Phase i clinical study of NMK36: A new PET tracer with the synthetic amino acid analogue anti-[ 18F]FACBC

Annals of Nuclear Medicine

Volumn 25, Issue 6, 2011, Pages 414-418

  Asano, Yuji ^a   Inoue, Yusuke ^a   Ikeda, Yasuhiko ^b   Kikuchi, Kei ^c   Hara, Toshimasa ^a   Taguchi, Chikako ^a   Tokushige, Takanori ^c   Maruo, Hideki ^c   Takeda, Tohoru ^b   Nakamura, Tomomi ^b   Fujita, Tomoe ^b   Kumagai, Yuji ^b   Hayakawa, Kazushige ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c KITASATO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Amino acid; Anti 18F FACBC; NMK36; PET; Phase I

Indexed keywords

FIBRINOGEN; NMK 36; TRACER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD PRESSURE; BLOOD SAMPLING; BODY TEMPERATURE; BRAIN; BREATHING RATE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DOSIMETRY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG SAFETY; DRUG TOLERABILITY; DRUG UPTAKE; ECG ABNORMALITY; FIBRINOGEN BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INJECTION SITE ERYTHEMA; LIVER; MALE; NORMAL HUMAN; PANCREAS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PULSE RATE; RADIATION ABSORPTION; RADIATION DOSE; SIDE EFFECT; SKELETAL MUSCLE; URINALYSIS; URINARY EXCRETION; VENOUS BLOOD; WHOLE BODY SCINTISCANNING;

AMINO ACIDS; CARBOXYLIC ACIDS; CYCLOBUTANES; HUMANS; MALE; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RADIOMETRY; SAFETY; YOUNG ADULT;

EID: 80052337215     PISSN: 09147187     EISSN: 18646433     Source Type: Journal    
DOI: 10.1007/s12149-011-0477-z     Document Type: Article

References (15)

1. Kosuda S, Kison PV, Greenough R, Grossman HB, Wahl RL. Preliminary assessment of fluorine-18 fluorodeoxyglucose positron emission tomography in patients with bladder cancer. Eur J Nucl Med. 1997;24:615-20 (Pubitemid 27299740)
2. Shreve PD, Grossman HB, Gross MD, Wahl RL. Metastatic prostate cancer: initial findings of PET with 2-deoxy-2-[F- 18]fluoro-D-glucose. Radiology. 1996;199:751-6
3. Engel H, Steinert H, Buck A, Berthold T, Huch Böni RA, von Schulthess GK. Whole-body PET: physiological and artifactual fluorodeoxyglucose accumulations. J Nucl Med. 1996;37:441-6 (Pubitemid 26094269)
4. Oka S, Hattori R, Kurosaki F, Toyama M, Williams LA, Yu W, et al. A preliminary study of anti-1-amino-3-18F-fluorocyclobutyl- 1-carboxylic acid for the detection of prostate cancer. J NucI Med. 2007;48:46-55 (Pubitemid 47555375)
5. Shoup TM, Goodman MM. Synthesis of [F-18]-1-amino-3- fluorocyclobutane-1- carboxylic acid (FACBC): a PET tracer for tumor delineation. J Label Comp Radiopharm. 1999;42:215-25 (Pubitemid 29099532)
6. Shoup TM, Olson J, Hoffman JM, Vote J, Eshima D, Shim L, et al. Synthesis and evaluation of [18F] 1-amino-3-fluorocyclobutane- 1-carboxylic acid to image brain tumors. J NucI Med. 1999;40:331-8 (Pubitemid 29077098)
7. Schuster DM, Votaw JR, Nieh PT, Yu W, Nye JA, Master V, et al. Initial experience with the radiotracer anti-1-amino-3-18Ffluorocyclobutane- 1-carboxylic acid with PET/CT in prostate carcinoma. J Nucl Med. 2007;48:56-63 (Pubitemid 47555376)
8. Nye JA, Schuster DM, Yu W, Camp VM, Goodman MM, Votaw JR. Biodistribution and radiation dosimetry of the synthetic nonmetabolized amino acid analogue anti-18F-FACBC in humans. J Nucl Med. 2007;48:1017-20 (Pubitemid 46909932)
9. Michael G, Richard B, Eric C. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005;46:1023-7
10. Tanaka G. Japanese reference man 1988-III. Masses of organs and tissues and other physical properties. Nippon Igaku Hoshasen Gakkai Zasshi. 1988 Apr 25;48:509-13 (in Japanese)
11. Cloutier R, Smith S, Watson E, Snyder W, Warner G. Dose to the fetus from radionuclides in the bladder. Health Phys. 1973; 25:147-61
12. Deloar HM, Fujikawa T, Nakamura T, Itoh M, Imai D, Miyake M, et al. Estimation of internal absorbed dose of L-[methyl-11C] methionine using whole- body positron emission tomography. Eur J Nucl Med. 1998;25:629-33 (Pubitemid 28297838)
13. Pauleit D, Floeth F, Herzog H, Hamacher K, Tellmann L, Müller HW, et al. Whole-body distribution and dosimetry of O-(2-[18F] fluoroethyl)-L- tyrosine. Eur J Nucl Med Mol Imaging. 2003;30:519-24 (Pubitemid 36559830)
14. ICRP. Annals of the ICRP, Publication 80. Oxford: Pergamon; 1998.
15. ICRP. Annals of the ICRP, Publication 62. Oxford: Pergamon Press; 1991.