Tuning the dependency between stiffness and permeability of a cell encapsulating hydrogel with hydrophilic pendant chains

Acta Biomaterialia

Volumn 7, Issue 10, 2011, Pages 3719-3728

  Cha, Chaenyung ^a   Jeong, Jae Hyun ^a   Shim, Jongwon ^b   Kong, Hyunjoon ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b AmorePacific Corporation   (South Korea)

Author keywords

Cell encapsulation; Decoupled control; Hydrogel; Permeability; Stiffness

Indexed keywords

CELL CULTURE; CELL ENGINEERING; CROSSLINKING; ENDOTHELIAL CELLS; ETHYLENE GLYCOL; HYDROGELS; INVERSE PROBLEMS; MECHANICAL PERMEABILITY; POLYETHYLENE GLYCOLS; POLYOLS; STIFFNESS MATRIX;

CELL ENCAPSULATIONS; CROSS LINKING; DECOUPLED CONTROL; DESIGN STRATEGIES; DIACRYLATES; HYDROPHILICS; MATRIX; MECHANICAL STIFFNESS; PERMEABILITY; POLYMER CHAINS;

STIFFNESS;

ACRYLIC ACID DERIVATIVE; MACROGOL; POLYETHYLENE GLYCOL DIACRYLATE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; CELL ENCAPSULATION; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CELL VIABILITY; CROSS LINKING; FIBROBLAST; HYDROGEL; HYDROPHILICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RIGIDITY;

EID: 80052266986     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2011.06.017     Document Type: Article

References (44)

1. A.C. Jen, M.C. Wake, and A.G. Mikos Review: hydrogels for cell immobilization Biotechnol Bioeng 50 1996 357 364 (Pubitemid 26126669)
2. K.T. Nguyen, and J.L. West Photopolymerizable hydrogels for tissue engineering applications Biomaterials 23 2002 4307 4314
3. J.L. Drury, and D.J. Mooney Hydrogels for tissue engineering: scaffold design variables and applications Biomaterials 24 2003 4337 4351 (Pubitemid 36960132)
4. K.Y. Lee, and D.J. Mooney Hydrogels for tissue engineering Chem Rev 101 2001 1869 1880
5. D.S.W. Benoit, M.P. Schwartz, A.R. Durney, and K.S. Anseth Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells Nat Mater 7 2008 816 823
6. L.M. Weber, K.N. Hayda, K. Haskins, and K.S. Anseth The effects of cell-matrix interactions on encapsulated [beta]-cell function within hydrogels functionalized with matrix-derived adhesive peptides Biomaterials 28 2007 3004 3011 (Pubitemid 46560870)
7. S.R. Peyton, C.B. Raub, V.P. Keschrumrus, and A.J. Putnam The use of poly(ethylene glycol) hydrogels to investigate the impact of ECM chemistry and mechanics on smooth muscle cells Biomaterials 27 2006 4881 4893 (Pubitemid 43866921)
8. A. Batorsky, J. Liao, A.W. Lund, G.E. Plopper, and J.P. Stegemann Encapsulation of adult human mesenchymal stem cells within collagen-agarose microenvironments Biotechnol Bioeng 92 2005 492 500 (Pubitemid 41737240)
9. B. Geiger, J.P. Spatz, and A.D. Bershadsky Environmental sensing through focal adhesions Nat Rev Mol Cell Biol 10 2009 21 33
10. F. Brandl, F. Sommer, and A. Goepferich Rational design of hydrogels for tissue engineering: impact of physical factors on cell behavior Biomaterials 28 2007 134 146 (Pubitemid 44537395)
11. K.S. Anseth, C.N. Bowman, and L. Brannon-Peppas Mechanical properties of hydrogels and their experimental determination Biomaterials 17 1996 1647 1657 (Pubitemid 26278972)
12. M.W. Tibbitt, and K.S. Anseth Hydrogels as extracellular matrix mimics for 3D cell culture Biotechnol Bioeng 103 2009 655 663
13. E. Cukierman, R. Pankov, and K.M. Yamada Cell interactions with three-dimensional matrices Curr Opin Cell Biol 14 2002 633 640
14. J.W. Gunn, S.D. Turner, and B.K. Mann Adhesive and mechanical properties of hydrogels influence neurite extension J Biomed Mater Res Part A 72A 2005 91 97 (Pubitemid 39628337)
15. K. Bott, Z. Upton, K. Schrobback, M. Ehrbar, J.A. Hubbell, and M.P. Lutolf The effect of matrix characteristics on fibroblast proliferation in 3D gels Biomaterials 31 2010 8454 8464
16. R.H. Li, D.H. Altreuter, and F.T. Gentile Transport characterization of hydrogel matrices for cell encapsulation Biotechnol Bioeng 50 1996 365 373 (Pubitemid 26126670)
17. T.S. Karande, J.L. Ong, and C.M. Agrawal Diffusion in musculoskeletal tissue engineering scaffolds: design issues related to porosity, permeability, architecture, and nutrient mixing Ann Biomed Eng 32 2004 1728 1743 (Pubitemid 40121305)
18. K.M. Yamada, and E. Cukierman Modeling tissue morphogenesis and cancer in 3D Cell 130 2007 601 610 (Pubitemid 47268064)
19. G.M. Cruise, D.S. Scharp, and J.A. Hubbell Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels Biomaterials 19 1998 1287 1294 (Pubitemid 28391475)
20. L.M. Weber, C.G. Lopez, and K.S. Anseth Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function J Biomed Mater Res Part A 90A 2009 720 729
21. C. Cha, R.E. Kohman, and H. Kong Biodegradable polymer crosslinker: independent control of stiffness, toughness, and hydrogel degradation rate Adv Funct Mater 19 2009 3056 3062
22. C. Cha, S.Y. Kim, L. Cao, and H. Kong Decoupled control of stiffness and permeability with a cell-encapsulating poly(ethylene glycol) dimethacrylate hydrogel Biomaterials 31 2010 4864 4871
23. D.M. Soumpasis Theoretical analysis of fluorescence photobleaching recovery experiments Biophys J 41 1983 95 97 (Pubitemid 13114325)
24. F. Brandl, F. Kastner, R.M. Gschwind, T. Blunk, J. Teßar, and A. Göferich Hydrogel-based drug delivery systems: comparison of drug diffusivity and release kinetics J Control Release 142 2010 221 228
25. T. Vermonden, S.S. Jena, D. Barriet, R. Censi, J. van der Gucht, and W.E. Hennink Macromolecular diffusion in self-assembling biodegradable thermosensitive hydrogels Macromolecules 43 2009 782 789
26. K. Kalyanasundaram, and J.K. Thomas Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems J Am Chem Soc 99 1977 2039 2044
27. V. Glushko, M.S.R. Thaler, and C.D. Karp Pyrene fluorescence fine structure as a polarity probe of hydrophobic regions: behavior in model solvents Arch Biochem Biophys 210 1981 33 42
28. Y. Maeda, N. Taniguchi, and I. Ikeda Changes in the hydration state of a block copolymer of poly(N-isopropylacrylamide) and poly(ethylene oxide) on thermosensitive micellization in water Macromol Rapid Commun 22 2001 1390 1393
29. S. Grugel, G. Finkenzeller, K. Weindel, B. Barleon, and D. Marmé Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells J Biol Chem 270 1995 25915 25919
30. D. Wang, H.-J.S. Huang, A. Kazlauskas, and W.K. Cavenee Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase Cancer Res 59 1999 1464 1472 (Pubitemid 29160112)
31. K.S. Anseth, A.T. Metters, S.J. Bryant, P.J. Martens, J.H. Elisseeff, and C.N. Bowman In situ forming degradable networks and their application in tissue engineering and drug delivery J Control Release 78 2002 199 209 (Pubitemid 34081865)
32. C. Chu, J.J. Schmidt, K. Carnes, Z. Zhang, H.J. Kong, and M.-C. Hofmann Three-dimensional synthetic niche components to control germ cell proliferation Tissue Eng Part A 15 2009 255 262
33. M. Tunyogi-Csapo, T. Koreny, C. Vermes, J.O. Galante, J.J. Jacobs, and T.T. Glant Role of fibroblasts and fibroblast-derived growth factors in periprosthetic angiogenesis J Orthop Res 25 2007 1378 1388 (Pubitemid 47523368)
34. B.J. Broker, R. Chakrabarti, T. Blynman, J. Roesler, M.B. Wang, and E.S. Srivatsan Comparison of growth factor expression in fetal and adult fibroblasts - a preliminary report Arch Otolaryngol Head Neck Surg 125 1999 676 680 (Pubitemid 29269844)
35. D. Kessler, S. Dethlefsen, I. Haase, M. Plomann, F. Hirche, and T. Krieg Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype J Biol Chem 276 2001 36575 36585
36. B. Eckes, M.C. Zweers, Z.G. Zhang, R. Hallinger, C. Mauch, and M. Aumailley Mechanical tension and integrin α2β1 regulate fibroblast functions J Investig Dermatol Symp P 11 2006 66 72 (Pubitemid 44413146)
37. Y. Liu, and M.B. Huglin Effective crosslinking densities and elastic moduli of some physically crosslinked hydrogels Polymer 36 1995 1715 1718
38. X. Qu, A. Wirs, and A.C. Albertsson Novel pH-sensitive chitosan hydrogels: swelling behavior and states of water Polymer 41 2000 4589 4598 (Pubitemid 30184651)
39. Y. Hou, C.A. Schoener, K.R. Regan, D. Munoz-Pinto, M.S. Hahn, and M.A. Grunlan Photo-cross-linked PDMSstar-PEG hydrogels: synthesis, characterization, and potential application for tissue engineering scaffolds Biomacromolecules 11 2010 648 656
40. W. Lee, N.-J. Cho, A. Xiong, J.S. Glenn, and C.W. Frank Hydrophobic nanoparticles improve permeability of cell-encapsulating poly(ethylene glycol) hydrogels while maintaining patternability Proc Nat Acad Sci 2010 10.1073/pnas.1005211107
41. N. Huebsch, P.R. Arany, A.S. Mao, D. Shvartsman, O.A. Ali, and S.A. Bencherif Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate Nat Mater 9 2010 518 526
42. E.A. Klein, L. Yin, D. Kothapalli, P. Castagnino, F.J. Byfield, and T. Xu Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening Curr Biol 19 2009 1511 1518
43. M.P. Lutolf, J.L. Lauer-Fields, H.G. Schmoekel, A.T. Metters, F.E. Weber, and G.B. Fields Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics Proc Nat Acad Sci 100 2003 5413 5418 (Pubitemid 36542719)
44. D.E. Discher, D.J. Mooney, and P.W. Zandstra Growth factors, matrices, and forces combine and control stem cells Science 324 2009 1673 1677