Effects of granulocyte-colony stimulating factor on chromosome aneuploidy and replication asynchrony in healthy peripheral blood stem cell donors

Blood

Volumn 118, Issue 9, 2011, Pages 2602-2608

  Hirsch, Betsy ^a,b   Oseth, LeAnn ^b   Cain, Meghan ^b   Trader, Erin ^b   Pulkrabek, Shelley ^a   Lindgren, Bruce ^b   Luo, Xianghua ^a,b   Clay, Mary ^a   Miller, John ^a   Confer, Dennis ^a   Weisdorf, Daniel ^a,b   McCullough, Jeffrey ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR;

ANEUPLOIDY; ARTICLE; BLOOD DONOR; CHROMOSOMAL INSTABILITY; CHROMOSOME 15; CHROMOSOME 17; CHROMOSOME 21; CHROMOSOME 22; CHROMOSOME 7; CHROMOSOME 8; CHROMOSOME MAP; CHROMOSOME REPLICATION; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCUS; GENOTOXICITY; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; RISK ASSESSMENT; STEM CELL MOBILIZATION;

EID: 80052415559     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-04-348508     Document Type: Article

References (31)

1. Ballen K.K., King R.J., Chitphakdithai P., et al. The National Marrow Donor Program 20 years of unrelated donor hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2008;14:2-7.
2. Pusic I., DiPersio J.F. The use of clinical factors in hematopoietic stem cell transplantation. Curr Pharmaceutical Design. 2008;14(20):1950-1961.
3. Eapen M., Rubinstein P., Zhang M.J., et al. Comparable long-term survival after unrelated and HLAmatched sibling donor hematopoietic stem cell transplantations for acute leukemia in children younger than 18 months. J Clin Oncol. 2006;24(1):145-151. (Pubitemid 46630506)
4. Pulsipher M.A., Nagler A., Iannone R., Nelson R.M. Weighing the risks of G-CSF administration, leukopheresis, and standard marrow harvest: Ethical and safety considerations for normal pediatric hematopoietic cell donors. Pediatr Blood Cancer. 2006;46(4):422-433. (Pubitemid 43334647)
5. Pamphilon D., Mackinnon S., Nacheva E., et al. The use of granulocyte colony-stimulating factor in volunteer blood and marrow registry donors [letter]. Bone Marrow Transplant. 2006;38(10):699-700. (Pubitemid 44669686)
6. Anderlini P., Champlin R.E. Biologic and molecular effects of granulocyte-colony-stimulating factor in healthy individuals: Recent findings and current challenges. Blood. 2008;111(4):1767-1772. (Pubitemid 351451480)
7. Anderlini P. Effects and safety of granulocyte colony-stimulating factor in healthy volunteers. Curr Opin Hematol. 2009;16(1):35-40.
8. McCullough J., Kahn J., Adamson J., et al. Hematopoietic growth factors: Use in normal blood and stem cell donors: Clinical and ethical issues. Summary of a conference. Transfusion. 2008;48(9):2008-2025.
9. Bennett C.L., Evens A.M., Andritsos L.A., et al. Haematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: Report from the Research on Adverse Drug Events and Reports (RADAR) project. Br J Haematol. 2006;135(5):642-650. (Pubitemid 44674074)
10. Hsia C.C., Linenberger M., Howson-Jan K., et al. Acute myeloid leukemia in a healthy hematopoietic stem cell donor following past exposure to a short course of G-CSF [letter]. Bone Marrow Transplant. 2008;42(6):431-432.
11. Makita K., Ohta K., Mugitani A., et al. Acute myelogenous leukemia in a donor after granulocyte colony-stimulating factor-primed peripheral blood stem cell harvest. Bone Marrow Transplant. 2004;33(6):661-665. (Pubitemid 38455931)
12. De la Rubia J., De Arriba F., Arbona C., et al. Follow-up of healthy donors receiving granulocyte colony-stimulating factor for peripheral blood progenitor cell mobilization and collection. Results of the Spanish Donor Registry. Haematologica. 2008;93(5):735-740. (Pubitemid 351669314)
13. Martino M., Console G., Dattola A., et al. Short and long-term safety of lenograstim administration in healthy peripheral haematopoietic progenitor cell donors: A single centre experience. Bone Marrow Transplant. 2009;44(3):163-168.
14. Quillen K., Wong E., Scheinberg P., et al. Granulocyte transfusions in severe aplastic anemia: An eleven-year experience. Haematologica. 2009;94(12):1661-1668.
15. Hölig K., Kramer M., Kroschinsky F., et al. Safety and efficacy of hematopoietic stem cell collection from mobilized peripheral blood in unrelated volunteers: 12 years of single-center experience in 3,928 donors. Blood. 2009;114(18):3757-3763.
16. Tassi C., Tazzari P.L., Bonifazi F., et al. Short- and long-term haematological surveillance of healthy donors of allogeneic peripheral haematopoietic progenitors mobilized with G-CSF: A single institution prospect study. Bone Marrow Transplant. 2005;26:289-294. (Pubitemid 41195160)
17. Pulsipher M.A., Chitphakdithai P., Miller J.P., et al. Adverse events among 2,408 unrelated donors of peripheral blood stem cells: Results of a prospective trial from the National Marrow Donor Program. Blood. 2009;113(15):3604-3611.
18. Kaplinsky C., Trakhtenbrot L., Hardan I., et al. Tetraploid myeloid cells in donors of peripheral blood stem cells treated with rhG-CSF. Bone Marrow Transplantation. 2003;32(1):31-34. (Pubitemid 36850277)
19. Shapira M.Y., Kaspler P., Samuel S., Shoshan S., Or R. Granulocyte colony stimulating factor does not include long-term DNA instability in healthy peripheral blood stem cell donors. Am J Hematol. 2003;73(1):33-36. (Pubitemid 36504575)
20. Hernández J.M., Castilla C., Gutiérrez N.C., et al. Mobilisation with G-CSF in healthy donors promotes a high but temporal deregulation of genes. Leukemia. 2005;19(6):1088-1091. (Pubitemid 40867267)
21. Amarigilio N., Jocob-Hirsch J., Shimoni A., Leiba M., Rechavi G., Nagler A. Changes in gene expression pattern following granulocyte colonystimulating factor administration to normal stem cell sibling donors. Acta Hematol. 2007;117(2):65-67.
22. Nagler A., Korenstein-Ilan A., Amiel A., Avivi L. Granulocyte colony-stimulating factor generates epigenetic and genetic alterations in lymphocytes of normal volunteer donors of stem cells. Exp Hematol. 2004;32(1):122-130. (Pubitemid 38064408)
23. Haase D. Cytogenetic features in myelodysplastic syndromes. Ann Hematol. 2008;87:515-527.
24. Sloand E.M., Yong A.S.M., Ramkissoon S., et al. Granulocyte colony-stimulating factor preferentially stimulates proliferation of monosomy 7 cells bearing the isoform IV receptor. Proc Natl Acad Sci U S A. 2006;103(39):14483-14488. (Pubitemid 44484776)
25. Nagasawa M., Tomizawa D., Tsuji Y., et al. Pancytopenia presenting with monosomy 7 which disappeared after immunosuppressive therapy. Leuk Res. 2004;28(3):315-319. (Pubitemid 37550067)
26. Grigg A.P., Roberts A.W., Raunow H., et al. Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers. Blood. 1995;86(12):4437-4445.
27. Stroncek D.F., Clay M.E., Petzoldt M.L., et al. Treatment of normal individuals with granulocyte-colony-stimulating factor: Donor experiences and the effects on peripheral blood CD34+ cell counts and on the collection of peripheral blood stem cells. Transfusion. 1996;36(7):601-610. (Pubitemid 26256427)
28. Anderlini P., Przepiorka D., Seong C., et al. Factors affecting mobilization of CD34+ cells in normal donors treated with filgrastim. Transfusion. 1997;37(5):507-512. (Pubitemid 27203941)
29. Kojima S., Ohara A., Tsuchida M., et al. Risk factors for evolution of acquired aplastic anemia into myelodysplastic syndrome and acute myeloid leukemia after immunosuppressive therapy in children. Blood. 2002;100(3):786-790. (Pubitemid 34832602)
30. Donadieu J., Leblanc T., Meunier B.B., et al. Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia: Experience of the French Severe Chronic Neutropenia Study Group. Haematologica. 2005;90(1):45-53. (Pubitemid 40193753)
31. + cells and does not require cell division. Blood. 2010;115(4):910-911.