Intestinal permeability of the constituents from the roots of saposhnikovia divaricata in the human caco-2 cell monolayer model

Planta Medica

Volumn 77, Issue 13, 2011, Pages 1531-1535

  Zhao, Bo ^a,b   Yang, Xin Bao ^c,d   Yang, Xiu Wei ^b   Wu, Qi ^b   Wang, Ying ^b   Zhang, Lian Xue ^a   Xu, Wei ^b  

^a JILIN AGRICULTURAL UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c XIYUAN HOSPITAL   (China)

^d BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Caco2 cell monolayer; chromones; coumarins; Saposhnikovia divaricata; Umbelliferae

Indexed keywords

3' O ANGELOYLHAMAUDOL; 5 METHOXY 7 (3,3 DIMETHYLALLYLOXY)COUMARIN; ANOMALIN; ATENOLOL; CHROMONE DERIVATIVE; CIMIFUGIN; COUMARIN DERIVATIVE; DECURSIN; DECURSINOL ANGELATE; PLANT MEDICINAL PRODUCT; PRIM O GLUCOSYLCIMIFUGIN; PROPRANOLOL; SEC O GLUCOSYLHAMAUDOL; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG DIFFUSION; DRUG PENETRATION; DRUG TRANSPORT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; MEDICINAL PLANT; MONOLAYER CULTURE; PLANT ROOT; SAPOSHNIKOVIA DIVARICATA;

APIACEAE; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CHROMONES; COUMARINS; HUMANS; INTESTINAL ABSORPTION; INTESTINES; PLANT EXTRACTS; PLANT ROOTS; TIME FACTORS;

APIACEAE; SAPOSHNIKOVIA DIVARICATA;

EID: 80052393716     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1270741     Document Type: Article

References (17)

1. Yee S Y. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth. Pharm Res 1997 14 763-766
2. Han Z M., Yang R Y., Wang Y H., Han M, Kong W W., Yang L M. Extraction of chromone from Saposhnicovia by ultrasonic wave. Lishizhen Med Mater Med Res 2008 19 3035-3037
3. Yoshikawa M, Nishida N, Ninomiya K, Ohgushi T, Kubo M, Morikawa T, Matsuda H. Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D-galactosamine/lipopolysaccharide induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages. Bioorg Med Chem 2006 14 456-463 (Pubitemid 41767605)
4. Ma Y, Jung J Y., Jung Y J., Choi J H., Jeong W S., Song Y S., Kang J S., Bi K, Kim M J. Anti-inflammatory activities of coumarins isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 cells. J Food Sci Nutr 2009 14 179-187
5. Lee S H., Lee Y S., Jung S H., Shin K H., Kim B K., Kang S S. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch Pharm Res 2003 26 727-730
6. Wang C C., Chen L G., Yang L L. Inducible nitric oxide synthase inhibitor of the Chinese herb I. Saposhnikovia divaricata (Turcz.) Schischk. Cancer Lett 1999 145 151-157
7. Wang L, Liang R X., Cao Y, Ye J X. Effect of prim - O -glucosylcimifugin and 4- O - -D-glucosyl-5- O -methylvisamminol on proliferation of smooth muscle cell stimulated by TNF-. China J Chin Mater Med 2008 33 2157-2160
8. Xue B Y., Li W, Li L, Xiao Y Q. A pharmacodynamic research on chromone glucosides of Fangfen. China J Chin Mater Med 2000 25 297-299
9. Madgula V, Avula B, Reddy N, Khan I, Khan S. Transport of decursin and decursinol angelate across Caco-2 and MDR-MDCK cell monolayers. Planta Med 2007 73 330-335
10. Kim K M., Kim M J., Kang J S. Absorption, distribution, metabolism, and excretion of decursin and decursinol angelate from Angelica gigas Nakai. J Microbiol Biotechnol 2009 19 1569-1572
11. Zhao B, Yang X B., Yang X W., Zhang L X. Chemical constituents of roots of Saposhnikovia divaricata. China J Chin Mater Med 2010 35 1569-1572
12. Yang X W., Huang X, Ma L, Wu Q, Xu W. The intestinal permeability of neolignans from the seeds of Myristica fragrans in the Caco-2 cell monolayer model. Planta Med 2010 76 1587-1591
13. Gao J, Hugger E D., Beck-Westermeyer M S., Borchardt R T. Estimating intestinal mucosal permeation of compounds using Caco-2 cell monolayers. Taylor G Current protocols in pharmacology. Chichester John Wiley & Sons, Inc. 2000 7.2.1-7.2.23
14. Yang X W., Yang X D., Wang Y, Ma L, Zhang Y, Yang X G., Wang K. Establishment of Caco-2 cell monolayer model and standard operation procedure for assessing intestinal absorption of chemical components of traditional Chinese medicine. J Chin Integr Med 2007 5 634-641 (Pubitemid 350186610)
15. Wu Q, Yang X W. The constituents of Cibotium barometz and their permeability in the human Caco-2 monolayer cell model. J Ethnopharmacol 2009 125 417-422
16. Yang X W., Guo Q M., Wang Y. Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model. J Chin Integr Med 2008 6 392-398 (Pubitemid 351586134)
17. Yang X W., Guo Q M., Wang Y, Xu W, Tian L, Tian X J. Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 cell model. Bioorg Med Chem Lett 2007 17 1107-1111 (Pubitemid 46177600)