Interleukin 6 blockade as steroid-sparing treatment for 2 patients with giant cell arteritis

Journal of Rheumatology

Volumn 38, Issue 9, 2011, Pages 2080-2081

  Sciascia, Savino ^a   Rossi, Daniela ^a   Roccatello, Dario ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; CORTICOSTEROID; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 INHIBITOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; METFORMIN; METHOTREXATE; PREDNISONE; TOCILIZUMAB; UNCLASSIFIED DRUG;

ACUTE PHASE RESPONSE; AGED; ANAMNESIS; CASE REPORT; COMORBIDITY; DIABETES MELLITUS; DISEASE ACTIVITY; DRUG DOSE REDUCTION; DRUG MEGADOSE; DRUG TOLERABILITY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GIANT CELL ARTERITIS; HIGH RISK PATIENT; HUMAN; HYPERTENSION; IMMUNOASSAY; LETTER; PRIORITY JOURNAL; TREATMENT OUTCOME;

AGED; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIRHEUMATIC AGENTS; FEMALE; GIANT CELL ARTERITIS; HUMANS; INTERLEUKIN-6; STEROIDS;

EID: 80052318064     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.110496     Document Type: Letter

References (13)

1. Lawrence R.C., Helmick C.G., Arnett F.C., Deyo R.A., Felson D.T., Giannini E.H., et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 1998;41:778-799 (Pubitemid 28225778)
2. Nesher G., Sonnenblick M., Friedlander Y. Analysis of steroid related complications and mortality in temporal arteritis: A 15-year survey of 43 patients. J Rheumatol 1994;21:1283-1286 (Pubitemid 24234666)
3. Pipitone N., Boiardi L., Salvarani C. Are steroids alone sufficient for the treatment of giant cell arteritis? Best Pract Res Clin Rheumatol 2005;19:277-292 (Pubitemid 40568180)
4. Jover J.A., Hernandez-Garcia C., Morado I.C., Banares A., Fernandez-Gutiérrez B. Combined treatment of giant cell arteritis with methotrexate and prednisone: A randomized, double-blind, placebo-controlled trial. Ann Intern Med 2001;134:106-114 (Pubitemid 32096337)
5. Mahr A.D., Jover J.A., Spiera R.F., Hernandez-Garcia C., Fernandez-Gutierrez B., La Valley M.P., et al. Adjunctive methotrexate for treatment of giant cell arteritis. An individual patient data meta-analysis. Arthritis Rheum 2007;56:2789-2797 (Pubitemid 47237299)
6. Pipitone N., Salvarani C. Improving therapeutic options for patients with giant cell arteritis. Curr Opin Rheumatol 2008;20:17-22. (Pubitemid 351339427)
7. Martínez-Taboada V.M., Rodríguez-Valverde V., Carreño L., López-Longo J., Figueroa M., Belzunegui J., et al. A double blind placebo controlled trial of etanercept in giant cell arteritis and corticosteroid side effects. Ann Rheum Dis 2008;67:625-630 (Pubitemid 351571925)
8. Hoffmann G.S., Cid M.C., Rendt-Zagar K., Merkel P.A., Weyand C.M., Stone J.H., et al. Infliximab for maintenance of glucocorticosteroid-induced remission of giant cell arteritis. Ann Intern Med 2007;146:621-630 (Pubitemid 351650517)
9. García-Martínez A., Hernández-Rodríguez J., Espígol-Frigolé G., Prieto-González S., Butjosa M., Segarra M., et al. Clinical relevance of persistently elevated circulating cytokines (tumor necrosis factor alpha and interleukin-6) in the long-term followup of patients with giant cell arteritis. Arthritis Care Res 2010;62:835-841
10. Dasgupta B., Borg F.A., Hassan N., Alexander L., Barraclough K., Bourke B., et al. BSR and BHPR Standards, Guidelines and Audit Working Group. BSR and BHPR guidelines for the management of giant cell arteritis. Rheumatology 2010;49:1594-1597
11. Hishimoto N., Nakahara H., Yoshio-Hoshino N., Mima T. Successful treatment of a patient with Takayasu arteritis using a humanized anti-interleukin-6 receptor antibody. Arthritis Rheum 2008;58:1197-1200 (Pubitemid 351564023)
12. Seitz M., Reichenbach S., Bonel H.M., Adler S., Wermelinger F., Villiger P.M. Rapid induction of remission in large vessel vasculitis by IL-6 blockade. A case series. Swiss Med Wkly 2011;17:141.
13. Bannwarth B., Richez C. Clinical safety of tocilizumab in rheumatoid arthritis. Expert Opin Drug Saf 2011;10:123-131