Detection of Brk expression in non-small cell lung cancer: Clinicopathological relevance

Tumor Biology

Volumn 32, Issue 5, 2011, Pages 873-880

  Fan, Chuifeng ^a   Zhao, Yang ^a   Liu, Di ^a   Zhang, Xiupeng ^a   Wang, Enhua ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Brk; E cadherin; IHC; Ki67; NSCLC; P53

Indexed keywords

KI 67 ANTIGEN; PROTEIN BAK; PROTEIN P53; UVOMORULIN;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CELL; CANCER SIZE; CANCER STAGING; CELL NUCLEUS; CLINICAL FEATURE; CONTROLLED STUDY; CYTOPLASM; ENZYME ANALYSIS; ENZYME LOCALIZATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

EID: 80052341805     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-011-0188-z     Document Type: Article

References (22)

1. PJ Mitchell KT Barker JE Martindale T Kamalati PN Lowe MJ Page BA Gusterson MR Crompton 1994 Cloning and characterization of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumors Oncogene 9 2383 2390 8036022 1:CAS:528:DyaK2cXlvFOgs70%3D (Pubitemid 24228691)
2. KT Barker LE Jackson MR Crompton 1997 BRK tyrosine kinase expression in a high proportion of human breast carcinomas Oncogene 15 799 805 9266966 10.1038/sj.onc.1201241 1:CAS:528:DyaK2sXls1Krsr0%3D (Pubitemid 27390132)
3. X Llor MS Serfas W Bie V Vasioukhin M Polonskaia J Derry CM Abbott 1999 Tyner AL:BRK/Sik expression in the gastrointestinal tract and in colon tumors Clin Cancer Res 5 1767 1777 10430081 1:CAS:528:DyaK1MXltVCqt74%3D (Pubitemid 29334458)
4. DJ Easty PJ Mitchell K Patel VA Flørenes RA Spritz DC Bennett 1997 Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma Int J Cancer 71 1061 1065 9185712 10.1002/(SICI)1097- 0215(19970611)71:6<1061::AID-IJC24>3.0.CO;2-F 1:CAS:528:DyaK2sXktVyrsb4%3D (Pubitemid 27252891)
5. B Joon-Seol L Seung-Taek 2001 The human PTK6 interacts with a 23-kDa tyrosine-phosphorylated protein and is localized in cytoplasm in breast carcinoma T-47D cells J Biochem Mol Biol 34 33 38
6. JJ Derry GS Prins V Ray AL Tyner 2003 Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells Oncogene 22 4212 4220 12833144 10.1038/sj.onc.1206465 1:CAS:528:DC%2BD3sXkvFSktbY%3D (Pubitemid 36876242)
7. AJ Harvey MR Crompton 2003 Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation Oncogene 22 5006 5010 12902983 10.1038/sj.onc.1206577 1:CAS:528:DC%2BD3sXmtVems7c%3D (Pubitemid 37026399)
8. HY Chen CH Shen YT Tsai FC Lin YP Huang RH Chen 2004 Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin Mol Cell Biol 24 10558 10572 15572663 10.1128/MCB.24.24.10558-10572.2004 1:CAS:528:DC%2BD2cXhtFShu7bJ (Pubitemid 39603116)
9. CH Shen HY Chen MS Lin FY Li CC Chang ML Kuo J Settleman RH Chen 2008 Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion Cancer Res 68 7779 7787 18829532 10.1158/0008-5472.CAN-08-0997 1:CAS:528:DC%2BD1cXhtF2msL%2FE
10. B Xiang K Chatti H Qiu B Lakshmi A Krasnitz J Hicks M Yu WT Miller SK Muthuswamy 2008 Brk is coamplified with ErbB2 to promote proliferation in breast cancer Proc Natl Acad Sci 105 12463 12468 18719096 10.1073/pnas.0805009105 1:CAS:528:DC%2BD1cXhtVKqsLnO
11. I Barlat F Maurier M Duchesne E Guitard B Tocque F Schweighoffer 1997 A role for Sam68 in cell cycle progression antagonized by a spliced variant within the KH domain J Biol Chem 272 3129 3132 9013542 10.1074/jbc.272.6.3129 1:CAS:528:DyaK2sXhtFenu78%3D (Pubitemid 27066796)
12. KE Lukong D Larocque AL Tyner S Richard 2005 Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression J Biol Chem 280 38639 38647 16179349 10.1074/jbc.M505802200 1:CAS:528:DC%2BD2MXht1SktLvE (Pubitemid 43853766)
13. HI Kim ST Lee 2009 Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus J Biochem 146 1 133 139 10.1093/jb/mvp050
14. Sobin DHWC. International Union Against Cancer (UICC): TNM classification of malignant tumors. New York: Wiley-Liss; 2002.
15. Travis WDBE, Muller-Hermelink HK, Harris CC. World Health Organization classification of tumors: pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: IARC Press; 2004.
16. EY Siyanova MS Serfas IA Mazo AL Tyner 1994 Tyrosine kinase gene expression in the mouse small intestine Oncogene 9 2053 2057 8208550 1:CAS:528:DyaK2cXltVWisro%3D (Pubitemid 24194173)
17. TC Wang SH Jee TF Tsai YL Huang WL Tsai RH Chen 2005 Role of breast tumour kinase in the in vitro differentiation of HaCaT cells Br J Dermatol 153 282 289 16086737 10.1111/j.1365-2133.2005.06604.x 1:CAS:528:DC%2BD2MXhtVWjsLfN (Pubitemid 41228423)
18. BJ Petro RC Tan AL Tyner MW Lingen K Watanabe 2004 Differential expression of the non-receptor tyrosine kinase BRK in oral squamous cell carcinoma and normal oral epithelium Oral Oncol 40 1040 1047 15509496 10.1016/j.oraloncology.2004.05.010 1:CAS:528:DC%2BD2cXptFKqurk%3D (Pubitemid 39422790)
19. V Vasioukhin MS Serfas EY Siyanova M Polonskaia VJ Costigan B Liu A Thomason AL Tyner 1995 A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract Oncogene 10 349 357 7838533 1:CAS:528:DyaK2MXjtlSht7c%3D
20. V Vasioukhin AL Tyner 1997 A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation Proc Natl Acad Sci 94 14477 14482 9405638 10.1073/pnas.94.26.14477 1:CAS:528:DyaK1cXislWquw%3D%3D (Pubitemid 28041399)
21. O Ikeda A Mizushima Y Sekine C Yamamoto R Muromoto A Nanbo K Oritani A Yoshimura T Matsuda 2010 Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells Cancer Sci 10.1111/j.1349-7006. 2010.01842.x Epub ahead of print
22. KE Lukong S Richard 2008 Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration Cell Signal 20 432 442 18077133 10.1016/j.cellsig.2007.11.003 1:CAS:528:DC%2BD1cXislKmuw%3D%3D