Why ultra high performance liquid chromatography produces more tailing peaks than high performance liquid chromatography, why it does not matter and how it can be addressed

Journal of Chromatography A

Volumn 1218, Issue 39, 2011, Pages 6914-6921

  Petersson, Patrik ^a   Forssen, Patrik ^b   Edström, Lena ^c   Samie, Farzad ^a   Tatterton, Stephen ^d   Clarke, Adrian ^d,e   Fornstedt, Torgny ^b  

^a ASTRAZENECA R AND D   (Sweden)

^b KARLSTAD UNIVERSITY   (Sweden)

^c Department of Physical and Analytical Chemistry ^*  (Sweden)

^d ASTRAZENECA   (United Kingdom)

^e NOVARTIS PHARMA AG   (Switzerland)

Author keywords

HPLC; Isotherm; Particle size; Simulation; Translation; UHPLC

Indexed keywords

HIGHER T; HPLC; HPLC SEPARATION; INJECTION VOLUME; OBJECTIVE QUALITY MEASURES; PEAK WIDTHS; POROUS PARTICLE; SIMULATION; SUPERFICIALLY POROUS PARTICLES; THEORETICAL PLATES; UHPLC; UNITED STATES PHARMACOPEIAS; WIDE SPREADS;

COMPUTER SIMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; PARTICLE SIZE; POROUS MATERIALS;

CHROMATOGRAPHY;

ACETONITRILE; METOPROLOL;

ANALYTIC METHOD; ANALYTICAL PARAMETERS; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; COMPUTER SIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; MATHEMATICAL COMPUTING; MEDICAL LITERATURE; PARTICLE SIZE; PHASE SEPARATION; PREDICTIVE VALUE; PRIORITY JOURNAL; QUALITY CONTROL; SEPARATION TECHNIQUE; TEMPERATURE MEASUREMENT; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETONITRILES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; METOPROLOL; MODELS, CHEMICAL; PARTICLE SIZE; POROSITY; REPRODUCIBILITY OF RESULTS;

EID: 80052306412     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.08.018     Document Type: Article

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