Enzymes of the ornithine-glutamate-proline pathway in the sheep abomasal nematode parasites Haemonchus contortus and Teladorsagia circumcincta

Experimental Parasitology

Volumn 129, Issue 2, 2011, Pages 115-119

  Umair, S ^a   Leung, Y M ^a   Bland, R J ^b   Simpson, H V ^a  

^a MASSEY UNIVERSITY   (New Zealand)

^b AGRESEARCH GRASSLANDS   (New Zealand)

Author keywords

1 Pyrroline 5 carboxylate dehydrogenase (E.C. 1.5.1.12); 1 Pyrroline 5 carboxylate reductase (E.C. 1.5.1.2); 1 Pyrroline 5 carboxylate synthase (E.C. 1.2.1.41); Haemonchus contortus; Ornithine aminotransferase (E.C. 2.6.1.13); Proline oxidase (E.C. 1.5.99.8); Teladorsagia (Ostertagia) circumcincta

Indexed keywords

GLUTAMIC ACID; HYDROXYLAMINE; ORNITHINE; ORNITHINE OXOACID AMINOTRANSFERASE; PROLINE; PROLINE DEHYDROGENASE; PYRIDOXAL 5 PHOSPHATE; PYRROLINE 5 CARBOXYLATE DEHYDROGENASE; PYRROLINE 5 CARBOXYLATE REDUCTASE; PYRROLINE 5 CARBOXYLATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; HAEMONCHUS CONTORTUS; NEMATODE; NEMATODE LIFE CYCLE STAGE; NONHUMAN; PH; PRIORITY JOURNAL; TELADORSAGIA CIRCUMCINCTA;

ABOMASUM; ANIMALS; FECES; GLUTAMIC ACID; HAEMONCHIASIS; HAEMONCHUS; ORNITHINE; ORNITHINE-OXO-ACID TRANSAMINASE; PROLINE; PROLINE OXIDASE; PYRROLINE CARBOXYLATE REDUCTASES; SHEEP; SHEEP DISEASES; TRICHOSTRONGYLOIDEA; TRICHOSTRONGYLOIDIASIS;

HAEMONCHUS CONTORTUS; OVIS ARIES; TELADORSAGIA CIRCUMCINCTA;

EID: 80052399272     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2011.07.006     Document Type: Article

References (21)

1. Aral B., Kamoun P. The proline biosynthesis in living organisms. Amino Acids 1997, 13:189-217.
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 1976, 72:248-254.
3. Burton R.S. Proline synthesis during osmotic stress in megalopa stage larvae of the blue crab, Callinectes sapidus. Biological Bulletin 1992, 182:409-415.
4. Ertel J., Isseroff H. Proline in fascioliasis: I comparative activities of ornithine-delta-transaminase and proline oxidase in Fasciola and in mammalian livers. Journal of Parasitology 1974, 60:575-577.
5. Fahmy A.S., Mohamed S.A., Girgis R.B., Abdel-Ghaffar F.A. Enzymes of Δ1-pyroline-5-carboxylate metabolism in the camel tick Hyalomma dromedarii during embryogenesis. Purification and characterization of Δ1-pyroline-5-carboxylate dehydrogenase. Comparative Biochemistry and Physiology 1997, 118B:229-237.
6. Goldberg M., Flescher E., Lengy J. Schistosoma mansoni: partial purification and properties of ornithine-delta-transaminase. Experimental Parasitology 1979, 47:333-341.
7. Grantham B.D., Barrett J. Amino acid catabolism in the nematodes Heligmosomoides polygyrus and Panagrellus redivivus. Parasitology 1986, 93:495-504.
8. Isseroff H., Bock K., Owezarek A., Smith K.R. Schistosomaisis: proline production and release by ova. Journal of Parasitology 1983, 96:285-289.
9. Lee J.H., Park N.Y., Lee M.H., Chio S.H. Characterization of the Vibrio vulnificus putAP operon, encoding proline dehydrogenase and proline permease, and its differential expression in response to osmotic stress. Journal of Bacteriology 2003, 185:3842-3852.
10. Mazelis M., Creveling R.K. l-proline dehydrogenase of Triticum vulgare germ: purification, properties and cofactor interactions. Phytochemistry 1974, 13:559-565.
11. McNamer A.D., Stewart C.R. Nicotinamide adenine dinucleotide-dependent proline dehydrogenase in Chlorella. Plant Physiology 1974, 53:440-444.
12. Mezl V.A., Knox W.E. Properties and analysis of a stable derivative of pyrroline-5-carboxylic acid for use in metabolic studies. Analytical Biochemistry 1976, 74:430-440.
13. Momamed S.A., Mohamed T.M., Fahmy A.S., El-Badry A.O., Abdel-Gany S.S. Fasciola gigantica: enzymes of the ornithine-proline-glutamate pathway-Characterization of Δ1-pyrroline-5-carboxylate dehydrogenase. Experimental Parasitology 2008, 118:47-53.
14. Obungu V.H., Kiaria J.K., Njogu R.M., Olembo N.K. Catabolism of proline by procyclic cultures forms of Trypanosoma congolense. Comparative Biochemistry and Physiology 1999, 123B:59-65.
15. Scaraffia P.Y., Wells M.A. Proline can be utilized as an eregy substrate during flight of Aedes aegypti females. Journal of Insect Physiology 2003, 49:591-601.
16. Scaraffia P.Y., Isoe J., Murillo A., Wells M.A. Ammonia metabolism in Aedes aegypti. Insect Biochemistry and Molecular Biology 2005, 35:491-503.
17. Simpson H.V., Simpson B.H., Simcock D.C., Reynolds G.W., Pomroy W.E. Abomasal secretion in sheep receiving adult Ostertagia circumcincta that are prevented from contact with the mucosa. New Zealand Veterinary Journal 1999, 47:20-24.
18. Umair S., Patchett M.L., Bland R.J., Simpson H.V. Arginine metabolism in the sheep abomasal nematode parasites Haemonchus contortus and Teladorsagia circumcincta. Experimental Parasitology 2011, 127:506-514.
19. Umair S., Bland R.J., Simpson H.V. Glutamate synthase, but not GABA shunt enzymes, contributes to nitrogen metabolism of the sheep abomasal nematode parasites Haemonchus contortus and Teladorsagia circumcincta. Experimental Parasitology 2011, 127:9-13.
20. Wu G., Morris S.M. Arginine metabolism: nitric oxide and beyond. Biochemical Journal 1998, 336:1-17.
21. Zolg W., Ottow J.C. Improved thin-layer technique for detection of arginine dihydrolase among the Pseudomonas species. Applied Microbiology 1973, 26:1001-1003.