The novel immunosuppressive protein kinase C inhibitor sotrastaurin has no pro-viral effects on the replication cycle of hepatitis B or C virus

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  von Hahn, Thomas ^a   Schulze, Andreas ^b   Wust, Ivan Chicano ^a   Heidrich, Benjamin ^a   Becker, Thomas ^a   Steinmann, Eike ^c   Helfritz, Fabian A ^a   Rohrmann, Katrin ^a   Urban, Stephan ^b   Manns, Michael P ^a   Pietschmann, Thomas ^c   Ciesek, Sandra ^a,c  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; SOTRASTAURIN; TACROLIMUS; CALCINEURIN; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG COMPETITION; DRUG EFFECT; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; VIRUS ENTRY; VIRUS GENOME; VIRUS INFECTIVITY; VIRUS REPLICATION; VIRUS TRANSMISSION; DRUG ANTAGONISM; GENETICS; METABOLISM; PATHOGENICITY; PHYSIOLOGY; TUMOR CELL LINE;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

CALCINEURIN; CELL LINE, TUMOR; CYCLOSPORINE; HEPACIVIRUS; HEPATITIS B VIRUS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRROLES; QUINAZOLINES; RNA, VIRAL; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 80052418719     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024142     Document Type: Article

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