran, B.7
  • 93
    • 33744903928 scopus 로고    scopus 로고
    • Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes
    • Zaks K, Jordan M, Guth A et al. Effcient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes. J. Immunol. 176(12), 7335-7345 (2006). (Pubitemid 43849034)
    • (2006) Journal of Immunology , vol.176 , Issue.12 , pp. 7335-7345
    • Zaks, K.1    Jordan, M.2    Guth, A.3    Sellins, K.4    Kedl, R.5    Izzo, A.6    Bosio, C.7    Dow, S.8
  • 94
    • 9444229988 scopus 로고    scopus 로고
    • Shaping of adaptive immune responses to soluble proteins by TLR agonists: A role for IFN-α/β
    • DOI 10.1111/j.0818-9641.2004.01285.x
    • Durand V, Wong SY, Tough DF, Le BA. Shaping of adaptive immune responses to soluble proteins by TLR agonists: a role for IFN-a/b. Immunol. Cell Biol. 82(6), 596-602 (2004). (Pubitemid 39563960)
    • (2004) Immunology and Cell Biology , vol.82 , Issue.6 , pp. 596-602
    • Durand, V.1    Wong, S.Y.C.2    Tough, D.F.3    Le Bon, A.4
  • 95
    • 39149125164 scopus 로고    scopus 로고
    • Type i interferon as a stimulus for cross-priming
    • Le Bon A, Tough DF. Type I interferon as a stimulus for cross-priming. Cytokine Growth Factor Rev. 19(1), 33-40 (2008).
    • (2008) Cytokine Growth Factor Rev. , vol.19 , Issue.1 , pp. 33-40
    • Le Bon, A.1    Tough, D.F.2
  • 96
    • 0033039278 scopus 로고    scopus 로고
    • + T cells to intracellular bacteria
    • DOI 10.1016/S0952-7915(99)80016-8
    • + T cells to intracellular bacteria. Curr. Opin. Immunol. 11(1), 89-93 (1999). (Pubitemid 29082343)
    • (1999) Current Opinion in Immunology , vol.11 , Issue.1 , pp. 89-93
    • Harty, J.T.1    Bevan, M.J.2
  • 97
    • 53849109907 scopus 로고    scopus 로고
    • Putting endotoxin to work for us: Monophosphoryl lipid A as a safe and effective vaccine adjuvant
    • Casella CR, Mitchell TC. Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant. Cell. Mol. Life Sci. 65(20), 3231-3240 (2008).
    • (2008) Cell. Mol. Life Sci. , vol.65 , Issue.20 , pp. 3231-3240
    • Casella, C.R.1    Mitchell, T.C.2
  • 98
    • 77951213492 scopus 로고    scopus 로고
    • Preclinical development of AS04
    • Garcon N. Preclinical development of AS04. Methods Mol. Biol. 626, 15-27 (2010).
    • (2010) Methods Mol. Biol. , vol.626 , pp. 15-27
    • Garcon, N.1
  • 99
    • 77949889253 scopus 로고    scopus 로고
    • Clinical update of the AS04-Adjuvanted human Papillomavirus-16/18 cervical cancer vaccine, cervarix
    • Schwarz T. Clinical update of the AS04-Adjuvanted human Papillomavirus-16/18 cervical cancer vaccine, cervarix. Adv. Ther. 26(11), 983-998 (2009).
    • (2009) Adv. Ther. , vol.26 , Issue.11 , pp. 983-998
    • Schwarz, T.1
  • 100
    • 71649087760 scopus 로고    scopus 로고
    • Sustained effcacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: Ana lysis of a randomised placebo-controlled trial up to 6+4 years
    • The GlaxoSmithKline Vaccine HPV-007 Study Group
    • The GlaxoSmithKline Vaccine HPV-007 Study Group: Sustained effcacy and immunogenicity of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine: ana lysis of a randomised placebo-controlled trial up to 6+4 years. The Lancet 374(9706), 1975-1985 (2009).
    • (2009) The Lancet , vol.374 , Issue.9706 , pp. 1975-1985
  • 102
    • 77249176352 scopus 로고    scopus 로고
    • AS04, an aluminum salt-and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity
    • Didierlaurent AM, Morel S, Lockman L et al. AS04, an aluminum salt-and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity. J. Immunol. 183(10), 6186-6197 (2009).
    • (2009) J. Immunol. , vol.183 , Issue.10 , pp. 6186-6197
    • Didierlaurent, A.M.1    Morel, S.2    Lockman, L.3
  • 105
    • 52349119606 scopus 로고    scopus 로고
    • Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): A versatile adjuvant for vaccines with different immunological requirements
    • Agger EM, Rosenkrands I, Hansen J et al. Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements. PloS One 3(9), e3116 (2008).
    • (2008) PloS One , vol.3 , Issue.9
    • Agger, E.M.1    Rosenkrands, I.2    Hansen, J.3
  • 106
    • 0031841564 scopus 로고    scopus 로고
    • Liposomes containing lipid a serve as an adjuvant for induction of antibody and cytotoxic T-cell responses against RTS,S malaria antigen
    • Richards RL, Rao M, Wassef NM, Glenn GM, Rothwell SW, Alving CR. Liposomes containing lipid A serve as an adjuvant for induction of antibody and cytotoxic T-cell responses against RTS,S malaria antigen. Infect. Immun. 66(6), 2859-2865 (1998). (Pubitemid 28261796)
    • (1998) Infection and Immunity , vol.66 , Issue.6 , pp. 2859-2865
    • Richards, R.L.1    Rao, M.2    Wassef, N.M.3    Glenn, G.M.4    Rothwell, S.W.5    Alving, C.R.6
  • 108
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
    • DOI 10.1038/35099560
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kB by Toll-like receptor 3. Nature 413(6857), 732-738 (2001). (Pubitemid 33009951)
    • (2001) Nature , vol.413 , Issue.6857 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 111
    • 0014569955 scopus 로고
    • Foot-and-mouth disease virus inhibition induced in mice by synthetic double-stranded RNA (polyriboinosinic and polyribocytidylic acids)
    • Richmond JY, Hamilton LD. Foot-and-mouth disease virus inhibition induced in mice by synthetic double-stranded RNA (polyriboinosinic and polyribocytidylic acids). Proc. Natl Acad. Sci. USA 64(1), 81-86 (1969).
    • (1969) Proc. Natl Acad. Sci. USA , vol.64 , Issue.1 , pp. 81-86
    • Richmond, J.Y.1    Hamilton, L.D.2
  • 113
    • 0033168630 scopus 로고    scopus 로고
    • Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells
    • Verdijk RM, Mutis T, Esendam B et al. Polyriboinosinic polyribocytidylic acid (poly(I:C)) induces stable maturation of functionally active human dendritic cells. J. Immunol. 163(1), 57-61 (1999). (Pubitemid 29295824)
    • (1999) Journal of Immunology , vol.163 , Issue.1 , pp. 57-61
    • Verdijk, R.M.1    Mutis, T.2    Esendam, B.3    Kamp, J.4    Melief, C.J.M.5    Brand, A.6    Goulmy, E.7
  • 114
    • 33745404635 scopus 로고    scopus 로고
    • Nasal immunization with anthrax protective antigen protein adjuvanted with polyriboinosinic-polyribocytidylic acid induced strong mucosal and systemic immunities
    • DOI 10.1007/s11095-006-0206-9
    • Sloat BR, Cui Z. Nasal immunization with anthrax protective antigen protein adjuvanted with polyriboinosinic-polyribocytidylic acid induced strong mucosal and systemic immunities. Pharm. Res. 23(6), 1217-1226 (2006). (Pubitemid 43946144)
    • (2006) Pharmaceutical Research , vol.23 , Issue.6 , pp. 1217-1226
    • Sloat, B.R.1    Cui, Z.2
  • 117
    • 17844384773 scopus 로고    scopus 로고
    • Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling: Evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity
    • Salem ML, Kadima AN, Cole DJ, Gillanders WE. Defning the antigen-specifc T-cell response to vaccination and poly(I:C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity. J. Immunother. 28(3), 220-228 (2005). (Pubitemid 40593987)
    • (2005) Journal of Immunotherapy , vol.28 , Issue.3 , pp. 220-228
    • Salem, M.L.1    Kadima, A.N.2    Cole, D.J.3    Gillanders, W.E.4
  • 119
  • 120
    • 79955065280 scopus 로고    scopus 로고
    • + T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method
    • + T-cell responses by poly(I:C) incorporated into the CAF01 adjuvant via a double emulsion method. J. Control. Release 150(3), 307-317 (2011).
    • (2011) J. Control. Release , vol.150 , Issue.3 , pp. 307-317
    • Nordly, P.1    Rose, F.2    Christensen, D.3
  • 121
    • 33845568917 scopus 로고    scopus 로고
    • Inhibitory effect of the polyinosinic-polycytidylic acid/cationic liposome on the progression of murine B16F10 melanoma
    • DOI 10.1002/eji.200636053
    • Fujimura T, Nakagawa S, Ohtani T, Ito Y, Aiba S. Inhibitory effect of the polyinosinic-polycytidylic acid/cationic liposome on the progression of murine B16F10 melanoma. Eur. J. Immunol. 36(12), 3371-3380 (2006). (Pubitemid 44932738)
    • (2006) European Journal of Immunology , vol.36 , Issue.12 , pp. 3371-3380
    • Fujimura, T.1    Nakagawa, S.2    Ohtani, T.3    Ito, Y.4    Aiba, S.5
  • 123
    • 74049118785 scopus 로고    scopus 로고
    • + T-cell responses after vaccination with NY-ESO-1 peptide CpG 7909 and Montanide ISA-51: Association with survival
    • + T-cell responses after vaccination with NY-ESO-1 peptide, CpG 7909 and Montanide ISA-51: association with survival. Int. J. Cancer 126(4), 909-918 (2010).
    • (2010) Int. J. Cancer , vol.126 , Issue.4 , pp. 909-918
    • Karbach, J.1    Gnjatic, S.2    Bender, A.3
  • 124
    • 79151471698 scopus 로고    scopus 로고
    • Pitfalls of vaccinations with WT1-Proteinase3-and MUC1-derived peptides in combination with MontanideISA51 and CpG7909
    • Kuball J, de Boer K, Wagner E et al. Pitfalls of vaccinations with WT1-, Proteinase3-and MUC1-derived peptides in combination with MontanideISA51 and CpG7909. Cancer Immunol. Immunother. 60(2), 161-171 (2011).
    • (2011) Cancer Immunol. Immunother. , vol.60 , Issue.2 , pp. 161-171
    • Kuball, J.1    De Boer, K.2    Wagner, E.3
  • 125
    • 33846319348 scopus 로고    scopus 로고
    • The innate signaling of dangers and the dangers of innate signaling
    • DOI 10.1038/ni1420, PII NI1420
    • Sansonetti PJ. The innate signaling of dangers and the dangers of innate signaling. Nat. Immunol. 7(12), 1237-1242 (2006). (Pubitemid 46111240)
    • (2006) Nature Immunology , vol.7 , Issue.12 , pp. 1237-1242
    • Sansonetti, P.J.1
  • 126
    • 65649141586 scopus 로고    scopus 로고
    • Pathogen recognition in the innate immune response
    • Kumar H, Kawai T, Akira S. Pathogen recognition in the innate immune response. Biochem. J. 420, 1-16 (2009).
    • (2009) Biochem. J. , vol.420 , pp. 1-16
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 128
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • Kato H, Takeuchi O, Sato S et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441(7089), 101-105 (2006).
    • (2006) Nature , vol.441 , Issue.7089 , pp. 101-105
    • Kato, H.1    Takeuchi, O.2    Sato, S.3
  • 130
    • 45749111446 scopus 로고    scopus 로고
    • Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    • DOI 10.1038/nature06939, PII NATURE06939
    • Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA. Crucial role for the Nalp3 infammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453(7198), 1122-1126 (2008). (Pubitemid 351871731)
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1122-1126
    • Eisenbarth, S.C.1    Colegio, O.R.2    O'Connor Jr., W.3    Sutterwala, F.S.4    Flavell, R.A.5
  • 131
    • 56149119563 scopus 로고    scopus 로고
    • Cutting edge: Alum adjuvant stimulates infammatory dendritic cells through activation of the NALP3 infammasome
    • Kool M, Petrilli V, De ST et al. Cutting edge: alum adjuvant stimulates infammatory dendritic cells through activation of the NALP3 infammasome. J. Immunol. 181(6), 3755-3759 (2008).
    • (2008) J. Immunol. , vol.181 , Issue.6 , pp. 3755-3759
    • Kool, M.1    Petrilli, V.2    De, S.T.3
  • 132
    • 50849112477 scopus 로고    scopus 로고
    • The Nlrp3 infammasome is critical for aluminium hydroxide-mediated IL-1 b secretion but dispensable for adjuvant activity
    • Franchi L, Nunez G. The Nlrp3 infammasome is critical for aluminium hydroxide-mediated IL-1 b secretion but dispensable for adjuvant activity. Eur. J. Immunol. 38(8), 2085-2089 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , Issue.8 , pp. 2085-2089
    • Franchi, L.1    Nunez, G.2
  • 133
    • 60549116006 scopus 로고    scopus 로고
    • Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcR gamma-Syk-Card9-dependent innate immune activation
    • Werninghaus K, Babiak A, Gross O et al. Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcR gamma-Syk-Card9-dependent innate immune activation. J. Exp. Med. 206(1), 89-97 (2009).
    • (2009) J. Exp. Med. , vol.206 , Issue.1 , pp. 89-97
    • Werninghaus, K.1    Babiak, A.2    Gross, O.3
  • 134
    • 77951932177 scopus 로고    scopus 로고
    • Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate
    • Schoenen H, Bodendorfer B, Hitchens K et al. Cutting edge: mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J. Immunol. 184(6), 2756-2760 (2010).
    • (2010) J. Immunol. , vol.184 , Issue.6 , pp. 2756-2760
    • Schoenen, H.1    Bodendorfer, B.2    Hitchens, K.3
  • 135
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991-1045 (1994). (Pubitemid 24140436)
    • (1994) Annual Review of Immunology , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 136
    • 41149118513 scopus 로고    scopus 로고
    • How dying cells alert the immune system to danger
    • DOI 10.1038/nri2215, PII NRI2215
    • Kono H, Rock KL. How dying cells alert the immune system to danger. Nat. Rev. Immunol. 8(4), 279-289 (2008). (Pubitemid 351432799)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.4 , pp. 279-289
    • Kono, H.1    Rock, K.L.2
  • 137
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of infammation
    • Medzhitov R. Origin and physiological roles of infammation. Nature 454(7203), 428-435 (2008).
    • (2008) Nature , vol.454 , Issue.7203 , pp. 428-435
    • Medzhitov, R.1
  • 138
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • DOI 10.1038/15200
    • Gallucci S, Lolkema M, Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5(11), 1249-1255 (1999). (Pubitemid 29535601)
    • (1999) Nature Medicine , vol.5 , Issue.11 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 139
    • 33846990935 scopus 로고    scopus 로고
    • Friendly and dangerous signals: Is the tissue in control?
    • DOI 10.1038/ni0107-11, PII NI0107-11
    • Matzinger P. Friendly and dangerous signals: is the tissue in control? Nat. Immunol. 8(1), 11-13 (2007). (Pubitemid 46242350)
    • (2007) Nature Immunology , vol.8 , Issue.1 , pp. 11-13
    • Matzinger, P.1
  • 140
    • 13944260898 scopus 로고    scopus 로고
    • + T cell populations lacking helper function
    • DOI 10.1038/ni1162
    • + T cell populations lacking helper function. Nat. Immunol. 6(2), 163-170 (2005). (Pubitemid 40268197)
    • (2005) Nature Immunology , vol.6 , Issue.2 , pp. 163-170
    • Sporri, R.1    Reis E Sousa, C.2
  • 142
    • 78049458472 scopus 로고    scopus 로고
    • Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems
    • Mohanan D, Slutter B, Henriksen-Lacey M et al. Administration routes affect the quality of immune responses: a cross-sectional evaluation of particulate antigen-delivery systems. J. Control. Release 147(3), 342-349 (2010).
    • (2010) J. Control. Release , vol.147 , Issue.3 , pp. 342-349
    • Mohanan, D.1    Slutter, B.2    Henriksen-Lacey, M.3
  • 144
    • 17644371966 scopus 로고    scopus 로고
    • Mucosal immunity and vaccines
    • DOI 10.1038/nm1213
    • Holmgren J, Czerkinsky C. Mucosal immunity and vaccines. Nat. Med. 11(4), S45-S53 (2005). (Pubitemid 40562303)
    • (2005) Nature Medicine , vol.11 , Issue.4 SUPPL.
    • Holmgren, J.1    Czerkinsky, C.2
  • 145
    • 79953036467 scopus 로고    scopus 로고
    • Immunoglobulin responses at the mucosal interface
    • Cerutti A, Chen K, Chorny A. Immunoglobulin responses at the mucosal interface. Annu. Rev. Immunol. 29, 273-293 (2011).
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 273-293
    • Cerutti, A.1    Chen, K.2    Chorny, A.3
  • 146
    • 0023243066 scopus 로고
    • The common mucosal immune system and current strategies for induction of immune responses in external secretions
    • Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J. Clin. Immunol. 7(4), 265-276 (1987). (Pubitemid 17146794)
    • (1987) Journal of Clinical Immunology , vol.7 , Issue.4 , pp. 265-276
    • Mestecky, J.1
  • 147
    • 77953770453 scopus 로고    scopus 로고
    • The future of mucosal immunology: Studying an integrated system-wide organ
    • Gill N, Wlodarska M, Finlay BB. The future of mucosal immunology: studying an integrated system-wide organ. Nat. Immunol. 11(7), 558-560 (2010).
    • (2010) Nat. Immunol. , vol.11 , Issue.7 , pp. 558-560
    • Gill, N.1    Wlodarska, M.2    Finlay, B.B.3
  • 148
    • 0035284751 scopus 로고    scopus 로고
    • Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract
    • Gallichan WS, Woolstencroft RN, Guarasci T, McCluskie MJ, Davis HL, Rosenthal KL. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J. Immunol. 166(5), 3451-3457 (2001). (Pubitemid 33117348)
    • (2001) Journal of Immunology , vol.166 , Issue.5 , pp. 3451-3457
    • Gallichan, W.S.1    Woolstencroft, R.N.2    Guarasci, T.3    McCluskie, M.J.4    Davis, H.L.5    Rosenthal, K.L.6
  • 149
    • 77958452906 scopus 로고    scopus 로고
    • Vaccination strategies to promote mucosal antibody responses
    • Chen K, Cerutti A. Vaccination strategies to promote mucosal antibody responses. Immunity 33(4), 479-491 (2010).
    • (2010) Immunity , vol.33 , Issue.4 , pp. 479-491
    • Chen, K.1    Cerutti, A.2
  • 150
    • 14744303986 scopus 로고    scopus 로고
    • Mucosal adjuvants
    • DOI 10.1016/j.vaccine.2004.11.010
    • Freytag LC, Clements JD. Mucosal adjuvants. Vaccine 23(15), 1804-1813 (2005). (Pubitemid 40331849)
    • (2005) Vaccine , vol.23 , Issue.15 SPEC. ISS. , pp. 1804-1813
    • Freytag, L.C.1    Clements, J.D.2
  • 151
    • 76849091128 scopus 로고    scopus 로고
    • Nanotechnology solutions for mucosal immunization
    • Chadwick S, Kriegel C, Amiji M. Nanotechnology solutions for mucosal immunization. Adv. Drug Delivery Rev. 62(4-5), 394-407 (2010).
    • (2010) Adv. Drug Delivery Rev. , vol.62 , Issue.4-5 , pp. 394-407
    • Chadwick, S.1    Kriegel, C.2    Amiji, M.3
  • 153
    • 78149435470 scopus 로고    scopus 로고
    • Nasal vaccine innovation
    • Jabbal-Gill I. Nasal vaccine innovation. J. Drug Targeting 18(10), 771-786 (2010).
    • (2010) J. Drug Targeting , vol.18 , Issue.10 , pp. 771-786
    • Jabbal-Gill, I.1
  • 154
    • 78149463086 scopus 로고    scopus 로고
    • Bioadhesive delivery systems for mucosal vaccine delivery
    • Baudner BC, O'Hagan DT. Bioadhesive delivery systems for mucosal vaccine delivery. J. Drug Targeting 18(10), 752-770 (2010).
    • (2010) J. Drug Targeting , vol.18 , Issue.10 , pp. 752-770
    • Baudner, B.C.1    O'Hagan, D.T.2
  • 155
    • 34247205938 scopus 로고    scopus 로고
    • Pulmonary vaccine delivery
    • DOI 10.1586/14760584.6.2.213
    • Lu D, Hickey AJ. Pulmonary vaccine delivery. Expert Rev. Vaccines 6(2), 213-226 (2007). (Pubitemid 46607457)
    • (2007) Expert Review of Vaccines , vol.6 , Issue.2 , pp. 213-226
    • Lu, D.1    Hickey, A.J.2
  • 156
    • 79955106944 scopus 로고    scopus 로고
    • Opportunities and challenges of the pulmonary route for vaccination
    • Blank F, Stumbles P, von Garnier C. Opportunities and challenges of the pulmonary route for vaccination. Expert Opin. Drug Deliv. 8(5), 547-563 (2011).
    • (2011) Expert Opin. Drug Deliv. , vol.8 , Issue.5 , pp. 547-563
    • Blank, F.1    Stumbles, P.2    Von Garnier, C.3
  • 157
    • 77249171801 scopus 로고    scopus 로고
    • Respiratory administration of measles vaccine
    • Omer SB, Hiremath GS, Halsey NA. Respiratory administration of measles vaccine. Lancet 375(9716), 706-708 (2010).
    • (2010) Lancet , vol.375 , Issue.9716 , pp. 706-708
    • Omer, S.B.1    Hiremath, G.S.2    Halsey, N.A.3
  • 158
    • 33845906339 scopus 로고    scopus 로고
    • Inhaling medicines: Delivering drugs to the body through the lungs
    • DOI 10.1038/nrd2153, PII NRD2153
    • Patton JS, Byron PR. Inhaling medicines: delivering drugs to the body through the lungs. Nat. Rev. Drug Discovery 6(1), 67-74 (2007). (Pubitemid 46020287)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.1 , pp. 67-74
    • Patton, J.S.1    Byron, P.R.2
  • 161
    • 79251475565 scopus 로고    scopus 로고
    • Enhancing oral vaccine potency by targeting intestinal M cells
    • Azizi A, Kumar A, az-Mitoma F, Mestecky J. Enhancing oral vaccine potency by targeting intestinal M cells. PLoS Pathog. 6(11), e1001147 (2010).
    • (2010) PLoS Pathog. , vol.6 , Issue.11
    • Azizi, A.1    Kumar, A.2    Az-Mitoma, F.3    Mestecky, J.4
  • 162
    • 58149380346 scopus 로고    scopus 로고
    • Delivery systems: A vaccine strategy for overcoming mucosal tolerance?
    • Mann JFS, Acevedo R, del Campo J, Perez O, Ferro VA. Delivery systems: a vaccine strategy for overcoming mucosal tolerance? Expert Rev. Vaccines 8(1), 103-112 (2008).
    • (2008) Expert Rev. Vaccines , vol.8 , Issue.1 , pp. 103-112
    • Jfs, M.1    Acevedo, R.2    Del Campo, J.3    Perez, O.4    Ferro, V.A.5
  • 163
    • 79952943125 scopus 로고    scopus 로고
    • Designing oral vaccines targeting intestinal dendritic cells
    • Devriendt B, De Geest BG, Cox E. Designing oral vaccines targeting intestinal dendritic cells. Expert Opin. Drug Deliv. 8(4), 467-483 (2011).
    • (2011) Expert Opin. Drug Deliv. , vol.8 , Issue.4 , pp. 467-483
    • Devriendt, B.1    De Geest, B.G.2    Cox, E.3
  • 164
    • 78649772289 scopus 로고    scopus 로고
    • Advances in transcutaneous vaccine delivery: Do all ways lead to Rome? J
    • Bal SM, Ding Z, van RE, Jiskoot W, Bouwstra JA. Advances in transcutaneous vaccine delivery: do all ways lead to Rome? J. Control. Release 148(3), 266-282 (2010).
    • (2010) Control. Release , vol.148 , Issue.3 , pp. 266-282
    • Bal, S.M.1    Ding, Z.2    Van Re Jiskoot, W.3    Bouwstra, J.A.4
  • 165
    • 77957019574 scopus 로고    scopus 로고
    • Infuence of microneedle shape on the transport of a fuorescent dye into human skin in vivo
    • Bal SM, Kruithof AC, Zwier R et al. Infuence of microneedle shape on the transport of a fuorescent dye into human skin in vivo. J. Control. Release 147(2), 218-224 (2010).
    • (2010) J. Control. Release , vol.147 , Issue.2 , pp. 218-224
    • Bal, S.M.1    Kruithof, A.C.2    Zwier, R.3
  • 166
    • 77955473764 scopus 로고    scopus 로고
    • Microneedle-based transcutaneous immunisation in mice with N-trimethyl chitosan adjuvanted diphtheria toxoid formulations
    • Bal SM, Ding Z, Kersten GF, Jiskoot W, Bouwstra JA. Microneedle-based transcutaneous immunisation in mice with N-trimethyl chitosan adjuvanted diphtheria toxoid formulations. Pharm. Res. 27(9), 1837-1847 (2010).
    • (2010) Pharm. Res. , vol.27 , Issue.9 , pp. 1837-1847
    • Bal, S.M.1    Ding, Z.2    Kersten, G.F.3    Jiskoot, W.4    Bouwstra, J.A.5
  • 167
    • 79955647601 scopus 로고    scopus 로고
    • Small is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunisation
    • Bal SM, Slutter B, Jiskoot W, Bouwstra JA. Small is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunisation. Vaccine 29(23), 4025-4032 (2011).
    • (2011) Vaccine , vol.29 , Issue.23 , pp. 4025-4032
    • Bal, S.M.1    Slutter, B.2    Jiskoot, W.3    Bouwstra, J.A.4
  • 168
    • 77349113775 scopus 로고    scopus 로고
    • Effcient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations
    • Bal SM, Slutter B, van Riet E et al. Effcient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations. J. Control. Release 142(3), 374-383 (2010).
    • (2010) J. Control. Release , vol.142 , Issue.3 , pp. 374-383
    • Bal, S.M.1    Slutter, B.2    Van Riet, E.3
  • 169
    • 79957469396 scopus 로고    scopus 로고
    • A rational, systematic approach for the development of vaccine formulations
    • Morefeld GL. A rational, systematic approach for the development of vaccine formulations. AAPS J. 13(2), 191-200 (2011).
    • (2011) AAPS J. , vol.13 , Issue.2 , pp. 191-200
    • Morefeld, G.L.1
  • 171
    • 21344448185 scopus 로고    scopus 로고
    • Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model
    • DOI 10.1016/j.ijpharm.2005.03.035, PII S0378517305002449, Selected Contribution from the 5th European Workshop on Particulate Systems
    • Foged C, Brodin B, Frokjaer S, Sundblad A. Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int. J. Pharm. 298(2), 315-322 (2005). (Pubitemid 40910735)
    • (2005) International Journal of Pharmaceutics , vol.298 , Issue.2 , pp. 315-322
    • Foged, C.1    Brodin, B.2    Frokjaer, S.3    Sundblad, A.4
  • 172
    • 0037435928 scopus 로고    scopus 로고
    • Liposomes and ISCOMs
    • DOI 10.1016/S0264-410X(02)00540-6, PII S0264410X02005406
    • Kersten GF, Crommelin DJ. Liposomes and ISCOMs. Vaccine 21(9-10), 915-920 (2003). (Pubitemid 36126426)
    • (2003) Vaccine , vol.21 , Issue.9-10 , pp. 915-920
    • Kersten, G.F.A.1    Crommelin, D.J.A.2
  • 173
    • 77956494575 scopus 로고    scopus 로고
    • Nano-microparticles as immune adjuvants: Correlating particle sizes and the resultant immune responses
    • Oyewumi MO, Kumar A, Cui Z. Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses. Expert Rev. Vaccines 9(9), 1095-1107 (2010).
    • (2010) Expert Rev. Vaccines , vol.9 , Issue.9 , pp. 1095-1107
    • Oyewumi, M.O.1    Kumar, A.2    Cui, Z.3
  • 174
    • 78049288264 scopus 로고    scopus 로고
    • Vaccine delivery: A matter of size, geometry, kinetics and molecular patterns
    • Bachmann MF, Jennings GT. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nat. Rev. Immunol. 10(11), 787-796 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , Issue.11 , pp. 787-796
    • Bachmann, M.F.1    Jennings, G.T.2
  • 177
    • 0035145332 scopus 로고    scopus 로고
    • Antigen processing in the endocytic compartment
    • DOI 10.1016/S0952-7915(00)00177-1
    • Watts C. Antigen processing in the endocytic compartment. Curr. Opin. Immunol. 13(1), 26-31 (2001). (Pubitemid 32096956)
    • (2001) Current Opinion in Immunology , vol.13 , Issue.1 , pp. 26-31
    • Watts, C.1
  • 178
    • 77955667522 scopus 로고    scopus 로고
    • + T cell vaccines: It's not rocket science (yet)
    • + T cell vaccines: it's not rocket science (yet). Curr. Opin. Immunol. 22(3), 402-410 (2010).
    • (2010) Curr. Opin. Immunol. , vol.22 , Issue.3 , pp. 402-410
    • Yewdell, J.W.1
  • 179
    • 0029149603 scopus 로고
    • Major histocompatibility complex class i presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis
    • Reis e Sousa C, Germain RN. Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis. J. Exp. Med. 182(3), 841-851 (1995).
    • (1995) J. Exp. Med. , vol.182 , Issue.3 , pp. 841-851
    • Reis, E.1    Sousa, C.2    Germain, R.N.3
  • 180
    • 0028910938 scopus 로고
    • A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class i molecules
    • Kovacsovics-Bankowski M, Rock KL. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267(5195), 243-246 (1995).
    • (1995) Science , vol.267 , Issue.5195 , pp. 243-246
    • Kovacsovics-Bankowski, M.1    Rock, K.L.2
  • 181
    • 0035940056 scopus 로고    scopus 로고
    • Liposomes to target the lymphatics by subcutaneous administration
    • DOI 10.1016/S0169-409X(01)00154-5, PII S0169409X01001545
    • Oussoren C, Storm G. Liposomes to target the lymphatics by subcutaneous administration. Adv. Drug Delivery Rev. 50(1-2), 143-156 (2001). (Pubitemid 32727280)
    • (2001) Advanced Drug Delivery Reviews , vol.50 , Issue.1-2 , pp. 143-156
    • Oussoren, C.1    Storm, G.2
  • 182
    • 0035940071 scopus 로고    scopus 로고
    • The physiology of the lymphatic system
    • Swartz MA. The physiology of the lymphatic system. Adv. Drug Delivery Rev. 50(1-2), 3-20 (2001).
    • (2001) Adv. Drug Delivery Rev. , vol.50 , Issue.1-2 , pp. 3-20
    • Swartz, M.A.1
  • 183
    • 47049100427 scopus 로고    scopus 로고
    • Nanoparticles target distinct dendritic cell populations according to their size
    • Manolova V, Flace A, Bauer M, Schwarz K, Saudan P, Bachmann MF. Nanoparticles target distinct dendritic cell populations according to their size. Eur. J. Immunol. 38(5), 1404-1413 (2008).
    • (2008) Eur. J. Immunol. , vol.38 , Issue.5 , pp. 1404-1413
    • Manolova, V.1    Flace, A.2    Bauer, M.3    Schwarz, K.4    Saudan, P.5    Bachmann, M.F.6
  • 184
    • 0033822039 scopus 로고    scopus 로고
    • B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms
    • Vos Q, Lees A, Wu ZQ, Snapper CM, Mond JJ. B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms. Immunol. Rev. 176, 154-170 (2000).
    • (2000) Immunol. Rev. , vol.176 , pp. 154-170
    • Vos, Q.1    Lees, A.2    Wu, Z.Q.3    Snapper, C.M.4    Mond, J.J.5
  • 185
    • 33748041958 scopus 로고    scopus 로고
    • Effects of protein aggregates: An Immunologic perspective
    • DOI 10.1208/aapsj080359, 59
    • Rosenberg AS. Effects of protein aggregates: an immunologic perspective. AAPS J. 8(3), E501-E507 (2006). (Pubitemid 44294011)
    • (2006) AAPS Journal , vol.8 , Issue.3
    • Rosenberg, A.S.1
  • 186
    • 20344396891 scopus 로고    scopus 로고
    • The innate functions of dendritic cells in peripheral lymphoid tissues
    • Steinman RM, Bonifaz L, Fujii S et al. The innate functions of dendritic cells in peripheral lymphoid tissues. Adv. Exp. Med. Biol. 560, 83-97 (2005).
    • (2005) Adv. Exp. Med. Biol. , vol.560 , pp. 83-97
    • Steinman, R.M.1    Bonifaz, L.2    Fujii, S.3
  • 187
    • 0034684659 scopus 로고    scopus 로고
    • CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo
    • den Haan JM, Lehar SM, Bevan MJ. CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo. J. Exp. Med. 192(12), 1685-1696 (2000).
    • (2000) J. Exp. Med. , vol.192 , Issue.12 , pp. 1685-1696
    • Den Haan, J.M.1    Lehar, S.M.2    Bevan, M.J.3
  • 189
    • 34250893815 scopus 로고    scopus 로고
    • Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo
    • DOI 10.1038/nri2103, PII NRI2103
    • Villadangos JA, Schnorrer P. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat. Rev. Immunol. 7(7), 543-555 (2007). (Pubitemid 46987783)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.7 , pp. 543-555
    • Villadangos, J.A.1    Schnorrer, P.2
  • 192
    • 2342625401 scopus 로고    scopus 로고
    • Interaction of dendritic cells with antigen-containing liposomes: Effect of bilayer composition
    • DOI 10.1016/j.vaccine.2003.11.008, PII S0264410X03007783
    • Foged C, Arigita C, Sundblad A, Jiskoot W, Storm G, Frokjaer S. Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition. Vaccine 22(15-16), 1903-1913 (2004). (Pubitemid 38581059)
    • (2004) Vaccine , vol.22 , Issue.15-16 , pp. 1903-1913
    • Foged, C.1    Arigita, C.2    Sundblad, A.3    Jiskoot, W.4    Storm, G.5    Frokjaer, S.6
  • 193
    • 0035845725 scopus 로고    scopus 로고
    • Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages?
    • DOI 10.1016/S0168-3659(01)00412-6, PII S0168365901004126
    • Thiele L, Rothen-Rutishauser B, Jilek S, Wunderli-Allenspach H, Merkle HP, Walter E. Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages? J. Control. Release 76(1-2), 59-71 (2001). (Pubitemid 32786885)
    • (2001) Journal of Controlled Release , vol.76 , Issue.1-2 , pp. 59-71
    • Thiele, L.1    Rothen-Rutishauser, B.2    Jilek, S.3    Wunderli-Allenspach, H.4    Merkle, H.P.5    Walter, E.6
  • 194
    • 0035845758 scopus 로고    scopus 로고
    • Hydrophilic poly(DL-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells
    • DOI 10.1016/S0168-3659(01)00413-8, PII S0168365901004138
    • Walter E, Dreher D, Kok M et al. Hydrophilic poly(DL-lactide-co- glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells. J. Control. Release 76(1-2), 149-168 (2001). (Pubitemid 32786893)
    • (2001) Journal of Controlled Release , vol.76 , Issue.1-2 , pp. 149-168
    • Walter, E.1    Dreher, D.2    Kok, M.3    Thiele, L.4    Kiama, S.G.5    Gehr, P.6    Merkle, H.P.7
  • 195
    • 0037073643 scopus 로고    scopus 로고
    • Effects of cellulose derivatives and poly(ethylene oxide)-poly(propylene oxide) tri-block copolymers (Pluronic® surfactants) on the properties of alginate based microspheres and their interactions with phagocytic cells
    • DOI 10.1016/S0168-3659(02)00281-X, PII S016836590200281X
    • Kidane A, Guimond P, Rob Ju Tc et al. Effects of cellulose derivatives and poly(ethylene oxide)-poly(propylene oxide) tri-block copolymers (Pluronic surfactants) on the properties of alginate based microspheres and their interactions with phagocytic cells. J. Control. Release 85(1-3), 181-189 (2002). (Pubitemid 35449464)
    • (2002) Journal of Controlled Release , vol.85 , Issue.1-3 , pp. 181-189
    • Kidane, A.1    Guimond, P.2    Ju, T.-C.R.3    Sanchez, M.4    Gibson, J.5    North, A.6    HogenEsch, H.7    Bowersock, T.L.8
  • 196
    • 85157068108 scopus 로고    scopus 로고
    • Aerosolized PLA and PLGA nanoparticles enhance humoral, mucosal and cytokine responses to hepatitis B vaccine
    • Thomas CM, Rawat A, Hope-Weeks LJ, Ahsan F. Aerosolized PLA and PLGA nanoparticles enhance humoral, mucosal and cytokine responses to hepatitis B vaccine. Mol. Pharm. (2010).
    • (2010) Mol. Pharm.
    • Thomas, C.M.1    Rawat, A.2    Hope-Weeks, L.J.3    Ahsan, F.4
  • 197
    • 31544467293 scopus 로고    scopus 로고
    • Diphtheria toxoid loaded poly-(ε-caprolactone) nanoparticles as mucosal vaccine delivery systems
    • DOI 10.1016/j.ymeth.2005.11.003, PII S1046202305002276
    • Singh J, Pandit S, Bramwell VW, Alpar HO. Diphtheria toxoid loaded poly-([e]-caprolactone) nanoparticles as mucosal vaccine delivery systems. Methods 38(2), 96-105 (2006). (Pubitemid 43163469)
    • (2006) Methods , vol.38 , Issue.2 , pp. 96-105
    • Singh, J.1    Pandit, S.2    Bramwell, V.W.3    Alpar, H.O.4
  • 198
    • 2942627626 scopus 로고    scopus 로고
    • Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses
    • Seong SY, Matzinger P. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol. 4(6), 469-478 (2004). (Pubitemid 38745558)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.6 , pp. 469-478
    • Seong, S.-Y.1    Matzinger, P.2
  • 199
    • 33645533255 scopus 로고    scopus 로고
    • Role of target geometry in phagocytosis
    • Champion JA, Mitragotri S. Role of target geometry in phagocytosis. Proc. Natl Acad. Sci. USA 103(13), 4930-4934 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.13 , pp. 4930-4934
    • Champion, J.A.1    Mitragotri, S.2
  • 201
    • 34547699645 scopus 로고    scopus 로고
    • Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response
    • DOI 10.1016/j.vaccine.2007.06.049, PII S0264410X07007359
    • Hansen B, Sokolovska A, Hogenesch H, Hem SL. Relationship between the strength of antigen adsorption to an aluminum-containing adjuvant and the immune response. Vaccine 25(36), 6618-6624 (2007). (Pubitemid 47211514)
    • (2007) Vaccine , vol.25 , Issue.36 , pp. 6618-6624
    • Hansen, B.1    Sokolovska, A.2    HogenEsch, H.3    Hem, S.L.4
  • 202
    • 33845187202 scopus 로고    scopus 로고
    • Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants
    • DOI 10.1016/j.vaccine.2006.09.039, PII S0264410X0601036X
    • Romero MI, Shi Y, Hogenesch H, Hem SL. Potentiation of the immune response to non-adsorbed antigens by aluminum-containing adjuvants. Vaccine 25(5), 825-833 (2007). (Pubitemid 44856127)
    • (2007) Vaccine , vol.25 , Issue.5 , pp. 825-833
    • Romero Mendez, I.Z.1    Shi, Y.2    HogenEsch, H.3    Hem, S.L.4
  • 203
    • 70350596338 scopus 로고    scopus 로고
    • Protein adsorption and displacement at lipid layers determined by total internal refection fuorescence (TIRF)
    • Jorgensen L, Wood GK, Rosenkrands I, Petersen C, Christensen D. Protein adsorption and displacement at lipid layers determined by total internal refection fuorescence (TIRF). J. Liposome Res. 19(2), 99-104 (2009).
    • (2009) J. Liposome Res. , vol.19 , Issue.2 , pp. 99-104
    • Jorgensen, L.1    Wood, G.K.2    Rosenkrands, I.3    Petersen, C.4    Christensen, D.5
  • 204
    • 17144427675 scopus 로고    scopus 로고
    • Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens
    • DOI 10.1074/jbc.M500687200
    • Jones LS, Peek LJ, Power J, Markham A, Yazzie B, Middaugh CR. Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. J. Biol. Chem. 280(14), 13406-13414 (2005). (Pubitemid 40517228)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.14 , pp. 13406-13414
    • Jones, L.S.1    Peek, L.J.2    Power, J.3    Markham, A.4    Yazzie, B.5    Middaugh, C.R.6
  • 205
    • 0018642534 scopus 로고
    • Topographic antigenic determinants on cytochrome c. Immunoadsorbent separation of the rabbit antibody populations directed against horse cytochrome c
    • Jemmerson R, Margoliash E. Topographic antigenic determinants on cytochrome c. Immunoadsorbent separation of the rabbit antibody populations directed against horse cytochrome c. J. Biol. Chem. 254(24), 12706-12716 (1979). (Pubitemid 10137662)
    • (1979) Journal of Biological Chemistry , vol.254 , Issue.24 , pp. 12706-12716
    • Jemmerson, R.1    Margoliash, E.2
  • 207
    • 0035925666 scopus 로고    scopus 로고
    • The adjuvanted influenza vaccines with novel adjuvants: Experience with the MF59-adjuvanted vaccine
    • DOI 10.1016/S0264-410X(00)00499-0, PII S0264410X00004990
    • Podda A. The adjuvanted infuenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine. Vaccine 19(17-19), 2673-2680 (2001). (Pubitemid 32234288)
    • (2001) Vaccine , vol.19 , Issue.17-19 , pp. 2673-2680
    • Podda, A.1
  • 208
    • 9244230047 scopus 로고    scopus 로고
    • Iscomatrix adjuvant for antigen delivery
    • Pearse MJ, Drane D. Iscomatrix adjuvant for antigen delivery. Adv. Drug Delivery Rev. 57(3), 465-474 (2005).
    • (2005) Adv. Drug Delivery Rev. , vol.57 , Issue.3 , pp. 465-474
    • Pearse, M.J.1    Drane, D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.