Rapid and sensitive determination of udenafil in plasma by LC-MS/MS for intranasal pharmacokinetic study in rats

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 9, 2011, Pages 1083-1088

  Ku, Wan Sung ^a   Cho, Hyun Jong ^a   Yoon, In Soo ^a   Kim, Jeong Hoon ^b   Cha, Bong Jin ^b   Kim, Jung Sun ^c   Kim, Kyeong Mi ^d   Kang, Shin Kwon ^d   Chung, Suk Jae ^a   Shim, Chang Koo ^a   Kim, Dae Duk ^a  

^a Seoul National University   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

^c Dongseo University   (South Korea)

^d Korea Maintenance and Control Co Ltd   (South Korea)

Author keywords

Intranasal delivery; LC MS MS; Liquid liquid extraction; Pharmacokinetics; Udenafil

Indexed keywords

UDENAFIL;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DEVICE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ADMINISTRATION, INTRANASAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LIQUID-LIQUID EXTRACTION; MALE; METHYLENE CHLORIDE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; SULFONES; TANDEM MASS SPECTROMETRY;

EID: 80052296098     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.1083     Document Type: Article

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