A role for Tctex-1 (DYNLT1) in controlling primary cilium length

European Journal of Cell Biology

Volumn 90, Issue 10, 2011, Pages 865-871

  Palmer, Krysten J ^a   MacCarthy Morrogh, Lucy ^a   Smyllie, Nicola ^a   Stephens, David J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Cilia; Dynein

Indexed keywords

ALPHA TUBULIN; AXONEMAL DYNEIN; CYTOPLASMIC DYNEIN; DYNEIN ADENOSINE TRIPHOSPHATASE; LAMIN; PROTEIN SUBUNIT; SMALL INTERFERING RNA;

ARTICLE; AXONEME; CELL FUNCTION; CELL LABELING; CELL MEMBRANE; EPITHELIUM CELL; EUKARYOTIC FLAGELLUM; HEAVY CHAIN; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; RNA INTERFERENCE;

ANALYSIS OF VARIANCE; AXONEMAL DYNEINS; CELL LINE; CILIA; CYTOPLASMIC DYNEINS; DYNEINS; EPITHELIAL CELLS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; LAMIN TYPE A; RNA INTERFERENCE;

EID: 80052417992     PISSN: 01719335     EISSN: 16181298     Source Type: Journal    
DOI: 10.1016/j.ejcb.2011.05.003     Document Type: Article

References (39)

1. Baker K., Beales P.L. Making sense of cilia in disease: the human ciliopathies. Am. J. Med. Genet. C 2009, 151C:281-295.
2. Besschetnova T.Y., Kolpakova-Hart E., Guan Y., Zhou J., Olsen B.R., Shah J.V. Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr. Biol. 2010, 20:182-187.
3. Chuang J.Z., Yeh T.Y., Bollati F., Conde C., Canavosio F., Caceres A., Sung C.H. The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. Dev. Cell 2005, 9:75-86.
4. Cole D.G. The intraflagellar transport machinery of Chlamydomonas reinhardtii. Traffic 2003, 4:435-442.
5. Dagoneau N., Goulet M., Genevieve D., Sznajer Y., Martinovic J., Smithson S., Huber C., Baujat G., Flori E., Tecco L., Cavalcanti D., Delezoide A.L., Serre V., Le Merrer M., Munnich A., Cormier-Daire V. DYNC2H1 mutations cause asphyxiating thoracic dystrophy and short rib-polydactyly syndrome, type III. Am. J. Hum. Genet. 2009, 84:706-711.
6. Engel B.D., Ludington W.B., Marshall W.F. Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model. J. Cell Biol. 2009, 187:81-89.
7. Gibbons B.H., Asai D.J., Tang W.J., Hays T.S., Gibbons I.R. Phylogeny and expression of axonemal and cytoplasmic dynein genes in sea urchins. Mol. Biol. Cell 1994, 5:57-70.
8. Grissom P.M., Vaisberg E.A., McIntosh J.R. Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2. Mol. Biol. Cell 2002, 13:817-829.
9. Hattula K., Furuhjelm J., Tikkanen J., Tanhuanpaa K., Laakkonen P., Peranen J. Characterization of the Rab8-specific membrane traffic route linked to protrusion formation. J. Cell Sci. 2006, 119:4866-4877.
10. Iomini C., Babaev-Khaimov V., Sassaroli M., Piperno G. Protein particles in Chlamydomonas flagella undergo a transport cycle consisting of four phases. J. Cell Biol. 2001, 153:13-24.
11. Ishikawa H., Marshall W.F. Ciliogenesis: building the cell's antenna. Nat. Rev. Mol. Cell Biol. 2011, 12:222-234.
12. King S.J., Bonilla M., Rodgers M.E., Schroer T.A. Subunit organization in cytoplasmic dynein subcomplexes. Protein Sci. 2002, 11:1239-1250.
13. King S.M. Dynein-independent functions of DYNLL1/LC8: redox state sensing and transcriptional control. Sci. Signal. 2008, 1:pe51.
14. Li A., Saito M., Chuang J.Z., Tseng Y.Y., Dedesma C., Tomizawa K., Kaitsuka T., Sung C.H. Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. Nat. Cell Biol. 2011, 13:402-411.
15. Lo K.W., Kogoy J.M., Rasoul B.A., King S.M., Pfister K.K. Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex. J. Biol. Chem. 2007, 282:36871-36878.
16. Mikami A., Tynan S.H., Hama T., Luby-Phelps K., Saito T., Crandall J.E., Besharse J.C., Vallee R.B. Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells. J. Cell Sci. 2002, 115:4801-4808.
17. Nachury M.V., Loktev A.V., Zhang Q., Westlake C.J., Peranen J., Merdes A., Slusarski D.C., Scheller R.H., Bazan J.F., Sheffield V.C., Jackson P.K. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 2007, 129:1201-1213.
18. Palmer K.J., Hughes H., Stephens D.J. Specificity of cytoplasmic dynein subunits in discrete membrane-trafficking steps. Mol. Biol. Cell 2009, 20:2885-2899.
19. Paschal B.M., Shpetner H.S., Vallee R.B. MAP 1C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like properties. J. Cell Biol. 1987, 105:1273-1282.
20. Pazour G.J., Dickert B.L., Witman G.B. The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assembly. J. Cell Biol. 1999, 144:473-481.
21. Pazour G.J., Wilkerson C.G., Witman G.B. A dynein light chain is essential for the retrograde particle movement of intraflagellar transport (IFT). J. Cell Biol. 1998, 141:979-992.
22. Perrone C.A., Tritschler D., Taulman P., Bower R., Yoder B.K., Porter M.E. A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and mammalian cells. Mol. Biol. Cell 2003, 14:2041-2056.
23. Pfister K.K., Fisher E.M., Gibbons I.R., Hays T.S., Holzbaur E.L., McIntosh J.R., Porter M.E., Schroer T.A., Vaughan K.T., Witman G.B., King S.M., Vallee R.B. Cytoplasmic dynein nomenclature. J. Cell Biol. 2005, 171:411-413.
24. Piperno G., Fuller M.T. Monoclonal antibodies specific for an acetylated form of alpha-tubulin recognize the antigen in cilia and flagella from a variety of organisms. J. Cell Biol. 1985, 101:2085-2094.
25. Porter M.E., Bower R., Knott J.A., Byrd P., Dentler W. Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas. Mol. Biol. Cell 1999, 10:693-712.
26. Rajagopalan V., Subramanian A., Wilkes D.E., Pennock D.G., Asai D.J. Dynein-2 affects the regulation of ciliary length but is not required for ciliogenesis in Tetrahymena thermophila. Mol. Biol. Cell 2009, 20:708-720.
27. Rana A.A., Barbera J.P., Rodriguez T.A., Lynch D., Hirst E., Smith J.C., Beddington R.S. Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates. Development 2004, 131:4999-5007.
28. Rompolas P., Pedersen L.B., Patel-King R.S., King S.M. Chlamydomonas FAP133 is a dynein intermediate chain associated with the retrograde intraflagellar transport motor. J. Cell Sci. 2007, 120:3653-3665.
29. Rozen S., Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 2000, 132:365-386.
30. Satir P., Pedersen L.B., Christensen S.T. The primary cilium at a glance. J. Cell Sci. 2010, 123:499-503.
31. Scholey J.M. Intraflagellar transport motors in cilia: moving along the cell's antenna. J. Cell Biol. 2008, 180:23-29.
32. Schroer T.A., Steuer E.R., Sheetz M.P. Cytoplasmic dynein is a minus end-directed motor for membranous organelles. Cell 1989, 56:937-946.
33. Signor D., Wedaman K.P., Orozco J.T., Dwyer N.D., Bargmann C.I., Rose L.S., Scholey J.M. Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegans. J. Cell Biol. 1999, 147:519-530.
34. Tai A.W., Chuang J.Z., Sung C.H. Localization of Tctex-1, a cytoplasmic dynein light chain, to the Golgi apparatus and evidence for dynein complex heterogeneity. J. Biol. Chem. 1998, 273:19639-19649.
35. Vaisberg E.A., Grissom P.M., McIntosh J.R. Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles. J. Cell Biol. 1996, 133:831-842.
36. Vallee R.B., Williams J.C., Varma D., Barnhart L.E. Dynein: an ancient motor protein involved in multiple modes of transport. J. Neurobiol. 2004, 58:189-200.
37. Watson P., Stephens D.J. Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells. J. Cell Sci. 2006, 119:2758-2767.
38. Yeh T.Y., Peretti D., Chuang J.Z., Rodriguez-Boulan E., Sung C.H. Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. Traffic 2006, 7:1495-1502.
39. Yoshimura S., Egerer J., Fuchs E., Haas A.K., Barr F.A. Functional dissection of Rab GTPases involved in primary cilium formation. J. Cell Biol. 2007, 178:363-369.