Effects of organic solvents on the barrier properties of human nail

Journal of Pharmaceutical Sciences

Volumn 100, Issue 10, 2011, Pages 4244-4257

  Smith, Kelly A ^a   Hao, Jinsong ^a   Li, S Kevin ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Human nail plate; Hydration; Organic solvent effects; Transungual transport; Ungual uptake

Indexed keywords

ALCOHOL; MACROGOL; PROPYLENE GLYCOL; TETRYLAMMONIUM; UREA; WATER; MACROGOL DERIVATIVE; SOLVENT;

ADULT; AGED; ARTICLE; CASE REPORT; CONTROLLED STUDY; DRUG FORMULATION; GRAVIMETRY; HUMAN; HUMAN TISSUE; HYDRATION; IN VITRO STUDY; ION TRANSPORT; MALE; NAIL; PH; PHYSICAL CHEMISTRY; VISCOSITY; WATER PERMEABILITY; WATER TRANSPORT; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MEDICINAL CHEMISTRY; METABOLISM; MIDDLE AGED; PERMEABILITY; PHARMACEUTICS; PROCEDURES; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; HUMANS; MALE; MIDDLE AGED; NAILS; PERMEABILITY; POLYETHYLENE GLYCOLS; PROPYLENE GLYCOL; SOLVENTS; TECHNOLOGY, PHARMACEUTICAL; TETRAETHYLAMMONIUM; UREA; VISCOSITY; WATER;

EID: 80052263785     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22590     Document Type: Article

References (28)

1. Dawber RPR, deBerker DAR, Baran R. 2001. Science of the nail apparatus. In Baran and Dawber's diseases of the nails and their management; Baran R, Dawber RPR, deBerker DAR, Haneke E, Tosti A, Eds. Oxford: Blackwell Science, pp 1-48.
2. Walters KA, Flynn GL, Marvel JR. 1983. Physicochemical characterization of the human nail: Permeation pattern for water and the homologous alcohols and differences with respect to the stratum corneum. J Pharm Pharmacol 35:28-33.
3. Mertin D, Lippold BC. 1997. In vitro permeability of the human nail and of a keratin membrane from bovine hooves: Influence of the partition coefficient octanol/water and the water solubility of drugs on their permeability and maximum flux. J Pharm Pharmacol 49:30-34.
4. Gunt HB, Kasting GB. 2007. Effect of hydration on the permeation of ketoconazole through human nail plate in vitro. Eur J Pharm Sci 32:254-260.
5. Burch GE, Windsor TE. 1946. Diffusion of water through dead plantar, palmer, and torsal human skin and through toenails. Arch Dermatol Syph 51:39-41.
6. Baden HP. 1970. The physical properties of nail. J Invest Dermatol 55:115-122.
7. Spruit D. 1971. Measurement of water vapor loss through human nail in vivo. J Invest Dermatol 56:359-361.
8. Smith KA, Hao J, Li SK. 2010. Influence of pH on transungual passive and iontophoretic transport. J Pharm Sci 99:1955-1967.
9. Jemec GB, Agner T, Serup J. 1989. Transonychial water loss: Relation to sex, age, and nail-plate thickness. Br J Dermatol 121:443-446.
10. Gunt HB, Miller MA, Kasting GB. 2007. Water diffusivity in human nail plate. J Pharm Sci 96:3352-3362.
11. Malhotra GG, Zatz JL. 2000. Characterization of the physical factors affecting nail permeation using water as a probe. J Cosmet Sci 51:367-377.
12. Dutet J, Delgado-Charro MB. 2009. In vivo transungual iontophoresis: Effect of DC current application on ionic transport and on transonychial water loss. J Controlled Release 140:117-125.
13. Hao J, Smith KA, Li SK. 2009. Time-dependent electrical properties of human nail upon hydration in vivo. J Pharm Sci 99:107-118.
14. Prescribing information for Penalc (ciclopirox) topical solution, 8%. Dermik Laboratories and Sanofi-Aventis, 2006.
15. Package leaflet: information for the user of Curanail (amorolfine) 5% nail lacquer. Galderma, 2010.
16. Gunt HB, Kasting GB. 2006. Hydration effect on human nail permeability. J Cosmet Sci 57:183-184.
17. Gunt HB, Kasting GB. 2007. Equilibrium water sorption characteristics of the human nail. J Cosmet Sci 58:1-9.
18. Hao J, Smith KA, Li SK. 2008. Chemical method to enhance transungual transport and iontophoresis efficiency. Int J Pharm 357:61-69.
19. Smith KA, Hao J, Li SK. 2009. Effects of ionic strength on passive and iontophoretic transport of cationic permeant across human nail. Pharm Res 26:1446-1455.
20. Murthy SN, Wiskirchen DE, Bowers CP. 2007. Iontophoretic drug delivery across human nail. J Pharm Sci 96:305-311.
21. Schulz B, Chan D, Backstrom J, Rubhausen M, Wittern KP, Wessel S, Wepf R, Williams S. 2002. Hydration dynamics of human fingernails: An ellipsometric study. Phys Rev E Stat Nonlin Soft Matter Phys 65:061913.
22. Lorincz AL, Stoughton RB. 1958. Specific metabolic processes of skin. J Am Physiol Soc 38:481-502.
23. Atkins PW. 1986. Physical chemistry. New York City: Freeman and Company.
24. Martin A. 1993. Physical pharmacy-Physical chemical principles in the pharmaceutical sciences. Philadelphia: Lippincott Williams & Wilkins.
25. Deen WM. 1987. Hindered transport of large molecules in liquid-filled pores. AIChE J 33:1409-1425.
26. Zhu H, Peck KD, Li SK, Ghanem AH, Higuchi WI. 2001. Quantification of pore induction in human epidermal membrane during iontophoresis: The importance of background electrolyte selection. J Pharm Sci 90:932-942.
27. Khengar RH, Jones SA, Turner RB, Forbes B, Brown MB. 2007. Nail swelling as a preformulation screen for the selection and optimisation of ungual penetration enhancers. Pharm Res 24:2207-2212.
28. Murthy SN, Vaka SR, Sammeta SM, Nair AB. 2009. TranScreen-N: Method for rapid screening of transungual drug delivery enhancers. J Pharm Sci 98:4264-4271.