Valproate-induced fanconi syndrome in a 27-year-old woman

Journal of General Internal Medicine

Volumn 26, Issue 9, 2011, Pages 1072-1074

  Patel, Sandeep M ^a   Graff Radford, Jonathan ^a   Wieland, Mark L ^a  

^a MAYO CLINIC   (United States)

Author keywords

adult; Fanconi syndrome; valproate; valproic acid

Indexed keywords

ALPRAZOLAM; CALCIUM; ELECTROLYTE; LAMOTRIGINE; OXYCODONE PLUS PARACETAMOL; PHOSPHATE; POTASSIUM; PREGABALIN; PROTEIN; RETINOL BINDING PROTEIN; VALPROIC ACID; VITAMIN D;

ACHILLES REFLEX; ACIDURIA; ADULT; ANKLE EDEMA; ANKLE INJURY; ARTICLE; CASE REPORT; CONFUSION; DISEASE SURVEILLANCE; DISORIENTATION; DRUG BLOOD LEVEL; DRUG INDUCED DISEASE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ECCHYMOSIS; ELECTROLYTE URINE LEVEL; FALLING; FAMILY HISTORY; FANCONI RENOTUBULAR SYNDROME; FATIGUE; FEMALE; FRACTURE; GLUCOSURIA; HUMAN; HYPOCALCEMIA; HYPOKALEMIA; HYPOPHOSPHATEMIA; HYPOURICEMIA; KIDNEY TUBULE FUNCTION; LEG SWELLING; MEDICAL HISTORY; MENTAL HEALTH; NEUROLOGIC EXAMINATION; PHYSICAL EXAMINATION; POLYDIPSIA; POLYURIA; PROTEIN URINE LEVEL; RADIOGRAPHY; RANGE OF MOTION; TONIC CLONIC SEIZURE; TUBULAR DYSFUNCTION; URINALYSIS; VALPROATE INDUCED FANCONI SYNDROME; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; WEAKNESS;

ADULT; FANCONI SYNDROME; FEMALE; HUMANS; VALPROIC ACID;

EID: 80052278477     PISSN: 08848734     EISSN: 15251497     Source Type: Journal    
DOI: 10.1007/s11606-011-1708-7     Document Type: Article

References (18)

1. GR Lenoir JL Perignon MC Gubler, et al. 1981 Valproic acid: a possible cause of proximal tubular renal syndrome J Pediatr 98 3 503 4 6782217 1:STN:280:DyaL3M7ksVCnuw%3D%3D Mar. (Pubitemid 11106272)
2. E Hawkins E Brewer 1993 Renal toxicity induced by valproic acid (Depakene) Pediatr Pathol 13 6 863 8 8108303 10.3109/15513819309048273 1:STN:280:DyaK2c7ltFWqtw%3D%3D Nov-Dec. (Pubitemid 23343992)
3. MB Lande MS Kim C Bartlett, et al. 1993 Reversible Fanconi syndrome associated with valproate therapy J Pediatr 123 2 320 2 7688423 10.1016/S0022-3476(05)81712-3 1:STN:280:DyaK3szkslSrsQ%3D%3D Aug. (Pubitemid 23221121)
4. GC Smith JW Balfe SW Kooh 1995 Anticonvulsants as a cause of Fanconi syndrome Nephrol Dial Transplant 10 4 543 5 7624000 1:STN:280: DyaK2MzkvFOrug%3D%3D
5. S Altunbasak D Yildizas A Anarat, et al. 2001 Renal tubular dysfunction in epileptic children on valproic acid therapy Pediatr Nephrol 16 3 256 9 11322374 10.1007/s004670000535 1:STN:280:DC%2BD3M3ivFGhsg%3D%3D Mar. (Pubitemid 32229848)
6. H Yoshikawa T Watanabe T Abe 2002 Fanconi syndrome caused by sodium valproate: report of three severely disabled children Eur J Paediatr Neurol 6 3 165 7 12363104 10.1053/ejpn.2002.0585 (Pubitemid 35023679)
7. EL Zaki JE Springate 2002 Renal injury from valproic acid: case report and literature review Pediatr Neurol 27 4 318 9 12435575 10.1016/S0887-8994(02) 00447-2 Oct. (Pubitemid 35341708)
8. M Knorr J Schaper M Harjes, et al. 2004 Fanconi syndrome caused by antiepileptic therapy with valproic Acid Epilepsia 45 7 868 71 15230715 10.1111/j.0013-9580.2004.05504.x Jul. (Pubitemid 38890990)
9. SL Jaffe M Sanford 2005 Valproate-induced proximal renal tubular dysfunction: clinically relevant in the severely disabled epileptic population Epilepsia 46 4 599 600 15816962 10.1111/j.0013-9580.2005.t01-1-64204-2.x Apr. (Pubitemid 40470691)
10. T Watanabe H Yoshikawa S Yamazaki, et al. 2005 Secondary renal Fanconi syndrome caused by valproate therapy Pediatr Nephrol 20 6 814 7 15785938 10.1007/s00467-005-1827-7 Jun. (Pubitemid 40663170)
11. H Ono 2007 A severe disabled case of incomplete Fanconi syndrome after discontinuation of carnitine supplementation during valproate sodium therapy No To Hattatsu 39 3 226 7 17515139 1:STN:280:DC%2BD2szgsVCrtA%3D%3D May
12. BL Clarke AG Wynne DM Wilson, et al. 1995 Osteomalacia associated with adult Fanconi's syndrome: clinical and diagnostic features Clin Endocrinol (Oxf) 43 4 479 90 10.1111/j.1365-2265.1995.tb02621.x 1:STN:280:DyaK28%2Fks1ynsg%3D%3D Oct.
13. A Thirumurugan A Thewles RD Gilbert, et al. 2004 Urinary L-lactate excretion is increased in renal Fanconi syndrome Nephrol Dial Transplant 19 7 1767 73 15128879 10.1093/ndt/gfh213 1:CAS:528:DC%2BD2cXltVWlurg%3D Jul. (Pubitemid 38961385)
14. FX Coude G Grimber A Pelet, et al. 1983 Action of the antiepileptic drug, valproic acid, on fatty acid oxidation in isolated rat hepatocytes Biochem Biophys Res Commun 115 2 730 6 6414476 10.1016/S0006-291X(83)80205-8 1:CAS:528:DyaL3sXlsFajsLk%3D Sep 15 (Pubitemid 13011006)
15. Y Ohtani F Endo I Matsuda 1982 Carnitine deficiency and hyperammonemia associated with valproic acid therapy J Pediatr 101 5 782 5 6813444 10.1016/S0022-3476(82)80320-X 1:STN:280:DyaL3s%2Fjt1yltw%3D%3D Nov. (Pubitemid 12006715)
16. BS Kendler 1986 Carnitine: an overview of its role in preventive medicine Prev Med 15 4 373 90 3532087 10.1016/0091-7435(86)90005-8 1:CAS:528: DyaL28XlslSqu7w%3D Jul. (Pubitemid 16051427)
17. R Graf R Gossrau HJ Merker, et al. 1985 Enzyme cytochemistry combined with electron microscopy, pharmacokinetics, and clinical chemistry for the evaluation of the effects of steady-state valproic acid concentrations on the mouse Histochemistry 83 4 347 58 3934114 10.1007/BF00684382 1:CAS:528: DyaL2MXlvV2ksLs%3D (Pubitemid 16249064)
18. JC Whitin DM Tham S Bhamre, et al. 1998 Plasma glutathione peroxidase and its relationship to renal proximal tubule function Mol Genet Metab 65 3 238 45 9851889 10.1006/mgme.1998.2760 1:CAS:528:DyaK1MXmtFem Nov. (Pubitemid 28565100)