Pregnancy, microchimerism, and the maternal grandmother

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Gammill, Hilary S ^a,b   Waldorf, Kristina M Adams ^a,b   Aydelotte, Tessa M ^a   Lucas, Joëlle ^a   Leisenring, Wendy M ^a   Lambert, Nathalie C ^c   Nelson, J Lee ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN;

ADULT; ARTICLE; BLOOD; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENOTYPE; GESTATIONAL AGE; HUMAN; MATERNAL GRANDMOTHER; MATERNAL WELFARE; MICROCHIMERISM; OBSTETRIC CARE; POLYMERASE CHAIN REACTION; PREECLAMPSIA; PREGNANCY; PROSPECTIVE STUDY; PUERPERIUM; RELATIVE; THIRD TRIMESTER PREGNANCY; CASE CONTROL STUDY; CHILD; CHIMERA; GENETICS; LONGITUDINAL STUDY; MOTHER;

ADULT; CASE-CONTROL STUDIES; CHILD; CHIMERISM; FEMALE; HUMANS; LONGITUDINAL STUDIES; MOTHERS; PRE-ECLAMPSIA; PREGNANCY;

EID: 80052278512     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024101     Document Type: Article

References (28)

1. Gammill HS, Nelson JL, (2010) Naturally acquired microchimerism. Int J Dev Biol 54: 531-543.
2. Maloney S, Smith A, Furst DE, Myerson D, Rupert K, et al. (1999) Microchimerism of maternal origin persists into adult life. J Clin Invest 104: 41-47.
3. van Rood JJ, Claas F, (2000) Both self and non-inherited maternal HLA antigens influence the immune response. Immunology Today 21: 269-273.
4. Feitsma AL, Worthington J, van der Helm-van Mil AHM, Plant D, Thomson W, et al. (2007) Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. Proc Natl Acad Sci U S A 104: 19966-19970.
5. Redman CWG, Sacks GP, Sargent IL, (1999) Preeclampsia: An excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol 180: 499-506.
6. Hiby SE, Walker JJ, O'Shaughnessy KM, Redman CWG, Carrington M, et al. (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med 200: 957-965.
7. Adams Waldorf KM, Gammill HS, Lucas J, Aydelotte TM, Leisenring WM, et al. (2010) Dynamic changes in fetal microchimerism in maternal peripheral blood mononuclear cells, CD4+ and CD8+ cells in normal pregnancy. Placenta 31: 589-594.
8. ACOG, (2002) Practice Bulletin No. 33: Diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol 99: 159-167.
9. NHBPEP, (2000) Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol 183: S1-S22.
10. Lambert NC, Erickson TD, Yan Z, Pang JM, Guthrie KA, et al. (2004) Quantification of maternal microchimerism by HLA-specific real-time polymerase chain reaction: Studies of healthy women and women with scleroderma. Arthritis Rheum 50: 906-914.
11. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, et al. (1988) Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239: 487-491.
12. Jonsson AM, Uzunel M, Gotherstrom C, Papadogiannakis N, Westgren M, (2008) Maternal microchimerism in human fetal tissues. Am J Obstet Gynecol 198: 325.e321-325.e326.
13. Loubiere LS, Lambert NC, Flinn LJ, Erickson TD, Yan Z, et al. (2006) Maternal microchimerism in healthy adults in lymphocytes, monocyte//macrophages and NK cells. Lab Invest 86: 1185-1192.
14. Stevens AM, Hermes HM, Rutledge JC, Buyon JP, Nelson JL, (2003) Myocardial-tissue-specific phenotype of maternal microchimerism in neonatal lupus congenital heart block. Lancet 362: 1617-1623.
15. Cuddapah Sunku C, Gadi V, deLavaldeLacoste B, Guthrie K, Nelson J, (2010) Maternal and fetal microchimerism in granulocytes. Chimerism 1: 11-14.
16. Gammill HS, Guthrie KA, Aydelotte TM, Adams Waldorf KM, Nelson JL, (2010) Effect of parity on fetal and maternal microchimerism: Interaction of grafts within a host? Blood 116: 2706-2712.
17. Billingham RE, Brent L, Medawar PB, (1953) Actively acquired tolerance of foreign cells. Nature 172: 603-606.
18. Owen RD, Wood HR, Foord AG, Sturgeon P, Baldwin LG, (1954) Evidence for actively acquired tolerance to Rh antigens. Proc Natl Acad Sci USA 40: 420-424.
19. Dutta P, Burlingham WJ, (2009) Tolerance to noninherited maternal antigens in mice and humans. Curr Opin Organ Transplant 14: 439-447.
20. van Rood JJ, Loberiza FR, Zhang MJ, Oudshoorn M, Claas F, et al. (2002) Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling. Blood 99: 1572-1577.
21. Mold JE, Michaelsson J, Burt TD, Muench MO, Beckerman KP, et al. (2008) Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 322: 1562-1565.
22. Dutta P, Molitor-Dart M, Bobadilla JL, Roenneburg DA, Yan Z, et al. (2009) Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice. Blood 114: 3578-3587.
23. Dutta P, Dart M, Roenneburg D, Torrealba J, Burlingham W, (2011) Pretransplant immune-regulation predicts allograft tolerance. Am J Transplant 11: 1-6.
24. Akiyama Y, Caucheteux S, Vernochet C, Iwamoto Y, Tanaka K, et al. (2011) Transplantation tolerance to a single noninherited MHC Class I maternal alloantigen studied in a TCR-transgenic mouse model. J Immunol 186: 1442-1449.
25. Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, et al. (2011) In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature 474: 216-219.
26. Lo Y, Tein M, Lau T, Haines C, Leung T, et al. (1998) Quantitative analysis of fetal DNA in maternal plasma and serum: Implications for noninvasive prenatal diagnosis. Am J Hum Genet 62: 768-775.
27. Milman N, Graudal N, Nielsen O, Agger A, (1997) Serum erythropoietin during normal pregnancy: relationship to hemoglobin and iron status markers and impact of iron supplementation in a longitudinal, placebo-controlled study on 118 women. Int J Hematol 66: 159-168.
28. Luppi P, Powers R, Verma V, Edmunds L, Plymire D, et al. (2010) Maternal circulating CD34+VEGFR-2+ and CD133+VEGFR-2 + progenitor cells increase during normal pregnancy but are reduced in women with preeclampsia. Reproductive Sciences 17: 643-652.