Enhanced replication of hepatitis B virus with frameshift in the precore region found in fulminant hepatitis patients

Journal of Infectious Diseases

Volumn 204, Issue 7, 2011, Pages 1017-1025

  Inoue, Jun ^a   Ueno, Yoshiyuki ^a   Wakui, Yuta ^a   Fukushima, Koji ^a   Kondo, Yasuteru ^a   Kakazu, Eiji ^a   Ninomiya, Masashi ^a   Niitsuma, Hirofumi ^a   Shimosegawa, Tooru ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EMTRICITABINE; LAMIVUDINE; NUCLEOTIDE; PRECORE PROTEIN; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; FRAMESHIFT MUTATION; GENE DELETION; GENE INSERTION; GENE SEQUENCE; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; JAPAN; MAJOR CLINICAL STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UNINDEXED SEQUENCE; VALIDATION STUDY; VIRUS CHARACTERIZATION; VIRUS ISOLATION; VIRUS MUTATION; VIRUS REPLICATION; VIRUS STRAIN;

ADULT; AGED; DNA, VIRAL; FEMALE; FRAMESHIFT MUTATION; GENOTYPE; HEP G2 CELLS; HEPATITIS B VIRUS; HUMANS; JAPAN; LIVER FAILURE, ACUTE; MALE; MIDDLE AGED; MUTAGENESIS, INSERTIONAL; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; VIRAL CORE PROTEINS; VIRUS REPLICATION;

EID: 80052416557     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir485     Document Type: Article

References (37)

1. Hasegawa K., Huang J., Rogers S.A., Blum H.E. Liang T.J. Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. J Virol 1994; 68:1651-1659 (Pubitemid 24065731)
2. Baumert T.F., Rogers S.A., Hasegawa K., Liang T.J. Two core promotor mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication. J Clin Invest 1996; 98:2268-2276 (Pubitemid 26394200)
3. Rivero M., Crespo J., Fabrega E., et al. Apoptosis mediated by the Fas system in the fulminant hepatitis by hepatitis B virus. J Viral Hepat 2002; 9:107-113 (Pubitemid 36002473)
4. Okamoto H., Tsuda F., Sakugawa H., et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol 1988; 69:2575-2583
5. Norder H., Courouce A.M., Coursaget P., et al. Genetic diversity of hepatitis B virus strains derived worldwide: Genotypes, subgenotypes, and HBsAg subtypes. Intervirology 2004; 47:289-309. (Pubitemid 39541275)
6. Olinger C.M., Jutavijittum P., Hubschen J.M., et al. Possible new hepatitis B virus genotype, southeast Asia. Emerging Infect Dis 2008; 14:1777-1780
7. Tatematsu K., Tanaka Y., Kurbanov F., et al. A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype. J Virol 2009; 83:10538-10547
8. Kao J.H., Chen P.J., Lai M.Y., Chen D.S. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000; 118:554-559
9. Imamura T., Yokosuka O., Kurihara T., et al. Distribution of hepatitis B viral genotypes and mutations in the core promoter and precore regions in acute forms of liver disease in patients from Chiba, Japan. Gut 2003; 52:1630-1637 (Pubitemid 37363449)
10. Ozasa A., Tanaka Y., Orito E., et al. Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection. Hepatology 2006; 44:326-334 (Pubitemid 44214871)
11. Kusakabe A., Tanaka Y., Mochida S., et al. Case-control study for the identification of virological factors associated with fulminant hepatitis B. Hepatol Res 2009; 39:648-656
12. Hou J., Lin Y., Waters J., et al. Detection and significance of a G1862T variant of hepatitis B virus in Chinese patients with fulminant hepatitis. J Gen Virol 2002; 83:2291-2298 (Pubitemid 34993736)
13. Kosaka Y., Takase K., Kojima M., et al. Fulminant hepatitis B: induction by hepatitis B virus mutants defective in the precore region and incapable of encoding e antigen. Gastroenterology 1991; 100:1087-1094
14. Liang T.J., Hasegawa K., Rimon N., Wands J.R., Ben-Porath E. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med 1991; 324:1705-1709
15. Omata M., Ehata T., Yokosuka O., Hosoda K., Ohto M. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991; 324:1699-1704
16. Scaglioni P.P., Melegari M., Wands J.R. Posttranscriptional regulation of hepatitis B virus replication by the precore protein. J Virol 1997; 71:345-353 (Pubitemid 26412298)
17. Fattovich G., Bortolotti F., Donato F. Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol 2008; 48:335-352
18. Matsuura K., Tanaka Y., Hige S., et al. Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype A. J Clin Microbiol 2009; 47:1476-1483
19. Takahashi M., Nishizawa T., Gotanda Y., et al. High prevalence of antibodies to hepatitis A and E viruses and viremia of hepatitis B, C, and D viruses among apparently healthy populations in Mongolia. Clin Diagn Lab Immunol 2004; 11:392-398 (Pubitemid 38380823)
20. Inoue J., Ueno Y., Nagasaki F., et al. Enhanced intracellular retention of a hepatitis B virus strain associated with fulminant hepatitis. Virology 2009; 395:202-209
21. Liu Y., Hussain M., Wong S., Fung S.K., Yim H.J., Lok A.S. A genotypein-dependent real-time PCR assay for quantification of hepatitis B virus DNA. J Clin Microbiol 2007; 45:553-558
22. Inoue J., Ueno Y., Kanno N., et al. Living related liver transplantation for acute fulminant hepatitis B: Experience from two possible hyper-acute cases. Tohoku J Exp Med 2005; 205:197-204. (Pubitemid 40268238)
23. Nagasaki F., Ueno Y., Niitsuma H., et al. Analysis of the entire nucleotide sequence of hepatitis B causing consecutive cases of fatal fulminant hepatitis in Miyagi prefecture Japan. J Med Virol 2008; 80:967-973 (Pubitemid 351657006)
24. Sugauchi F., Orito E., Ohno T., et al. Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in Japan. Hepatol Res 2006; 36:107-114 (Pubitemid 44480642)
25. Santantonio T., Jung M.C., Miska S., Pastore G., Pape G.R., Will H. High prevalence and heterogeneity of HBV preC mutants in anti- HBe-positive carriers with chronic liver disease in southern Italy. J Hepatol 1991; 13(Suppl 4):S78-S81
26. Okamoto H., Yotsumoto S., Akahane Y., et al. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 1990; 64:1298-1303 (Pubitemid 20087771)
27. Shin I.T., Tanaka Y., Tateno Y., Mizokami M. Development and public release of a comprehensive hepatitis virus database. Hepatol Res 2008; 38:234-243 (Pubitemid 351193951)
28. Lok A.S., Akarca U., Greene S. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci U S A 1994; 91:4077-4081 (Pubitemid 24139576)
29. Kozak M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol 1987; 196:947-950
30. Inoue J. Factors involved in the development of fulminant hepatitis B: are the mutations of hepatitis B virus implicated? Hepatol Res 2009; 39:1053-1055
31. Milich D., Liang T.J. Exploring the biological basis of hepatitis B e antigen in hepatitis B virus infection. Hepatology 2003; 38:1075-1086 (Pubitemid 37314815)
32. Sainokami S., Abe K., Sato A., et al. Initial load of hepatitis B virus (HBV), its changing profile, and precore/core promoter mutations correlate with the severity and outcome of acute HBV infection. J Gastroenterol 2007; 42:241-249 (Pubitemid 46488234)
33. Ogawa M., Hasegawa K., Naritomi T., Torii N., Hayashi N. Clinical features and viral sequences of various genotypes of hepatitis B virus compared among patients with acute hepatitis B. Hepatol Res 2002; 23:167-177 (Pubitemid 36104395)
34. Chu C.J., Hussain M., Lok A.S. Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology 2002; 122:1756-1762 (Pubitemid 34651418)
35. Sugauchi F., Kumada H., Sakugawa H., et al. Two subtypes of genotype B (Ba and Bj) of hepatitis B virus in Japan. Clin Infect Dis 2004; 38:1222-1228 (Pubitemid 38608562)
36. Ryu D.K., Kim S., Ryu W.S. Hepatitis B virus polymerase suppresses translation of pregenomic RNA via a mechanism involving its interaction with 5′ stem-loop structure. Virology 2008; 373:112-123
37. Ahn S.H., Kramvis A., Kawai S., et al. Sequence variation upstream of precore translation initiation codon reduces hepatitis B virus e antigen production. Gastroenterology 2003; 125:1370-1378 (Pubitemid 37409757)